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Carcinoma in situ of oral cavity

CD2_INSITU_ORALCAVITY

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • not C3_ORALCAVITY
519030

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C0[1-6]
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 2

1 out of 7 registries used, show all original rules.

35

4. Check minimum number of events

None

35

5. Include endpoints

74

6. Filter based on genotype QC (FinnGen only)

74

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF12
Parent code in ICD-10
D00-D09
Name in latin
Carcinoma in situ labii (oris)

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 74 26 48
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 68.07 70.39 66.81

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
65
Matched controls
648
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
90.1
25.5
27
5
EJB10
NOMESCO Finland
Excision of lesion of apex or body of tongue
+∞
15.2
14
*
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
34.7
14.3
18
7
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
95.6
14.2
15
*
K13.29
ICD-10 Finland
Indefinite leukoplakia
72.3
11.0
12
*
D00.00
ICD-10 Finland
Cancer in situ on the lip red border
+∞
10.7
10
*
8070/2-C00.1
ICD-O-3
Squamous cell carcinoma in situ, NOS, of external lower lip
+∞
9.6
9
*
C02.11
ICD-10 Finland
Malignant neoplasm of border of tongue
+∞
9.6
9
*
EJB30
NOMESCO Finland
Excision of lesion of floor of mouth
+∞
7.4
7
*
K13.78
ICD-10 Finland
Other change in the oral mucosa
16.2
7.2
11
8
EP1AE
NOMESCO Finland
Neck ultrasound examination
11.3
7.2
13
14
D00.05
ICD-10 Finland
In situ cancer of the pharyngeal part of the tongue
+∞
6.3
6
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
9.5
6.2
12
15
WX110
NOMESCO Finland
Local anesthesy
4.2
6.0
52
317

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
22
57
5.07
8.43
1.6
1.3
—
—
—
0
0
42
215
3.20
5.71
3.5
2.2
—
—
—
0
0
16
48
3.98
4.94
10.7
8.0
—
—
—
0
0
10
25
4.47
3.84
11.8
7.2
—
—
—
0
0
15
54
3.23
3.50
1.7
1.3
—
—
—
0
0
28
146
2.48
3.29
7.0
3.2
85.1
84.8
%
0.02
28
140
33
189
2.35
3.13
3.9
2.2
—
—
—
0
0
11
38
3.23
2.71
13.5
6.9
0.7
0.7
%
0.03
11
38
30
174
2.22
2.69
3.1
2.8
1.4
0.5
e6/l
0.77
19
126
5
7
7.55
2.59
1.4
2.7
9.5
12.5
%
—
5
7
29
169
2.18
2.55
3.1
2.8
—
—
—
0
0
31
187
2.13
2.49
3.4
3.0
84.9
379.3
e6/l
0.40
20
142
15
66
2.60
2.44
2.1
1.5
—
—
—
0
0
5
8
6.60
2.41
6.0
2.4
—
—
—
0
0
33
210
2.03
2.26
3.7
3.6
75.9
133.3
e6/l
0.36
21
154
7
20
3.75
2.11
1.4
2.1
—
—
—
0
0
10
38
2.89
2.11
14.7
6.3
0.9
1.4
%
—
10
38
5
10
5.27
2.10
1.8
2.8
50.6
68.0
%
—
5
10
8
27
3.19
2.00
2.0
2.5
0.6
0.7
%
—
8
27
9
190
0.40
2.00
4.1
2.9
—
—
—
0
0
21
120
2.05
1.88
1.3
1.7
1452.9
1291.7
nmol/l
0.25
14
88
9
35
2.78
1.87
1.9
3.6
132.0
130.1
g/l
—
9
35
8
29
2.97
1.85
2.0
2.5
1.7
1.6
%
—
8
29
21
126
1.93
1.63
1.6
1.3
—
—
—
0
0
6
20
3.17
1.61
1.5
4.5
—
—
—
0
0
37
267
1.77
1.59
6.9
9.3
1.6
1.3
inr
—
8
80
12
58
2.28
1.59
2.5
4.4
—
—
—
0
0
65
566
2.22
1.56
25.5
15.4
40.1
24.3
mg/l
1.76
55
468
29
196
1.79
1.55
5.2
5.2
—
—
—
0
0
5
17
3.08
1.38
1.8
2.8
—
—
—
0
0
33
243
1.65
1.25
1.9
2.0
98.1
93.0
pmol/l
0.25
14
121
13
72
1.98
1.24
1.5
1.6
—
—
—
0
0
65
584
1.93
1.15
18.2
15.2
—
—
—
0
0
11
59
2.02
1.14
1.3
1.4
—
—
—
0
0
36
276
1.59
1.13
6.0
5.1
0.6
0.6
e9/l
1.00
30
236
24
167
1.65
1.11
3.7
3.2
44.6
461.4
mg/l
0.57
18
108
9
45
2.14
1.10
9.7
4.4
24.0
24.6
mmol/l
—
9
45
10
171
0.52
1.09
2.8
2.5
370.0
10825.3
umol/l
—
10
145
36
278
1.57
1.09
6.0
5.2
0.0
0.0
e9/l
0.41
30
240
36
281
1.55
1.02
6.1
5.3
1.6
1.9
e9/l
1.07
31
246
10
54
1.98
1.02
1.4
1.6
—
—
—
0
0
7
36
2.04
1.00
1.3
1.4
—
—
—
0
0
0
30
0.00
1.00
0.0
1.2
—
255.1
—
0
24
24
172
1.59
0.98
3.5
3.0
5.1
7.5
mmol/l
4.72
19
143
25
181
1.58
0.98
10.0
4.2
—
—
—
0
0
56
486
1.63
0.97
31.9
16.8
35.4
40.1
%
1.61
38
322
10
165
0.54
0.96
3.2
3.6
—
—
—
0
0
8
43
1.96
0.91
1.4
1.5
—
—
—
0
0
32
251
1.48
0.86
7.5
10.4
0.0
0.0
e9/l
0.62
25
209
65
595
1.76
0.80
29.8
18.4
86.4
84.4
umol/l
0.12
65
595
51
443
1.49
0.79
32.5
19.7
13.9
13.9
%
0.04
51
432
7
118
0.55
0.76
5.1
5.6
—
—
—
0
0
14
198
0.64
0.73
4.8
4.3
—
—
—
0
0
24
183
1.46
0.72
4.2
3.8
7.7
12.7
mg/mmol
0.51
16
114
23
174
1.47
0.72
4.0
2.8
—
—
—
0
0
47
406
1.43
0.72
3.6
3.6
15.0
14.9
pmol/l
0.14
42
361
7
42
1.73
0.70
6.0
1.5
—
—
—
0
0
7
43
1.69
0.69
2.1
2.3
—
—
—
0
0
59
537
1.49
0.63
7.2
6.1
41.8
40.7
mmol/mol
0.33
53
496
19
142
1.45
0.63
7.7
6.0
—
—
—
0
0
0
23
0.00
0.59
0.0
1.2
—
—
—
0
0
9
63
1.49
0.55
2.2
1.9
—
—
—
0
0
37
319
1.32
0.51
12.2
9.5
4.3
4.3
e9/l
0.03
32
278
45
399
1.33
0.51
4.1
4.2
—
—
—
0
0
44
389
1.32
0.51
4.5
4.3
—
—
—
0
0
7
47
1.54
0.49
2.6
2.0
371.6
327.1
nmol/l
—
7
41
7
49
1.47
0.47
1.6
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
3.2
—
15.3
—
0
6
0
16
0.00
0.41
0.0
2.1
—
—
—
0
0
16
129
1.31
0.34
2.3
3.5
—
—
—
0
0
7
56
1.28
0.30
12.0
3.7
—
—
—
0
0
8
62
1.33
0.29
1.3
1.4
—
—
—
0
0
52
551
0.81
0.28
4.5
4.1
1.6
1.3
mmol/l
0.84
45
490
12
95
1.31
0.28
4.0
1.5
—
—
—
0
0
5
40
1.27
0.23
1.2
1.5
—
—
—
0
0
5
40
1.27
0.23
4.0
2.6
—
7.4
—
0
6
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
2.7
—
6.3
—
0
11
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
3.1
—
—
—
0
0
0
10
0.00
0.21
0.0
4.0
—
86.5
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
16.6
—
0
12
0
12
0.00
0.21
0.0
4.1
—
57.7
—
0
12
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
54
564
0.84
0.20
4.8
4.6
1.5
1.4
mmol/l
0.31
46
504
6
75
0.78
0.16
1.3
1.3
—
—
—
0
0
28
261
1.12
0.12
3.2
4.1
28.0
52.9
ng/l
1.10
19
206
55
566
0.89
0.11
4.6
4.6
4.3
4.5
mmol/l
0.73
48
512
20
213
0.92
0.07
2.9
3.5
—
—
—
0
0
57
581
0.92
0.05
5.4
5.2
2.3
2.6
mmol/l
2.31
51
517
0
5
0.00
0.00
0.0
1.2
—
32.2
—
0
5
0
6
0.00
0.00
0.0
1.2
—
289.8
—
0
6
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
1.7
—
0
6
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
5
51
0.98
0.00
1.8
2.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
2.8
—
341.8
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
11.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
0.8
—
0
8
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
7.3
—
0
6
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
6.9
—
0
8
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_ORALCAVITY – Carcinoma in situ of oral cavity

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).