Compression of brain

G6_COMPBRAIN

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G93.5 Hospital discharge: ICD-9 — 3484 Cause of death: ICD-10 — G93.5 Cause of death: ICD-9 — 3484 2 out of 7 registries used, show all original rules.	36
4. Check minimum number of events None	36
5. Include endpoints None	36
6. Filter based on genotype QC (FinnGen only)	36

Control definitions (FinnGen only)

Control exclude: G6_OTHNEU

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G93
Name in latin: Compressio encephali

NAME	G6_COMPBRAIN
CONTROL_EXCLUDE	G6_OTHNEU
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G935
HD_ICD_9	3484
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G935
COD_ICD_9	3484
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Compression of brain based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	499	217	273
Only index persons	277	125	152
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.00	0.01
Median age at first event (years)
Whole population	55.50	56.32	54.58
Only index persons	55.00	56.56	53.71

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	36	16	20
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	50.86	45.98	54.76

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

+∞

8.66

2.1

0.0

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

+∞

6.42

1.8

0.0

1.8

—

mmol/l

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

7.10

3.95

2.8

1.8

93.7

297.6

ng/l

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

6.93

3.19

34.1

10.0

—

(3023368) Bacteria identified in Blood by Culture

3.53

3.06

6.6

5.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

115

2.98

2.56

4.5

3.3

—

(3019060) Gas panel - Arterial blood

4.84

2.50

37.7

3.7

—

(3009542) Hematocrit [Volume Fraction] of Blood

250

0.39

1.94

35.3

13.3

41.8

41.3

—

203

(3024561) Albumin [Mass/volume] in Serum or Plasma

102

2.53

1.91

6.9

3.8

31.8

36.5

g/l

2.08

(3026008) Bacteria identified in Urine by Culture

2.52

1.70

7.5

2.8

—

(3019309) Folate [Moles/volume] in Red Blood Cells

2.81

1.60

1.7

1.5

1066.7

1052.1

nmol/l

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

247

0.46

1.42

19.2

11.1

86.0

85.0

ml/min/173m2

0.04

206

(21494755) Public health laboratory ask at order entry panel

0.00

1.23

0.0

1.3

—

(3022145) Colonoscopy Study observation

0.00

1.23

0.0

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.28

1.21

4.4

1.7

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

147

2.03

1.19

17.6

5.0

7.6

6.6

mmol/l

0.80

129

(3010813) Leukocytes [#/volume] in Blood

300

0.45

1.19

36.6

18.3

8.1

6.7

e9/l

1.89

293

(3026361) Erythrocytes [#/volume] in Blood

300

0.45

1.19

36.6

18.1

4.3

4.6

e12/l

2.22

293

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

138

2.01

1.18

4.3

5.9

10.8

11.7

umol/l

0.21

132

(3007461) Platelets [#/volume] in Blood

299

0.46

1.14

36.6

18.1

266.1

246.5

e9/l

0.70

293

(3003338) MCHC [Mass/volume]

246

0.52

1.06

34.9

15.2

332.6

333.0

g/l

0.07

246

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

1.03

0.0

2.3

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.00

1.02

0.0

1.7

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

1.00

0.0

1.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.10

1.00

3.0

1.9

—

(3044640) Blood type and Crossmatch panel - Blood

1.95

0.98

2.8

1.8

—

(3003694) ABO and Rh group [Type] in Blood

1.96

0.91

1.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

0.81

0.0

2.1

—

(3033658) Prothrombin time (PT) actual/Normal

1.89

0.78

5.0

3.3

97.0

93.8

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

281

0.56

0.74

27.6

14.0

77.9

76.1

umol/l

0.10

281

(3042936) Bacteria identified in Isolate by Culture

1.78

0.72

2.7

1.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

1.72

0.71

1.9

1.7

97.1

97.2

pmol/l

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

242

0.61

0.66

7.4

4.7

44.1

38.8

mmol/mol

0.80

232

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

286

0.59

0.62

11.5

9.3

36.8

25.8

u/l

0.80

280

(3021447) Carbon dioxide [Partial pressure] in Venous blood

0.00

0.61

0.0

3.7

—

5.9

—

(3002032) Base excess in Venous blood by calculation

0.00

0.61

0.0

3.7

—

3.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.66

0.61

2.8

1.8

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

1.59

0.50

2.1

71.0

58.8

u/l

0.27

(3037467) Urinalysis macro (dipstick) panel - Urine

175

1.48

0.46

8.1

4.2

—

(40768797) Stomach Pathology biopsy report

1.65

0.44

1.2

—

(40758558) Short blood count panel - Blood

1.46

0.43

5.8

7.6

—

(3013512) EKG study

1.43

0.42

6.9

3.7

—

(40761536) Microorganisms panel - Urine sediment

0.00

0.42

0.0

3.5

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.42

0.0

5.3

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.42

0.0

1.4

—

(3024354) Oxygen [Partial pressure] in Venous blood

0.00

0.42

0.0

2.8

—

4.0

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

1.38

0.41

5.4

3.5

1163.8

1648.9

ng/l

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.41

0.0

1.0

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.7

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.41

0.0

1.3

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

105

0.69

0.35

3.0

2.2

96.0

90.6

ug/l

—

(3021589) Normoblasts [#/volume] in Blood

105

0.69

0.35

11.0

10.1

0.0

e9/l

—

(40761511) CBC panel - Blood by Automated count

276

0.69

0.35

27.5

11.2

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

1.27

0.28

3.9

3.4

2.4

mmol/l

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

262

0.75

0.25

37.3

13.9

4.0

mmol/l

0.22

256

(3019550) Sodium [Moles/volume] in Serum or Plasma

262

0.75

0.25

38.7

13.6

140.1

139.8

mmol/l

0.29

255

(40768804) Tissue Pathology biopsy report

100

0.74

0.25

2.9

2.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.22

0.0

1.4

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.22

0.0

1.4

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.22

0.0

1.0

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.22

0.0

1.4

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.22

0.0

3.5

—

56.4

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.22

0.0

7.1

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.22

0.0

1.3

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.00

0.22

0.0

6.4

—

16.3

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.22

0.0

1.5

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.22

0.0

1.2

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.22

0.0

1.9

—

268.9

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.22

0.0

1.3

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

0.00

0.22

0.0

4.9

—

24.6

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.21

0.0

2.7

—

25.3

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.21

0.0

1.8

—

0.8

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.21

0.0

1.9

—

(1002224) Polysomnography panel

0.00

0.21

0.0

1.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.21

0.0

1.8

—

1.1

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

161

0.79

0.21

7.4

11.1

4.6

4.3

e9/l

0.15

139

(3025941) Bacteria identified in Stool by Culture

0.00

0.20

0.0

1.5

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

2.2

—

(3022621) pH of Urine by Test strip

0.00

0.20

0.0

1.7

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.20

0.0

1.3

—

(3013707) Erythrocyte sedimentation rate by Westergren method

190

0.80

0.19

5.2

3.3

14.9

10.2

mm/h

0.69

177

(3041096) Erythrocytes [Presence] in Urine by Automated

1.20

0.18

2.8

3.0

—

(42870588) Differential panel, method unspecified - Blood

1.28

0.18

5.2

—

(3018010) Neutrophils/100 leukocytes in Blood

128

0.80

0.17

5.4

4.9

62.2

58.7

0.40

119

(3013115) Eosinophils [#/volume] in Blood

137

0.81

0.15

6.3

5.8

0.2

e9/l

0.16

121

(3019198) Lymphocytes [#/volume] in Blood

136

0.82

0.14

5.2

5.5

1.7

e9/l

0.04

118

(3006504) Eosinophils/100 leukocytes in Blood

124

0.84

0.11

5.4

5.0

2.4

3.0

0.31

116

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

194

0.86

0.10

3.1

3.8

—

(3006315) Basophils [#/volume] in Blood

133

0.85

0.09

5.2

5.5

0.0

e9/l

0.19

114

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

0.76

0.09

1.6

1.0

1.5

mmol/l

—

(3018418) pH of Serum or Plasma

1.10

0.09

4.0

3.8

—

7.4

—

(3022096) Basophils/100 leukocytes in Blood

122

0.86

0.08

5.1

4.9

0.5

0.6

0.14

112

(3015736) pH of Urine

100

0.87

0.07

2.8

3.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

0.89

0.07

3.4

3.7

—

(3001604) Monocytes [#/volume] in Blood

131

0.87

0.07

5.2

5.6

0.6

e9/l

0.06

112

(3002030) Lymphocytes/100 leukocytes in Blood

128

0.91

0.03

5.2

5.1

20.9

26.5

1.37

120

(3044889) 12 lead EKG panel

165

0.95

0.00

3.9

3.4

—

(3019069) Monocytes/100 leukocytes in Blood

124

0.95

0.00

5.4

8.0

8.7

0.41

116

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.0

1.4

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

0.0

4.8

—

8.6

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

2.2

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.2

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.0

1.4

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

2.2

—

4.0

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.4

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

2.2

—

108.2

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

3.0

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.0

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

1.0

—

(4268621)

0.00

0.0

1.8

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.0

1.1

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.3

—

(40768443) Skin Pathology biopsy report

0.00

0.0

1.5

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

60.2

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.0

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.1

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

3.7

—

7.0

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.6

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.3

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.0

1.3

—

(4094501)

0.00

0.0

1.3

—

(36304419) Bacteria [Presence] in Urine

1.04

0.00

2.7

2.4

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(4034850)

0.00

0.0

7.0

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.0

1.5

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.6

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

5.8

—

8.8

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

1.2

—

4.7

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

2.9

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

3.7

—

1.4

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.4

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

1.2

—

9.4

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.2

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

1.1

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

4.1

—

0.0

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

0.94

0.00

5.0

2.5

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.7

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_COMPBRAIN and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_COMPBRAIN.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: G6_COMPBRAIN – Compression of brain

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Compression of brain

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints