Risteys · G6

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G52.2 Hospital discharge: ICD-9 — 3523 Hospital discharge: ICD-8 — 35603 Cause of death: ICD-10 — G52.2 Cause of death: ICD-9 — 3523 Cause of death: ICD-8 — 35603 2 out of 7 registries used, show all original rules.	43
4. Check minimum number of events None	43
5. Include endpoints None	43
6. Filter based on genotype QC (FinnGen only)	43

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	387	184	199
Only index persons	268	135	133
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.00	0.01
Median age at first event (years)
Whole population	54.09	55.79	52.32
Only index persons	51.21	51.95	50.46

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	43	25	18
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	51.81	49.55	54.96

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

4.89

4.79

8.8

8.2

kpa

4.8

5.1

0.49

(3027801) Oxygen [Partial pressure] in Arterial blood

4.89

4.79

8.8

8.2

kpa

11.0

11.8

0.31

(3002173) Hemoglobin [Mass/volume] in Arterial blood

4.81

4.44

9.0

9.2

g/l

123.4

121.5

0.10

(3016502) Oxygen saturation in Arterial blood

4.37

3.95

9.0

8.7

95.8

96.0

0.03

(3026008) Bacteria identified in Urine by Culture

103

3.33

3.63

5.9

3.0

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

6.02

3.60

4.9

10.9

0.5

0.8

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

6.02

3.60

4.8

11.0

1.9

1.6

—

(3031040) Bacteria [#/volume] in Urine by Automated count

226

3.94

3.51

6.6

4.2

—

93.2

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

229

3.83

3.49

4.5

3.2

u/l

97.4

47.5

0.43

218

(3018418) pH of Serum or Plasma

110

3.05

3.15

8.0

4.5

7.4

—

(3044640) Blood type and Crossmatch panel - Blood

109

2.81

2.73

2.0

2.2

—

(3032080) INR in Blood by Coagulation assay

145

2.73

2.59

7.4

7.6

inr

1.2

1.3

—

(21494755) Public health laboratory ask at order entry panel

3.65

2.39

1.2

1.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

116

2.58

2.34

4.3

3.3

—

(3020891) Body temperature

4.79

2.23

4.7

6.1

—

(3049717) Cytology report of Urine Cyto stain

5.49

2.13

3.8

3.2

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

3.43

1.89

14.0

9.9

mmol/l

26.0

24.2

—

(3000991) Gas panel - Venous blood

3.43

1.89

6.3

10.0

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

152

2.31

1.88

3.5

ng/l

16.9

64.4

1.30

(3002032) Base excess in Venous blood by calculation

3.04

1.83

20.1

6.1

mmol/l

2.7

2.1

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

3.04

1.83

20.3

6.2

kpa

5.9

5.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

242

2.56

1.82

7.6

4.4

—

(3023368) Bacteria identified in Blood by Culture

2.37

1.81

9.1

4.3

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.14

1.73

1.3

5.1

mmol/l

26.4

24.5

—

(36304419) Bacteria [Presence] in Urine

2.22

1.62

3.8

2.8

—

(3000494) Fungus identified in Specimen by Culture

2.59

1.61

2.3

1.3

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.59

1.61

26.0

7.9

mmol/l

1.1

1.0

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.62

1.57

15.8

9.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.65

1.54

3.0

1.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

171

2.10

1.52

4.6

4.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.57

1.51

3.7

1.6

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

145

2.06

1.46

16.3

5.1

g/l

34.6

35.5

0.36

136

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.86

1.42

25.8

5.3

g/l

123.0

121.7

—

(4010399)

2.86

1.42

1.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.41

1.41

8.0

1.4

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

147

2.02

1.39

3.5

2.4

nmol/l

74.5

79.3

0.52

129

(3012544) pH of Venous blood

2.65

1.38

19.8

5.9

—

(3044889) 12 lead EKG panel

247

2.16

1.34

4.1

3.7

—

(3029937) Albumin [Presence] in Urine by Test strip

106

2.00

1.28

4.2

4.0

estimate

0.0

—

(3022217) INR in Platelet poor plasma by Coagulation assay

2.35

1.26

47.0

18.8

—

1.3

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.84

1.25

30.2

5.2

mmol/l

25.0

24.3

—

(3024354) Oxygen [Partial pressure] in Venous blood

2.51

1.23

2.8

3.4

kpa

4.2

4.6

—

(3019060) Gas panel - Arterial blood

2.51

1.23

13.0

5.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

143

1.92

1.22

2.4

1.8

pmol/l

93.6

93.9

0.01

(4035726)

2.50

1.17

1.3

—

(3042936) Bacteria identified in Isolate by Culture

2.16

1.12

3.9

2.2

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

2.56

1.12

2.6

4.3

pmol/l

4.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

149

1.80

1.03

3.9

3.8

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.12

1.02

1.4

2.1

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

1.98

0.93

7.2

3.4

ng/l

665.4

236.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.84

0.91

2.3

2.0

—

(3000492) Spirometry study

2.16

0.91

1.3

1.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

183

1.70

0.88

5.5

4.8

estimate

0.0

—

(40761535) Cells panel - Urine sediment

2.08

0.88

2.2

3.1

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

2.01

0.85

6.8

6.7

mmol/l

1.2

—

(3035350) Ketones [Presence] in Urine by Test strip

185

1.67

0.83

4.2

3.7

estimate

0.0

—

(3022621) pH of Urine by Test strip

0.00

0.80

0.0

2.0

—

(42870588) Differential panel, method unspecified - Blood

112

1.68

0.78

6.4

6.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

2.00

0.78

1.4

2.4

—

(3025941) Bacteria identified in Stool by Culture

2.22

0.77

1.0

1.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.70

0.76

3.7

1.8

—

(3009261) Glucose [Presence] in Urine by Test strip

189

1.61

0.74

4.3

3.7

estimate

0.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.69

0.69

3.2

3.1

—

(40758558) Short blood count panel - Blood

1.64

0.67

4.1

6.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.62

0.0

2.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.00

0.61

0.0

1.2

—

(3002385) Erythrocyte distribution width [Ratio]

302

1.60

0.54

37.4

17.6

14.1

13.9

0.29

297

(3015736) pH of Urine

142

1.46

0.50

4.1

3.3

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

106

1.48

0.47

3.3

3.0

u/l

77.4

26.7

0.59

101

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

233

1.43

0.45

3.4

3.0

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.69

0.45

2.2

2.6

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.69

0.45

1.8

1.7

—

(3003694) ABO and Rh group [Type] in Blood

1.47

0.44

1.3

1.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.49

0.42

1.0

1.4

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.2

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.41

0.0

2.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.46

0.41

3.5

7.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.41

0.0

1.0

—

(40761536) Microorganisms panel - Urine sediment

1.48

0.41

6.8

5.5

—

(3022145) Colonoscopy Study observation

1.50

0.37

1.5

1.4

—

(1761868) Lipid panel - Serum or Plasma

138

0.73

0.32

2.8

2.4

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.35

0.28

1.6

1.4

mmol/l

1.3

1.5

0.35

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

116

1.31

0.26

5.1

4.8

ug/l

1.5

4.8

0.63

102

(3041096) Erythrocytes [Presence] in Urine by Automated

108

1.29

0.23

4.6

3.8

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.25

0.23

2.6

3.8

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.21

0.0

1.3

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.5

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.3

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.21

0.0

1.5

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.21

0.0

1.2

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.6

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.21

0.0

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.21

0.0

1.5

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.21

0.0

1.0

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(3008898) HLA-B27 [Presence]

0.00

0.20

0.0

1.1

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.20

0.0

1.0

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

2.4

—

(3003338) MCHC [Mass/volume]

301

1.25

0.18

38.0

17.8

g/l

332.3

331.6

0.16

301

(3009542) Hematocrit [Volume Fraction] of Blood

322

1.27

0.15

36.1

14.5

40.2

40.1

0.06

241

(40768804) Tissue Pathology biopsy report

155

0.86

0.11

2.6

1.9

—

(40768797) Stomach Pathology biopsy report

1.15

0.09

1.0

1.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.13

0.09

1.9

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

1.07

0.08

1.6

2.9

ug/l

0.5

0.8

—

(3013512) EKG study

101

1.12

0.04

3.4

3.9

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

2.3

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.5

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.0

1.1

—

12.5

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.0

1.2

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

4.5

—

3.9

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.0

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

2.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.1

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.2

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.84

0.00

1.4

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

7.6

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

4.0

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

0.0

1.3

—

94.5

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

2.0

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

0.94

0.00

1.8

1.5

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.4

—

188.4

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3004809) Band form neutrophils/100 leukocytes in Blood

0.00

0.0

6.5

—

1.2

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

4.5

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.3

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.1

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

4.5

—

105.7

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.2

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

2.0

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

1.4

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(3023183) Ammonium ion [Moles/volume] in Plasma

0.00

0.0

11.0

—

28.0

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

1.6

—

257.3

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

2.7

—

15.5

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_DISVAG and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_DISVAG.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: G6_DISVAG – Disorders of vagus nerve

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	G6_DISVAG
CONTROL_EXCLUDE	G6_NERPLEX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G522
HD_ICD_9	3523
HD_ICD_8	35603
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G522
COD_ICD_9	3523
COD_ICD_8	35603
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Disorders of vagus nerve

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints