Kwashiorkor

E4_KWASHIORKOR

kwashiorkor: A syndrome produced by severe protein deficiency, characterized by retarded growth, changes in skin and hair pigment, edema, and pathologic changes in the liver, including fatty infiltration, necrosis, and fibrosis. The word is a local name in Gold Coast, Africa, meaning 'displaced child'. Although first reported from Africa, kwashiorkor is now known throughout the world, but mainly in the tropics and subtropics. It is considered to be related to marasmus. (From Dorland, 27th ed)

Suggest a new description

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E40 Hospital discharge: ICD-9 — 260 Hospital discharge: ICD-8 — 268 Cause of death: ICD-10 — E40 Cause of death: ICD-9 — 260 Cause of death: ICD-8 — 268 2 out of 7 registries used, show all original rules.	56
4. Check minimum number of events None	56
5. Include endpoints None	56
6. Filter based on genotype QC (FinnGen only)	55

Control definitions (FinnGen only)

Control exclude: E4_MALNUTRITION

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E40-E46
Name in latin: Malnutritio gravis ex deficientia proteinica

NAME	E4_KWASHIORKOR
CONTROL_EXCLUDE	E4_MALNUTRITION
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E40
HD_ICD_9	260
HD_ICD_8	268
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E40
COD_ICD_9	260
COD_ICD_8	268
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Kwashiorkor based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	708	362	337
Only index persons	543	277	266
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	50.60	49.94	50.91
Only index persons	39.10	35.23	43.14

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	55	27	28
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	41.60	29.30	53.46

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
56: Matched controls
560

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E40

ICD-10 Finland

Kwashiorkor

+∞

32.5

26899

ICD-8 Finland

Nutritional marasmus

+∞

18.8

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3003396) Base excess in Arterial blood by calculation

3.72

3.84

3.6

6.9

4.42

1.28

mmol/l

—

(3019060) Gas panel - Arterial blood

4.46

3.41

3.5

4.8

—

(40760888) Immunoglobulin light chains.free panel - Serum

7.69

2.60

2.6

5.3

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

7.69

2.60

2.6

5.3

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

6.72

2.42

2.0

1.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

153

2.31

2.36

2.2

1.9

89.27

95.14

pmol/l

0.31

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

5.03

2.34

1.3

1.8

—

(3012516) Albumin [Mass/volume] in Urine

2.42

2.30

3.2

3.3

2387.34

73.58

mg/l

0.48

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

5.97

2.26

2.8

2.6

1184.60

185.41

ug/l

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

4.66

2.21

1.3

1.7

—

(3019150) Specific gravity of Urine by Refractometry

2.44

2.19

6.1

4.8

1.02

kg/l

—

(3026008) Bacteria identified in Urine by Culture

125

2.25

2.13

3.6

3.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.80

2.08

1.7

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.65

2.04

4.7

5.7

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.73

2.00

1.8

1.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.37

1.84

2.0

1.8

—

(3006315) Basophils [#/volume] in Blood

211

2.05

1.83

4.7

5.7

0.05

0.04

e9/l

0.23

191

(3001604) Monocytes [#/volume] in Blood

211

2.05

1.83

4.7

5.6

0.68

0.60

e9/l

0.80

189

(40768797) Stomach Pathology biopsy report

2.43

1.83

1.4

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

203

2.03

1.79

5.3

6.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

3.18

1.79

1.6

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.41

1.70

2.2

1.5

—

(3035350) Ketones [Presence] in Urine by Test strip

216

1.97

1.67

6.2

4.0

0.00

estimate

—

(3013115) Eosinophils [#/volume] in Blood

216

1.97

1.67

5.0

5.9

0.20

0.19

e9/l

0.11

197

(3019198) Lymphocytes [#/volume] in Blood

217

1.96

1.64

4.8

5.7

1.76

1.68

e9/l

0.25

198

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.39

1.56

6.9

4.7

1.12

1.07

mmol/l

0.23

(3031040) Bacteria [#/volume] in Urine by Automated count

268

1.96

1.56

6.9

4.4

—

7001.50

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

3.55

1.56

2.4

2.7

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.07

1.55

5.2

3.0

—

(3020682) Albumin/Creatinine [Ratio] in Urine

106

2.03

1.53

3.5

3.9

16.66

11.15

mg/mmol

0.15

(3019069) Monocytes/100 leukocytes in Blood

203

1.89

1.49

4.7

5.5

8.72

0.00

194

(3009261) Glucose [Presence] in Urine by Test strip

222

1.89

1.49

6.2

4.0

0.00

estimate

—

(3022217) INR in Platelet poor plasma by Coagulation assay

205

1.86

1.43

25.1

12.4

1.20

1.22

inr

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

3.12

1.39

1.0

1.4

—

(3006504) Eosinophils/100 leukocytes in Blood

199

1.81

1.34

4.7

5.1

2.64

2.90

0.27

190

(3002030) Lymphocytes/100 leukocytes in Blood

209

1.80

1.32

4.6

5.2

22.60

26.52

1.61

200

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.11

1.30

4.8

2.0

2.23

2.39

g/l

0.38

(3021601) Nitrite [Presence] in Urine by Test strip

220

1.78

1.27

8.9

5.3

0.00

estimate

—

(3023368) Bacteria identified in Blood by Culture

114

1.85

1.22

6.6

4.5

—

(3022096) Basophils/100 leukocytes in Blood

195

1.74

1.19

4.7

4.9

0.70

0.69

0.04

183

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

2.64

1.17

2.8

1.4

—

(3018010) Neutrophils/100 leukocytes in Blood

205

1.73

1.17

4.7

5.0

60.30

58.06

0.44

196

(3003694) ABO and Rh group [Type] in Blood

105

0.43

1.16

1.0

1.3

—

(3023520) Reticulocytes [#/volume] in Blood

2.43

1.15

1.1

3.6

75.73

71.81

e9/l

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

142

1.77

1.15

3.0

3.2

34.10

30.87

u/l

0.21

135

(3024561) Albumin [Mass/volume] in Serum or Plasma

169

1.74

1.14

7.8

3.7

34.26

35.88

g/l

0.76

162

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

391

1.99

1.13

4.2

4.6

1.95

1.87

mu/l

0.21

352

(3022948) Iron [Moles/volume] in Serum or Plasma

1.94

1.06

4.8

2.1

12.41

15.03

umol/l

0.41

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

1.01

0.0

1.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

178

1.61

0.90

7.2

4.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

317

1.62

0.86

3.8

4.1

14.15

14.74

pmol/l

0.81

289

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.82

0.85

4.5

3.8

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.78

0.83

7.8

7.0

101.88

103.54

mmol/l

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

406

0.63

0.81

22.8

12.3

79.59

82.29

ml/min/173m2

0.25

338

(1002224) Polysomnography panel

0.00

0.81

0.0

1.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

139

1.56

0.73

7.9

3.1

—

(3025941) Bacteria identified in Stool by Culture

1.93

0.70

1.4

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.67

0.68

2.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.60

0.65

2.7

4.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

297

1.48

0.65

7.8

4.3

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.70

0.65

1.5

1.9

1.63

1.24

—

(3022621) pH of Urine by Test strip

1.73

0.63

12.0

3.0

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.73

0.63

5.6

2.7

0.54

0.74

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

1.56

0.53

2.1

2.2

0.86

0.82

mmol/l

0.38

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.59

0.51

1.3

2.3

5.34

6.28

umol/l

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.56

0.50

2.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

150

1.40

0.49

4.3

2.8

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.49

0.48

12.1

8.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

0.60

0.47

6.0

2.2

—

(3002385) Erythrocyte distribution width [Ratio]

371

1.39

0.44

27.6

16.7

13.83

14.96

2.51

366

(4200892) Spirometry reversibility

1.62

0.43

1.0

1.3

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.62

0.43

5.6

2.7

0.80

1.59

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.56

0.42

2.4

1.5

9.03

8.86

g/l

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

1.43

0.42

3.4

2.0

2.32

3.26

mg/l

0.81

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.42

0.0

5.1

—

30.38

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

1.52

0.41

7.8

6.0

1.54

1.45

mmol/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.43

0.41

1.4

1.5

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

252

1.31

0.39

7.1

10.7

5.01

4.20

e9/l

0.97

229

(3001122) Ferritin [Mass/volume] in Serum or Plasma

187

1.29

0.34

4.2

2.7

143.48

93.16

ug/l

0.49

173

(3002256) Pathology report gross observation

1.37

0.32

1.0

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.34

0.32

2.0

1.5

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.21

0.0

2.5

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.0

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.0

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

428

1.26

0.21

4.3

4.2

4.59

4.66

mmol/l

0.16

393

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.21

0.0

1.2

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.21

0.0

1.2

—

(40768793) Breast Pathology biopsy report

0.00

0.20

0.0

1.4

—

(40768443) Skin Pathology biopsy report

0.00

0.20

0.0

1.0

—

(1761868) Lipid panel - Serum or Plasma

172

0.83

0.19

2.6

3.0

—

(40768804) Tissue Pathology biopsy report

171

0.83

0.18

2.3

2.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

439

0.83

0.17

26.5

13.6

22.06

21.57

mg/l

0.03

346

(3013512) EKG study

125

0.85

0.11

7.0

4.0

—

(3044889) 12 lead EKG panel

284

1.12

0.10

4.5

4.0

—

(40761536) Microorganisms panel - Urine sediment

1.15

0.10

5.6

3.6

—

(3000492) Spirometry study

1.05

0.09

1.2

1.4

—

(3000494) Fungus identified in Specimen by Culture

1.10

0.09

2.2

1.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.09

0.08

2.1

1.5

—

(40758558) Short blood count panel - Blood

112

0.87

0.08

5.9

7.1

—

(3035941) MCH [Entitic mass]

486

0.91

0.08

32.8

20.5

30.49

30.37

0.22

481

(3009542) Hematocrit [Volume Fraction] of Blood

486

0.91

0.08

33.2

20.7

38.67

40.55

0.66

465

(3000963) Hemoglobin [Mass/volume] in Blood

486

0.91

0.08

33.0

20.8

135.71

135.51

g/l

0.03

481

(3024731) MCV [Entitic volume]

485

0.93

0.08

32.8

20.7

91.27

91.20

0.03

480

(3020564) Creatinine [Moles/volume] in Serum or Plasma

468

1.18

0.07

24.5

15.7

81.25

78.30

umol/l

0.23

468

(3044640) Blood type and Crossmatch panel - Blood

129

0.91

0.04

3.8

2.2

—

(3003338) MCHC [Mass/volume]

371

1.08

0.03

30.4

18.2

333.05

332.22

g/l

0.25

371

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

192

1.06

0.02

3.3

2.4

—

(40761511) CBC panel - Blood by Automated count

453

1.09

0.02

26.0

13.6

—

(3029937) Albumin [Presence] in Urine by Test strip

123

1.07

0.02

7.9

4.5

0.00

estimate

—

(3021589) Normoblasts [#/volume] in Blood

184

1.05

0.00

12.4

9.7

0.00

e9/l

-0.00

154

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

285

1.04

0.00

3.6

3.1

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

124

0.96

0.00

4.5

3.9

21.66

20.25

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

192

0.98

0.00

7.2

4.4

37.82

38.05

ng/l

0.00

137

(36304419) Bacteria [Presence] in Urine

118

1.02

0.00

5.3

2.6

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3044941) Cell count panel - Synovial fluid

0.00

0.0

1.2

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.3

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

0.90

0.00

2.6

1.9

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

2.4

—

(40768800) Prostate Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

3.6

—

97.10

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

2.0

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

-0.00

0.0

1.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

-0.00

0.0

1.0

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3004775) Volume in Urine collected for unspecified duration

0.00

-0.00

0.0

1.0

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3022145) Colonoscopy Study observation

1.00

-0.00

1.8

1.4

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

-0.00

0.0

1.0

—

34.80

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.1

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

4.6

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3000012) Reticulocyte production index

0.00

-0.00

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

1.2

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

177.80

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.4

—

(3042631) Mycobacterium sp identified in Specimen

0.00

-0.00

0.0

6.2

—

(3045424) Erythrocytes [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

-0.00

0.0

1.4

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

-0.00

0.0

3.0

—

(3042936) Bacteria identified in Isolate by Culture

1.02

-0.00

8.2

1.5

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

2.0

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

3.8

—

20.78

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.3

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

-0.00

0.0

1.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.2

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

-0.00

0.0

1.0

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

-0.00

0.0

1.0

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

-0.00

0.0

1.4

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

2.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_KWASHIORKOR and mortality.

Females

Parameter	HR [95% CI]	p-value
E4_KWASHIORKOR	3.646 [2.07, 6.42]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.332

During the follow-up period (1.1.1998 — 31.12.2019), 72 out of 146 females with E4_KWASHIORKOR died.

Males

Parameter	HR [95% CI]	p-value
E4_KWASHIORKOR	3.065 [1.53, 6.16]	0.002
Birth year	0.987 [0.98, 1.0]	0.009

During the follow-up period (1.1.1998 — 31.12.2019), 75 out of 143 males with E4_KWASHIORKOR died.

Mortality risk

Mortality risk for people of age

years, who have E4_KWASHIORKOR.

N-year risk	Females	Males
1	0.411%	0.628%
5	2.095%	3.623%
10	4.87%	9.362%
15	9.43%	16.697%
20	16.387%	26.306%

Relationships between endpoints

↥

Index endpoint: E4_KWASHIORKOR – Kwashiorkor

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Kwashiorkor

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints