Hypergammalglobulinemia, unspecified

D3_HYPERGAMMAGLONAS

immune system disease: A disorder resulting from an abnormality in the immune system.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D89.2 Cause of death: ICD-10 — D89.2 2 out of 7 registries used, show all original rules.	35
4. Check minimum number of events None	35
5. Include endpoints None	35
6. Filter based on genotype QC (FinnGen only)	35

Control definitions (FinnGen only)

Control exclude: D3_IMMUNEMECHANISM

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D89
Name in latin: Hypergammaglobulinaemia non specificata

NAME	D3_HYPERGAMMAGLONAS
CONTROL_EXCLUDE	D3_IMMUNEMECHANISM
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D892
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D892
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Hypergammalglobulinemia, unspecified based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	225	103	120
Only index persons	169	84	85
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	66.41	65.47	67.14
Only index persons	64.83	64.44	65.22

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	35	15	20
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	60.02	51.45	66.45

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3020630) Protein [Mass/volume] in Serum or Plasma

7.98

6.56

4.6

1.7

74.2

67.9

g/l

1.00

(40768446) Kidney Pathology biopsy report

+∞

6.43

1.8

0.0

—

(3004588) Protein electrophoresis panel - Serum or Plasma

8.35

6.34

4.6

1.6

—

(3012565) Volume of 24 hour Urine

+∞

5.33

2.6

0.0

1890.0

—

(42870588) Differential panel, method unspecified - Blood

3.76

3.60

10.3

5.2

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

116

3.87

3.57

16.0

5.6

1.2

mmol/l

0.01

(3022096) Basophils/100 leukocytes in Blood

113

3.55

3.22

11.0

6.0

0.6

0.7

0.18

108

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

11.34

3.07

2.8

1.2

0.2

g/l

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

11.34

3.07

2.8

1.4

1.3

0.9

g/l

—

(3002030) Lymphocytes/100 leukocytes in Blood

116

3.41

3.03

11.2

6.4

28.5

26.6

0.34

111

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

7.76

2.99

1.5

1.4

—

(3018418) pH of Serum or Plasma

3.37

2.97

14.1

3.3

7.4

—

(3015171) Extractable nuclear Ab [Units/volume] in Serum

9.44

2.84

1.2

1.3

—

(1616796) Gas panel - Central venous blood

8.08

2.63

5.8

1.7

—

(3013290) Carbon dioxide [Partial pressure] in Blood

8.08

2.63

5.8

2.0

4.6

5.3

kpa

—

(3027315) Oxygen [Partial pressure] in Blood

8.08

2.63

5.8

2.0

9.1

7.2

kpa

—

(40768443) Skin Pathology biopsy report

7.05

2.45

1.2

1.1

—

(3022313) Gas panel - Capillary blood

6.26

2.29

7.6

1.8

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

5.62

2.14

3.0

5.5

23.9

24.6

mmol/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.53

2.09

2.0

1.9

—

(4035726)

3.38

1.83

2.3

1.2

—

(3042936) Bacteria identified in Isolate by Culture

3.04

1.79

2.3

1.8

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

4.29

1.78

8.6

2.2

4.8

4.7

kpa

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

4.29

1.78

8.2

2.0

-2.3

0.6

mmol/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.24

1.75

2.4

1.3

—

(3019225) pH of Specimen

3.40

1.66

9.5

5.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.84

1.66

2.9

2.8

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

3.23

1.58

1.3

1.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.67

1.54

2.3

1.2

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

103

2.26

1.49

5.2

2.1

155.6

84.1

ug/l

1.03

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.46

1.49

1.8

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.46

1.49

1.4

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

2.46

1.46

10.3

4.9

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.93

1.43

2.2

1.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.25

1.41

1.8

1.7

—

(3013707) Erythrocyte sedimentation rate by Westergren method

197

2.24

1.32

7.5

3.9

31.3

10.7

mm/h

2.25

174

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.29

1.21

3.6

1.5

—

(3022948) Iron [Moles/volume] in Serum or Plasma

2.23

1.18

9.6

1.6

13.5

14.5

umol/l

—

(3037522) Nuclear Ab [Titer] in Serum

2.48

1.16

1.9

1.4

—

297.1

—

(3023368) Bacteria identified in Blood by Culture

2.12

1.14

8.8

3.7

—

(3012544) pH of Venous blood

2.60

1.13

5.8

3.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.12

1.09

3.7

2.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.24

1.07

4.6

1.3

—

(3015736) pH of Urine

105

1.96

1.07

5.6

3.0

—

(3032080) INR in Blood by Coagulation assay

106

1.94

1.03

12.8

7.7

1.3

1.1

inr

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

1.99

1.03

1.7

3.2

1150.8

976.8

ng/l

0.09

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.37

0.97

3.3

3.8

27.8

26.5

u/l

—

(3013512) EKG study

1.91

0.89

3.5

4.0

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

188

1.88

0.88

5.5

4.5

14.9

15.1

pmol/l

0.15

166

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

102

1.82

0.87

4.1

2.2

67.3

71.9

nmol/l

0.39

(36304419) Bacteria [Presence] in Urine

1.88

0.86

9.9

2.4

—

(40761536) Microorganisms panel - Urine sediment

2.16

0.76

19.4

3.4

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

143

1.72

0.76

10.4

6.7

9.1

11.4

umol/l

1.50

137

(3019832) Treponema pallidum Ab [Presence] in Serum

2.07

0.74

3.0

1.9

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

1.68

0.62

4.7

2.5

112.6

51.4

u/l

0.49

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.60

0.0

1.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

129

0.59

0.57

4.2

3.5

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

1.65

0.57

4.2

3.9

27.0

37.7

u/l

0.68

(40768797) Stomach Pathology biopsy report

1.60

0.54

1.0

1.3

—

(40758558) Short blood count panel - Blood

1.66

0.54

7.1

4.8

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

239

1.57

0.47

6.1

4.9

2.6

2.0

mu/l

0.96

212

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.49

0.46

8.8

2.9

—

(3021960) Folate [Moles/volume] in Serum or Plasma

1.57

0.45

2.3

1.4

19.5

18.6

nmol/l

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.42

0.0

1.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

111

1.44

0.38

2.6

1.8

80.5

93.2

pmol/l

—

(1761868) Lipid panel - Serum or Plasma

105

0.69

0.36

3.4

3.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

103

1.42

0.35

11.8

2.7

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.30

0.30

1.6

1.7

1.3

1.4

mmol/l

—

(3026008) Bacteria identified in Urine by Culture

1.31

0.29

3.6

3.0

—

(3003338) MCHC [Mass/volume]

223

0.76

0.25

26.1

17.3

331.9

332.5

g/l

0.12

223

(3037467) Urinalysis macro (dipstick) panel - Urine

177

1.30

0.24

10.8

4.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

158

1.29

0.23

4.1

2.9

—

(3035350) Ketones [Presence] in Urine by Test strip

129

1.28

0.22

10.3

3.6

0.0

estimate

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.22

0.0

1.2

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.22

0.0

2.2

—

(40768793) Breast Pathology biopsy report

0.00

0.22

0.0

1.1

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.22

0.0

1.2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.75

0.18

13.7

3.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

107

0.79

0.16

11.6

3.7

—

(3009542) Hematocrit [Volume Fraction] of Blood

236

0.82

0.14

20.2

15.0

38.5

40.4

0.78

170

(3044889) 12 lead EKG panel

187

1.16

0.09

5.5

3.8

—

(3031040) Bacteria [#/volume] in Urine by Automated count

177

1.16

0.09

8.0

4.0

—

26.2

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

177

1.16

0.09

5.8

3.2

49.8

63.5

u/l

0.52

169

(3000963) Hemoglobin [Mass/volume] in Blood

294

0.92

0.09

41.6

19.9

127.7

135.8

g/l

2.19

289

(3035941) MCH [Entitic mass]

294

0.92

0.09

40.9

19.6

31.0

30.4

0.77

289

(3024731) MCV [Entitic volume]

294

0.92

0.09

41.1

19.7

93.2

91.1

1.12

289

(3010813) Leukocytes [#/volume] in Blood

294

0.92

0.09

41.4

19.7

6.9

6.5

e9/l

0.51

287

(3026361) Erythrocytes [#/volume] in Blood

294

0.92

0.09

41.2

19.7

4.2

4.5

e12/l

3.01

286

(3007461) Platelets [#/volume] in Blood

293

0.94

0.09

41.4

19.8

250.2

247.1

e9/l

0.07

287

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

280

1.21

0.08

21.4

10.8

21.8

26.3

u/l

1.70

273

(40761511) CBC panel - Blood by Automated count

277

0.89

0.08

27.3

12.7

—

(3044640) Blood type and Crossmatch panel - Blood

0.82

0.08

3.6

2.1

—

(3002385) Erythrocyte distribution width [Ratio]

219

1.15

0.07

31.7

16.2

13.6

0.05

214

(40768804) Tissue Pathology biopsy report

105

1.07

0.00

3.0

2.0

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

245

0.94

0.00

9.2

6.1

41.5

40.0

mmol/mol

0.30

226

(3009261) Glucose [Presence] in Urine by Test strip

132

0.98

0.00

11.8

3.6

0.0

estimate

—

(3021601) Nitrite [Presence] in Urine by Test strip

129

1.01

0.00

14.8

4.8

0.0

estimate

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

5.0

—

4.1

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.6

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

2.4

—

6.0

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

5.4

—

19.6

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(4268621)

0.00

0.0

1.6

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.4

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

5.0

—

(4027681)

0.00

0.0

1.4

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

5.0

—

105.8

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.4

—

100.4

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

1.5

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.7

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.7

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.7

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

272

1.15

0.00

32.1

14.7

4.0

mmol/l

0.28

267

(3003694) ABO and Rh group [Type] in Blood

0.91

0.00

2.2

1.5

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

228.0

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

5.5

—

1.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.02

0.00

3.8

2.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.0

1.4

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.3

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3019150) Specific gravity of Urine by Refractometry

0.96

0.00

4.3

3.0

—

1.0

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(4034850)

0.00

0.0

5.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.7

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.0

1.4

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

1.6

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

3.1

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.1

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.7

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.0

1.4

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

5.5

—

9.5

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

3.0

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.7

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

8.0

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.7

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

282

1.17

0.00

35.9

15.6

113.8

78.5

umol/l

1.48

282

Mortality – FinRegistry

↥

Association

Association between endpoint D3_HYPERGAMMAGLONAS and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
D3_HYPERGAMMAGLONAS	2.562 [1.51, 4.34]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.015

During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 109 males with D3_HYPERGAMMAGLONAS died.

Mortality risk

Mortality risk for people of age

years, who have D3_HYPERGAMMAGLONAS.

N-year risk	Females	Males
1	No data	0.467%
5	No data	2.937%
10	No data	7.793%
15	No data	14.578%
20	No data	23.334%

Relationships between endpoints

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Index endpoint: D3_HYPERGAMMAGLONAS – Hypergammalglobulinemia, unspecified

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Hypergammalglobulinemia, unspecified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints