Lipodystrophy, not elsewhere classified

E4_LIPODYST

lipodystrophy: a medical condition characterized by abnormal or degenerative conditions of the body's adipose tissue. ("Lipo" is Greek for "fat", and "dystrophy" is Greek for "abnormal or degenerative condition".)

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E88.1# Hospital discharge: ICD-9 — 2726 Cause of death: ICD-10 — E88.1# Cause of death: ICD-9 — 2726 2 out of 7 registries used, show all original rules.	54
4. Check minimum number of events None	54
5. Include endpoints None	54
6. Filter based on genotype QC (FinnGen only)	54

Control definitions (FinnGen only)

Control exclude: E4_METABOLIA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E88
Name in latin: Lipodystrophia non alibi classificata

NAME	E4_LIPODYST
CONTROL_EXCLUDE	E4_METABOLIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E881
HD_ICD_9	2726
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E881
COD_ICD_9	2726
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Lipodystrophy, not elsewhere classified based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	334	268	64
Only index persons	300	253	47
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	43.45	43.19	44.22
Only index persons	43.54	42.71	48.02

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	54	43	11
Unadjusted period prevalence (%)	0.01	0.01	0.00
Median age at first event (years)	50.48	49.01	56.23

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3022313) Gas panel - Capillary blood

6.00

2.97

1.7

1.9

—

(4306422)

9.01

2.80

1.4

1.0

—

(3012516) Albumin [Mass/volume] in Urine

123

2.52

2.65

4.9

2.8

16.7

18.1

mg/l

0.05

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.28

2.58

4.6

1.3

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

6.74

2.42

1.4

1.0

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

5.38

2.12

3.0

1.9

151.8

146.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

328

2.53

2.01

7.7

3.8

—

(3029937) Albumin [Presence] in Urine by Test strip

133

0.31

1.98

11.0

3.7

—

0.0

—

(3020682) Albumin/Creatinine [Ratio] in Urine

131

2.15

1.88

5.6

3.4

2.6

2.4

mg/mmol

0.05

(3048929) Epstein Barr virus Ab [Presence] in Serum

4.47

1.86

1.0

1.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.69

1.80

3.9

1.5

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

206

2.03

1.72

7.3

4.5

1.2

mmol/l

0.00

173

(40761536) Microorganisms panel - Urine sediment

0.00

1.60

0.0

3.5

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

0.00

1.60

0.0

3.8

—

1.2

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

3.33

1.47

1.8

1.6

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.62

1.44

4.4

1.5

—

(3003327) Ova and parasites identified in Stool by Light microscopy

3.13

1.39

1.8

1.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

165

1.82

1.28

2.3

2.0

104.6

96.3

pmol/l

0.43

(3012544) pH of Venous blood

2.29

1.25

2.5

3.4

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

186

1.77

1.20

7.7

4.2

1.2

mmol/l

0.17

166

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

196

1.76

1.18

4.0

2.1

76.8

77.1

nmol/l

0.02

171

(40760892) CBC W Ordered Manual Differential panel - Blood

107

0.41

1.17

14.0

6.0

—

(3002179) Metamyelocytes/100 leukocytes in Blood

0.00

0.98

0.0

7.8

—

0.2

—

(3018418) pH of Serum or Plasma

131

1.69

0.96

3.4

3.6

—

7.4

—

(36660697) Celiac disease serology panel - Serum

2.06

0.94

1.4

1.1

—

(3000991) Gas panel - Venous blood

2.12

0.90

14.5

4.5

—

(3019060) Gas panel - Arterial blood

2.29

0.78

2.6

4.8

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

413

1.77

0.76

8.3

5.0

40.8

38.7

mmol/mol

0.67

376

(3044889) 12 lead EKG panel

336

0.65

0.75

4.4

3.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.76

0.71

2.9

1.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.76

0.71

2.9

1.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.76

0.71

1.1

1.5

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.94

0.70

1.2

1.3

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.94

0.70

1.2

2.1

126.2

135.0

g/l

—

(3022217) INR in Platelet poor plasma by Coagulation assay

1.72

0.70

37.9

11.0

—

1.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.68

0.68

2.0

1.6

—

(3000494) Fungus identified in Specimen by Culture

1.74

0.66

3.6

1.5

—

(1761868) Lipid panel - Serum or Plasma

158

0.62

0.65

2.5

2.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

190

0.64

0.65

6.6

3.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.69

0.64

2.4

1.5

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

0.00

0.62

0.0

1.6

—

1230.1

—

(3027801) Oxygen [Partial pressure] in Arterial blood

1.75

0.59

14.3

4.7

13.0

11.7

kpa

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.75

0.59

14.3

4.7

5.0

4.9

kpa

—

(3019225) pH of Specimen

1.70

0.58

2.7

2.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

101

1.52

0.57

1.7

1.3

2.0

2.3

g/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

293

1.43

0.55

2.6

3.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

204

1.42

0.55

3.8

3.9

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

166

1.43

0.55

2.6

2.9

14.2

26.9

ng/l

1.85

110

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

1.55

0.55

2.2

1.8

0.5

0.9

mg/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.49

0.55

1.7

—

(42870588) Differential panel, method unspecified - Blood

149

1.42

0.51

10.9

5.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

459

1.73

0.50

16.5

11.0

21.0

19.9

mg/l

0.10

338

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.56

0.50

1.7

2.8

26.6

29.7

u/l

—

(3023368) Bacteria identified in Blood by Culture

1.49

0.49

2.8

3.9

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

439

1.54

0.45

16.7

10.6

81.0

82.7

ml/min/173m2

0.20

356

(3002173) Hemoglobin [Mass/volume] in Arterial blood

1.67

0.44

16.0

5.0

116.4

121.3

g/l

—

(3022621) pH of Urine by Test strip

1.67

0.44

7.4

2.2

—

(40768797) Stomach Pathology biopsy report

1.44

0.44

1.9

1.3

—

(3016502) Oxygen saturation in Arterial blood

1.62

0.43

16.6

4.8

97.1

96.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

134

0.69

0.41

7.6

2.9

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.44

0.36

21.2

4.4

107.3

104.2

mmol/l

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

452

1.56

0.36

5.6

4.6

1.9

mu/l

0.04

405

(3042936) Bacteria identified in Isolate by Culture

1.43

0.33

2.7

2.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

435

1.39

0.33

21.7

11.6

38.8

40.2

0.43

317

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

113

1.32

0.30

1.7

1.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

151

1.29

0.30

5.2

3.0

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

1.36

0.30

15.8

2.6

0.8

mmol/l

—

(3009261) Glucose [Presence] in Urine by Test strip

238

0.81

0.25

6.6

3.4

—

0.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.30

0.25

2.0

—

(3021601) Nitrite [Presence] in Urine by Test strip

236

0.82

0.23

10.2

4.5

—

0.0

—

(3044640) Blood type and Crossmatch panel - Blood

127

1.25

0.23

2.1

—

(4035726)

1.21

0.22

1.4

1.3

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.21

0.0

1.3

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(4281824)

0.00

0.21

0.0

1.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

3.2

—

84.6

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

4.0

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

0.00

0.21

0.0

4.9

—

1.5

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

0.00

0.21

0.0

4.6

—

1.0

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.20

0.0

1.4

—

(4034850)

0.00

0.20

0.0

7.1

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.19

0.19

2.7

7.8

—

(3003694) ABO and Rh group [Type] in Blood

130

1.21

0.18

1.4

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

130

1.21

0.18

2.9

1.8

123.4

119.2

u/l

0.08

120

(3013512) EKG study

122

1.20

0.16

5.1

3.0

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

377

0.86

0.13

4.5

3.9

15.1

14.7

pmol/l

0.41

335

(36304419) Bacteria [Presence] in Urine

124

1.17

0.13

4.6

2.7

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

105

1.18

0.12

4.9

3.7

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.20

0.12

1.3

1.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.10

0.10

1.2

1.4

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.07

0.10

3.0

2.5

6.5

10.5

umol/l

—

(3002256) Pathology report gross observation

0.79

0.09

1.2

—

(3035350) Ketones [Presence] in Urine by Test strip

234

0.90

0.08

6.3

3.4

—

0.0

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

1.08

0.08

6.4

4.7

1.8

ug/l

—

(40768804) Tissue Pathology biopsy report

197

1.11

0.08

3.3

2.1

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

459

1.18

0.07

6.9

4.8

2.5

2.8

mmol/l

1.67

412

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.12

0.07

2.0

1.6

—

(3002385) Erythrocyte distribution width [Ratio]

402

0.89

0.07

23.3

13.4

13.2

13.7

2.01

394

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

447

1.20

0.07

5.3

4.5

6.0

5.8

mmol/l

0.43

403

(3000850) Epithelial cells [#/volume] in Urine

0.84

0.07

5.4

2.5

8.8

5.2

e6/l

—

(3026493) Urate [Moles/volume] in Serum or Plasma

103

0.85

0.07

7.7

2.6

41810.2

11551.0

umol/l

—

(3026008) Bacteria identified in Urine by Culture

139

1.11

0.06

4.0

2.4

—

(40758558) Short blood count panel - Blood

112

1.09

0.03

10.3

6.5

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

141

0.99

0.00

6.0

2.3

55.3

52.9

u/l

0.18

127

(3018572) Chloride [Moles/volume] in Blood

0.00

0.0

6.6

—

107.3

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.4

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3011985) Renin [Units/volume] in Plasma

0.00

0.0

1.0

—

22.2

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.0

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.3

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

8.4

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

1.9

—

(3039000) Anion gap in Blood

0.00

0.0

6.6

—

10.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.4

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.1

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

2.1

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

2.6

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.5

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.0

1.6

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

2.8

—

3.3

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.0

1.4

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.4

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.0

1.3

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.4

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

34.2

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

2.0

—

4.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.0

1.8

—

34.3

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.5

—

6.5

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

0.92

0.00

1.6

2.3

2.4

2.5

mmol/l

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.2

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.3

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

3.0

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.2

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

2.6

—

32.4

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

2.6

—

2.1

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

2.0

—

14.5

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

3.7

—

60.9

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

489

1.02

0.00

21.8

13.1

75.1

72.1

umol/l

0.47

489

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.0

—

89.7

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.0

1.4

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.4

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.4

—

144.7

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.0

1.0

—

(4027681)

0.00

0.0

1.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.0

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.2

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_LIPODYST and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_LIPODYST.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_LIPODYST – Lipodystrophy, not elsewhere classified

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Lipodystrophy, not elsewhere classified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints