Disorders of hypoglossal nerve

G6_DISHYP

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G52.3 Hospital discharge: ICD-9 — 3525 Hospital discharge: ICD-8 — 35604 Cause of death: ICD-10 — G52.3 Cause of death: ICD-9 — 3525 Cause of death: ICD-8 — 35604 2 out of 7 registries used, show all original rules.	45
4. Check minimum number of events None	45
5. Include endpoints None	45
6. Filter based on genotype QC (FinnGen only)	45

Control definitions (FinnGen only)

Control exclude: G6_NERPLEX

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: G52
Name in latin: Morbositates nervi hypoglossi

NAME	G6_DISHYP
CONTROL_EXCLUDE	G6_NERPLEX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G523
HD_ICD_9	3525
HD_ICD_8	35604
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G523
COD_ICD_9	3525
COD_ICD_8	35604
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Disorders of hypoglossal nerve based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	288	131	155
Only index persons	253	114	139
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.01
Median age at first event (years)
Whole population	58.35	61.34	55.77
Only index persons	57.78	60.91	55.20

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	45	26	19
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	59.63	60.54	58.40

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3044290) Cell count panel - Cerebral spinal fluid

16.18

4.74

1.1

1.4

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

162

3.94

4.48

9.4

6.3

1.2

mmol/l

0.06

131

(3004588) Protein electrophoresis panel - Serum or Plasma

5.30

4.34

1.2

3.0

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

9.64

3.37

1.3

7.3

0.0

g/l

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

2.99

2.89

1.9

2.2

2.8

3.0

mg/l

0.17

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

5.58

2.49

1.3

4.7

—

(3032080) INR in Blood by Coagulation assay

148

2.55

2.40

11.5

7.5

1.3

inr

—

(3044889) 12 lead EKG panel

260

2.26

1.51

3.2

4.0

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.42

1.44

3.7

3.8

1.1

1.0

mmol/l

—

(3021589) Normoblasts [#/volume] in Blood

164

1.99

1.41

5.7

11.4

0.0

e9/l

0.00

137

(3015736) pH of Urine

141

1.92

1.26

2.4

3.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.03

1.18

2.8

4.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

164

1.82

1.12

4.0

3.9

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

349

2.31

1.06

17.0

14.1

80.5

78.2

ml/min/173m2

0.25

288

(4010399)

2.43

1.06

1.0

1.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.18

1.05

1.6

1.5

—

(3005719) IgG [Mass/volume] in Serum or Plasma

0.00

1.02

0.0

3.1

—

9.2

—

(3007164) IgA [Mass/volume] in Serum or Plasma

1.92

0.92

1.2

1.6

1.9

2.5

g/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

126

1.71

0.89

3.7

2.8

—

(3028026) IgM [Mass/volume] in Serum or Plasma

0.00

0.82

0.0

2.2

—

1.4

—

(1761868) Lipid panel - Serum or Plasma

137

0.57

0.77

3.3

3.1

—

(3019060) Gas panel - Arterial blood

2.03

0.73

10.8

4.7

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.96

0.71

1.0

1.7

—

(3044640) Blood type and Crossmatch panel - Blood

116

1.59

0.67

2.9

2.0

—

(40768804) Tissue Pathology biopsy report

144

1.55

0.66

2.8

2.0

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

0.00

0.62

0.0

1.2

—

37.6

—

(3023368) Bacteria identified in Blood by Culture

101

1.56

0.59

7.6

4.3

—

(3021960) Folate [Moles/volume] in Serum or Plasma

1.56

0.56

1.4

1.6

30.1

24.0

nmol/l

0.55

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

159

1.46

0.53

2.1

1.9

90.0

94.4

pmol/l

—

(3018095) Leukocytes [#/volume] in Urine

131

1.48

0.53

3.8

3.3

9.2

61.1

e6/l

1.48

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.52

0.48

3.3

1.9

—

(3003694) ABO and Rh group [Type] in Blood

1.47

0.43

1.3

1.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

326

1.52

0.42

19.2

15.2

38.9

40.4

0.77

229

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.41

0.0

2.9

—

8.2

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.41

0.0

2.9

—

5.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.38

0.40

2.7

2.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

361

1.60

0.37

19.7

14.6

36.1

22.1

mg/l

1.39

285

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.42

0.36

1.7

1.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.42

0.36

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.38

0.35

1.7

1.9

—

(3026493) Urate [Moles/volume] in Serum or Plasma

0.69

0.35

4.4

3.6

368.3

15009.0

umol/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

201

0.75

0.33

2.5

2.8

—

(3037467) Urinalysis macro (dipstick) panel - Urine

250

1.32

0.32

3.9

4.5

—

(3012516) Albumin [Mass/volume] in Urine

1.34

0.28

2.4

3.0

81.8

46.2

mg/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.39

0.24

3.4

4.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.21

0.22

10.6

8.1

—

(3020682) Albumin/Creatinine [Ratio] in Urine

109

1.27

0.22

2.8

4.0

10.4

4.5

mg/mmol

—

(1002224) Polysomnography panel

0.00

0.21

0.0

1.1

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.21

0.0

1.3

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.21

0.0

2.6

—

1.5

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.21

0.0

2.5

—

(1616796) Gas panel - Central venous blood

0.00

0.21

0.0

2.2

—

(4094501)

0.00

0.21

0.0

1.2

—

(40768793) Breast Pathology biopsy report

0.00

0.21

0.0

1.4

—

(3042936) Bacteria identified in Isolate by Culture

1.20

0.20

1.5

1.4

—

(3022217) INR in Platelet poor plasma by Coagulation assay

1.20

0.20

41.2

28.7

—

1.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

149

1.23

0.19

3.5

4.6

—

(36304419) Bacteria [Presence] in Urine

101

1.26

0.19

3.1

2.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

160

1.21

0.18

3.8

15.8

43.9

ng/l

0.83

114

(3000850) Epithelial cells [#/volume] in Urine

1.14

0.16

2.9

2.6

3.6

4.8

e6/l

—

(42870588) Differential panel, method unspecified - Blood

124

1.19

0.13

4.4

5.4

—

(3022145) Colonoscopy Study observation

1.12

0.10

1.2

—

(3002256) Pathology report gross observation

1.07

0.10

1.6

1.2

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

117

1.16

0.09

4.8

5.1

2.9

2.0

ug/l

0.41

104

(40758558) Short blood count panel - Blood

1.16

0.08

12.4

7.0

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

1.01

0.00

3.4

4.0

38.3

22.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

111

0.99

0.00

2.9

3.7

—

(3013512) EKG study

115

0.94

0.00

3.8

4.5

—

(3026008) Bacteria identified in Urine by Culture

116

1.05

0.00

3.1

3.5

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.00

0.00

2.6

1.6

9.9

13.5

umol/l

—

(4268621)

0.00

0.0

2.6

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.6

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

1.5

—

31.4

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(4281824)

0.00

0.0

1.0

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

2.3

—

55.8

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.0

2.0

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

25.1

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.7

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.3

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.7

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

2.3

—

4.3

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

1.4

—

231.4

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.4

—

(4306422)

0.00

0.0

1.6

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.2

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

1.3

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

2.4

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

5.4

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.4

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

0.00

0.0

1.3

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.5

—

127.7

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.4

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

4.4

—

51.0

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

0.2

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.0

1.7

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.7

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

2.7

—

88.6

—

(40760892) CBC W Ordered Manual Differential panel - Blood

0.95

0.00

3.8

5.6

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.2

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

1.7

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

1.1

—

531.1

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.3

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.2

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

2.8

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.0

1.5

—

(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

1.6

—

26.9

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.7

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

3.0

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.4

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

40.3

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_DISHYP and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_DISHYP.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: G6_DISHYP – Disorders of hypoglossal nerve

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Disorders of hypoglossal nerve

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints