Risteys · D3_FUNCPOLYMORPHONUCNEUTRO

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D71 Hospital discharge: ICD-9 — 2881 Cause of death: ICD-10 — D71 Cause of death: ICD-9 — 2881 2 out of 7 registries used, show all original rules.	30
4. Check minimum number of events None	30
5. Include endpoints None	30
6. Filter based on genotype QC (FinnGen only)	30

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	189	97	90
Only index persons	142	76	66
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	43.39	50.56	34.71
Only index persons	40.96	48.51	32.26

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	30	19	11
Unadjusted period prevalence (%)	0.01	0.01	0.00
Median age at first event (years)	45.09	47.87	40.30

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(42870588) Differential panel, method unspecified - Blood

5.89

5.25

20.7

6.0

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

5.21

4.07

3.8

2.2

34.8

29.4

0.43

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

12.05

3.67

3.0

2.8

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

6.28

3.58

30.2

7.5

324.1

226.5

u/l

—

(4035726)

5.94

3.44

1.6

1.2

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

9.00

3.21

5.3

4.6

3.8

3.5

g/l

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

11.61

3.09

1.2

1.0

—

(3006315) Basophils [#/volume] in Blood

124

3.30

2.47

15.9

5.7

0.1

0.0

e9/l

0.62

112

(3037756) Immunofixation for Serum or Plasma

7.21

2.47

1.0

1.5

—

(3001604) Monocytes [#/volume] in Blood

125

3.26

2.45

15.8

5.7

0.5

0.6

e9/l

0.42

112

(40758558) Short blood count panel - Blood

3.19

2.31

34.5

10.3

—

(3019198) Lymphocytes [#/volume] in Blood

128

3.12

2.20

15.9

6.1

1.8

1.9

e9/l

0.09

115

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

2.87

2.03

1.9

2.1

77.0

91.7

pmol/l

0.82

(3048929) Epstein Barr virus Ab [Presence] in Serum

5.21

2.02

1.4

—

(3042936) Bacteria identified in Isolate by Culture

3.03

1.66

2.1

3.5

—

(40768804) Tissue Pathology biopsy report

2.50

1.59

2.4

1.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

178

0.46

1.19

3.4

3.5

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

2.45

1.15

2.3

1.3

1.4

1.3

—

(3000494) Fungus identified in Specimen by Culture

2.45

1.15

2.6

2.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.65

1.13

1.2

3.2

—

(3026493) Urate [Moles/volume] in Serum or Plasma

2.23

1.08

7.5

3.3

317.5

6928.7

umol/l

—

(3019832) Treponema pallidum Ab [Presence] in Serum

2.52

1.00

1.7

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

2.01

0.91

7.1

3.6

608.3

1153.6

ng/l

1.12

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

2.09

0.87

13.7

3.5

5.7

4.6

umol/l

—

(3033658) Prothrombin time (PT) actual/Normal

2.00

0.85

6.8

4.1

68.1

87.7

—

(3044640) Blood type and Crossmatch panel - Blood

1.87

0.81

13.3

2.5

—

(3023368) Bacteria identified in Blood by Culture

1.90

0.79

9.6

4.2

—

(3002256) Pathology report gross observation

2.29

0.79

1.2

1.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.81

0.66

12.7

2.5

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

0.00

0.63

0.0

3.8

—

133.6

—

(4010399)

0.00

0.63

0.0

1.2

—

(3000991) Gas panel - Venous blood

0.00

0.63

0.0

11.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

123

1.64

0.57

16.1

5.3

—

(3021589) Normoblasts [#/volume] in Blood

106

1.60

0.52

22.9

9.1

0.0

e9/l

0.38

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.55

0.47

2.0

1.8

—

(3003694) ABO and Rh group [Type] in Blood

1.59

0.47

2.9

1.6

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.80

0.46

2.0

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.42

0.0

2.5

—

0.8

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.42

0.0

1.4

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.42

0.0

3.4

—

49.0

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.42

0.0

1.5

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.42

0.0

2.4

—

2.0

—

(1761868) Lipid panel - Serum or Plasma

0.60

0.40

2.2

2.7

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.53

0.38

2.3

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.42

0.34

2.4

1.5

—

(3013512) EKG study

1.45

0.32

7.5

4.9

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.34

0.31

4.4

4.6

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.22

0.0

1.0

—

(40768793) Breast Pathology biopsy report

0.00

0.22

0.0

1.1

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.22

0.0

3.2

—

6.3

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.22

0.0

3.2

—

1.2

—

(40768443) Skin Pathology biopsy report

0.00

0.21

0.0

1.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.21

0.0

3.3

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

0.00

0.21

0.0

51.5

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.20

0.0

1.2

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

3.6

—

24.9

—

(3018418) pH of Serum or Plasma

1.33

0.20

13.4

4.0

—

7.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.22

0.18

1.8

3.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.25

0.14

4.7

2.7

—

(3026782) Osmolality of Urine

1.16

0.10

3.3

2.6

537.2

504.4

mosm/kgh2o

—

(3009508) Creatinine [Moles/volume] in Urine

1.14

0.09

3.2

2.7

5.4

7.3

mmol/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

0.80

0.09

1.6

2.7

—

(3000850) Epithelial cells [#/volume] in Urine

0.77

0.09

3.2

2.1

2.6

4.6

e6/l

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.17

0.09

1.9

1.6

2.5

1.3

mmol/l

—

(3002582) Erythrocytes [#/volume] in Urine

1.12

0.08

5.1

2.7

10.3

14.7

e6/l

—

(3026008) Bacteria identified in Urine by Culture

1.07

0.08

2.3

3.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

179

1.17

0.07

4.3

3.9

—

(3015736) pH of Urine

108

0.89

0.03

1.8

2.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

104

0.94

0.00

1.8

3.2

—

(3044889) 12 lead EKG panel

169

1.01

0.00

4.5

3.5

—

(3031040) Bacteria [#/volume] in Urine by Automated count

169

1.01

0.00

6.2

4.3

—

40.6

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

3.4

—

108.0

—

(3010421) pH of Blood

0.00

0.0

2.5

—

7.4

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.2

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

231

0.98

0.00

42.4

18.1

40.8

40.1

0.10

176

(3003181) Sodium [Moles/volume] in Urine

0.00

0.0

1.2

—

51.0

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

2.4

—

8.7

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

743.4

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.0

1.1

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.2

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.7

—

(3024928) Oxygen saturation in Venous blood

0.00

0.0

6.4

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

5.4

—

14.1

—

(3037121) Protein [Mass/volume] in Urine

0.00

0.0

1.4

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

2.4

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

227

1.06

0.00

32.2

13.5

92.4

84.0

ml/min/173m2

0.85

184

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.2

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

0.92

0.00

3.3

2.0

2513.1

154.3

u/l

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.4

—

(4034850)

0.00

0.0

30.6

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3030467) Casts [#/volume] in Urine by Automated count

1.00

0.00

4.9

2.4

0.4

0.3

e6/l

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

0.00

0.0

1.6

—

24.9

—

(36304419) Bacteria [Presence] in Urine

1.03

0.00

4.9

2.3

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

249

1.02

0.00

37.8

18.7

3.9

4.0

mmol/l

0.08

244

(3008898) HLA-B27 [Presence]

0.00

0.0

1.0

—

(1616796) Gas panel - Central venous blood

0.00

0.0

1.6

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.0

1.2

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.0

1.4

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

3.0

—

4.2

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

3.4

—

3.9

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.2

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

2.4

—

4.9

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.6

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

4.7

—

29.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.6

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.8

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

3.4

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint D3_FUNCPOLYMORPHONUCNEUTRO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_FUNCPOLYMORPHONUCNEUTRO.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: D3_FUNCPOLYMORPHONUCNEUTRO – Functional disorders of polymorphonuclear neutrophils

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	D3_FUNCPOLYMORPHONUCNEUTRO
CONTROL_EXCLUDE	D3_BLOODOTHER
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D71
HD_ICD_9	2881
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D71
COD_ICD_9	2881
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Functional disorders of polymorphonuclear neutrophils

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints