Compression of brain

G6_COMPBRAIN

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G93.5 Hospital discharge: ICD-9 — 3484 Cause of death: ICD-10 — G93.5 Cause of death: ICD-9 — 3484 2 out of 7 registries used, show all original rules.	41
4. Check minimum number of events None	41
5. Include endpoints None	41
6. Filter based on genotype QC (FinnGen only)	38

Control definitions (FinnGen only)

Control exclude: G6_OTHNEU

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G93
Name in latin: Compressio encephali

NAME	G6_COMPBRAIN
CONTROL_EXCLUDE	G6_OTHNEU
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G935
HD_ICD_9	3484
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G935
COD_ICD_9	3484
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Compression of brain based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	499	217	273
Only index persons	277	125	152
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.00	0.01
Median age at first event (years)
Whole population	55.50	56.32	54.58
Only index persons	55.00	56.56	53.71

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	38	17	21
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	55.69	51.45	59.12

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

+∞

9.75

2.0

0.0

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

+∞

6.40

1.8

0.0

1.83

—

mmol/l

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

6.97

4.29

2.9

1.7

114.90

272.56

ng/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

127

3.86

4.22

3.1

2.2

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

6.34

3.38

30.0

10.1

—

(3023368) Bacteria identified in Blood by Culture

3.11

2.87

6.3

5.3

—

(3022217) INR in Platelet poor plasma by Coagulation assay

133

2.94

2.82

10.1

15.4

1.00

1.22

inr

—

(3019060) Gas panel - Arterial blood

4.47

2.62

33.1

3.3

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

121

2.77

2.56

9.0

4.1

32.05

35.98

g/l

1.97

115

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

5.20

2.36

2.8

3.0

5.13

4.96

kpa

—

(3026008) Bacteria identified in Urine by Culture

2.52

2.00

6.7

3.3

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

174

2.35

1.80

15.0

5.1

7.33

6.68

mmol/l

0.65

153

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

161

2.18

1.58

4.5

5.5

10.29

11.64

umol/l

0.37

151

(21494755) Public health laboratory ask at order entry panel

0.00

1.43

0.0

1.3

—

(3019225) pH of Specimen

3.20

1.40

21.6

2.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.33

1.37

4.9

1.7

—

(3044640) Blood type and Crossmatch panel - Blood

2.02

1.22

3.3

1.9

—

(3019309) Folate [Moles/volume] in Red Blood Cells

2.22

1.18

1.8

1131.90

1177.95

nmol/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.07

1.07

2.9

1.7

—

(1761868) Lipid panel - Serum or Plasma

112

0.46

1.03

2.0

2.7

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

1.02

0.0

2.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

1.02

0.0

2.1

—

(3003694) ABO and Rh group [Type] in Blood

1.94

0.98

1.6

1.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.98

0.98

3.5

1.8

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.12

0.96

4.6

2.4

1.90

2.48

g/l

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

108

1.79

0.92

2.0

2.1

91.96

96.20

pmol/l

0.22

(3009542) Hematocrit [Volume Fraction] of Blood

342

0.54

0.82

38.9

19.9

39.83

40.84

0.53

327

(3010813) Leukocytes [#/volume] in Blood

342

0.54

0.82

40.1

19.9

7.89

6.85

e9/l

1.53

333

(3026361) Erythrocytes [#/volume] in Blood

342

0.54

0.82

40.1

19.7

4.26

4.54

e12/l

2.16

333

(3003338) MCHC [Mass/volume]

271

0.59

0.81

33.9

16.6

333.59

332.56

g/l

0.23

271

(3037467) Urinalysis macro (dipstick) panel - Urine

207

1.70

0.80

7.2

4.7

—

(3007461) Platelets [#/volume] in Blood

341

0.55

0.78

40.1

19.8

258.90

246.27

e9/l

0.45

333

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

285

0.62

0.69

7.5

5.0

42.86

39.33

mmol/mol

0.57

271

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.62

0.0

1.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.62

0.0

1.3

—

(3002179) Metamyelocytes/100 leukocytes in Blood

0.00

0.62

0.0

3.2

—

0.67

—

(3021440) Promyelocytes/100 leukocytes in Blood

0.00

0.62

0.0

3.6

—

0.00

—

(3025159) Blasts/100 leukocytes in Blood

0.00

0.62

0.0

3.5

—

0.00

—

(3017181) Myelocytes/100 leukocytes in Blood

0.00

0.61

0.0

3.5

—

0.33

—

(40768797) Stomach Pathology biopsy report

1.63

0.56

1.2

1.3

—

(3042936) Bacteria identified in Isolate by Culture

1.55

0.50

2.7

1.8

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

322

0.66

0.47

29.2

15.5

101.62

79.64

umol/l

0.45

322

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.64

0.44

1.4

1.8

—

(3021589) Normoblasts [#/volume] in Blood

124

0.65

0.43

12.1

11.7

0.01

0.00

e9/l

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.42

0.0

1.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.42

0.0

2.0

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.42

0.0

6.2

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.42

0.0

2.2

—

1.05

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.53

0.42

11.2

9.1

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.42

0.0

1.5

—

(3028026) IgM [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.7

—

0.88

—

(3022621) pH of Urine by Test strip

0.00

0.41

0.0

1.5

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.41

0.0

1.4

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.7

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

1.45

0.39

5.2

3.6

2.37

2.35

mmol/l

0.26

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

328

0.68

0.39

11.8

9.4

33.90

25.22

u/l

0.73

319

(3013512) EKG study

1.42

0.34

7.7

4.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.40

0.24

3.0

1.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.30

0.22

2.8

3.4

—

(3008898) HLA-B27 [Presence]

0.00

0.21

0.0

1.1

—

(40768443) Skin Pathology biopsy report

0.00

0.21

0.0

1.4

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.21

0.0

2.4

—

4.77

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.21

0.0

1.4

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.21

0.0

2.4

—

9.06

—

(3012501) Base excess in Blood by calculation

0.00

0.21

0.0

2.4

—

1.64

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.21

0.0

8.0

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.21

0.0

1.2

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.21

0.0

1.3

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.6

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

3.9

—

0.00

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.21

0.0

1.3

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.21

0.0

1.3

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.21

0.0

1.0

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.21

0.0

3.5

—

25.20

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.2

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

5.2

—

17.15

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.20

0.0

2.1

—

0.80

—

(1002224) Polysomnography panel

0.00

0.20

0.0

1.1

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.20

0.0

1.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

2.2

—

(40758558) Short blood count panel - Blood

1.20

0.17

5.8

6.6

—

(40761511) CBC panel - Blood by Automated count

313

0.85

0.10

30.7

12.8

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

303

0.85

0.10

41.7

15.4

140.00

139.65

mmol/l

0.35

294

(3023103) Potassium [Moles/volume] in Serum or Plasma

303

0.85

0.10

40.1

15.6

3.98

4.02

mmol/l

0.28

295

(3026782) Osmolality of Urine

1.11

0.09

5.1

3.1

522.43

539.21

mosm/kgh2o

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

0.81

0.08

1.8

1.5

1.00

1.43

mg/l

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.08

0.08

1.5

1.7

1.04

1.42

mmol/l

—

(3018010) Neutrophils/100 leukocytes in Blood

151

0.89

0.06

6.1

5.1

62.37

58.76

0.63

141

(3001122) Ferritin [Mass/volume] in Serum or Plasma

129

0.90

0.04

4.7

2.5

123.92

95.11

ug/l

0.34

118

(3019198) Lymphocytes [#/volume] in Blood

159

0.91

0.04

5.9

5.7

1.67

1.73

e9/l

0.11

141

(40768804) Tissue Pathology biopsy report

118

0.91

0.03

2.8

2.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

117

0.92

0.02

4.7

2.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

144

1.07

0.01

5.9

6.4

—

(3044889) 12 lead EKG panel

196

0.94

0.01

3.9

3.7

—

(3001604) Monocytes [#/volume] in Blood

153

0.97

0.00

5.9

5.7

0.63

0.62

e9/l

0.06

132

(3006504) Eosinophils/100 leukocytes in Blood

145

0.95

0.00

6.1

5.3

2.29

3.03

0.46

136

(3019069) Monocytes/100 leukocytes in Blood

145

1.05

0.00

6.1

5.6

8.48

8.81

0.20

136

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

215

0.95

0.00

3.5

3.7

—

(3006315) Basophils [#/volume] in Blood

154

0.96

0.00

5.9

5.8

0.04

e9/l

0.09

133

(3022096) Basophils/100 leukocytes in Blood

142

0.98

0.00

5.9

5.2

0.53

0.60

0.21

131

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

122

0.98

0.00

3.3

4.4

—

(3013115) Eosinophils [#/volume] in Blood

159

1.01

0.00

6.4

5.9

0.17

0.21

e9/l

0.29

141

(3013707) Erythrocyte sedimentation rate by Westergren method

222

0.98

0.00

5.1

3.5

13.95

11.50

mm/h

0.38

206

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

0.0

1.3

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.1

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

61.43

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

1.1

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.1

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

0.00

0.0

3.7

—

2.19

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

2.9

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.0

2.1

—

1.26

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

2.9

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.3

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.0

1.3

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

1.57

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.3

—

(40768800) Prostate Pathology biopsy report

0.00

-0.00

0.0

1.2

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

-0.00

0.0

1.2

—

90.46

—

(4034850) Laboratory test

0.00

-0.00

0.0

7.0

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.3

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.6

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

-0.00

0.0

1.7

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3002030) Lymphocytes/100 leukocytes in Blood

150

1.00

-0.00

5.9

5.3

21.25

26.14

1.45

141

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

-0.00

0.0

1.4

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

0.00

-0.00

0.0

1.4

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.6

—

4.00

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

0.96

—

(40768806) Pleura Pathology biopsy report

0.00

-0.00

0.0

2.3

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.2

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.6

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

-0.00

0.0

1.3

—

(3000850) Epithelial cells [#/volume] in Urine

0.86

-0.00

3.8

2.5

2.62

3.41

e6/l

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

1.2

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

0.00

-0.00

0.0

4.3

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.6

—

108.00

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

4.5

—

9.57

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.9

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

-0.00

0.0

1.8

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

-0.00

0.0

5.3

—

7.53

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.3

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

-0.00

0.0

1.0

—

0.87

—

(3025130) Human papilloma virus identified in Specimen

0.00

-0.00

0.0

1.4

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

-0.00

0.0

5.3

—

1.72

—

(36304419) Bacteria [Presence] in Urine

0.91

-0.00

3.1

2.5

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.3

—

0.25

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3005033) Fetal Nuchal fold Thickness US

0.00

-0.00

0.0

1.3

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

-0.00

0.0

1.3

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

5.0

—

39.45

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.4

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.4

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_COMPBRAIN and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_COMPBRAIN.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: G6_COMPBRAIN – Compression of brain

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Compression of brain

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints