Hypotony of eye

H7_HYPOTONYEYE

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H44.4 Hospital discharge: ICD-9 — 3603 Cause of death: ICD-10 — H44.4 Cause of death: ICD-9 — 3603 2 out of 7 registries used, show all original rules.	46
4. Check minimum number of events None	46
5. Include endpoints None	46
6. Filter based on genotype QC (FinnGen only)	46

Control definitions (FinnGen only)

Control exclude: H7_VITREOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H44
Name in latin: Hypotonia oculi

NAME	H7_HYPOTONYEYE
CONTROL_EXCLUDE	H7_VITREOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H444
HD_ICD_9	3603
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H444
COD_ICD_9	3603
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Hypotony of eye based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	339	172	164
Only index persons	309	157	152
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	64.21	68.73	59.51
Only index persons	62.95	67.65	58.08

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	46	26	20
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	64.80	64.29	65.46

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3020564) Creatinine [Moles/volume] in Serum or Plasma

390

+∞

2.91

24.5

17.4

78.3

78.2

umol/l

0.00

390

(40758558) Short blood count panel - Blood

2.92

2.89

9.1

6.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.49

2.80

2.3

1.3

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.89

2.25

2.9

1.6

2.2

2.4

g/l

0.57

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.08

2.17

2.0

1.4

—

(36304419) Bacteria [Presence] in Urine

113

2.16

1.66

3.6

2.8

—

(3037467) Urinalysis macro (dipstick) panel - Urine

254

2.30

1.65

5.3

4.9

—

(3042936) Bacteria identified in Isolate by Culture

2.77

1.59

1.1

1.7

—

(3018095) Leukocytes [#/volume] in Urine

143

2.03

1.49

5.0

3.7

395.0

49.8

e6/l

0.53

100

(3035350) Ketones [Presence] in Urine by Test strip

180

2.02

1.48

6.2

4.4

0.0

estimate

—

(3025159) Blasts/100 leukocytes in Blood

2.66

1.46

6.3

6.9

—

0.0

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.66

1.46

2.6

2.7

30.7

29.7

u/l

—

(42870588) Differential panel, method unspecified - Blood

118

2.04

1.45

9.5

4.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.84

1.42

1.7

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.35

1.40

1.8

1.3

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

2.35

1.40

10.3

4.0

270.7

239.1

u/l

—

(3045414) Leukocytes [Presence] in Urine

2.98

1.32

2.4

1.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.40

1.29

4.3

1.6

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.60

1.29

2.0

1.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

187

1.90

1.26

8.5

5.9

0.0

estimate

—

(3009261) Glucose [Presence] in Urine by Test strip

188

1.88

1.23

6.6

4.4

0.0

estimate

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.11

1.23

2.1

1.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

152

1.86

1.19

1.8

93.8

98.1

pmol/l

0.18

(40760892) CBC W Ordered Manual Differential panel - Blood

2.02

1.18

10.0

7.0

—

(3030467) Casts [#/volume] in Urine by Automated count

117

1.88

1.17

4.0

2.9

0.1

0.5

e6/l

1.27

(3002582) Erythrocytes [#/volume] in Urine

126

1.87

1.16

3.9

3.0

61.2

584.7

e6/l

0.47

(3026008) Bacteria identified in Urine by Culture

109

1.89

1.15

2.2

3.3

—

(3023368) Bacteria identified in Blood by Culture

101

1.90

1.13

5.3

3.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

137

1.81

1.09

4.5

2.9

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.24

1.08

2.0

1.5

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.00

1.00

0.0

2.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

348

2.14

1.00

4.5

5.2

2.2

2.0

mu/l

0.35

312

(3000494) Fungus identified in Specimen by Culture

2.09

0.95

1.1

1.3

—

(3002179) Metamyelocytes/100 leukocytes in Blood

2.22

0.93

7.0

6.6

—

0.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.82

0.90

7.0

4.3

—

(3044889) 12 lead EKG panel

274

1.72

0.84

5.1

4.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.79

0.80

1.6

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

333

1.81

0.79

20.2

14.7

38.2

39.8

0.36

226

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.31

0.79

1.2

1.3

—

(3000330) Specific gravity of Urine by Test strip

2.21

0.77

2.4

5.0

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.93

0.77

1.1

1.5

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

1.82

0.76

4.2

2.9

0.8

ug/l

—

(3017732) Neutrophils [#/volume] in Blood

2.12

0.75

2.4

3.4

3.9

3.7

e9/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.78

0.72

4.4

3.5

—

(3021960) Folate [Moles/volume] in Serum or Plasma

1.62

0.66

1.4

20.3

19.4

nmol/l

0.11

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

172

1.53

0.66

3.7

3.6

—

(3019309) Folate [Moles/volume] in Red Blood Cells

1.67

0.63

2.1

1.8

1579.5

1248.8

nmol/l

0.55

(3015736) pH of Urine

145

1.53

0.63

5.8

4.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

213

1.51

0.62

3.0

2.9

—

(3022217) INR in Platelet poor plasma by Coagulation assay

1.58

0.61

37.5

25.1

—

1.4

—

(3020682) Albumin/Creatinine [Ratio] in Urine

122

1.48

0.52

3.5

3.8

2.4

5.3

mg/mmol

0.79

(3041096) Erythrocytes [Presence] in Urine by Automated

104

1.50

0.51

4.9

4.0

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

1.54

0.48

2.1

2.0

2.4

2.5

mmol/l

0.16

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

358

1.59

0.46

20.9

13.7

76.7

77.9

ml/min/173m2

0.11

288

(3003694) ABO and Rh group [Type] in Blood

1.49

0.46

1.6

1.3

—

(40761535) Cells panel - Urine sediment

1.58

0.43

5.0

3.0

—

(3022313) Gas panel - Capillary blood

0.00

0.42

0.0

2.2

—

(40768443) Skin Pathology biopsy report

0.00

0.42

0.0

1.1

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.00

0.41

0.0

3.9

—

61.7

—

(40761536) Microorganisms panel - Urine sediment

1.44

0.39

5.6

3.9

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

114

1.33

0.29

7.1

5.2

3.1

2.3

ug/l

0.41

100

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

146

1.26

0.24

6.5

4.3

—

(3002256) Pathology report gross observation

1.32

0.24

1.0

1.3

—

(3032080) INR in Blood by Coagulation assay

164

0.79

0.23

7.7

5.9

1.3

1.2

inr

—

(3002032) Base excess in Venous blood by calculation

1.28

0.23

6.6

3.0

2.5

2.2

mmol/l

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

2.6

—

3.9

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

2.6

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

2.6

—

107.7

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

0.21

0.0

1.1

—

0.9

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

572.0

—

(3037121) Protein [Mass/volume] in Urine

0.00

0.21

0.0

3.7

—

0.1

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.9

—

(40768797) Stomach Pathology biopsy report

1.29

0.21

1.2

1.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

1.9

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.21

0.0

4.5

—

25.1

—

(1761868) Lipid panel - Serum or Plasma

141

0.80

0.20

3.1

2.9

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

0.76

0.17

1.7

1.6

1.2

0.8

mg/l

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

375

1.26

0.16

23.7

13.7

24.6

21.3

mg/l

0.26

295

(3016502) Oxygen saturation in Arterial blood

1.18

0.10

1.8

6.3

96.8

96.4

—

(3012544) pH of Venous blood

1.18

0.10

6.6

3.0

—

(3027801) Oxygen [Partial pressure] in Arterial blood

1.10

0.10

1.8

6.0

10.9

11.9

kpa

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.10

0.10

1.8

6.0

4.7

5.0

kpa

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

133

0.87

0.09

3.9

2.8

46.5

29.3

u/l

0.55

120

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.82

0.08

1.7

1.5

—

(40768804) Tissue Pathology biopsy report

138

1.13

0.07

1.9

2.1

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

249

1.10

0.06

1.9

3.1

73.5

46.4

u/l

0.41

234

(3013826) Glucose [Moles/volume] in Serum or Plasma

229

1.10

0.06

4.0

4.7

6.3

6.7

mmol/l

0.69

218

(3013512) EKG study

124

1.07

0.01

5.4

4.1

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

127

1.03

0.00

4.2

2.8

2271.3

1062.4

ng/l

0.36

103

(3044640) Blood type and Crossmatch panel - Blood

115

0.94

0.00

2.2

2.1

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

138

1.02

0.00

2.5

2.7

2.4

2.3

mmol/l

0.08

119

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.1

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

1.4

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

2.0

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

0.00

0.0

2.2

—

3.2

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

1.3

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

4.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

2.0

—

92.0

—

(3011648) Oxygen content in Venous blood

0.00

0.0

2.3

—

10.7

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

259.8

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.0

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

0.96

0.00

2.6

1.5

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.2

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

2.1

—

195.9

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

1.6

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.0

1.6

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

9.3

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

0.89

0.00

1.6

2.2

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(4027681)

0.00

0.0

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.02

0.00

30.8

9.2

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.4

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(4268621)

0.00

0.0

1.6

—

(3003181) Sodium [Moles/volume] in Urine

0.00

0.0

1.6

—

48.1

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(4306422)

0.00

0.0

1.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.2

—

6.3

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.0

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.1

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

1198.3

—

(3011985) Renin [Units/volume] in Plasma

0.00

0.0

1.0

—

15.6

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.3

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.0

2.3

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.4

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

2.3

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

2.4

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.3

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_HYPOTONYEYE and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_HYPOTONYEYE.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: H7_HYPOTONYEYE – Hypotony of eye

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Hypotony of eye

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints