Subclinical iodine-deficiency hypothyroidism

E4_IODHYPSUB

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E02 Cause of death: ICD-10 — E02 2 out of 7 registries used, show all original rules.	47
4. Check minimum number of events None	47
5. Include endpoints None	47
6. Filter based on genotype QC (FinnGen only)	47

Control definitions (FinnGen only)

Control exclude: E4_THYROID

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E00-E07
Name in latin: Hypothyreosis subclinica ex deficientia iodi

NAME	E4_IODHYPSUB
CONTROL_EXCLUDE	E4_THYROID
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E02
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E02
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Subclinical iodine-deficiency hypothyroidism based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	326	238	86
Only index persons	302	223	79
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	64.28	63.43	66.30
Only index persons	62.37	60.81	66.78

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	47	30	17
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	59.56	59.45	59.76

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

162

3.36

3.86

2.3

1.7

68.5

101.3

pmol/l

2.12

(3003327) Ova and parasites identified in Stool by Light microscopy

7.81

2.61

1.2

1.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

145

2.55

2.49

4.0

3.8

38.0

59.0

ng/l

0.29

106

(3005719) IgG [Mass/volume] in Serum or Plasma

3.97

2.39

2.8

1.6

9.1

9.7

g/l

—

(3001604) Monocytes [#/volume] in Blood

189

2.40

2.15

9.0

5.3

0.6

e9/l

0.09

164

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

5.44

2.12

1.0

1.6

—

(3006315) Basophils [#/volume] in Blood

190

2.37

2.11

9.1

5.3

0.0

e9/l

0.20

165

(3028026) IgM [Mass/volume] in Serum or Plasma

3.73

2.05

3.6

1.4

7.9

1.1

g/l

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

4.94

1.99

1.0

1.1

0.2

0.3

g/l

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

4.52

1.87

1.0

1.1

1.3

1.4

g/l

—

(3021589) Normoblasts [#/volume] in Blood

180

2.17

1.78

13.3

9.7

0.0

e9/l

0.51

145

(3013115) Eosinophils [#/volume] in Blood

200

2.17

1.75

9.0

5.9

0.2

e9/l

0.24

177

(3000494) Fungus identified in Specimen by Culture

2.62

1.66

1.1

1.5

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

2.98

1.65

3.4

2.1

315.9

299.6

nmol/l

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.34

1.62

2.5

2.6

0.4

3.7

e6/l

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

2.27

1.60

1.5

1.1

1.2

0.7

u/ml

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.86

1.58

5.9

8.6

93.5

93.0

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.97

1.48

6.0

6.4

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.29

1.36

2.9

1.9

2.1

2.3

g/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

138

1.94

1.35

4.8

2.7

—

(40768797) Stomach Pathology biopsy report

2.32

1.33

1.1

1.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.98

1.32

1.0

1.1

—

(3032080) INR in Blood by Coagulation assay

157

1.91

1.31

6.7

7.4

1.1

inr

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.11

1.31

2.3

2.5

0.5

1.0

e6/l

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.21

1.30

4.7

5.7

107.5

103.8

mmol/l

2.40

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.49

1.23

6.5

8.6

0.7

0.9

—

(3023368) Bacteria identified in Blood by Culture

107

1.92

1.21

4.3

4.2

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

363

2.47

1.20

12.2

3.3

2.1

1.9

mu/l

0.43

327

(3004588) Protein electrophoresis panel - Serum or Plasma

2.56

1.18

4.6

2.3

—

(36304419) Bacteria [Presence] in Urine

108

1.90

1.18

2.9

2.6

—

(40768804) Tissue Pathology biopsy report

174

1.78

1.08

2.3

2.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.42

1.06

1.6

1.5

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.40

0.97

6.5

8.4

1.7

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.40

0.97

1.3

—

(3000991) Gas panel - Venous blood

2.31

0.95

7.8

9.0

—

(42870588) Differential panel, method unspecified - Blood

125

1.71

0.91

6.3

4.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

108

1.73

0.89

2.9

3.0

—

(1761868) Lipid panel - Serum or Plasma

119

1.67

0.82

3.1

3.0

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

233

1.64

0.82

12.2

11.2

3.7

4.2

e9/l

0.91

207

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.31

0.79

2.0

1.3

—

(3012544) pH of Venous blood

1.99

0.78

3.6

3.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.99

0.78

3.1

1.6

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.21

0.77

1.8

1.5

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

377

2.07

0.77

20.1

13.3

79.1

79.4

ml/min/173m2

0.02

309

(3013512) EKG study

121

1.63

0.77

6.6

4.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.68

0.75

1.8

1.9

—

(3044640) Blood type and Crossmatch panel - Blood

149

1.60

0.75

2.3

2.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

277

1.64

0.75

7.8

3.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.71

0.58

1.7

1.5

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

1.71

0.58

6.5

7.7

127.0

118.2

g/l

—

(3013707) Erythrocyte sedimentation rate by Westergren method

308

1.53

0.55

5.5

4.0

14.7

12.1

mm/h

0.29

282

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

159

1.45

0.52

3.8

3.4

—

(3003396) Base excess in Arterial blood by calculation

1.61

0.51

5.9

6.8

-0.0

1.7

mmol/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

113

1.48

0.51

2.1

—

(3002385) Erythrocyte distribution width [Ratio]

334

1.51

0.46

27.3

17.3

13.7

13.9

0.36

326

(40760892) CBC W Ordered Manual Differential panel - Blood

1.51

0.46

9.6

5.1

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.43

0.44

1.1

1.4

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

1.49

0.43

2.5

3.6

2.5

2.4

mmol/l

0.05

(40761535) Cells panel - Urine sediment

1.57

0.43

5.6

3.3

—

(3008898) HLA-B27 [Presence]

0.00

0.42

0.0

1.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.40

0.41

1.8

1.6

—

(3016502) Oxygen saturation in Arterial blood

1.53

0.38

6.0

7.3

96.5

95.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

197

1.33

0.36

3.6

4.0

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.38

0.35

2.0

1.6

—

(3042936) Bacteria identified in Isolate by Culture

1.26

0.28

2.5

1.7

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

3.5

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.21

0.0

1.5

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.8

—

84.0

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.5

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.21

0.0

1.6

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

2.0

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.32

0.21

2.0

1.7

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.29

0.21

1.7

1.5

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3002256) Pathology report gross observation

1.18

0.20

1.2

1.3

—

(3044889) 12 lead EKG panel

269

1.20

0.18

5.1

4.0

—

(3026008) Bacteria identified in Urine by Culture

134

1.18

0.13

3.9

2.5

—

(3003694) ABO and Rh group [Type] in Blood

105

1.19

0.12

1.9

1.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

104

1.08

0.01

4.3

3.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

234

1.05

0.00

3.0

2.9

—

(40758558) Short blood count panel - Blood

115

1.06

0.00

10.1

8.3

—

(3003338) MCHC [Mass/volume]

336

1.04

0.00

28.7

18.7

330.7

332.3

g/l

0.67

336

(3009542) Hematocrit [Volume Fraction] of Blood

342

0.98

0.00

25.0

15.2

38.0

39.5

0.28

246

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

248

1.02

0.00

2.8

2.7

31.2

49.5

u/l

2.28

232

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.1

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.3

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

1.1

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(3026179) Normetanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

0.4

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.1

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

3.0

—

(3044941) Cell count panel - Synovial fluid

0.00

0.0

1.2

—

(3039000) Anion gap in Blood

0.00

0.0

6.1

—

9.6

—

(44806118)

0.00

0.0

1.8

—

(3018572) Chloride [Moles/volume] in Blood

0.00

0.0

6.1

—

104.9

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

2.0

—

(44790048)

0.00

0.0

1.8

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

0.0

1.8

—

0.6

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

2.4

—

(3021788) Differential panel - Synovial fluid

0.00

0.0

1.4

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

6.1

—

177.8

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

4.4

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.4

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.0

1.0

—

66.2

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.91

0.00

1.0

1.3

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.0

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(44790047)

0.00

0.0

1.8

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.4

—

(44790049)

0.00

0.0

1.8

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.2

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.4

—

89.6

—

(3019150) Specific gravity of Urine by Refractometry

0.95

0.00

4.0

3.8

—

1.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_IODHYPSUB and mortality.

Females

Parameter	HR [95% CI]	p-value
E4_IODHYPSUB	1.248 [0.81, 1.93]	0.321
Birth year	0.995 [0.99, 1.0]	0.261

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 212 females with E4_IODHYPSUB died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_IODHYPSUB.

N-year risk	Females	Males
1	0.133%	No data
5	0.77%	No data
10	1.857%	No data
15	3.379%	No data
20	5.813%	No data

Relationships between endpoints

↥

Index endpoint: E4_IODHYPSUB – Subclinical iodine-deficiency hypothyroidism

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Subclinical iodine-deficiency hypothyroidism

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints