Malignant neoplasm of lip, excluding all cancers (controls excluding all cancers)

C3_LIP_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C00&
  • Hospital discharge: ICD-9 140
  • Hospital discharge: ICD-8 140
  • Cause of death: ICD-10 C00&
  • Cause of death: ICD-9 140
  • Cause of death: ICD-8 140
  • Cancer registry: Topography ICD-O-3 C00
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

396

4. Check minimum number of events

None

396

5. Include endpoints

None

396

6. Filter based on genotype QC (FinnGen only)

396

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of lip, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 396 99 297
Unadjusted period prevalence (%) 0.11 0.03 0.13
Median age at first event (years) 68.92 72.30 67.79

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
260
Matched controls
2610
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8070/3-C00.1
ICD-O-3
Squamous cell carcinoma, NOS, of external lower lip
+∞
230.9
186
*
EAA10
NOMESCO Finland
Excision of lesion of lip
169.9
96.9
97
9
C44.02
ICD-10 Finland
Spinocellular carcinoma of the lip skin
+∞
92.3
83
*
C00.1
ICD-10 Finland
Malignant neoplasm: External lower lip
+∞
80.4
73
*
EAA30
NOMESCO Finland
Partial excision of lower lip
+∞
64.3
59
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
28.7
56.7
78
38
EP1AE
NOMESCO Finland
Neck ultrasound examination
33.5
50.3
66
26
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
+∞
47.3
44
*
TEA00
NOMESCO Finland
Biopsy of lip
111.1
43.4
46
5
L57.0
ICD-10 Finland
Actinic keratosis
10.9
38.0
78
98
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
11.3
33.3
66
76
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
30.8
29
*
QAE99
NOMESCO Finland
Other excision or repair surgery of skin and subcutaneous tissue in head and neck
72.5
28.6
32
5
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
27.6
26
*
8070/3-C00.9
ICD-O-3
Squamous cell carcinoma, NOS, of lip, NOS
+∞
27.6
26
*
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
+∞
26.5
25
*
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
16.4
25.9
42
30
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
99.9
25.2
27
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
24.3
23
*
C00.9
ICD-10 Finland
Malignant neoplasm: Lip, unspecified
+∞
23.3
22
*
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
+∞
22.2
21
*
130
Kela drug reimbursment
Malignant tumour
+∞
21.1
20
*
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
22.4
20.9
30
15
1401A
ICD-9 Finland
Malignant neoplasm of lip, Lower lip, vermilion border
+∞
20.0
19
*
116
Kela drug reimbursment
Prostate cancer
+∞
19.0
18
*
C44.09
ICD-10 Finland
Malignant tumor of the lip skin other or unspecified histology
+∞
19.0
18
*
C00.4
ICD-10 Finland
Malignant neoplasm: Lower lip, inner aspect
+∞
17.9
17
*
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
39.8
17.9
22
6
D10.09
ICD-10 Finland
Benign tumor of the lip UNS
102.0
17.8
19
*
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
+∞
15.8
15
*
PJA12
NOMESCO Finland
Sentinel node biopsy
169.6
15.6
16
*
4382
FHL
Lip resection and / or plastic
+∞
14.7
14
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
14.7
14
*
D06BB10
ATC
imiquimod; topical
12.4
14.6
26
23
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
9.3
14.5
30
36
C44.00
ICD-10 Finland
Malignant tumor of the lip skin without histology
+∞
13.7
13
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
13.7
13
*
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
22.6
13.5
19
9
R23.8
ICD-10 Finland
Other and unspecified skin changes
4.2
13.5
54
151
SPAT1153
SPAT
Removal of sutures
3.0
13.2
93
403
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.5
13.0
69
244
D23.0
ICD-10 Finland
Benign neoplasm: Skin of lip
52.7
13.0
15
*
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
13.2
12.9
22
18
EAB20
NOMESCO Finland
Plastic repair of lip
+∞
12.6
12
*
8070/3-C00.0
ICD-O-3
Squamous cell carcinoma, NOS, of external upper lip
+∞
12.6
12
*
C44.39
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face other or unspecified histology
+∞
12.6
12
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
17.4
11.8
18
11
A04AA02
ATC
granisetron; systemic, transdermal
+∞
11.5
11
*
14011
ICD-8 Finland
Malignant neoplasm of lip, Lower lip
+∞
11.5
11
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
36.8
11.4
14
*
ZXC50
NOMESCO Finland
Cryotherapy
9.8
10.7
21
23
L02AE02
ATC
leuprorelin; implant, parenteral
114.3
10.5
11
*
C44.20
ICD-10 Finland
Malignant tumor of the skin of the outer ear and of the outer ear canal without histology
+∞
10.5
10
*
EAA20
NOMESCO Finland
Partial excision of upper lip
+∞
10.5
10
*
C00.0
ICD-10 Finland
Malignant neoplasm: External upper lip
+∞
10.5
10
*
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
11.3
10.5
19
18
ZZR00
NOMESCO Finland
Flap of skin
34.0
10.4
13
*
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
21.0
9.9
14
7
S77
ICPC
Malignant neoplasm of skin
31.3
9.5
12
*
4381
FHL
Exemption of local change
103.6
9.5
10
*
8070/3-C00.4
ICD-O-3
Squamous cell carcinoma, NOS, of mucosa of lower lip
+∞
9.4
9
*
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
+∞
9.4
9
*
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
+∞
9.4
9
*
C44.21
ICD-10 Finland
Basocellular carcinoma of the skin of the outer ear and the outer ear canal
+∞
9.4
9
*
XX3DW
NOMESCO Finland
Time consuming IT work
6.2
9.1
24
42
D23.3
ICD-10 Finland
Benign neoplasm: Skin of other and unspecified parts of face
16.3
9.1
14
9
K13.09
ICD-10 Finland
Disease of the lips UNS
38.1
9.1
11
*
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
17.0
8.6
13
8
TQW99
NOMESCO Finland
Other minor procedure on skin
7.1
8.5
20
30
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
92.9
8.5
9
*
L57.8
ICD-10 Finland
Other skin changes due to chronic exposure to nonionizing radiation
92.9
8.5
9
*
WF002
NOMESCO Finland
Radical radiotherapy
+∞
8.4
8
*
C44.11
ICD-10 Finland
Basocellular carcinoma of the skin of the eyelids including the corner of the eye
+∞
8.4
8
*
C44.62
ICD-10 Finland
Spinocellular carcinoma of the skin of the upper extremity including the shoulder
+∞
8.4
8
*
D10.00
ICD-10 Finland
Upper lip tumor in upper lip on lip lip border
+∞
8.4
8
*
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
+∞
8.4
8
*
C00.3
ICD-10 Finland
Malignant neoplasm: Upper lip, inner aspect
+∞
8.4
8
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
8.3
119
719
A03FA01
ATC
metoclopramide; systemic, rectal
3.5
8.0
37
117
C44.71
ICD-10 Finland
Basocellular carcinoma of the skin of the lower extremity including the hip
46.4
7.8
9
*
ZXC15
NOMESCO Finland
Use of photodynamic technique
46.4
7.8
9
*
WX110
NOMESCO Finland
Local anesthesy
2.1
7.6
133
865
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
13.9
7.5
12
9
JN4CD
NOMESCO Finland
Very extensive body CT
13.9
7.5
12
9
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
82.3
7.5
8
*
D04.0
ICD-10 Finland
Carcinoma in situ: Skin of lip
+∞
7.3
7
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
7.3
7
*
D10.04
ICD-10 Finland
Lower lip tumor in the lower lip mucosa
+∞
7.3
7
*
QAE30
NOMESCO Finland
Excision and repair of surgical scar in head or neck
+∞
7.3
7
*
EAB99
NOMESCO Finland
Other reconstructive operations on lip
+∞
7.3
7
*
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
+∞
7.3
7
*
8070/3-C44.3
ICD-O-3
Squamous cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
7.3
7
*
C44.0
ICD-10 Finland
Malignant neoplasm: Skin of lip
+∞
7.3
7
*
8070/3-C44.2
ICD-O-3
Squamous cell carcinoma, NOS, of external ear
+∞
7.3
7
*
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
+∞
7.3
7
*
TQW40
NOMESCO Finland
Remowal of suture of skin
5.1
7.0
21
44
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
41.1
6.8
8
*
K13.03
ICD-10 Finland
Keilit UNS
41.1
6.8
8
*
JN4AD
NOMESCO Finland
Body CT examination
6.0
6.6
17
30
S18
ICPC
Laceration/cut
2.0
6.5
102
625
J01DB01
ATC
cefalexin; oral
2.0
6.5
180
1368
D10.03
ICD-10 Finland
Lower lip tumor in the lower lip at the lip red border
71.5
6.5
7
*
XQ848
NOMESCO Finland
Dermatological photography
8.5
6.4
13
16
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
9.6
6.4
12
13
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
18.6
6.3
9
5
K13.29
ICD-10 Finland
Indefinite leukoplakia
18.6
6.3
9
5
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
+∞
6.3
6
*
C44.01
ICD-10 Finland
Basocellular carcinoma of the lip skin
+∞
6.3
6
*
C44.22
ICD-10 Finland
Spinocellular carcinoma of the skin of the outer ear and the outer ear canal
+∞
6.3
6
*
C03.1
ICD-10 Finland
Malignant neoplasm: Lower gum
+∞
6.3
6
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
+∞
6.3
6
*
PJ5AQ
NOMESCO Finland
Sentinell lymphnode SPECT with low dose CT
+∞
6.3
6
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
6.3
6
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
6.3
6
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
6.3
6
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
6.3
6
*
L02BB03
ATC
bicalutamide; oral
+∞
6.3
6
*
EAA99
NOMESCO Finland
Other excision of lip
+∞
6.3
6
*
D00.00
ICD-10 Finland
Cancer in situ on the lip red border
+∞
6.3
6
*

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_LIP_EXALLC – Malignant neoplasm of lip, excluding all cancers (controls excluding all cancers)

GWS hits: 1

This endpoint is excluded (different definition than used in FinnGen).