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Carcinoma in situ of oral cavity

Endpoint Browser

CD2_INSITU_ORALCAVITY

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

  • not C3_ORALCAVITY
518700

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 — C0[1-6]
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 2

1 out of 7 registries used, show all original rules.

38

4. Check minimum number of events

None

38

5. Include endpoints

83

6. Filter based on genotype QC (FinnGen only)

79

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF12
Parent code in ICD-10
D00-D09
Name in latin
Carcinoma in situ labii (oris)

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 79 30 49
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 70.11 72.50 68.65

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
83
Matched controls
830
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
115.1
29.1
30
*
D00.00
ICD-10 Finland
Cancer in situ on the lip red border
+∞
17.3
16
*
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
24.4
15.7
22
12
EJB10
NOMESCO Finland
Excision of tumor or other lesion of apex or body of tongue
70.2
15.4
17
*
K13.29
ICD-10 Finland
Indefinite leukoplakia
+∞
15.0
14
*
C02.11
ICD-10 Finland
Malignant neoplasm of border of tongue
+∞
12.8
12
*
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
20.5
12.3
18
11
8070/2-C00.1
ICD-O-3
Squamous cell carcinoma in situ, NOS, of external lower lip
+∞
10.6
10
*
SAA03
NOMESCO Finland
Extended examination of mouth
4.4
10.2
47
191
EJB30
NOMESCO Finland
Excision of tumor or other lesion of floor of the mouth
112.3
9.6
10
*
K13.78
ICD-10 Finland
Other change in the oral mucosa
18.4
9.4
14
9
WX402
NOMESCO Finland
General anaesthesia
4.6
9.2
28
82
D00.06
ICD-10 Finland
Cancer in situ in another part of the tongue
+∞
8.5
8
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
49.9
7.9
9
*
EAA30
NOMESCO Finland
Partial excision of lower lip
+∞
7.4
7
*
L57.0
ICD-10 Finland
Actinic keratosis
4.2
7.4
24
73
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
75.4
6.5
7
*
WZC00
NOMESCO Finland
Treatment plan or consultation
3.2
6.4
40
186
K13.28
ICD-10 Finland
Other leukoplakia or disorder of epithelium of the palate or tongue
+∞
6.3
6
*
C021, 8077, 2
ICD-O-3
+∞
6.3
6
*
D00.05
ICD-10 Finland
In situ cancer of the pharyngeal part of the tongue
+∞
6.3
6
*
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
7.9
6.0
13
19

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
27
70
5.23
10.40
1.6
1.3
—
—
—
0
0
48
242
3.33
6.76
3.6
2.2
—
—
—
0
0
16
55
3.36
4.00
8.2
8.3
—
—
—
0
0
31
164
2.42
3.48
5.7
3.5
86.71
84.98
%
0.11
31
158
16
60
3.06
3.46
1.7
1.3
—
—
—
0
0
18
74
2.83
3.32
2.1
1.5
—
—
—
0
0
37
217
2.27
3.24
3.3
2.3
—
—
—
0
0
49
324
2.25
3.20
9.5
5.9
1.20
1.21
mmol/l
0.56
42
273
22
105
2.49
3.03
2.3
2.5
1.45
1.88
e6/l
0.16
11
61
16
65
2.81
3.01
1.3
2.3
0.23
0.21
g/l
0.37
16
59
6
10
6.36
2.74
12.5
2.1
—
—
—
0
0
26
146
2.14
2.43
1.5
1.3
—
—
—
0
0
36
229
2.01
2.42
4.3
3.1
2.36
2.34
mmol/l
0.35
31
197
32
197
2.02
2.34
2.8
2.8
1.29
0.45
e6/l
0.80
20
147
9
29
3.35
2.30
10.2
6.5
—
—
—
0
0
34
215
1.98
2.30
3.1
2.9
81.32
332.11
e6/l
0.39
21
165
31
191
1.99
2.25
2.9
2.8
—
—
—
0
0
37
243
1.94
2.23
3.3
3.6
72.37
112.21
e6/l
0.26
22
177
18
90
2.28
2.21
7.5
5.3
102.89
104.42
mmol/l
0.37
18
90
10
216
0.39
2.13
3.9
3.1
—
—
—
0
0
9
32
3.03
2.07
2.2
2.3
0.69
0.76
%
—
9
32
49
360
1.88
2.06
11.2
15.6
1.46
1.31
inr
—
10
107
11
45
2.67
2.02
9.8
7.9
0.67
0.68
%
0.01
11
45
10
39
2.77
2.02
2.2
2.5
135.00
129.41
g/l
—
10
39
9
34
2.84
1.93
2.2
2.3
1.58
1.52
%
—
9
34
7
23
3.23
1.84
1.4
1.9
—
—
—
0
0
5
15
3.48
1.54
2.6
2.0
—
—
—
0
0
73
638
2.20
1.53
23.3
15.5
37.22
24.55
mg/l
1.48
61
525
10
45
2.39
1.53
10.7
7.3
0.83
1.40
%
—
10
45
23
145
1.81
1.50
1.3
1.7
1484.85
1233.73
nmol/l
0.55
17
111
6
22
2.86
1.46
1.5
4.2
—
—
—
0
0
13
68
2.08
1.43
1.2
1.4
—
—
—
0
0
74
663
2.07
1.39
17.9
15.1
—
—
—
0
0
77
704
2.30
1.30
33.2
22.9
38.47
40.19
%
1.31
66
655
41
317
1.58
1.22
7.0
5.3
0.57
0.62
e9/l
0.56
34
272
41
317
1.58
1.22
6.9
5.3
0.04
0.04
e9/l
0.48
35
273
0
33
0.00
1.19
0.0
1.2
—
201.51
—
0
28
41
321
1.55
1.13
7.0
5.4
1.61
1.89
e9/l
0.80
36
282
11
61
1.93
1.04
1.4
1.6
—
—
—
0
0
13
77
1.82
1.02
1.5
1.6
—
—
—
0
0
74
675
1.89
1.01
27.8
18.6
84.42
83.00
umol/l
0.09
74
675
36
281
1.50
0.97
2.0
2.0
97.22
91.05
pmol/l
0.30
16
139
8
42
2.00
0.92
1.3
1.4
—
—
—
0
0
13
195
0.60
0.86
5.5
2.5
361.92
11086.33
umol/l
1.45
13
163
8
46
1.82
0.85
9.1
5.8
23.71
24.72
mmol/l
—
8
46
22
159
1.52
0.84
9.3
5.9
—
—
—
0
0
25
189
1.46
0.77
4.1
3.2
43.84
399.88
mg/l
0.56
20
125
35
283
1.41
0.75
7.8
10.3
0.00
0.00
e9/l
0.62
28
235
60
533
1.45
0.75
29.2
18.8
14.29
15.44
%
1.25
60
524
27
209
1.43
0.73
6.9
4.1
—
—
—
0
0
37
305
1.38
0.70
6.8
6.1
—
—
—
0
0
51
445
1.38
0.68
4.4
4.3
—
—
—
0
0
5
28
1.83
0.67
1.8
1.2
—
—
—
0
0
53
467
1.37
0.65
3.5
3.7
14.99
14.90
pmol/l
0.08
47
414
8
49
1.70
0.64
1.4
1.5
—
—
—
0
0
8
52
1.59
0.61
11.5
1.5
—
—
—
0
0
8
54
1.53
0.59
2.4
1.9
400.50
336.91
nmol/l
—
8
47
10
65
1.61
0.58
2.1
2.0
—
—
—
0
0
51
452
1.33
0.57
4.0
4.2
—
—
—
0
0
42
365
1.31
0.53
14.2
9.5
4.03
4.36
e9/l
0.36
37
318
7
45
1.61
0.50
2.1
2.5
—
—
—
0
0
14
184
0.71
0.48
2.7
3.9
—
—
—
0
0
18
226
0.74
0.47
4.7
4.3
—
—
—
0
0
26
215
1.30
0.46
3.9
2.9
—
—
—
0
0
5
32
1.60
0.43
3.2
2.7
26.18
24.68
mmol/l
—
5
32
25
208
1.29
0.42
4.4
3.6
8.49
11.62
mg/mmol
0.31
19
133
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
3.3
—
15.36
—
0
7
5
36
1.41
0.39
2.6
4.0
—
—
—
0
0
21
174
1.28
0.36
1.6
1.6
18.37
19.43
nmol/l
0.14
16
141
6
46
1.33
0.34
1.2
1.5
—
—
—
0
0
18
150
1.26
0.29
2.4
3.9
—
—
—
0
0
9
75
1.22
0.26
1.2
1.3
—
—
—
0
0
5
38
1.34
0.23
3.0
1.2
0.92
1.25
g/l
—
5
32
13
107
1.25
0.23
3.2
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
2.7
—
6.28
—
0
11
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
4.0
—
87.50
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
4.1
—
57.67
—
0
12
0
12
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
7
60
1.18
0.18
1.4
1.3
—
—
—
0
0
8
69
1.18
0.17
10.9
3.5
—
—
—
0
0
7
87
0.79
0.15
1.0
1.3
—
—
—
0
0
31
289
1.12
0.13
3.1
4.4
25.00
50.66
ng/l
1.33
22
228
5
46
1.09
0.10
7.2
1.7
9.02
10.26
g/l
—
5
39
5
47
1.07
0.09
4.0
2.2
—
7.44
—
0
7
6
56
1.08
0.09
1.8
3.6
—
—
—
0
0
32
332
0.94
0.05
4.0
5.4
0.00
0.00
estimate
—
5
66
63
638
0.95
0.02
4.7
4.7
1.41
1.42
mmol/l
0.08
56
574
32
327
0.97
0.01
2.6
4.1
0.00
0.01
estimate
—
5
72
62
622
0.99
0.00
4.2
4.2
1.55
1.30
mmol/l
0.87
55
558
66
657
1.02
0.00
5.5
5.3
2.26
2.63
mmol/l
2.92
61
589
26
257
1.02
0.00
2.7
3.9
—
5.85
—
0
20
64
641
0.99
0.00
4.7
4.7
4.19
4.49
mmol/l
1.46
57
583
5
51
0.98
0.00
1.8
4.8
1.24
1.21
mmol/l
—
5
45
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
0.78
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
32.71
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
11.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.0
—
344.86
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
26.00
—
0
5
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
7.32
—
0
6
0
5
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
6.87
—
0
9
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
11.26
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
171.76
—
0
5
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
289.83
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: CD2_INSITU_ORALCAVITY – Carcinoma in situ of oral cavity

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).