eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
920 |
6. Filter based on genotype QC (FinnGen only) |
920 |
Control definitions (FinnGen only)
- Control exclude
- H7_VITREOUS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorders of globe
based on the number of shared cases.
Similar with more cases:
- Disorders of vitreous body and globe
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9948 | 5247 | 4600 |
| Only index persons | 7619 | 4160 | 3459 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.15 | 0.13 |
| Only index persons | 0.14 | 0.15 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 66.32 | 70.47 | 61.57 |
| Only index persons | 63.06 | 68.34 | 56.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 920 | 488 | 432 |
| Unadjusted period prevalence (%) | 0.18 | 0.17 | 0.19 |
| Median age at first event (years) | 61.92 | 61.10 | 62.84 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 812
- Matched controls
- 8121
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H44.2
ICD-10 Finland
Degenerative myopia
+∞
216.6
198
*
H44.5
ICD-10 Finland
Degenerated conditions of globe
+∞
158.7
147
*
H44.0
ICD-10 Finland
Purulent endophthalmitis
+∞
157.5
146
*
H44.1
ICD-10 Finland
Other endophthalmitis
+∞
138.6
129
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
12.7
102.3
194
196
Z96.1
ICD-10 Finland
Presence of intraocular lens
6.6
100.9
311
700
S01ED51
ATC
timolol, combinations; ophthalmic
9.2
100.3
231
336
CKA10
NOMESCO Finland
Biopsy of vitreous body
+∞
100.1
94
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
23.6
85.9
125
62
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.2
79.4
488
2155
114
Kela drug reimbursment
Glaucoma
6.6
79.1
229
453
WX140
NOMESCO Finland
Parabulbar anesthesy
13.5
77.4
140
123
S01ED01
ATC
timolol; ophthalmic
9.8
68.7
147
179
H33.0
ICD-10 Finland
Retinal detachment with retinal break
19.5
64.8
100
58
S01EC01
ATC
acetazolamide; systemic
14.6
63.0
109
85
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
32.7
60.7
80
27
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
11.6
59.0
114
113
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.3
57.6
197
460
H43.1
ICD-10 Finland
Vitreous haemorrhage
192.4
52.6
54
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.7
52.0
163
340
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.2
51.8
416
2015
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
11.8
51.1
97
92
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.0
48.4
231
739
S01EE01
ATC
latanoprost; ophthalmic
5.9
47.3
143
283
H52.1
ICD-10 Finland
Myopia
13.5
45.2
80
65
H43.8
ICD-10 Finland
Other disorders of vitreous body
22.7
44.7
65
31
H26.4
ICD-10 Finland
After-cataract
4.4
42.9
176
484
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.7
42.6
159
397
H44.4
ICD-10 Finland
Hypotony of eye
+∞
41.0
39
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.7
40.0
437
2435
XCK00
NOMESCO Finland
Perimetry
5.3
38.9
128
277
H20.1
ICD-10 Finland
Chronic iridocyclitis
31.9
38.7
51
17
XCK10
NOMESCO Finland
Photography of fundus of eye
3.8
33.6
159
489
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
19.7
33.1
50
27
S01EX03
ATC
NA
7.9
33.0
78
108
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
91.3
32.0
35
*
H25.1
ICD-10 Finland
Senile nuclear cataract
2.6
31.5
320
1643
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
88.6
31.0
34
*
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
10.4
30.6
61
63
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
5.3
30.4
97
201
CKD40
NOMESCO Finland
Endophotocoagulation of retina
24.5
29.9
42
18
S01FA01
ATC
atropine; ophthalmic
38.7
29.5
37
10
H26.2
ICD-10 Finland
Complicated cataract
16.7
28.8
46
29
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.8
28.3
100
231
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
5.2
28.0
91
192
H44.8
ICD-10 Finland
Other disorders of globe
290.9
27.9
28
*
S01EC04
ATC
brinzolamide; ophthalmic
5.6
27.5
84
165
H16.0
ICD-10 Finland
Corneal ulcer
6.1
27.5
77
136
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
7.0
26.5
67
103
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
10.0
25.3
51
54
TCH12
NOMESCO Finland
Sample aspiration from anterior chambre
+∞
25.1
24
*
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
6.2
25.1
69
119
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
6.0
24.9
71
128
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
13.9
23.9
41
31
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
89.5
23.8
26
*
3643
FHL
Vitrectomy through pars Plana
128.8
23.7
25
*
S01EA03
ATC
apraclonidine; ophthalmic
12.6
23.0
41
34
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
26.8
22.8
31
12
H26.02
ICD-10 Finland
Presenil cataract
8.0
22.4
51
67
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
13.7
22.1
38
29
H44.3
ICD-10 Finland
Other degenerative disorders of globe
+∞
22.0
21
*
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
4.8
21.7
75
169
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
7.0
21.5
54
82
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
21.4
21.4
31
15
H40.0
ICD-10 Finland
Glaucoma suspect
3.6
21.3
102
311
Z3229
NOMESCO Finland
Other healthcare associate professional
3.3
21.1
112
370
CKC12
NOMESCO Finland
Photocoagulation of retina
6.6
20.7
54
87
S01EC03
ATC
dorzolamide; ophthalmic
8.0
20.6
47
62
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
12.1
20.4
37
32
H54.4
ICD-10 Finland
Blindness, monocular
59.0
20.0
23
*
ZXA00
NOMESCO Finland
Right side
2.2
19.9
275
1560
3600A
ICD-9 Finland
Disorders of the globe, Purulent endophthalmitis
+∞
19.9
19
*
H44.9
ICD-10 Finland
Disorder of globe, unspecified
+∞
19.9
19
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.8
19.7
136
537
H34.8
ICD-10 Finland
Other retinal vascular occlusions
7.2
19.7
48
70
XCD10
NOMESCO Finland
Electrophysiological examination of eye
6.4
19.5
52
86
XCH00
NOMESCO Finland
Eye pressure measurement
5.2
19.5
62
128
S01EB01
ATC
pilocarpine; ophthalmic
11.4
19.3
36
33
S01EE03
ATC
bimatoprost; ophthalmic
6.8
19.3
49
76
H3603, E103
ICD-10 Finland
NA
26.8
19.2
26
10
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
3.5
19.0
92
283
S01EE05
ATC
tafluprost; ophthalmic
5.1
18.5
59
122
CKD15
NOMESCO Finland
Injection of vitreous substitute
45.1
18.3
22
5
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
9.6
18.3
37
40
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
10.1
18.3
36
37
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
33.7
18.0
23
7
A10AA02
ATC
NA
5.2
18.0
56
113
H40.9
ICD-10 Finland
Glaucoma, unspecified
7.8
17.8
41
55
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
5.8
17.8
51
93
S01BC03
ATC
diclofenac; ophthalmic
6.1
17.8
49
85
Z97.0
ICD-10 Finland
Presence of artificial eye
+∞
17.8
17
*
3745
FHL
Hard membrane girding, cerclage with coagulation
+∞
17.8
17
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
37.6
17.7
22
6
CHF15
NOMESCO Finland
Cryotherapy of ciliary body
97.2
17.6
19
*
CDC00
NOMESCO Finland
Enucleation of eye
183.8
17.6
18
*
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
183.8
17.6
18
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
29.5
17.5
23
8
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
8.6
17.1
37
45
ZXA05
NOMESCO Finland
Left side
2.1
17.1
250
1434
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
7.8
17.1
39
52
WX002
NOMESCO Finland
Sedation and analgesia
2.3
16.8
187
947
36402
ICD-8 Finland
Iritis, Iridocyclitis, uveitis chronica
+∞
16.7
16
*
TCK20
NOMESCO Finland
Needle biopsy of vitreous body
+∞
16.7
16
*
A10AA01
ATC
NA
6.8
16.6
42
65
37520
ICD-8 Finland
Glaucoma, Secondary
92.0
16.6
18
*
WX142
NOMESCO Finland
Sub-tenon anesthesy
18.4
16.5
25
14
S01EA02
ATC
dipivefrine; ophthalmic
15.7
16.3
26
17
S01EE04
ATC
travoprost; ophthalmic
5.7
16.2
47
87
S01BC05
ATC
ketorolac; ophthalmic
3.7
15.9
72
210
H44.6
ICD-10 Finland
Retained (old) intraocular foreign body, magnetic
+∞
15.7
15
*
3608A
ICD-9 Finland
Disorders of the globe, Other disorders of globe[ANOPHTALMIA ARTEFACTA]
+∞
15.7
15
*
37861
ICD-8 Finland
Other diseases of eye, Phthisis et degeneratio bulbi
+∞
15.7
15
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
22.6
15.6
22
10
H27.0
ICD-10 Finland
Aphakia
45.9
15.1
18
*
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
7.7
14.8
34
46
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
81.6
14.6
16
*
25002
ICD-8 Finland
Diabetes mellitus, Retinopathia diabetica
152.6
14.5
15
*
Z94.7
ICD-10 Finland
Corneal transplant status
17.4
14.4
22
13
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
14.7
14.1
23
16
CKC30
NOMESCO Finland
Cryopexy of detached retina
30.6
13.9
18
6
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
4.9
13.8
45
96
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
24.3
13.8
19
8
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
4.6
13.8
48
110
H04.10
ICD-10 Finland
Dry eye syndrome
2.7
13.8
98
390
3641A
ICD-9 Finland
Disorders of iris and ciliary body, Chronic iridocyclitis
76.4
13.6
15
*
36609
ICD-8 Finland
Other inflammation of uveal tract, Unspecified
+∞
13.6
13
*
3602A
ICD-9 Finland
Disorders of the globe, Degenerative disorders of globe[MYOPIA MALIGNA]
+∞
13.6
13
*
XCD20
NOMESCO Finland
Photoangiography of eye
5.9
13.4
37
65
CKC20
NOMESCO Finland
Cryopexy of undetached retina
26.2
13.4
18
7
S01FA02
ATC
scopolamine; ophthalmic
11.2
13.1
24
22
H54.1
ICD-10 Finland
Severe visual impairment, binocular
50.8
12.9
15
*
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
32.6
12.6
16
5
CHD99
NOMESCO Finland
Other filtering operation
24.7
12.5
17
7
CKC15
NOMESCO Finland
Panretinal photocoagulation
13.4
12.5
21
16
H33.4
ICD-10 Finland
Traction detachment of retina
131.9
12.5
13
*
H16.9
ICD-10 Finland
Keratitis, unspecified
7.6
12.3
28
38
CKC60
NOMESCO Finland
Local buckling of sclera using implant
27.1
12.1
16
6
H33.3
ICD-10 Finland
Retinal breaks without detachment
5.5
12.1
35
66
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
21.7
12.0
17
8
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
5.1
12.0
37
75
CKC10
NOMESCO Finland
Local photocoagulation of retina
6.8
11.8
29
44
ZXD05
NOMESCO Finland
Urgent procedure
1.8
11.7
260
1692
H54.0
ICD-10 Finland
Blindness, binocular
65.9
11.6
13
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
19.2
11.6
17
9
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
13.9
11.5
19
14
37514
ICD-8 Finland
Glaucoma, Chronicum absolutum s. fero absolutum dolorosum
+∞
11.5
11
*
3656X
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA SECUNDARIA ALIA SEU NUD]
121.6
11.5
12
*
TCA15
NOMESCO Finland
Retrobulbar therapeutic injection into orbit
121.6
11.5
12
*
CKD60
NOMESCO Finland
Anterior vitrectomy
10.7
11.3
21
20
CGF10
NOMESCO Finland
Suture of laceration of cornea
35.5
11.3
14
*
3660C
ICD-9 Finland
Cataract, Infantile, juvenile and presenile cataract[CATARACTA PRAESENILIS]
20.4
11.2
16
8
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
9.4
11.0
22
24
H57.1
ICD-10 Finland
Ocular pain
4.5
11.0
38
87
H21.0
ICD-10 Finland
Hyphaema
43.9
10.9
13
*
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
43.9
10.9
13
*
H35.4
ICD-10 Finland
Peripheral retinal degeneration
12.1
10.9
19
16
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.6
10.9
84
350
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
28.4
10.7
14
5
3708
FHL
Trabeculectomy or equivalent
21.8
10.7
15
7
CFD10
NOMESCO Finland
Repair of conjunctiva
21.8
10.7
15
7
TCG10
NOMESCO Finland
Removal of sutures from cornea
13.1
10.7
18
14
H30.2
ICD-10 Finland
Posterior cyclitis
60.8
10.6
12
*
CKC65
NOMESCO Finland
Removal of buckling implant from sclera
60.8
10.6
12
*
CKD95
NOMESCO Finland
Extended combined vitectomy and lens procedure through pars plana
60.8
10.6
12
*
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
60.8
10.6
12
*
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
60.8
10.6
12
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
3.7
10.6
46
131
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
14.4
10.5
17
12
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
5.7
10.5
29
52
37002
ICD-8 Finland
Refractive errors, Myopia
111.4
10.4
11
*
S01EC54
ATC
brinzolamide, combinations; ophthalmic
6.9
10.4
25
37
H44.7
ICD-10 Finland
Retained (old) intraocular foreign body, nonmagnetic
+∞
10.4
10
*
H02AB06
ATC
prednisolone; systemic
1.6
10.4
366
2701
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
10.8
10.3
19
18
S01AX12
ATC
[U] norfloxacin; ophthalmic
19.1
10.3
15
8
ZXA10
NOMESCO Finland
Bilateral
1.9
10.3
160
917
H04AA01
ATC
glucagon; nasal, parenteral
6.6
10.1
25
39
S01AX11
ATC
[U] ofloxacin; ophthalmic
3.1
10.0
55
187
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
6.4
9.9
25
40
S01ED02
ATC
betaxolol; ophthalmic
6.4
9.9
25
40
37510
ICD-8 Finland
Glaucoma, Chronicum simplex
16.9
9.9
15
9
CKC70
NOMESCO Finland
Circular buckling of sclera
26.4
9.8
13
5
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
9.7
9.8
19
20
3604
FHL
Penetration of the cornea
55.6
9.7
11
*
H05.0
ICD-10 Finland
Acute inflammation of orbit
55.6
9.7
11
*
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
11.5
9.6
17
15
CHC05
NOMESCO Finland
Iridotomy
5.2
9.5
28
55
R3120
NOMESCO Finland
Training in mobility skills
101.1
9.4
10
*
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
17.8
9.4
14
8
3604A
ICD-9 Finland
Disorders of the globe, Degenerated conditions of globe
+∞
9.4
9
*
CAW99
NOMESCO Finland
Other operation on orbit
+∞
9.4
9
*
3661A
ICD-9 Finland
Cataract, Senile cataract
4.3
9.3
33
79
S01FA04
ATC
cyclopentolate; ophthalmic
7.4
9.3
21
29
H33.5
ICD-10 Finland
Other retinal detachments
13.9
9.2
15
11
H3603, E113
ICD-10 Finland
NA
11.6
9.1
16
14
S01AA12
ATC
tobramycin; ophthalmic
15.8
9.0
14
9
H43.3
ICD-10 Finland
Other vitreous opacities
24.3
8.9
12
5
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
8.7
8.8
18
21
H25.0
ICD-10 Finland
Senile incipient cataract
2.5
8.8
66
273
3747
FHL
Combined ablation and vitreous surgery with coagulation
50.5
8.7
10
*
3711
FHL
Cyclodiateria or cryocoagulation
50.5
8.7
10
*
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
4.0
8.6
33
85
H18.1
ICD-10 Finland
Bullous keratopathy
16.5
8.6
13
8
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
4.1
8.5
32
81
3102
FHL
Enucleation
90.9
8.4
9
*
3718X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Other corneal disorders
90.9
8.4
9
*
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
8.0
8.4
18
23
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
8.3
100
518
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
17.4
8.1
12
7
H01.0
ICD-10 Finland
Blepharitis
3.1
8.1
42
139
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.4
8.1
68
300
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
7.9
7.9
17
22
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
4.2
7.8
28
68
3663A
ICD-9 Finland
Cataract secondary to ocular disorders
15.2
7.7
12
8
H35.6
ICD-10 Finland
Retinal haemorrhage
15.2
7.7
12
8
H20.8
ICD-10 Finland
Other iridocyclitis
15.2
7.7
12
8
CFB00
NOMESCO Finland
Suture of conjunctiva
45.4
7.7
9
*
3744
FHL
Pericardial identification surgery with coagulation (includes epi- and intrascleral indications and eg Lincoff catheter)
45.4
7.7
9
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.3
7.5
71
330
CAE10
NOMESCO Finland
Revision and secondary implant in orbit
80.8
7.4
8
*
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
7.7
7.4
16
21
Z3231
NOMESCO Finland
Registered nurse
1.6
7.3
207
1413
36608
ICD-8 Finland
Other inflammation of uveal tract, Alia definita
+∞
7.3
7
*
CBH30
NOMESCO Finland
Tarsorraphy
+∞
7.3
7
*
E913A
ICD-9 Finland
Accidental mechanical suffocation
+∞
7.3
7
*
3700A
ICD-9 Finland
Keratitis, Corneal ulcer
+∞
7.3
7
*
N0830, E102
ICD-10 Finland
NA
+∞
7.3
7
*
R51.80
ICD-10 Finland
Headache
1.9
7.3
100
546
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
4.2
7.2
26
64
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
7.2
275
2020
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
30.3
7.2
9
*
H25.8
ICD-10 Finland
Other senile cataract
1.9
7.2
106
594
127
Kela drug reimbursment
Transplant complication
5.4
7.1
20
38
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
3.5
7.0
31
92
H53.1
ICD-10 Finland
Subjective visual disturbances
2.6
6.9
49
198
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
6.9
290
2174
H40.20
ICD-10 Finland
Acute glaucoma with closed ventricular angle
8.4
6.8
14
17
ZX198
NOMESCO Finland
Other local administration
6.8
6.8
16
24
H53.0
ICD-10 Finland
Amblyopia ex anopsia
9.4
6.8
13
14
37600
ICD-8 Finland
Detachment of retina, Primaria
40.4
6.8
8
*
L04AA01
ATC
[U] ciclosporin; systemic
4.8
6.7
21
45
ZXE00
NOMESCO Finland
One hour or less
1.5
6.7
293
2211
H35.36
ICD-10 Finland
Macular cyst
7.9
6.6
14
18
CHD00
NOMESCO Finland
Laser trabeculoplasty
4.7
6.6
21
46
CS494
NOMESCO Finland
Other visual field testing
3.8
6.6
26
70
H18.6
ICD-10 Finland
Keratoconus
12.4
6.6
11
9
CHD35
NOMESCO Finland
Laser goniopuncture
12.4
6.6
11
9
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
8.8
6.6
13
15
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
6.9
6.5
15
22
H40.11
ICD-10 Finland
Low pressure glaucoma
3.6
6.5
27
76
S01AD03
ATC
aciclovir; ophthalmic
3.0
6.5
37
129
CDC40
NOMESCO Finland
Evisceration of eye with insertion of prosthesis
70.4
6.4
7
*
ZZL00
NOMESCO Finland
Free graft of amniotic membrane
70.4
6.4
7
*
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
7.5
6.4
14
19
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
14.4
6.4
10
7
3651B
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA CAPSULARE (AVOKULMA)]
11.1
6.3
11
10
ZXD20
NOMESCO Finland
Day surgery
1.9
6.3
99
566
H21.1
ICD-10 Finland
Other vascular disorders of iris and ciliary body
18.2
6.3
9
5
36600
ICD-8 Finland
Other inflammation of uveal tract, Abscessus oculi. Uveitis suppurativa. Panophthalmitis
+∞
6.3
6
*
N083, E102
ICD-10 Finland
NA
+∞
6.3
6
*
CDC30
NOMESCO Finland
Evisceration of eye
+∞
6.3
6
*
H05.8
ICD-10 Finland
Other disorders of orbit
+∞
6.3
6
*
3649
FHL
Other measure in this category
+∞
6.3
6
*
CDC10
NOMESCO Finland
Enucleation of eye with insertion of prosthesis
+∞
6.3
6
*
37601
ICD-8 Finland
Detachment of retina, Secundaria
+∞
6.3
6
*
H28.0*E10.3
ICD-10 Finland
Other specified diabetes mellitus - Diabetic cataract
+∞
6.3
6
*
TCH10
NOMESCO Finland
Needle aspiration of aqueous from anterior chamber
+∞
6.3
6
*
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
7.7
6.1
13
17
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
6.1
159
1059
H26.1
ICD-10 Finland
Traumatic cataract
10.1
6.0
11
11
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
10.1
6.0
11
11
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLOBE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLOBE | 1.188 [1.07, 1.32] | 0.002 |
| Birth year | 0.998 [0.99, 1.01] | 0.557 |
During the follow-up period (1.1.1998 — 31.12.2019), 1511 out of 3733 females with H7_GLOBE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLOBE | 1.391 [1.21, 1.59] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.047 |
During the follow-up period (1.1.1998 — 31.12.2019), 1101 out of 2981 males with H7_GLOBE died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLOBE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.145% | 0.279% |
| 5 | 0.882% | 1.903% |
| 10 | 1.939% | 4.507% |
| 15 | 3.542% | 8.496% |
| 20 | 6.097% | 13.929% |
Relationships between endpoints
↥Index endpoint: H7_GLOBE – Disorders of globe
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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