No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditions
|
- |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
- Control exclude
- C3_CANCER, C3_CANCER_WIDE
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF12
- Parent code in ICD-10
- D00-D09
- Name in latin
- Carcinoma in situ labii (oris)
Similar endpoints
↥List of similar endpoints to
Carcinoma in situ of oral cavity
based on the number of shared cases.
Similar with more cases:
- Carcinoma in situ of oral cavity
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 206 | 81 | 124 |
| Only index persons | 184 | 77 | 107 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 67.27 | 69.00 | 66.20 |
| Only index persons | 66.06 | 66.10 | 66.03 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 74 | 26 | 48 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 68.07 | 70.39 | 66.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 65
- Matched controls
- 649
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
150.0
27.1
27
*
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
48.7
15.4
18
5
EJB10
NOMESCO Finland
Excision of lesion of apex or body of tongue
+∞
15.2
14
*
130
Kela drug reimbursment
Malignant tumour
+∞
12.9
12
*
K13.29
ICD-10 Finland
Indefinite leukoplakia
+∞
12.9
12
*
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
27.2
11.3
15
7
D00.00
ICD-10 Finland
Cancer in situ on the lip red border
+∞
10.7
10
*
8070/2-C00.1
ICD-O-3
Squamous cell carcinoma in situ, NOS, of external lower lip
+∞
9.6
9
*
C02.11
ICD-10 Finland
Malignant neoplasm of border of tongue
+∞
9.6
9
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
5.9
9.2
30
82
H02AB02
ATC
dexamethasone; systemic
58.1
8.9
10
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
24.0
8.8
12
6
K13.78
ICD-10 Finland
Other change in the oral mucosa
26.0
8.3
11
5
EP1AE
NOMESCO Finland
Neck ultrasound examination
15.9
8.3
13
10
EJB30
NOMESCO Finland
Excision of lesion of floor of mouth
+∞
7.4
7
*
A03FA01
ATC
metoclopramide; systemic, rectal
8.1
7.2
16
25
WX110
NOMESCO Finland
Local anesthesy
4.5
6.7
52
304
WX402
NOMESCO Finland
General anaesthesia
6.0
6.4
18
39
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
29.9
6.4
8
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
29.9
6.4
8
*
L57.0
ICD-10 Finland
Actinic keratosis
6.7
6.4
16
30
K13.28
ICD-10 Finland
Other leukoplakia or disorder of epithelium of the palate or tongue
+∞
6.3
6
*
D00.05
ICD-10 Finland
In situ cancer of the pharyngeal part of the tongue
+∞
6.3
6
*
Mortality – FinRegistry
↥Association
Association between endpoint CD2_INSITU_ORALCAVITY_EXALLC and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have CD2_INSITU_ORALCAVITY_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: CD2_INSITU_ORALCAVITY_EXALLC – Carcinoma in situ of oral cavity
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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