No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
953 |
4. Check minimum number of eventsNone |
953 |
5. Include endpointsNone |
953 |
6. Filter based on genotype QC (FinnGen only) |
953 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Oral leukoplakia, including avohilmo
based on the number of shared cases.
Similar with more cases:
- Oral leukoplakia and related diseases, including avohilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5452 | 2705 | 2719 |
| Only index persons | 5235 | 2615 | 2620 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.10 | 0.10 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 57.42 | 59.83 | 55.09 |
| Only index persons | 57.24 | 59.67 | 54.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 953 | 492 | 461 |
| Unadjusted period prevalence (%) | 0.18 | 0.17 | 0.20 |
| Median age at first event (years) | 58.31 | 58.23 | 58.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 861
- Matched controls
- 8610
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K13.21
ICD-10 Finland
Leukoplakia caused by tobacco
+∞
323.0
300
*
K13.20
ICD-10 Finland
Idiopathic leukoplakia
+∞
323.0
589
*
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
58.5
231.4
271
67
EKA10
NOMESCO Finland
Biopsy of cheek
34.9
154.0
202
75
K13.29
ICD-10 Finland
Indefinite leukoplakia
56.9
150.2
177
39
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
19.9
120.8
188
119
SAA03
NOMESCO Finland
Extended examination of mouth
4.6
96.7
536
2258
ECA20
NOMESCO Finland
Biopsy of gingiva
32.0
73.0
97
34
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
17.8
71.9
115
74
K13.28
ICD-10 Finland
Other leukoplakia or disorder of epithelium of the palate or tongue
99.6
67.1
73
8
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.4
61.0
428
1925
L43.8
ICD-10 Finland
Other lichen planus
21.9
60.2
89
45
SXA10
NOMESCO Finland
Epithel biopsy of mouth
23.7
58.3
84
39
K13.78
ICD-10 Finland
Other change in the oral mucosa
14.8
56.7
97
73
SAA02
NOMESCO Finland
Basic examination of mouth
3.2
51.9
644
4136
WZB00
NOMESCO Finland
Telephone receipt or other advice
3.2
49.7
359
1582
SBA00
NOMESCO Finland
Microbiological examinations
12.9
49.6
90
77
C02.11
ICD-10 Finland
Malignant neoplasm of border of tongue
110.5
48.3
52
5
SAA01
NOMESCO Finland
Simple examination of mouth
3.1
44.4
679
4719
EJB10
NOMESCO Finland
Excision of lesion of apex or body of tongue
46.9
43.7
53
12
EHA10
NOMESCO Finland
Biopsy of palate
33.8
41.5
54
17
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.7
40.3
450
2511
A07AA02
ATC
nystatin; oral
5.2
39.1
130
284
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
16.0
39.0
64
43
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
5.9
38.6
114
216
WX110
NOMESCO Finland
Local anesthesy
2.7
37.4
654
4621
SAA04
NOMESCO Finland
Special inverstigation of mouth
5.8
37.2
112
217
K13.2
ICD-10 Finland
Leukoplakia and other disturbances of oral epithelium, including tongue
64.3
32.3
37
6
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
5.5
31.3
97
194
L43.9
ICD-10 Finland
Lichen planus, unspecified
10.1
29.3
59
62
K13.22
ICD-10 Finland
Erythroplakia of oral epithelium, including tongue
68.5
29.1
33
5
B37.08
ICD-10 Finland
Other candidal stomatitis
26.1
29.0
40
16
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
2.3
28.2
372
2134
K05.31
ICD-10 Finland
Periodontitis pronounced
3.3
27.8
155
535
K02.1
ICD-10 Finland
Caries of dentine
2.1
25.2
515
3533
EB1AA
NOMESCO Finland
Tooth X-ray examination
2.1
22.7
507
3539
SFA10
NOMESCO Finland
Fillning on one surface of tooth
2.0
22.6
488
3360
D20
ICPC
Mouth/tongue/lip symptom/complaint
4.9
22.5
76
167
Z01.2
ICD-10 Finland
Dental examination
2.1
22.2
383
2399
SDA04
NOMESCO Finland
Very demanding parodonthologic therapy
2.3
21.5
251
1319
8070/3-C02.1
ICD-O-3
Squamous cell carcinoma, NOS, of border of tongue
61.6
21.0
24
*
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
2.0
20.5
517
3717
TEA00
NOMESCO Finland
Biopsy of lip
12.0
20.4
37
32
C03.1
ICD-10 Finland
Malignant neoplasm: Lower gum
49.3
20.2
24
5
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.8
20.0
137
536
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
2.0
19.7
391
2548
A01AB09
ATC
miconazole; local oral
3.1
19.7
119
428
EJ2S1
NOMESCO Finland
Photography of oral mucosa
107.5
19.6
21
*
N07BA03
ATC
varenicline; oral
4.0
19.2
79
211
WX290
NOMESCO Finland
Other blockade of nerve
2.0
18.9
383
2506
EBA00
NOMESCO Finland
Extraction of tooth
2.0
17.7
310
1906
K03.64
ICD-10 Finland
Dental calculus supragingival
2.1
17.3
253
1445
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
3.4
17.3
87
275
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
16.7
16.6
26
16
ZXC10
NOMESCO Finland
Use of laser
6.5
16.6
43
69
EKB00
NOMESCO Finland
Excision of lesion of cheek
17.1
16.1
25
15
WZA90
NOMESCO Finland
Other doctors statement
2.1
15.9
223
1247
SXC03
NOMESCO Finland
Other oral or dental procedure
10.7
15.8
30
29
D82
ICPC
Teeth/gum disease
1.9
15.8
301
1892
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
2.0
15.7
240
1385
GBB00
NOMESCO Finland
Tracheostomy
8.9
15.3
32
37
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
15.1
404
2837
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
12.7
14.9
26
21
SDA02
NOMESCO Finland
Parodonthologic therapy
1.9
14.9
293
1852
EJB40
NOMESCO Finland
Hemiglossectomy
57.7
14.8
17
*
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
16.8
14.8
23
14
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.8
14.7
422
3022
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.8
14.6
389
2717
EJW99
NOMESCO Finland
Other operation on tongue or floor of mouth
+∞
14.6
14
*
B37.03
ICD-10 Finland
Chronic atrophic candida infection in the mouth
36.7
14.5
18
5
K03.65
ICD-10 Finland
Deposits [accretions] on teeth betel
2.1
14.2
191
1044
EJB30
NOMESCO Finland
Excision of lesion of floor of mouth
43.2
14.1
17
*
A01AC01
ATC
triamcinolone; local oral
6.5
13.3
34
54
K05.30
ICD-10 Finland
Periodontitis complex
2.3
13.3
133
635
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.7
13.2
394
2822
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
11.8
12.9
23
20
Z72.0
ICD-10 Finland
Tobacco use
4.7
12.8
43
95
C06.0
ICD-10 Finland
Malignant neoplasm: Cheek mucosa
70.9
12.6
14
*
K13.6
ICD-10 Finland
Irritative hyperplasia of oral mucosa
8.9
12.6
26
30
K02.0
ICD-10 Finland
Caries limited to enamel
2.3
12.4
116
536
EDB00
NOMESCO Finland
Partial excision of mandible
38.1
12.2
15
*
D07AD01
ATC
clobetasol; topical
2.1
12.0
144
748
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.8
11.8
242
1532
EP1AE
NOMESCO Finland
Neck ultrasound examination
3.0
11.7
71
254
L43.3
ICD-10 Finland
Subacute (active) lichen planus
30.5
11.7
15
5
8070/3-C02.9
ICD-O-3
Squamous cell carcinoma, NOS, of tongue, NOS
65.9
11.6
13
*
L43.0
ICD-10 Finland
Hypertrophic lichen planus
11.3
11.6
21
19
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
2.4
11.3
99
442
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.8
11.2
229
1443
EBA10
NOMESCO Finland
Surgical removal of tooth
2.3
11.1
103
475
SDA01
NOMESCO Finland
Simple parodonthologic therapy
1.8
11.0
218
1355
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
5.4
11.0
32
61
B37.02
ICD-10 Finland
Chronic hyperplastic candidal stomatitis
43.9
10.9
13
*
K03.66
ICD-10 Finland
Tooth plaque
2.7
10.8
74
286
C02.10
ICD-10 Finland
Malignant neoplasm of tip of tongue
60.8
10.6
12
*
J02AC01
ATC
fluconazole; systemic
1.7
10.5
313
2201
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.9
10.3
179
1064
C04.0
ICD-10 Finland
Malignant neoplasm: Anterior floor of mouth
23.7
10.3
14
6
XQ802
NOMESCO Finland
Epicutan test
3.8
10.1
42
115
SBB10
NOMESCO Finland
Teeth copy
2.9
10.1
62
225
SCA01
NOMESCO Finland
Simple analysis and advice of nutrition with regard to dentistry
1.7
10.0
220
1412
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
7.1
9.8
23
33
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
10.2
9.5
18
18
K13.24
ICD-10 Finland
Gum problems in smokers
101.1
9.4
10
*
EJB99
NOMESCO Finland
Other excision on tongue and floor of mouth
101.1
9.4
10
*
PJ5AQ
NOMESCO Finland
Sentinell lymphnode SPECT with low dose CT
17.8
9.4
14
8
B37.01
ICD-10 Finland
Acute athrophy candidal stomatitis
30.4
9.4
12
*
8070/3-C03.1
ICD-O-3
Squamous cell carcinoma, NOS, of lower gum
+∞
9.4
9
*
K13.1
ICD-10 Finland
Cheek and lip biting
12.5
9.4
16
13
K12.10
ICD-10 Finland
Stomatitis NOS
10.8
9.3
17
16
A01AB04
ATC
amphotericin B; local oral
2.8
8.9
56
208
E0000UV
ATC
NA
1.6
8.8
311
2259
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
6.4
8.8
22
35
SPF00
NOMESCO Finland
Repatation of teeth prosthesis
3.8
8.8
36
98
SPAT1301
SPAT
No procedures
1.6
8.8
261
1811
L84
ICD-10 Finland
Corns and callosities
3.4
8.7
40
120
K14.9
ICD-10 Finland
Disease of tongue, unspecified
14.2
8.7
14
10
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.7
8.6
204
1332
EMAK
NOMESCO Finland
NA
3.1
8.5
45
150
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
3.6
8.4
36
102
D07AC01
ATC
betamethasone; topical
1.6
8.4
289
2080
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
8.0
8.4
18
23
JDB10
NOMESCO Finland
Percutaneous gastrostomy
6.1
8.2
21
35
SXC05
NOMESCO Finland
Other oral or dental procedure
2.7
8.1
55
214
B37.00
ICD-10 Finland
Acute pseudomembraneuous candidal stomatitis
22.3
8.0
11
5
SFA40
NOMESCO Finland
Replacement of krone of tooth
1.7
8.0
189
1229
J01CE02
ATC
phenoxymethylpenicillin; oral
1.5
8.0
550
4628
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.8
7.8
143
861
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.2
7.8
83
405
N05AH04
ATC
quetiapine; oral
1.8
7.8
134
788
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
7.6
110
608
E000001
ATC
NA
1.7
7.6
161
1012
K08.2
ICD-10 Finland
Atrophy of edentulous alveolar ridge
6.2
7.6
19
31
SGA02
NOMESCO Finland
Opening and dilatation of root canal of tooth
1.9
7.6
108
598
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
3.4
7.5
34
102
SFA00
NOMESCO Finland
Small filling
1.9
7.5
105
574
L43.2
ICD-10 Finland
Lichenoid drug reaction
80.8
7.4
8
*
8070/3-C06.0
ICD-O-3
Squamous cell carcinoma, NOS, of cheeck mucosa
80.8
7.4
8
*
P17
ICPC
Tobacco abuse
5.4
7.4
21
40
KMAK
NOMESCO Finland
NA
1.5
7.4
406
3228
-1
NOMESCO Finland
NA
1.6
7.3
255
1831
ECA30
NOMESCO Finland
Excision of lesion of gingiva
5.5
7.3
20
37
WX199
NOMESCO Finland
Other local analgesia
3.5
7.2
31
90
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
4.4
7.1
24
56
SPA02
NOMESCO Finland
Preparation for dental prosthetics
3.6
7.0
30
86
N05BA01
ATC
diazepam; systemic, rectal
1.8
7.0
118
691
SFC92
NOMESCO Finland
Other demanding adjuvant procedure of filling therapy
2.2
6.9
65
302
R03AC02
ATC
salbutamol; inhalant
1.5
6.9
412
3318
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.3
6.9
33
104
K05.10
ICD-10 Finland
Gingivitis (chronic) NOS
1.9
6.8
100
557
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
2.7
6.8
45
175
SGB10
NOMESCO Finland
Fiiling of rooth of tooth with one root channel
1.9
6.7
103
586
N06AX11
ATC
mirtazapine; oral
1.5
6.7
256
1872
C02.2
ICD-10 Finland
Malignant neoplasm: Ventral surface of tongue
22.7
6.7
9
*
B37.09
ICD-10 Finland
Unspecified candidal stomatitis
5.5
6.6
18
33
J01FF01
ATC
clindamycin; systemic
1.5
6.6
231
1652
K04.09
ICD-10 Finland
Pulpit UNS
3.0
6.6
35
119
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
3.7
6.5
26
71
T36
ICD-10 Finland
Poisoning by systemic antibiotics
2.7
6.5
42
160
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
6.5
369
2931
K12.18
ICD-10 Finland
Other forms of stomatitis
6.2
6.5
16
26
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
6.4
134
838
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.7
6.4
129
796
K14.61
ICD-10 Finland
Glossodynia
7.5
6.4
14
19
VALMI
NOMESCO Finland
NA
1.6
6.4
180
1223
SPAT1310
SPAT
Counselling related to known health issue
1.5
6.3
253
1863
SBA10
NOMESCO Finland
Measurement of excretion of saliva
5.6
6.3
17
31
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
1.9
6.3
83
447
8070/3-C04.9
ICD-O-3
Squamous cell carcinoma, NOS, of floor of mouth, NOS
26.9
6.2
8
*
EKC00
NOMESCO Finland
Suture of cheek
26.9
6.2
8
*
8070/3-C06.9
ICD-O-3
Squamous cell carcinoma, NOS, of mouth, NOS
26.9
6.2
8
*
EAA10
NOMESCO Finland
Excision of lesion of lip
4.5
6.2
20
45
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.8
6.2
102
594
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
6.1
214
1525
L01
ICPC
Neck symptom/complaint
1.8
6.1
108
643
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
6.1
331
2595
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.6
6.0
181
1248
M79.1
ICD-10 Finland
Myalgia
1.8
6.0
97
560
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
87
91
10.42
75.62
2.2
1.4
—
—
—
0
0
197
1019
2.18
19.12
4.9
4.6
30.8
32.0
%
0.74
131
679
239
1484
1.81
13.21
1.7
1.7
1151.2
1219.8
nmol/l
0.52
175
1118
819
7176
2.00
12.61
5.7
4.7
1.9
2.1
mu/l
0.51
725
6531
586
4720
1.63
11.62
4.9
5.1
6.9
6.7
mmol/l
1.22
556
4446
351
2506
1.63
11.36
2.3
2.1
257.0
224.0
u/l
0.19
325
2361
174
1027
1.85
11.16
7.6
7.2
—
—
—
0
0
473
3689
1.56
10.20
6.1
6.4
1.2
1.2
mmol/l
0.35
417
3350
432
3303
1.56
10.16
2.1
2.0
93.1
95.2
pmol/l
0.39
214
1696
71
310
2.39
10.13
1.8
1.8
—
—
—
0
0
504
4017
1.54
9.65
7.2
7.2
1.2
1.2
mmol/l
0.79
437
3418
66
286
2.40
9.58
1.6
1.7
—
—
—
0
0
724
6271
1.64
9.57
8.1
7.8
78.7
78.8
u/l
0.03
680
5887
451
3521
1.53
9.42
4.7
4.9
35.4
35.4
g/l
0.09
418
3283
627
5261
1.56
9.38
3.9
3.2
51.9
53.9
u/l
0.22
569
4895
276
1948
1.59
8.95
2.5
2.3
—
—
—
0
0
687
5912
1.58
8.95
5.1
4.2
13.1
12.5
mm/h
0.53
616
5453
689
5951
1.57
8.66
4.7
3.9
15.0
14.9
pmol/l
0.26
599
5384
527
4319
1.49
8.33
5.8
6.5
10.8
11.6
umol/l
0.88
497
4110
463
3715
1.48
8.02
4.1
4.1
—
—
—
0
0
66
319
2.15
7.44
4.1
3.9
24.9
24.9
mmol/l
0.04
60
303
400
3160
1.46
7.28
3.6
3.7
30.2
51.1
ng/l
1.03
288
2273
333
2559
1.46
6.91
2.8
2.6
57.2
56.8
u/l
0.04
309
2365
883
8276
1.91
6.47
20.4
17.0
139.2
139.7
mmol/l
5.63
863
8068
851
7890
1.73
6.47
17.8
14.7
23.3
24.5
mg/l
0.49
718
6285
403
3247
1.42
6.33
2.4
2.3
75.9
77.3
nmol/l
0.50
344
2892
883
8302
1.87
6.02
20.3
17.1
4.0
4.0
mmol/l
1.21
860
8082
814
7502
1.58
5.85
6.7
6.0
40.9
40.1
mmol/mol
0.63
736
6941
123
793
1.63
5.63
2.1
2.2
0.2
0.2
g/l
0.21
115
745
154
1052
1.55
5.52
25.8
23.3
1.3
1.2
inr
0.38
21
132
343
2743
1.39
5.41
3.2
3.6
2.4
2.4
mmol/l
0.11
288
2399
538
4629
1.37
5.39
9.1
9.4
4.4
4.1
e9/l
1.92
479
4060
139
935
1.57
5.33
2.7
1.9
1.7
1.5
%
2.37
116
811
88
533
1.72
5.10
6.9
8.4
24.6
24.7
mmol/l
0.05
82
500
590
5185
1.36
4.98
4.9
4.4
1248.7
2498.8
e6/l
—
7
78
252
1945
1.40
4.81
2.2
2.1
2.9
3.1
mg/l
0.59
209
1664
219
1659
1.42
4.64
1.3
1.2
1.0
1.7
u/ml
1.07
62
455
179
1312
1.45
4.53
1.9
1.9
—
—
—
0
0
135
954
1.48
4.11
6.7
9.0
5.1
5.1
kpa
0.33
130
918
135
954
1.48
4.11
6.6
9.0
11.8
12.1
kpa
0.41
129
921
25
104
2.44
4.08
1.6
1.4
—
—
—
0
0
27
117
2.35
4.04
5.1
4.9
386.9
371.9
umol/l
0.23
21
102
134
950
1.48
4.02
6.7
9.0
1.5
1.3
mmol/l
0.30
96
761
25
105
2.42
4.00
1.6
1.4
—
—
—
0
0
25
105
2.42
4.00
1.6
1.4
—
—
—
0
0
889
8499
1.69
4.00
12.8
10.8
26.4
26.9
u/l
0.41
855
8198
25
106
2.40
3.93
1.6
1.4
—
—
—
0
0
25
106
2.40
3.93
1.6
1.4
—
—
—
0
0
203
1561
1.38
3.89
4.2
3.9
1235.2
401.0
ng/l
0.39
156
1255
88
577
1.58
3.79
1.7
1.6
—
—
—
0
0
14
44
3.21
3.78
1.8
1.3
—
—
—
0
0
14
44
3.21
3.78
1.8
1.3
—
—
—
0
0
19
73
2.64
3.65
3.1
3.5
63.5
54.9
%
0.95
13
57
239
1909
1.34
3.56
1.7
1.5
18.7
20.6
nmol/l
1.44
202
1612
153
1140
1.41
3.52
2.5
2.4
2.3
2.3
g/l
0.37
145
1058
24
106
2.30
3.47
1.6
1.4
—
—
—
0
0
177
1356
1.37
3.45
3.4
3.4
0.8
0.8
mmol/l
0.36
163
1271
909
8779
1.77
3.44
27.0
21.7
135.1
136.1
g/l
1.14
894
8641
828
7846
1.42
3.34
5.3
4.7
6.0
6.0
mmol/l
0.34
739
7135
312
2611
1.29
3.28
3.7
3.2
7.0
7.5
mmol/l
1.27
253
2193
35
184
1.94
3.28
1.5
1.3
—
—
—
0
0
809
7650
1.38
3.17
4.7
4.1
1.5
1.3
mmol/l
0.97
719
6985
75
502
1.54
2.99
4.1
3.4
1.1
1.8
mmol/l
0.98
61
383
143
1086
1.37
2.94
5.7
5.8
1.0
1.0
mmol/l
0.42
132
1000
78
534
1.50
2.81
4.1
3.4
5.2
5.2
kpa
0.19
68
505
73
494
1.52
2.78
1.5
1.5
—
—
—
0
0
92
654
1.45
2.76
2.7
3.0
205.7
196.7
ng/l
0.09
84
602
99
718
1.42
2.67
2.2
2.5
5.4
6.9
ug/l
0.34
86
630
159
1248
1.33
2.64
2.4
2.4
12.5
13.1
umol/l
0.51
150
1152
140
1082
1.34
2.58
2.4
2.4
20.9
22.9
%
1.05
108
926
308
2641
1.25
2.54
4.0
4.0
4.2
8.8
mg/mmol
3.53
178
1674
39
233
1.70
2.49
1.5
1.4
—
—
—
0
0
8
21
3.83
2.46
1.5
1.9
—
—
—
0
0
36
211
1.73
2.46
1.9
1.7
11665.3
15271.9
e6/l
0.35
23
157
846
8136
1.35
2.30
5.8
5.1
2.7
2.8
mmol/l
2.74
767
7470
71
503
1.44
2.21
2.1
1.8
—
—
—
0
0
613
6547
0.82
2.20
21.1
18.1
13.8
13.7
%
0.70
601
6401
11
42
2.64
2.19
1.3
1.3
—
—
—
0
0
826
7928
1.31
2.18
5.3
4.5
1.4
1.5
mmol/l
0.49
747
7274
35
213
1.67
2.12
1.2
1.2
—
—
—
0
0
830
7978
1.31
2.12
5.4
4.6
4.6
4.7
mmol/l
1.25
754
7369
21
109
1.95
2.11
1.2
1.1
—
—
—
0
0
67
474
1.44
2.11
1.2
1.2
318.8
145.5
iu/ml
1.51
25
193
24
131
1.85
2.09
2.7
3.6
1.6
1.3
%
0.18
19
112
359
3181
1.21
2.08
2.9
2.7
137.6
141.9
ug/l
0.11
317
2916
297
2587
1.22
2.04
3.9
3.4
50.9
32.9
u/l
0.46
280
2464
116
909
1.31
1.97
5.1
4.3
224.4
254.8
u/l
1.92
107
859
5
11
4.56
1.94
1.0
1.1
—
—
—
0
0
10
39
2.58
1.92
1.8
1.2
—
—
—
0
0
10
39
2.58
1.92
1.8
1.2
—
—
—
0
0
63
457
1.41
1.76
2.0
1.7
—
—
—
0
0
59
425
1.41
1.72
4.1
3.1
4.5
4.6
pmol/l
0.23
50
369
30
187
1.62
1.71
2.2
1.9
—
—
—
0
0
30
187
1.62
1.71
1.6
1.7
5.5
4.7
iu/l
—
6
56
37
243
1.54
1.70
1.6
1.6
2.5
0.1
iu/ml
—
8
41
250
2178
1.20
1.69
2.5
2.7
1626.3
5523.9
umol/l
1.75
207
1885
10
42
2.40
1.68
1.3
1.1
—
—
—
0
0
49
680
0.71
1.60
3.1
4.1
1.2
1.2
mmol/l
0.22
41
599
256
2249
1.19
1.57
1.9
1.7
1.5
1.4
mmol/l
0.58
222
1890
202
1738
1.21
1.55
4.5
4.0
1.0
1.0
kg/l
0.02
29
229
5
15
3.35
1.52
2.8
1.9
20.7
16.5
umol/l
—
5
15
746
7153
1.20
1.51
19.0
15.8
39.0
40.1
%
1.70
461
5026
108
871
1.27
1.51
3.3
4.3
77.8
25.3
ug/l
0.36
90
724
9
38
2.38
1.46
2.0
2.4
—
—
—
0
0
18
102
1.78
1.45
1.6
1.6
64.8
61.3
%
0.17
13
72
5
16
3.14
1.44
1.6
2.8
—
—
—
0
0
135
1125
1.23
1.43
1.4
1.4
—
—
—
0
0
24
149
1.63
1.42
2.3
1.9
—
—
—
0
0
50
364
1.39
1.41
1.1
1.0
—
—
—
0
0
92
734
1.28
1.41
2.7
2.2
395.1
370.7
nmol/l
0.49
86
680
34
230
1.50
1.40
1.2
1.1
—
—
—
0
0
29
190
1.54
1.38
1.3
1.4
—
—
—
0
0
27
174
1.57
1.38
1.4
1.3
14.3
9.2
u/l
0.60
21
139
66
509
1.32
1.32
1.8
1.6
—
—
—
0
0
185
2118
0.84
1.30
4.5
4.0
0.0
0.0
estimate
0.69
39
697
26
170
1.54
1.27
2.5
3.1
0.8
0.9
nmol/l
0.54
18
135
8
35
2.30
1.27
1.3
2.1
79.1
56.5
ug/l
—
8
35
783
7574
1.19
1.26
14.4
13.6
81.5
79.4
ml/min/173m2
2.15
660
6266
199
2254
0.85
1.23
3.3
3.2
0.4
0.5
e6/l
0.25
163
1714
8
37
2.17
1.21
1.0
3.2
736.9
1529.1
u/ml
—
8
37
175
1524
1.18
1.19
3.0
3.1
2.4
2.5
mmol/l
0.78
153
1343
33
231
1.44
1.18
1.2
1.1
—
—
—
0
0
30
206
1.47
1.18
1.7
3.3
32.4
34.5
umol/l
0.16
25
173
23
149
1.56
1.18
1.1
1.7
—
—
—
0
0
7
31
2.27
1.10
1.1
3.0
—
74227.2
—
0
6
36
261
1.39
1.09
1.8
1.9
—
—
—
0
0
52
667
0.77
1.08
1.8
1.8
—
—
—
0
0
147
1687
0.85
1.07
2.7
3.0
0.6
0.7
ug/l
1.67
86
1081
193
1712
1.16
1.05
1.8
1.7
455.4
37288567.6
pmol/l
1.91
150
1416
78
637
1.24
1.04
4.1
3.7
74.4
85.2
ng/l
0.95
61
563
33
238
1.40
1.03
1.4
1.2
—
—
—
0
0
5
22
2.28
1.03
1.2
1.1
142.8
330.3
pmol/l
—
5
12
14
83
1.70
1.01
1.6
1.3
9161.1
127898.8
e6/l
—
7
61
37
274
1.36
1.00
3.4
3.5
44.5
75.3
mg/l
0.68
31
220
37
274
1.36
1.00
3.4
3.5
30.1
42.5
mg/l
0.54
30
222
5
110
0.45
1.00
1.0
1.1
—
—
—
0
0
270
2461
1.14
1.00
2.5
3.0
1110.3
1215.8
ng/l
0.28
229
2094
81
668
1.23
0.99
2.2
2.7
72.1
64.7
ml/min/173m2
0.87
38
271
0
30
0.00
0.97
0.0
1.1
—
77.4
—
0
5
9
50
1.81
0.96
1.4
1.9
—
—
—
0
0
113
1313
0.84
0.96
3.1
3.0
2.2
2.0
e6/l
0.19
71
726
0
32
0.00
0.95
0.0
4.5
—
—
—
0
0
24
166
1.46
0.95
1.1
1.2
—
8.3
—
0
12
107
914
1.19
0.93
2.4
2.8
9.0
9.1
umol/l
0.01
90
809
9
52
1.74
0.92
1.0
1.2
—
—
—
0
0
25
176
1.43
0.91
1.4
1.4
394.2
198.0
miu/ml
—
6
83
49
386
1.28
0.90
3.9
3.6
23.8
24.4
mmol/l
0.57
44
340
6
29
2.08
0.89
3.0
1.8
60.2
87.2
umol/l
—
6
18
197
1774
1.14
0.88
1.6
1.7
1.1
1.2
mg/l
0.06
145
1378
24
170
1.42
0.86
4.0
3.5
19.7
25.8
mg/l
0.36
11
102
31
230
1.36
0.85
1.2
1.6
—
—
—
0
0
10
167
0.59
0.85
4.1
3.7
55.9
57.4
%
—
10
167
32
239
1.35
0.85
1.3
1.4
247.1
278.3
ug/g
0.45
17
139
10
57
1.76
0.84
1.0
1.1
—
—
—
0
0
10
57
1.76
0.84
1.0
1.1
—
—
—
0
0
8
46
1.75
0.82
4.1
3.4
—
—
—
0
0
13
81
1.61
0.81
2.4
2.2
—
—
—
0
0
23
164
1.41
0.80
1.5
1.3
—
—
—
0
0
23
164
1.41
0.80
1.5
1.3
—
—
—
0
0
10
58
1.73
0.80
1.0
1.1
—
—
—
0
0
10
58
1.73
0.80
1.0
1.1
—
—
—
0
0
10
58
1.73
0.80
1.0
1.1
—
—
—
0
0
16
106
1.52
0.79
1.1
1.1
—
—
—
0
0
12
74
1.63
0.78
2.3
1.6
—
—
—
0
0
12
74
1.63
0.78
2.3
1.6
—
—
—
0
0
12
74
1.63
0.78
2.3
1.6
—
—
—
0
0
0
27
0.00
0.77
0.0
1.1
—
—
—
0
0
30
227
1.33
0.75
1.1
1.2
—
13.8
—
0
12
45
361
1.26
0.74
1.2
1.3
—
—
—
0
0
12
184
0.65
0.74
1.5
1.5
—
—
—
0
0
21
151
1.40
0.71
2.9
1.2
39.5
29.9
u/l
0.26
16
129
38
303
1.26
0.67
1.3
2.0
3.4
3.1
g/l
0.76
24
247
369
3892
0.92
0.66
3.8
3.7
0.0
0.0
estimate
0.00
39
719
126
1406
0.88
0.66
2.9
2.8
0.8
1.1
e6/l
0.63
84
813
16
111
1.45
0.66
1.2
1.1
—
—
—
0
0
107
946
1.15
0.65
2.0
1.8
—
—
—
0
0
5
29
1.73
0.64
4.0
2.1
—
—
—
0
0
5
29
1.73
0.64
4.0
2.1
—
—
—
0
0
31
391
0.79
0.63
3.6
3.6
53.4
47.6
%
0.75
31
384
5
30
1.67
0.61
4.0
2.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
16
114
1.41
0.59
1.1
1.7
—
—
—
0
0
74
848
0.86
0.58
3.5
3.4
—
—
—
0
0
22
167
1.32
0.57
1.0
1.1
—
—
—
0
0
11
73
1.51
0.56
1.2
1.4
—
—
—
0
0
6
37
1.63
0.55
3.5
1.9
—
—
—
0
0
6
37
1.63
0.55
3.5
1.9
—
—
—
0
0
6
37
1.63
0.55
3.5
1.9
—
—
—
0
0
6
37
1.63
0.55
3.5
1.9
—
—
—
0
0
142
1298
1.11
0.53
1.3
1.2
16.5
11.4
u/ml
0.30
44
506
72
632
1.15
0.51
2.8
2.3
12.0
13.3
nmol/l
0.79
62
562
27
216
1.26
0.50
1.7
2.4
75.1
87.5
ug/min
0.14
15
124
10
67
1.50
0.50
1.6
1.4
0.2
0.3
nmol/l
—
5
49
34
280
1.22
0.49
1.2
2.2
0.6
1.1
g/l
0.40
25
252
39
326
1.20
0.49
1.3
2.0
4.0
3.8
g/l
0.46
23
243
39
326
1.20
0.49
1.3
2.0
7.5
7.4
g/l
0.09
25
255
39
326
1.20
0.49
1.3
2.0
—
—
—
0
0
41
346
1.19
0.47
2.1
2.1
0.7
2.1
ug/l
0.97
35
313
17
129
1.32
0.46
1.2
1.6
—
—
—
0
0
24
192
1.26
0.45
1.8
1.9
—
—
—
0
0
85
763
1.13
0.45
4.2
3.4
1.1
2.1
mmol/l
1.17
73
607
375
3901
0.94
0.44
5.2
5.0
0.0
0.0
estimate
0.00
46
723
219
2321
0.93
0.44
4.1
4.1
20.4
21.0
%
0.23
85
1060
36
303
1.20
0.43
1.3
2.0
11.3
10.7
g/l
0.29
24
268
6
92
0.65
0.42
4.7
4.0
—
—
—
0
0
289
3028
0.93
0.42
3.9
3.9
—
—
—
0
0
12
87
1.38
0.42
2.3
1.8
—
—
—
0
0
22
176
1.26
0.42
2.0
2.2
124.7
129.2
g/l
0.33
14
131
34
287
1.19
0.40
5.4
2.9
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
7.9
—
0
10
5
35
1.43
0.39
1.0
1.7
—
—
—
0
0
472
4585
1.06
0.37
2.8
2.7
—
—
—
0
0
24
198
1.22
0.36
1.8
1.8
—
—
—
0
0
11
81
1.36
0.36
2.4
1.9
—
—
—
0
0
102
943
1.09
0.34
2.1
1.8
—
—
—
0
0
6
45
1.34
0.33
1.5
1.3
—
—
—
0
0
6
45
1.34
0.33
1.5
1.3
—
—
—
0
0
20
164
1.22
0.32
3.3
3.6
57.8
1735.6
u/ml
0.61
20
158
24
202
1.19
0.31
1.3
1.3
—
—
—
0
0
383
3941
0.95
0.29
3.9
3.7
0.0
0.0
estimate
0.80
39
697
298
2879
1.05
0.28
4.6
4.7
1.7
2.3
ug/l
2.10
258
2590
145
1374
1.07
0.27
1.3
1.3
64.8
32.9
iu/ml
0.95
40
423
30
262
1.15
0.27
1.3
2.0
37.6
37.7
g/l
0.03
22
231
9
72
1.25
0.25
1.3
1.1
—
—
—
0
0
17
143
1.19
0.23
2.0
1.9
—
—
—
0
0
5
39
1.28
0.23
1.0
1.0
—
—
—
0
0
7
93
0.75
0.22
1.1
2.0
—
—
—
0
0
24
210
1.15
0.22
1.4
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
32.2
—
0
7
5
43
1.16
0.21
2.2
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
5.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
14
117
1.20
0.20
1.2
1.7
—
—
—
0
0
14
117
1.20
0.20
1.1
1.1
—
17.3
—
0
7
13
155
0.84
0.20
1.2
1.2
—
—
—
0
0
10
122
0.82
0.19
1.1
1.8
—
—
—
0
0
6
53
1.13
0.18
1.3
1.2
16.0
11.6
u/l
—
6
46
7
58
1.21
0.18
1.6
1.7
—
—
—
0
0
12
100
1.20
0.18
1.0
1.4
289.3
313.0
pmol/l
—
7
83
8
70
1.14
0.16
1.3
1.1
—
—
—
0
0
8
72
1.11
0.16
2.6
2.5
—
—
—
0
0
13
111
1.17
0.16
1.2
1.3
0.6
0.7
nmol/l
0.86
13
101
9
79
1.14
0.15
1.6
1.8
—
—
—
0
0
15
171
0.88
0.14
1.5
1.6
—
—
—
0
0
15
131
1.15
0.14
1.7
1.2
—
—
—
0
0
22
198
1.11
0.14
1.3
1.1
—
—
—
0
0
81
775
1.05
0.13
2.2
2.5
74.8
33.8
u/l
0.63
68
661
22
241
0.91
0.12
1.7
1.6
—
—
—
0
0
73
699
1.05
0.12
3.3
2.7
67.4
66.8
g/l
0.34
61
642
165
1692
0.97
0.11
2.6
2.6
4.8
5.2
e6/l
0.27
148
1497
11
126
0.87
0.11
1.5
1.3
—
—
—
0
0
5
45
1.11
0.10
1.2
1.4
—
—
—
0
0
5
45
1.11
0.10
1.2
1.4
—
—
—
0
0
5
45
1.11
0.10
1.2
1.4
—
—
—
0
0
5
48
1.04
0.09
1.2
1.1
—
—
—
0
0
8
74
1.08
0.07
1.1
1.1
—
—
—
0
0
22
209
1.05
0.04
1.5
1.5
—
—
—
0
0
21
200
1.05
0.03
1.5
1.3
—
—
—
0
0
12
129
0.93
0.03
1.6
2.5
14428.1
127.8
u/ml
0.47
12
124
99
977
1.01
0.03
1.5
1.4
—
—
—
0
0
25
241
1.04
0.02
1.6
1.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
26
269
0.97
0.02
2.5
2.7
0.3
0.4
u/ml
0.24
15
151
13
136
0.96
0.00
1.2
1.1
—
—
—
0
0
19
185
1.03
0.00
1.2
2.2
0.8
0.9
nmol/l
0.41
14
154
8
81
0.99
0.00
1.3
1.6
—
—
—
0
0
7
69
1.01
0.00
1.0
1.0
—
—
—
0
0
6
64
0.94
0.00
1.7
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
16.6
—
0
5
0
5
0.00
0.00
0.0
4.8
—
—
—
0
0
5
49
1.02
0.00
1.2
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
76.6
—
0
7
5
55
0.91
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
0.00
1.2
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
49
1.02
0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
5.2
—
392.6
—
0
5
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
5
54
0.93
0.00
1.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint K11_ORAL_LEUCOPLACIA_INCLAVO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_ORAL_LEUCOPLACIA_INCLAVO | 1.138 [0.99, 1.31] | 0.067 |
| Birth year | 0.989 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 415 out of 2412 females with K11_ORAL_LEUCOPLACIA_INCLAVO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_ORAL_LEUCOPLACIA_INCLAVO | 1.208 [1.05, 1.39] | 0.008 |
| Birth year | 0.987 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 419 out of 2342 males with K11_ORAL_LEUCOPLACIA_INCLAVO died.
Mortality risk
Mortality risk for people of age
years, who have K11_ORAL_LEUCOPLACIA_INCLAVO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.085% | 0.16% |
| 5 | 0.554% | 1.325% |
| 10 | 1.446% | 3.321% |
| 15 | 2.758% | 6.967% |
| 20 | 4.837% | 11.545% |
Relationships between endpoints
↥Index endpoint: K11_ORAL_LEUCOPLACIA_INCLAVO – Oral leukoplakia, including avohilmo
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data