Oral leukoplakia

K11_ORAL_LEUCOPLACIA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

612

4. Check minimum number of events

None

612

5. Include endpoints

None

612

6. Filter based on genotype QC (FinnGen only)

612

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF6

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3606 1908 1678
Only index persons 3407 1821 1586
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.05
Only index persons 0.06 0.07 0.06
Median age at first event (years)
Whole population 58.48 60.03 56.73
Only index persons 58.24 59.79 56.47

-FinnGen-

Key figures

All Female Male
Number of individuals 612 328 284
Unadjusted period prevalence (%) 0.12 0.11 0.13
Median age at first event (years) 57.98 57.58 58.44

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
564
Matched controls
5639
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K13.20
ICD-10 Finland
Idiopathic leukoplakia
+∞
323.0
436
*
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
77.5
192.7
214
44
K13.21
ICD-10 Finland
Leukoplakia caused by tobacco
679.0
160.4
151
*
K13.29
ICD-10 Finland
Indefinite leukoplakia
126.4
128.8
135
14
EKA10
NOMESCO Finland
Biopsy of cheek
48.1
114.5
139
38
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
21.0
80.3
122
73
SAA03
NOMESCO Finland
Extended examination of mouth
4.7
64.6
337
1350
L43.8
ICD-10 Finland
Other lichen planus
21.9
52.7
78
41
ECA20
NOMESCO Finland
Biopsy of gingiva
38.5
51.4
65
19
K13.28
ICD-10 Finland
Other leukoplakia or disorder of epithelium of the palate or tongue
72.9
47.0
53
8
EJB10
NOMESCO Finland
Excision of lesion of apex or body of tongue
104.7
44.5
48
5
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
15.0
43.6
74
56
C02.11
ICD-10 Finland
Malignant neoplasm of border of tongue
66.9
43.0
49
8
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
9.0
42.2
94
123
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.6
42.2
276
1194
A07AA02
ATC
nystatin; oral
7.5
41.1
103
162
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
8.6
38.6
88
119
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
31.0
38.5
51
18
SXA10
NOMESCO Finland
Epithel biopsy of mouth
20.3
37.9
57
31
SBA00
NOMESCO Finland
Microbiological examinations
13.4
37.2
66
55
SAA04
NOMESCO Finland
Special inverstigation of mouth
7.8
37.1
90
134
WZB00
NOMESCO Finland
Telephone receipt or other advice
3.4
35.0
227
940
K13.78
ICD-10 Finland
Other change in the oral mucosa
13.5
30.7
54
44
L43.9
ICD-10 Finland
Lichen planus, unspecified
11.8
25.9
48
44
K13.22
ICD-10 Finland
Erythroplakia of oral epithelium, including tongue
94.4
24.9
27
*
SAA02
NOMESCO Finland
Basic examination of mouth
2.5
24.0
376
2486
C03.1
ICD-10 Finland
Malignant neoplasm: Lower gum
250.1
23.8
24
*
EHA10
NOMESCO Finland
Biopsy of palate
20.6
23.7
35
18
B37.08
ICD-10 Finland
Other candidal stomatitis
23.3
23.3
33
15
A01AB09
ATC
miconazole; local oral
4.0
22.4
97
278
TEA00
NOMESCO Finland
Biopsy of lip
21.1
21.9
32
16
GBB00
NOMESCO Finland
Tracheostomy
15.8
18.6
30
20
SAA01
NOMESCO Finland
Simple examination of mouth
2.2
17.5
398
2911
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
21.7
17.4
25
12
8070/3-C02.1
ICD-O-3
Squamous cell carcinoma, NOS, of border of tongue
43.5
17.4
21
5
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
17.4
252
1507
A01AC01
ATC
triamcinolone; local oral
10.2
16.4
32
33
K13.2
ICD-10 Finland
Leukoplakia and other disturbances of oral epithelium, including tongue
164.3
15.6
16
*
ZXC10
NOMESCO Finland
Use of laser
6.7
15.3
39
62
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.2
14.9
58
150
WX110
NOMESCO Finland
Local anesthesy
2.1
14.8
386
2875
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
19.0
14.8
22
12
SXC03
NOMESCO Finland
Other oral or dental procedure
11.3
14.6
27
25
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
3.0
14.4
91
345
EKB00
NOMESCO Finland
Excision of lesion of cheek
19.8
14.3
21
11
D20
ICPC
Mouth/tongue/lip symptom/complaint
5.0
14.3
46
98
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
14.9
14.2
23
16
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
9.4
13.9
28
31
C04.0
ICD-10 Finland
Malignant neoplasm: Anterior floor of mouth
+∞
13.6
13
*
C06.0
ICD-10 Finland
Malignant neoplasm: Cheek mucosa
143.3
13.5
14
*
EDB00
NOMESCO Finland
Partial excision of mandible
51.2
12.9
15
*
L43.3
ICD-10 Finland
Subacute (active) lichen planus
38.4
12.3
15
*
B37.03
ICD-10 Finland
Chronic atrophic candida infection in the mouth
38.4
12.3
15
*
K05.31
ICD-10 Finland
Periodontitis pronounced
2.9
12.2
77
288
L43.0
ICD-10 Finland
Hypertrophic lichen planus
18.5
12.1
18
10
EJB30
NOMESCO Finland
Excision of lesion of floor of mouth
47.7
11.9
14
*
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
12.1
11.9
21
18
EJB40
NOMESCO Finland
Hemiglossectomy
30.7
11.7
15
5
EJ2S1
NOMESCO Finland
Photography of oral mucosa
122.4
11.5
12
*
EJW99
NOMESCO Finland
Other operation on tongue or floor of mouth
122.4
11.5
12
*
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
3.5
11.2
53
163
J02AC01
ATC
fluconazole; systemic
1.9
11.2
223
1444
A01AB04
ATC
amphotericin B; local oral
3.5
10.7
50
152
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
1.9
10.7
201
1268
Z01.2
ICD-10 Finland
Dental examination
1.9
10.5
223
1468
8070/3-C02.9
ICD-O-3
Squamous cell carcinoma, NOS, of tongue, NOS
33.2
10.4
13
*
SXC05
NOMESCO Finland
Other oral or dental procedure
3.9
10.2
41
110
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.9
10.2
63
234
SBB10
NOMESCO Finland
Teeth copy
3.6
10.0
45
133
C02.10
ICD-10 Finland
Malignant neoplasm of tip of tongue
40.8
10.0
12
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
7.3
9.6
22
31
D07AC01
ATC
betamethasone; topical
1.8
9.5
202
1317
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
17.9
9.4
14
8
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
8.3
9.4
20
25
EBA00
NOMESCO Finland
Extraction of tooth
1.8
9.1
178
1127
K12.10
ICD-10 Finland
Stomatitis NOS
15.9
9.1
14
9
PJ5AQ
NOMESCO Finland
Sentinell lymphnode SPECT with low dose CT
24.5
8.9
12
5
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
8.9
267
1934
D07AD01
ATC
clobetasol; topical
2.1
8.9
105
547
K12.18
ICD-10 Finland
Other forms of stomatitis
14.3
8.7
14
10
EBA10
NOMESCO Finland
Surgical removal of tooth
2.6
8.6
64
265
B37.02
ICD-10 Finland
Chronic hyperplastic candidal stomatitis
28.0
8.5
11
*
8070/3-C03.1
ICD-O-3
Squamous cell carcinoma, NOS, of lower gum
91.4
8.4
9
*
8070/3-C04.9
ICD-O-3
Squamous cell carcinoma, NOS, of floor of mouth, NOS
+∞
8.4
8
*
K13.6
ICD-10 Finland
Irritative hyperplasia of oral mucosa
9.1
8.1
16
18
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.0
8.0
103
558
K08.2
ICD-10 Finland
Atrophy of edentulous alveolar ridge
8.6
7.9
16
19
SPF00
NOMESCO Finland
Repatation of teeth prosthesis
4.1
7.8
29
74
SPA02
NOMESCO Finland
Preparation for dental prosthetics
5.7
7.7
21
38
K05.30
ICD-10 Finland
Periodontitis complex
2.3
7.7
75
359
N07BA03
ATC
varenicline; oral
3.3
7.7
37
117
F17.20
ICD-10 Finland
Addiction relationship caused by tobacco addiction relationship currently independent
18.7
7.6
11
6
JDB10
NOMESCO Finland
Percutaneous gastrostomy
5.9
7.6
20
35
K02.1
ICD-10 Finland
Caries of dentine
1.6
7.6
280
2116
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
6.1
7.4
19
32
EJB99
NOMESCO Finland
Other excision on tongue and floor of mouth
81.1
7.4
8
*
8070/3-C06.0
ICD-O-3
Squamous cell carcinoma, NOS, of cheeck mucosa
81.1
7.4
8
*
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
11.1
7.3
13
12
JCW98
NOMESCO Finland
Other transluminal endoscopic procedure on oesophagus
+∞
7.3
7
*
EAA10
NOMESCO Finland
Excision of lesion of lip
6.4
7.3
18
29
B37.01
ICD-10 Finland
Acute athrophy candidal stomatitis
20.3
7.2
10
5
EBB15
NOMESCO Finland
Insertion of dental implant abutment
12.2
7.1
12
10
SDA04
NOMESCO Finland
Very demanding parodonthologic therapy
1.8
7.0
123
743
XQ802
NOMESCO Finland
Epicutan test
3.7
6.8
28
79
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.9
6.7
99
559
ECA30
NOMESCO Finland
Excision of lesion of gingiva
7.9
6.6
14
18
K14.61
ICD-10 Finland
Glossodynia
10.2
6.6
12
12
C02.2
ICD-10 Finland
Malignant neoplasm: Ventral surface of tongue
70.6
6.4
7
*
8070/3-C06.9
ICD-O-3
Squamous cell carcinoma, NOS, of mouth, NOS
70.6
6.4
7
*
B37.00
ICD-10 Finland
Acute pseudomembraneuous candidal stomatitis
14.5
6.4
10
7
D07AB02
ATC
hydrocortisone butyrate; topical
1.7
6.3
150
989
B37.09
ICD-10 Finland
Unspecified candidal stomatitis
7.1
6.2
14
20
J01CE02
ATC
phenoxymethylpenicillin; oral
1.6
6.2
351
2890
EBB10
NOMESCO Finland
Insertion of dental implant
7.8
6.1
13
17
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.6
6.1
280
2191

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
126
642
2.21
12.95
1.7
1.4
—
—
—
0
0
82
381
2.33
10.39
4.9
5.1
—
—
—
0
0
231
1617
1.69
8.54
2.4
2.1
181.1
220.5
u/l
0.33
220
1522
110
617
1.95
8.52
1.9
1.7
—
—
—
0
0
163
1047
1.76
8.17
1.7
1.7
1147.0
1224.2
nmol/l
0.47
127
782
12
17
7.18
8.02
5.9
1.9
—
—
—
0
0
307
2341
1.62
7.94
5.0
4.6
35.0
35.2
g/l
0.27
287
2189
386
3117
1.65
7.89
5.1
4.7
6.9
6.8
mmol/l
0.80
370
2921
520
4595
1.88
7.20
5.6
4.7
2.0
2.2
mu/l
0.46
475
4143
94
530
1.91
7.12
3.7
4.1
—
—
—
0
0
292
2248
1.57
6.94
6.9
9.2
1.3
1.2
inr
0.34
45
623
70
359
2.07
6.92
7.7
7.3
24.5
24.6
mmol/l
0.07
65
340
348
2804
1.56
6.65
6.1
6.4
11.1
11.5
umol/l
0.19
331
2664
266
2021
1.56
6.60
2.8
2.1
—
—
—
0
0
118
732
1.76
6.55
26.9
23.0
1.5
1.3
inr
0.63
16
92
310
2442
1.55
6.50
7.0
5.8
1.2
1.2
mmol/l
1.26
277
2208
222
1640
1.55
6.13
4.1
4.1
—
—
—
0
0
329
2648
1.52
6.11
8.0
6.6
1.2
1.2
mmol/l
1.63
290
2248
304
2407
1.52
6.09
4.7
4.1
—
—
—
0
0
178
1271
1.56
5.63
2.7
2.3
—
—
—
0
0
439
3794
1.56
5.61
5.3
4.2
14.1
13.1
mm/h
0.67
401
3478
101
636
1.70
5.27
6.6
7.0
1.7
1.2
mmol/l
0.74
73
508
271
2142
1.48
5.21
3.7
3.9
28.4
55.4
ng/l
1.05
210
1602
200
1492
1.51
5.10
4.5
4.3
—
—
—
0
0
101
642
1.69
5.08
6.5
6.9
5.1
5.1
kpa
0.11
96
616
101
642
1.69
5.08
6.5
6.9
11.8
12.0
kpa
0.16
96
618
82
492
1.77
5.07
2.2
2.6
5.7
6.5
ug/l
0.12
70
427
222
1694
1.49
5.06
6.2
5.6
—
—
—
0
0
276
2217
1.45
4.75
2.2
2.0
94.2
95.3
pmol/l
0.16
151
1111
122
830
1.59
4.68
3.6
3.4
0.8
0.8
mmol/l
0.17
115
772
120
1694
0.64
4.66
2.8
3.0
—
—
—
0
0
433
3794
1.48
4.63
4.6
3.9
15.2
14.9
pmol/l
1.10
390
3389
104
683
1.63
4.60
6.3
5.1
1.0
1.0
mmol/l
0.14
96
626
60
337
1.87
4.60
2.9
2.9
5.0
4.1
e9/l
0.85
46
255
305
2516
1.42
4.44
6.3
5.6
0.0
0.0
e9/l
1.41
273
2169
455
4044
1.49
4.38
8.5
7.7
80.6
78.9
u/l
0.35
431
3774
393
3411
1.43
4.18
5.4
4.6
1452.8
2899.8
e6/l
—
6
56
153
1130
1.47
3.97
4.9
4.1
1.0
1.0
kg/l
0.30
22
161
538
4993
1.64
3.91
20.0
15.3
25.2
24.5
mg/l
0.17
464
4016
309
2594
1.39
3.87
6.6
5.8
0.2
0.2
e9/l
0.39
277
2283
400
3510
1.40
3.81
5.1
4.5
—
—
—
0
0
70
436
1.68
3.80
2.9
3.0
212.6
214.5
ng/l
0.02
65
396
299
2505
1.38
3.75
6.4
5.6
0.6
0.6
e9/l
0.60
268
2151
304
2556
1.38
3.72
6.4
5.6
1.8
2.0
e9/l
0.67
274
2244
345
2962
1.38
3.70
8.5
9.1
4.5
4.1
e9/l
1.43
310
2605
212
1687
1.39
3.60
2.8
2.5
58.4
56.2
u/l
0.17
205
1561
210
1671
1.39
3.56
2.8
2.4
—
—
—
0
0
169
1299
1.42
3.49
2.2
2.1
2.9
3.2
mg/l
0.55
142
1114
559
5278
1.68
3.30
22.9
17.8
139.1
139.7
mmol/l
4.36
546
5143
224
1820
1.36
3.29
2.8
3.4
2.4
2.4
mmol/l
0.77
190
1583
70
459
1.59
3.13
1.6
1.4
—
—
—
0
0
48
285
1.74
3.12
8.2
9.1
—
—
—
0
0
70
464
1.57
3.00
4.0
3.3
—
—
—
0
0
137
1041
1.41
2.99
1.2
1.2
1.2
1.4
u/ml
0.21
40
281
124
927
1.42
2.96
1.3
1.4
2.5
2.6
g/l
0.26
75
545
279
2375
1.32
2.91
6.5
5.6
58.9
57.5
%
1.17
259
2214
558
5293
1.61
2.89
22.9
17.8
4.0
4.0
mmol/l
1.46
544
5154
135
1031
1.40
2.85
4.9
3.9
1741.9
330.3
ng/l
0.48
108
832
56
358
1.62
2.79
1.1
1.2
—
—
—
0
0
28
146
1.96
2.74
3.5
3.3
—
—
—
0
0
277
2372
1.31
2.71
7.4
6.0
8.5
8.8
%
0.85
258
2213
109
809
1.42
2.70
2.2
2.0
—
—
—
0
0
548
5190
1.53
2.70
19.7
14.5
—
—
—
0
0
61
402
1.57
2.69
1.5
1.4
—
—
—
0
0
9
24
3.79
2.68
2.1
1.9
—
—
—
0
0
275
2360
1.30
2.62
6.8
5.7
2.7
2.9
%
0.54
258
2191
98
719
1.43
2.59
2.4
2.3
20.1
22.2
%
0.94
74
619
280
2412
1.30
2.58
7.1
5.9
25.8
27.3
%
1.35
260
2235
45
279
1.66
2.54
2.4
2.5
—
—
—
0
0
509
4781
1.38
2.36
6.7
6.2
41.5
40.5
mmol/mol
0.54
467
4400
238
2027
1.28
2.34
2.9
2.7
138.3
138.3
ug/l
0.00
215
1842
197
1641
1.30
2.29
3.7
3.2
—
—
—
0
0
82
596
1.43
2.29
3.1
4.1
99.2
29.2
ug/l
0.37
69
495
265
2297
1.27
2.24
6.9
5.7
0.7
0.7
%
0.69
247
2136
24
422
0.55
2.20
2.9
3.9
—
—
—
0
0
65
457
1.47
2.16
2.0
2.8
71.2
71.0
e9/l
0.02
54
357
6
14
4.32
2.15
2.2
2.4
—
—
—
0
0
8
25
3.23
2.10
10.6
11.9
—
—
—
0
0
41
265
1.59
2.01
3.8
3.4
—
—
—
0
0
507
4797
1.33
1.93
4.6
4.2
1.3
1.3
mmol/l
0.00
455
4333
12
52
2.33
1.88
3.7
2.6
73.3
59.3
%
—
7
38
12
52
2.33
1.88
3.3
3.3
—
—
—
0
0
523
4977
1.35
1.87
5.2
4.9
6.0
6.0
mmol/l
0.02
480
4494
5
12
4.19
1.82
1.4
1.8
—
—
—
0
0
571
5520
1.51
1.81
29.3
22.4
30.6
30.4
pg
2.33
559
5432
571
5520
1.51
1.81
29.4
22.5
249.3
245.9
e9/l
0.53
555
5376
59
423
1.44
1.80
4.1
3.5
74.2
81.2
ng/l
0.49
49
379
571
5521
1.51
1.80
29.5
22.5
6.9
6.8
e9/l
1.15
555
5357
571
5521
1.51
1.80
29.5
22.5
4.4
4.5
e12/l
4.01
555
5357
571
5521
1.51
1.80
29.3
22.4
92.0
91.5
fl
2.38
559
5433
571
5522
1.51
1.79
29.6
22.6
133.2
134.9
g/l
1.98
561
5432
191
2211
0.80
1.76
9.2
9.9
0.0
0.0
e9/l
0.34
157
1815
23
132
1.77
1.76
2.3
2.5
1.6
1.6
mg/l
0.01
23
122
380
4093
0.81
1.72
22.3
18.8
13.9
13.8
%
0.82
372
4014
535
5125
1.35
1.68
5.7
5.3
2.6
2.7
mmol/l
2.54
494
4659
79
605
1.35
1.66
2.2
2.6
1.9
1.8
%
0.07
71
549
25
150
1.70
1.66
1.2
1.2
—
—
—
0
0
13
63
2.09
1.60
4.8
3.4
—
—
—
0
0
29
443
0.64
1.59
3.8
3.7
1.2
1.2
mmol/l
0.26
24
393
556
5367
1.39
1.58
12.9
11.0
25.1
25.9
u/l
0.81
533
5161
34
224
1.55
1.58
6.8
4.6
—
—
—
0
0
75
576
1.34
1.55
2.0
2.2
183.1
142.4
ug/g
0.26
65
452
161
1366
1.24
1.55
2.6
2.6
2289.6
7154.4
umol/l
1.33
137
1161
14
71
1.99
1.55
1.6
2.0
0.6
1.1
g/l
—
9
57
6
22
2.74
1.43
4.2
15.2
576.1
937.8
nmol/l
—
6
22
194
1694
1.21
1.41
2.6
3.1
1245.4
1325.5
ng/l
0.15
166
1461
9
41
2.21
1.37
3.7
1.7
8.3
11.6
%
—
9
41
10
47
2.15
1.34
1.2
1.4
—
—
—
0
0
20
121
1.67
1.32
2.5
3.1
0.8
0.9
nmol/l
1.02
13
100
28
185
1.54
1.31
3.8
3.8
32.0
32.1
mg/l
0.00
23
148
12
62
1.95
1.28
1.2
1.2
—
—
—
0
0
520
5003
1.26
1.26
5.2
4.7
4.5
4.6
mmol/l
1.05
475
4584
191
1683
1.20
1.25
3.6
3.1
6.6
7.3
mmol/l
2.00
163
1395
32
221
1.47
1.24
1.2
1.3
—
—
—
0
0
34
238
1.45
1.23
2.0
2.1
0.8
2.7
ug/l
0.89
28
215
516
4964
1.25
1.23
5.2
4.6
1.5
1.5
mmol/l
0.24
474
4510
5
19
2.64
1.22
1.2
1.5
134.6
140.7
nmol/l
—
5
19
552
5357
1.31
1.19
22.8
18.2
77.5
78.6
umol/l
0.33
552
5357
12
64
1.89
1.18
4.5
1.2
—
—
—
0
0
195
1729
1.19
1.18
4.0
4.0
3.0
8.4
mg/mmol
5.05
115
1085
11
57
1.95
1.17
1.1
1.2
—
—
—
0
0
5
20
2.51
1.15
5.6
3.6
—
—
—
0
0
5
113
0.44
1.13
1.2
1.2
18.8
21.7
e6/l
—
5
85
5
113
0.44
1.13
1.2
1.2
10.8
1123.0
e6/l
—
5
88
20
127
1.59
1.12
2.0
1.7
—
—
—
0
0
11
58
1.91
1.12
1.1
1.3
—
—
nmol/l
—
0
0
14
232
0.59
1.12
1.4
1.4
—
—
—
0
0
75
606
1.27
1.12
1.4
1.3
—
—
—
0
0
47
356
1.35
1.11
4.0
3.4
—
7.4
—
0
42
87
1046
0.80
1.10
2.7
3.0
0.6
0.7
ug/l
0.81
49
688
151
1317
1.19
1.10
1.7
1.5
19.2
20.6
nmol/l
0.63
132
1103
52
401
1.32
1.09
2.8
2.8
11.7
10.6
g/l
0.67
47
369
184
1635
1.18
1.08
3.6
3.2
390.2
287.8
mg/l
0.10
112
1046
10
52
1.94
1.06
9.1
1.3
—
—
—
0
0
12
67
1.81
1.05
1.2
1.3
0.6
0.6
nmol/l
0.08
12
60
73
593
1.26
1.05
2.4
2.7
10.7
8.0
umol/l
0.34
65
531
44
335
1.34
1.02
2.8
2.9
—
—
—
0
0
47
362
1.32
1.01
4.0
3.4
5.2
5.1
kpa
0.17
41
339
7
35
2.01
1.00
3.6
3.5
—
—
—
0
0
7
131
0.53
1.00
1.1
1.2
444.7
521.6
mg/l
—
7
123
136
1186
1.19
0.99
4.4
3.8
—
—
—
0
0
0
30
0.00
0.97
0.0
1.3
—
70.6
—
0
8
6
116
0.51
0.95
1.2
1.2
3.4
3.8
mmol/l
—
6
109
7
37
1.90
0.94
2.4
1.6
—
—
—
0
0
6
27
2.23
0.93
1.2
1.1
—
4.8
—
0
9
79
658
1.23
0.93
1.4
1.3
609.2
489.7
titre
0.24
13
149
37
280
1.34
0.91
1.1
1.2
226.8
133.2
iu/ml
0.69
14
112
8
42
1.92
0.89
6.0
1.1
—
—
—
0
0
145
1285
1.17
0.88
7.2
6.7
—
—
—
0
0
6
30
2.01
0.87
1.2
1.0
—
1.0
—
0
12
11
64
1.73
0.86
1.4
1.1
—
—
—
0
0
12
72
1.68
0.85
1.2
1.6
—
—
—
0
0
12
72
1.68
0.85
1.2
1.6
—
—
—
0
0
12
72
1.68
0.85
1.2
1.6
—
—
—
0
0
12
72
1.68
0.85
1.2
1.6
—
—
—
0
0
27
196
1.39
0.85
2.3
1.5
—
—
—
0
0
8
45
1.79
0.84
1.5
1.3
—
—
—
0
0
24
171
1.42
0.84
1.8
1.5
—
—
—
0
0
6
32
1.88
0.82
3.0
1.2
8.7
6.4
ug/l
—
6
27
8
47
1.71
0.81
1.3
1.2
—
—
—
0
0
0
24
0.00
0.79
0.0
1.3
—
65.8
—
0
16
85
727
1.20
0.78
1.2
1.2
—
—
—
0
0
0
26
0.00
0.78
0.0
1.3
—
—
—
0
0
5
98
0.51
0.78
1.0
1.2
—
—
—
0
0
0
27
0.00
0.77
0.0
2.3
—
—
—
0
0
0
28
0.00
0.76
0.0
1.3
—
—
—
0
0
120
1351
0.86
0.76
3.9
3.6
—
—
—
0
0
13
83
1.58
0.75
4.2
1.2
—
—
—
0
0
17
116
1.48
0.75
1.8
1.2
—
—
—
0
0
5
24
2.09
0.74
5.6
3.2
—
—
—
0
0
6
107
0.56
0.73
2.7
3.3
—
—
—
0
0
10
60
1.68
0.72
1.4
1.2
—
—
—
0
0
5
26
1.93
0.70
2.6
1.4
6.2
5.8
umol/l
—
5
14
20
144
1.40
0.68
2.3
1.6
14444.6
18477.6
e6/l
0.25
14
108
20
144
1.40
0.68
1.1
1.1
—
—
—
0
0
7
42
1.67
0.68
1.0
1.2
—
—
—
0
0
93
814
1.17
0.67
1.3
1.3
15.6
12.8
u/ml
0.11
32
314
75
645
1.19
0.67
1.3
1.3
—
—
—
0
0
13
87
1.50
0.63
4.2
1.2
—
—
—
0
0
6
101
0.59
0.62
2.8
2.6
—
—
—
0
0
124
1116
1.14
0.62
1.6
1.6
1.4
1.3
mg/l
0.13
95
872
19
139
1.38
0.61
5.1
4.2
—
—
—
0
0
13
88
1.49
0.61
4.3
1.2
—
—
—
0
0
13
88
1.49
0.61
4.4
1.2
—
—
—
0
0
11
163
0.67
0.60
3.4
5.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.4
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
1.2
—
0
16
48
401
1.21
0.59
3.4
2.5
—
—
—
0
0
22
166
1.34
0.59
1.3
1.4
238.2
284.8
ug/g
0.75
13
99
171
1849
0.90
0.58
3.8
3.8
23.3
138.5
e6/l
2.31
133
1340
16
115
1.40
0.57
2.0
2.1
117.9
127.2
g/l
0.87
11
85
14
98
1.44
0.57
4.0
2.4
50.4
63.9
%
1.20
14
98
15
107
1.41
0.56
2.8
3.7
44.9
437.8
u/ml
1.04
15
102
34
277
1.24
0.54
1.3
1.3
—
—
—
0
0
9
62
1.46
0.53
2.9
2.8
—
—
—
0
0
6
39
1.54
0.53
1.2
1.2
—
—
—
0
0
6
39
1.54
0.53
1.2
1.1
—
0.4
—
0
9
137
1255
1.12
0.53
1.3
1.3
—
—
—
0
0
6
96
0.62
0.52
1.5
1.5
—
—
—
0
0
6
41
1.47
0.50
2.3
2.4
—
—
—
0
0
6
41
1.47
0.50
2.7
2.2
4.0
2.1
ug/l
—
6
35
34
410
0.82
0.50
3.6
4.1
1.1
0.4
%
0.94
11
108
59
515
1.16
0.47
4.4
3.5
5.9
5.8
kpa
0.28
59
499
7
49
1.43
0.46
1.3
1.2
—
—
—
0
0
126
1159
1.11
0.46
1.7
1.7
458.7
437.0
pmol/l
0.35
101
946
58
509
1.15
0.44
4.4
3.5
1.6
2.1
mmol/l
0.41
51
410
94
853
1.12
0.44
1.4
1.3
69.5
37.4
iu/ml
0.57
23
278
11
78
1.42
0.43
1.4
1.1
—
—
—
0
0
5
31
1.62
0.43
1.2
1.0
—
—
—
0
0
16
122
1.32
0.42
4.4
2.9
—
—
—
0
0
12
87
1.39
0.42
2.6
1.2
—
—
—
0
0
6
94
0.63
0.42
1.3
2.4
—
—
—
0
0
5
32
1.57
0.42
1.0
1.3
1.1
1.1
promille
—
5
25
0
15
0.00
0.41
0.0
1.1
—
0.8
—
0
6
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
130
1398
0.91
0.40
3.5
3.2
—
—
—
0
0
5
34
1.47
0.40
1.0
1.1
—
—
—
0
0
8
60
1.34
0.40
1.5
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
10.8
—
0
9
8
61
1.32
0.39
1.5
1.1
—
—
—
0
0
34
397
0.85
0.38
3.8
4.3
0.2
0.1
%
0.38
12
112
118
1094
1.10
0.38
2.8
2.6
5.0
5.0
e6/l
0.02
106
970
15
116
1.30
0.37
4.1
3.7
19.6
28.9
mg/l
—
9
72
5
37
1.35
0.37
1.0
1.1
—
—
—
0
0
37
427
0.86
0.36
3.7
4.2
0.3
0.2
%
0.41
17
135
5
79
0.63
0.35
3.2
2.8
—
—
—
0
0
5
80
0.62
0.35
2.0
2.8
—
—
—
0
0
13
167
0.77
0.35
27.0
10.9
—
—
—
0
0
6
45
1.34
0.34
1.0
1.1
1.4
1.6
nmol/l
—
6
40
20
164
1.23
0.33
3.5
1.3
1.2
1.2
g/l
0.05
20
159
56
503
1.12
0.33
1.6
1.5
—
—
—
0
0
10
74
1.36
0.32
1.1
1.1
—
—
—
0
0
25
293
0.85
0.30
1.2
1.4
—
—
—
0
0
151
1592
0.93
0.30
3.5
3.3
33.5
108.4
e6/l
1.09
125
1240
168
1598
1.07
0.30
5.5
4.0
7.4
7.4
ph
0.83
17
303
25
213
1.18
0.29
1.9
1.9
—
—
—
0
0
8
110
0.72
0.29
1.0
1.2
—
—
—
0
0
54
491
1.11
0.27
1.7
1.5
—
—
—
0
0
31
352
0.87
0.26
1.4
1.4
—
—
—
0
0
29
253
1.15
0.26
3.7
3.4
64.9
69.6
u/ml
0.03
29
244
134
1410
0.94
0.26
1.9
1.6
1.4
1.4
mmol/l
0.13
122
1170
35
313
1.13
0.23
1.1
1.3
—
—
—
0
0
110
1041
1.07
0.23
2.6
3.0
2.5
2.5
mmol/l
0.03
93
920
451
4443
1.06
0.23
20.7
16.3
38.1
39.6
%
1.73
263
3013
139
1454
0.94
0.22
3.5
3.2
0.5
0.5
e6/l
0.14
114
1102
376
3688
1.05
0.22
4.1
4.1
—
—
—
0
0
51
469
1.10
0.22
2.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
3.6
—
0
5
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
14
117
1.20
0.20
1.7
2.2
—
—
—
0
0
175
1813
0.95
0.20
4.6
4.9
1.7
2.6
ug/l
2.05
156
1614
6
49
1.23
0.20
1.7
1.3
—
—
—
0
0
15
128
1.18
0.18
1.5
1.9
37.9
41.5
nmol/l
0.31
15
123
47
435
1.09
0.18
3.6
2.7
4.6
4.4
kpa
0.31
47
419
7
58
1.21
0.18
1.9
1.3
—
—
—
0
0
43
464
0.92
0.17
1.9
1.5
—
—
—
0
0
8
69
1.16
0.16
1.8
1.2
—
—
—
0
0
26
287
0.90
0.16
2.5
4.0
—
—
—
0
0
8
73
1.10
0.15
1.0
1.0
—
—
—
0
0
6
80
0.75
0.15
2.8
2.8
—
—
—
0
0
109
1050
1.05
0.14
2.9
2.9
570.3
556.1
mosm/kgh2o
0.25
94
893
11
94
1.17
0.13
1.6
1.6
—
—
—
0
0
11
94
1.17
0.13
1.6
2.1
185.8
221.3
pmol/l
1.08
11
87
415
4105
1.03
0.13
27.7
20.1
332.5
332.1
g/l
0.49
410
4080
43
456
0.94
0.12
4.0
4.1
0.7
0.9
%
0.52
18
151
45
427
1.06
0.10
8.9
7.5
—
—
—
0
0
6
56
1.07
0.08
4.0
2.9
—
—
—
0
0
5
64
0.78
0.08
4.2
3.1
4.6
5.7
nmol/l
—
5
64
59
569
1.04
0.08
2.0
1.6
—
—
—
0
0
6
75
0.80
0.07
2.0
1.4
32.0
30.9
g/l
—
6
66
104
1064
0.97
0.07
5.2
4.8
—
—
—
0
0
32
304
1.06
0.07
1.2
1.4
—
—
—
0
0
9
84
1.07
0.07
1.0
1.1
—
—
—
0
0
9
88
1.02
0.07
1.2
1.2
—
—
—
0
0
14
129
1.09
0.05
1.1
1.2
—
2.8
—
0
18
256
2539
1.01
0.04
4.2
3.8
0.0
0.0
estimate
0.50
22
450
10
109
0.92
0.04
1.2
1.2
—
—
—
0
0
21
200
1.05
0.04
1.7
3.0
0.3
0.2
g/l
—
5
79
136
1375
0.99
0.03
4.8
4.1
0.0
0.0
estimate
0.00
21
449
16
151
1.06
0.03
1.8
2.4
56.4
91.3
ug/min
—
7
90
14
132
1.06
0.02
1.2
1.3
—
—
—
0
0
27
279
0.97
0.02
4.6
3.2
25.4
25.1
mmol/l
0.14
27
271
18
173
1.04
0.01
1.9
1.7
—
—
—
0
0
18
187
0.96
0.01
1.2
1.1
—
—
—
0
0
10
106
0.94
0.01
1.4
1.5
—
—
—
0
0
22
226
0.97
0.00
2.3
2.9
—
—
—
0
0
11
105
1.05
0.00
1.9
1.7
—
—
—
0
0
10
96
1.04
0.00
1.9
1.5
—
—
—
0
0
14
144
0.97
0.00
1.0
1.1
—
—
—
0
0
15
148
1.01
0.00
1.2
1.2
—
741.7
—
0
6
250
2505
1.00
0.00
5.6
5.2
0.0
0.0
estimate
0.00
25
458
5
50
1.00
0.00
1.6
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
5.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
8
85
0.94
0.00
3.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
5
55
0.91
0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
7.9
—
0
7
6
66
0.91
0.00
1.5
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
19.2
—
0
6
0
7
0.00
0.00
0.0
1.1
—
1.9
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
7
77
0.91
0.00
1.7
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
250
2500
1.00
0.00
4.2
3.8
0.0
0.0
estimate
0.00
20
464
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint K11_ORAL_LEUCOPLACIA and mortality.

Females

Parameter HR [95% CI] p-value
K11_ORAL_LEUCOPLACIA 1.137 [1.0, 1.3] 0.059
Birth year 0.996 [0.99, 1.01] 0.414

During the follow-up period (1.1.1998 — 31.12.2019), 393 out of 1808 females with K11_ORAL_LEUCOPLACIA died.

Males

Parameter HR [95% CI] p-value
K11_ORAL_LEUCOPLACIA 1.285 [1.12, 1.48] < 0.001
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 392 out of 1574 males with K11_ORAL_LEUCOPLACIA died.

Mortality risk

Mortality risk for people of age

years, who have K11_ORAL_LEUCOPLACIA.

N-year risk Females Males
1 0.131% 0.218%
5 0.745% 1.537%
10 1.697% 3.884%
15 3.304% 7.288%
20 5.854% 12.14%

Relationships between endpoints

Index endpoint: K11_ORAL_LEUCOPLACIA – Oral leukoplakia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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