Risteys · K11_ORAL

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — K13.20, K13.21 Cause of death: ICD-10 — K13.20, K13.21 2 out of 7 registries used, show all original rules.	612
4. Check minimum number of events None	612
5. Include endpoints None	612
6. Filter based on genotype QC (FinnGen only)	612

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	3606	1908	1678
Only index persons	3407	1821	1586
Unadjusted period prevalence (%)
Whole population	0.05	0.05	0.05
Only index persons	0.06	0.07	0.06
Median age at first event (years)
Whole population	58.48	60.03	56.73
Only index persons	58.24	59.79	56.47

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	612	328	284
Unadjusted period prevalence (%)	0.12	0.11	0.13
Median age at first event (years)	57.98	57.58	58.44

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
564: Matched controls
5639

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

K13.20

ICD-10 Finland

Idiopathic leukoplakia

+∞

323.0

436

EJA10

NOMESCO Finland

Biopsy of tongue or floor of mouth

77.5

192.7

214

K13.21

ICD-10 Finland

Leukoplakia caused by tobacco

679.0

160.4

151

K13.29

ICD-10 Finland

Indefinite leukoplakia

126.4

128.8

135

EKA10

NOMESCO Finland

Biopsy of cheek

48.1

114.5

139

SBB00

NOMESCO Finland

Fotograf of mouth and teeth

21.0

80.3

122

SAA03

NOMESCO Finland

Extended examination of mouth

4.7

64.6

337

1350

L43.8

ICD-10 Finland

Other lichen planus

21.9

52.7

ECA20

NOMESCO Finland

Biopsy of gingiva

38.5

51.4

K13.28

ICD-10 Finland

Other leukoplakia or disorder of epithelium of the palate or tongue

72.9

47.0

EJB10

NOMESCO Finland

Excision of lesion of apex or body of tongue

104.7

44.5

K13.79

ICD-10 Finland

Change in the oral mucosa UNS

15.0

43.6

C02.11

ICD-10 Finland

Malignant neoplasm of border of tongue

66.9

43.0

WZC05

NOMESCO Finland

Specialty-specific consultation based on referral by dentist or doctor

9.0

42.2

123

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

3.6

42.2

276

1194

A07AA02

ATC

nystatin; oral

7.5

41.1

103

162

WZC10

NOMESCO Finland

Extensive specialist consultion with written report

8.6

38.6

119

K13.74

ICD-10 Finland

Lichen rubs planus in the mouth

31.0

38.5

SXA10

NOMESCO Finland

Epithel biopsy of mouth

20.3

37.9

SBA00

NOMESCO Finland

Microbiological examinations

13.4

37.2

SAA04

NOMESCO Finland

Special inverstigation of mouth

7.8

37.1

134

WZB00

NOMESCO Finland

Telephone receipt or other advice

3.4

35.0

227

940

K13.78

ICD-10 Finland

Other change in the oral mucosa

13.5

30.7

L43.9

ICD-10 Finland

Lichen planus, unspecified

11.8

25.9

K13.22

ICD-10 Finland

Erythroplakia of oral epithelium, including tongue

94.4

24.9

SAA02

NOMESCO Finland

Basic examination of mouth

2.5

24.0

376

2486

C03.1

ICD-10 Finland

Malignant neoplasm: Lower gum

250.1

23.8

EHA10

NOMESCO Finland

Biopsy of palate

20.6

23.7

B37.08

ICD-10 Finland

Other candidal stomatitis

23.3

A01AB09

ATC

miconazole; local oral

4.0

22.4

278

TEA00

NOMESCO Finland

Biopsy of lip

21.1

21.9

GBB00

NOMESCO Finland

Tracheostomy

15.8

18.6

SAA01

NOMESCO Finland

Simple examination of mouth

2.2

17.5

398

2911

PJD81

NOMESCO Finland

Excision of lymph nodes from upper part of neck

21.7

17.4

8070/3-C02.1

ICD-O-3

Squamous cell carcinoma, NOS, of border of tongue

43.5

17.4

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

2.2

17.4

252

1507

A01AC01

ATC

triamcinolone; local oral

10.2

16.4

K13.2

ICD-10 Finland

Leukoplakia and other disturbances of oral epithelium, including tongue

164.3

15.6

ZXC10

NOMESCO Finland

Use of laser

6.7

15.3

EP1AE

NOMESCO Finland

Neck ultrasound examination

4.2

14.9

150

WX110

NOMESCO Finland

Local anesthesy

2.1

14.8

386

2875

ZZQ00

NOMESCO Finland

Free microvascular graft of skin

19.0

14.8

SXC03

NOMESCO Finland

Other oral or dental procedure

11.3

14.6

K08.1

ICD-10 Finland

Loss of teeth due to accident, extraction or local periodontal disease

3.0

14.4

345

EKB00

NOMESCO Finland

Excision of lesion of cheek

19.8

14.3

D20

ICPC

Mouth/tongue/lip symptom/complaint

5.0

14.3

GDA98

NOMESCO Finland

Other bronchoscopic incision, excision of lesion or repair of lung

14.9

14.2

EN1BD

NOMESCO Finland

Very extensive CT examination of mouth and soft tissues of neck

9.4

13.9

C04.0

ICD-10 Finland

Malignant neoplasm: Anterior floor of mouth

+∞

13.6

C06.0

ICD-10 Finland

Malignant neoplasm: Cheek mucosa

143.3

13.5

EDB00

NOMESCO Finland

Partial excision of mandible

51.2

12.9

L43.3

ICD-10 Finland

Subacute (active) lichen planus

38.4

12.3

B37.03

ICD-10 Finland

Chronic atrophic candida infection in the mouth

38.4

12.3

K05.31

ICD-10 Finland

Periodontitis pronounced

2.9

12.2

288

L43.0

ICD-10 Finland

Hypertrophic lichen planus

18.5

12.1

EJB30

NOMESCO Finland

Excision of lesion of floor of mouth

47.7

11.9

PJD71

NOMESCO Finland

Extended sparing excision of cervical lymph nodes

12.1

11.9

EJB40

NOMESCO Finland

Hemiglossectomy

30.7

11.7

EJW99

NOMESCO Finland

Other operation on tongue or floor of mouth

122.4

11.5

EJ2S1

NOMESCO Finland

Photography of oral mucosa

122.4

11.5

SXB00

NOMESCO Finland

Removeal of sutres from oral mucosa

3.5

11.2

163

J02AC01

ATC

fluconazole; systemic

1.9

11.2

223

1444

A01AB04

ATC

amphotericin B; local oral

3.5

10.7

152

SDA03

NOMESCO Finland

Demanding parodonthologic therapy

1.9

10.7

201

1268

Z01.2

ICD-10 Finland

Dental examination

1.9

10.5

223

1468

8070/3-C02.9

ICD-O-3

Squamous cell carcinoma, NOS, of tongue, NOS

33.2

10.4

SXC05

NOMESCO Finland

Other oral or dental procedure

3.9

10.2

110

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

2.9

10.2

234

SBB10

NOMESCO Finland

Teeth copy

3.6

10.0

133

C02.10

ICD-10 Finland

Malignant neoplasm of tip of tongue

40.8

10.0

504

Kela drug reimbursment

Conditions requiring daily forced enteral nutrition

7.3

9.6

D07AC01

ATC

betamethasone; topical

1.8

9.5

202

1317

EB1CI

NOMESCO Finland

Cone beam imaging of teeth and jaws (3-4 quarters)

17.9

9.4

EP1CG

NOMESCO Finland

Extensive MRI examination of soft tissue of neck with high intesity magnet

8.3

9.4

EBA00

NOMESCO Finland

Extraction of tooth

1.8

9.1

178

1127

K12.10

ICD-10 Finland

Stomatitis NOS

15.9

9.1

PJ5AQ

NOMESCO Finland

Sentinell lymphnode SPECT with low dose CT

24.5

8.9

GD1AA

NOMESCO Finland

Thorax X-ray examination

1.7

8.9

267

1934

D07AD01

ATC

clobetasol; topical

2.1

8.9

105

547

K12.18

ICD-10 Finland

Other forms of stomatitis

14.3

8.7

EBA10

NOMESCO Finland

Surgical removal of tooth

2.6

8.6

265

B37.02

ICD-10 Finland

Chronic hyperplastic candidal stomatitis

28.0

8.5

8070/3-C03.1

ICD-O-3

Squamous cell carcinoma, NOS, of lower gum

91.4

8.4

8070/3-C04.9

ICD-O-3

Squamous cell carcinoma, NOS, of floor of mouth, NOS

+∞

8.4

K13.6

ICD-10 Finland

Irritative hyperplasia of oral mucosa

9.1

8.1

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

2.0

8.0

103

558

K08.2

ICD-10 Finland

Atrophy of edentulous alveolar ridge

8.6

7.9

SPF00

NOMESCO Finland

Repatation of teeth prosthesis

4.1

7.8

SPA02

NOMESCO Finland

Preparation for dental prosthetics

5.7

7.7

K05.30

ICD-10 Finland

Periodontitis complex

2.3

7.7

359

N07BA03

ATC

varenicline; oral

3.3

7.7

117

F17.20

ICD-10 Finland

Addiction relationship caused by tobacco addiction relationship currently independent

18.7

7.6

JDB10

NOMESCO Finland

Percutaneous gastrostomy

5.9

7.6

K02.1

ICD-10 Finland

Caries of dentine

1.6

7.6

280

2116

EB1AI

NOMESCO Finland

Cone beam imaging of teeth and jaws (one quarter)

6.1

7.4

EJB99

NOMESCO Finland

Other excision on tongue and floor of mouth

81.1

7.4

8070/3-C06.0

ICD-O-3

Squamous cell carcinoma, NOS, of cheeck mucosa

81.1

7.4

EN1AD

NOMESCO Finland

CT examination of mouth and soft tissues of neck

11.1

7.3

JCW98

NOMESCO Finland

Other transluminal endoscopic procedure on oesophagus

+∞

7.3

EAA10

NOMESCO Finland

Excision of lesion of lip

6.4

7.3

B37.01

ICD-10 Finland

Acute athrophy candidal stomatitis

20.3

7.2

EBB15

NOMESCO Finland

Insertion of dental implant abutment

12.2

7.1

SDA04

NOMESCO Finland

Very demanding parodonthologic therapy

1.8

7.0

123

743

XQ802

NOMESCO Finland

Epicutan test

3.7

6.8

L30.9

ICD-10 Finland

Dermatitis, unspecified

1.9

6.7

559

ECA30

NOMESCO Finland

Excision of lesion of gingiva

7.9

6.6

K14.61

ICD-10 Finland

Glossodynia

10.2

6.6

ZY020

NOMESCO Finland

Telephone, letter or other consultation without direct patient contact

2.6

6.5

198

C02.2

ICD-10 Finland

Malignant neoplasm: Ventral surface of tongue

70.6

6.4

8070/3-C06.9

ICD-O-3

Squamous cell carcinoma, NOS, of mouth, NOS

70.6

6.4

B37.00

ICD-10 Finland

Acute pseudomembraneuous candidal stomatitis

14.5

6.4

D07AB02

ATC

hydrocortisone butyrate; topical

1.7

6.3

150

989

B37.09

ICD-10 Finland

Unspecified candidal stomatitis

7.1

6.2

J01CE02

ATC

phenoxymethylpenicillin; oral

1.6

6.2

351

2890

EBB10

NOMESCO Finland

Insertion of dental implant

7.8

6.1

EB1AA

NOMESCO Finland

Tooth X-ray examination

1.6

6.1

280

2191

Mortality – FinRegistry

↥

Association

Association between endpoint K11_ORAL_LEUCOPLACIA and mortality.

Females

Parameter	HR [95% CI]	p-value
K11_ORAL_LEUCOPLACIA	1.137 [1.0, 1.3]	0.059
Birth year	0.996 [0.99, 1.01]	0.414

During the follow-up period (1.1.1998 — 31.12.2019), 393 out of 1808 females with K11_ORAL_LEUCOPLACIA died.

Males

Parameter	HR [95% CI]	p-value
K11_ORAL_LEUCOPLACIA	1.285 [1.12, 1.48]	< 0.001
Birth year	0.987 [0.98, 1.0]	0.008

During the follow-up period (1.1.1998 — 31.12.2019), 392 out of 1574 males with K11_ORAL_LEUCOPLACIA died.

Mortality risk

Mortality risk for people of age

years, who have K11_ORAL_LEUCOPLACIA.

N-year risk	Females	Males
1	0.131%	0.218%
5	0.745%	1.537%
10	1.697%	3.884%
15	3.304%	7.288%
20	5.854%	12.14%

Relationships between endpoints

↥

Index endpoint: K11_ORAL_LEUCOPLACIA – Oral leukoplakia

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	K11_ORAL_LEUCOPLACIA
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	K132[01]
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	K132[01]
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Oral leukoplakia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints