eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
985 |
6. Filter based on genotype QC (FinnGen only) |
956 |
Control definitions (FinnGen only)
- Control exclude
- H7_VITREOUS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorders of globe
based on the number of shared cases.
Similar with more cases:
- Disorders of vitreous body and globe
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9948 | 5247 | 4600 |
| Only index persons | 7619 | 4160 | 3459 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.15 | 0.13 |
| Only index persons | 0.14 | 0.15 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 66.32 | 70.47 | 61.57 |
| Only index persons | 63.06 | 68.34 | 56.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 956 | 513 | 443 |
| Unadjusted period prevalence (%) | 0.19 | 0.18 | 0.20 |
| Median age at first event (years) | 63.58 | 62.96 | 64.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 985
- Matched controls
- 9850
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H44.2
ICD-10 Finland
Degenerative myopia
3118.5
271.8
250
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
13.1
236.2
256
257
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
25.9
216.6
156
71
H44.0
ICD-10 Finland
Purulent endophthalmitis
+∞
212.4
196
*
S01ED51
ATC
timolol, combinations; ophthalmic
9.0
197.0
294
445
H44.5
ICD-10 Finland
Degenerated conditions of globe
+∞
185.4
172
*
WX140
NOMESCO Finland
Parabulbar anesthesy
11.8
180.6
204
214
H44.1
ICD-10 Finland
Other endophthalmitis
+∞
175.4
163
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
47.3
172.6
102
24
Z96.1
ICD-10 Finland
Presence of intraocular lens
6.0
159.1
403
1025
S01ED01
ATC
timolol; ophthalmic
11.2
154.3
178
191
CKA10
NOMESCO Finland
Biopsy of vitreous body
758.5
137.2
132
*
S01EC01
ATC
acetazolamide; systemic
14.4
135.8
129
102
114
Kela drug reimbursment
Glaucoma
6.2
132.2
276
578
H33.0
ICD-10 Finland
Retinal detachment with retinal break
12.9
126.7
129
114
S01EA05
ATC
brimonidine; ophthalmic
13.4
125.1
124
105
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
11.0
123.0
140
146
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.1
115.8
241
499
H43.8
ICD-10 Finland
Other disorders of vitreous body
17.6
114.5
96
60
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.7
113.0
255
568
H52.1
ICD-10 Finland
Myopia
12.5
107.1
110
98
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.1
102.9
592
2655
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.4
95.8
328
1014
H20.1
ICD-10 Finland
Chronic iridocyclitis
27.0
88.2
61
24
S01EE01
ATC
latanoprost; ophthalmic
5.7
86.0
183
381
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
15.8
85.3
75
51
H26.4
ICD-10 Finland
After-cataract
4.6
81.4
236
636
XCK00
NOMESCO Finland
Perimetry
5.9
79.4
159
312
H43.1
ICD-10 Finland
Vitreous haemorrhage
282.1
77.7
78
*
H26.2
ICD-10 Finland
Complicated cataract
18.7
74.6
60
34
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
28.6
72.3
49
18
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.5
71.2
203
536
S01EA03
ATC
apraclonidine; ophthalmic
20.0
70.6
55
29
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
5.7
70.0
142
281
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
37.4
68.9
43
12
S01EX03, ,
ATC
8.8
65.8
86
106
S01EC04
ATC
brinzolamide; ophthalmic
6.1
64.6
120
218
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.0
64.2
529
2718
XCK10
NOMESCO Finland
Photography of fundus of eye
4.2
63.3
195
543
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
16.3
62.7
54
35
CKD40
NOMESCO Finland
Endophotocoagulation of retina
15.8
61.8
54
36
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
5.1
54.3
125
275
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
5.1
53.7
121
261
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.8
52.9
560
3182
S01EC03
ATC
dorzolamide; ophthalmic
11.1
52.8
57
54
H44.4
ICD-10 Finland
Hypotony of eye
+∞
51.5
49
*
CKC12
NOMESCO Finland
Photocoagulation of retina
7.0
50.9
81
125
WX142
NOMESCO Finland
Sub-tenon anesthesy
20.3
50.4
39
20
S01BA07
ATC
fluorometholone; ophthalmic
10.5
50.0
56
56
S01BA04
ATC
prednisolone; ophthalmic
7.9
49.8
70
94
S01FA01
ATC
atropine; ophthalmic
17.9
46.5
38
22
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
6.4
46.4
80
134
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
13.1
46.3
45
36
H26.02
ICD-10 Finland
Presenil cataract
7.8
46.3
66
90
XCH00
NOMESCO Finland
Eye pressure measurement
4.9
44.4
104
231
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
6.0
44.4
82
147
S01BC03
ATC
diclofenac; ophthalmic
7.8
43.7
62
84
S01EC54
ATC
brinzolamide, combinations; ophthalmic
10.5
42.8
48
48
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
14.5
42.7
39
28
H16.0
ICD-10 Finland
Corneal ulcer
5.0
42.7
97
210
S01BA01
ATC
dexamethasone; ophthalmic
5.7
42.5
83
157
S01EE03
ATC
bimatoprost; ophthalmic
6.8
42.2
68
106
Z3229
NOMESCO Finland
Other healthcare associate professional
3.6
40.9
151
470
WX100
NOMESCO Finland
Conjunctival surface anesthesia
3.1
40.7
204
767
S01EE05
ATC
tafluprost; ophthalmic
5.3
40.6
86
175
S01EB01
ATC
pilocarpine; ophthalmic
13.1
40.2
39
31
H40.0
ICD-10 Finland
Glaucoma suspect
3.7
39.6
141
428
H44.8
ICD-10 Finland
Other disorders of globe
402.9
39.4
39
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
208.2
39.1
40
*
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
10.9
37.7
41
39
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
8.1
36.4
50
65
H25.1
ICD-10 Finland
Senile nuclear cataract
2.3
35.8
413
2320
XCD10
NOMESCO Finland
Electrophysiological examination of eye
6.1
35.3
63
109
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
6.5
34.6
58
94
H34.8
ICD-10 Finland
Other retinal vascular occlusions
6.6
34.5
57
91
S01EE04
ATC
travoprost; ophthalmic
6.4
34.3
58
95
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
5.0
33.5
75
160
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
7.6
30.7
44
60
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
7.2
29.9
45
65
TCH12
NOMESCO Finland
Sample aspiration from anterior chambre
+∞
29.3
28
*
ZXA00
NOMESCO Finland
Right side
2.2
28.8
340
1892
XCD20
NOMESCO Finland
Photoangiography of eye
6.9
27.4
43
65
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
3.2
27.0
114
383
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
7.3
26.9
40
57
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
5.7
26.5
50
91
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
96.0
25.8
28
*
H54.4
ICD-10 Finland
Blindness, monocular
45.6
25.6
31
7
H40.9
ICD-10 Finland
Glaucoma, unspecified
5.6
25.6
50
94
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
4.4
25.3
66
159
3643
FHL
Vitrectomy through pars Plana
92.5
24.8
27
*
WX002
NOMESCO Finland
Sedation and analgesia
2.3
24.4
237
1207
CHC05
NOMESCO Finland
Iridotomy
6.9
24.4
38
57
ZXA05
NOMESCO Finland
Left side
2.1
24.3
302
1696
H57.1
ICD-10 Finland
Ocular pain
4.6
23.9
58
132
Z97.0
ICD-10 Finland
Presence of artificial eye
89.0
23.8
26
*
H33.3
ICD-10 Finland
Retinal breaks without detachment
5.1
23.7
51
105
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
6.1
23.2
41
70
CHF15
NOMESCO Finland
Cryotherapy of ciliary body
235.2
22.7
23
*
XCW10
NOMESCO Finland
Assessment of vision
7.0
22.2
34
50
H04.10
ICD-10 Finland
Dry eye syndrome
2.7
22.1
136
560
CKC10
NOMESCO Finland
Local photocoagulation of retina
5.9
22.1
40
70
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
6.4
22.0
37
60
A10AA01, ,
ATC
5.1
22.0
47
96
H44.3
ICD-10 Finland
Other degenerative disorders of globe
+∞
22.0
21
*
H3603, E103,
ICD-10 Finland
29.8
21.9
29
10
S01BC05
ATC
ketorolac; ophthalmic
3.4
21.6
80
247
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
23.8
21.4
30
13
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.2
21.3
87
286
CKD15
NOMESCO Finland
Injection of vitreous substitute
26.1
20.5
28
11
A10AA02, ,
ATC
3.9
20.3
62
168
CKC20
NOMESCO Finland
Cryopexy of undetached retina
33.3
20.3
26
8
CKD60
NOMESCO Finland
Anterior vitrectomy
8.1
20.1
27
34
3600A
ICD-9 Finland
Disorders of the globe, Purulent endophthalmitis
+∞
19.9
19
*
H44.6
ICD-10 Finland
Retained (old) intraocular foreign body, magnetic
+∞
19.9
19
*
H44.9
ICD-10 Finland
Disorder of globe, unspecified
+∞
19.9
19
*
A10AB01
ATC
insulin (human); parenteral
4.1
19.8
55
139
CKD20
NOMESCO Finland
Removal of vitreous body substitute
19.9
19.6
29
15
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
32.0
19.3
25
8
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
4.7
19.3
45
99
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
20.5
19.1
28
14
ZXA10
NOMESCO Finland
Bilateral
2.1
18.8
223
1214
H16.9
ICD-10 Finland
Keratitis, unspecified
6.4
18.6
31
50
CHD99
NOMESCO Finland
Other filtering operation
30.7
18.4
24
8
Z94.7
ICD-10 Finland
Corneal transplant status
25.6
18.3
25
10
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
3.9
17.9
54
145
CDC00
NOMESCO Finland
Enucleation of eye
67.9
17.8
20
*
H54.1
ICD-10 Finland
Severe visual impairment, binocular
96.8
17.6
19
*
S01EA02
ATC
dipivefrine; ophthalmic
19.0
17.4
26
14
ZXD05
NOMESCO Finland
Urgent procedure
1.9
17.4
315
1979
S01ED02
ATC
betaxolol; ophthalmic
6.3
17.3
29
47
S01AX11
ATC
[U] ofloxacin
3.5
17.2
62
188
CS494
NOMESCO Finland
Other visual field testing
4.4
17.0
43
101
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
4.5
16.7
41
94
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
15.4
16.7
27
18
3602A
ICD-9 Finland
Disorders of the globe, Degenerative disorders of globe[MYOPIA MALIGNA]
+∞
16.7
16
*
3608A
ICD-9 Finland
Disorders of the globe, Other disorders of globe[ANOPHTALMIA ARTEFACTA]
+∞
16.7
16
*
37861
ICD-8 Finland
Other diseases of eye, Phthisis et degeneratio bulbi
+∞
16.7
16
*
37520
ICD-8 Finland
Glaucoma, Secondary
91.7
16.6
18
*
TCK20
NOMESCO Finland
Needle biopsy of vitreous body
91.7
16.6
18
*
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
172.8
16.5
17
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
23.5
16.5
23
10
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
15.7
16.2
26
17
127
Kela drug reimbursment
Transplant complication
7.2
16.2
24
34
CFD10
NOMESCO Finland
Repair of conjunctiva
48.3
16.1
19
*
3745
FHL
Hard membrane girding, cerclage with coagulation
61.0
15.8
18
*
3641A
ICD-9 Finland
Disorders of iris and ciliary body, Chronic iridocyclitis
+∞
15.7
15
*
H33.5
ICD-10 Finland
Other retinal detachments
22.5
15.6
22
10
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
3.6
15.4
52
151
H35.36
ICD-10 Finland
Macular cyst
15.1
15.4
25
17
S01FA04
ATC
cyclopentolate; ophthalmic
6.8
15.4
24
36
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
12.7
14.9
26
21
L04AA01
ATC
[U] ciclosporin
6.9
14.9
23
34
H18.1
ICD-10 Finland
Bullous keratopathy
25.5
14.7
20
8
36609
ICD-8 Finland
Other inflammation of uveal tract, Unspecified
+∞
14.6
14
*
CGF10
NOMESCO Finland
Suture of laceration of cornea
152.2
14.5
15
*
TCA15
NOMESCO Finland
Retrobulbar therapeutic injection into orbit
152.2
14.5
15
*
H02AB06
ATC
prednisolone; systemic
1.7
14.5
471
3458
H54.0
ICD-10 Finland
Blindness, binocular
43.2
14.1
17
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
14.7
14.1
23
16
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
11.1
14.1
26
24
A10AB04
ATC
insulin lispro; parenteral
3.9
14.0
41
108
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
54.1
13.8
16
*
CKC65
NOMESCO Finland
Removal of buckling implant from sclera
54.1
13.8
16
*
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
54.1
13.8
16
*
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
20.4
13.8
20
10
H27.0
ICD-10 Finland
Aphakia
15.0
13.6
22
15
H05.0
ICD-10 Finland
Acute inflammation of orbit
+∞
13.6
13
*
H04AA01
ATC
glucagon; nasal, parenteral
4.9
13.4
29
60
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
13.3
134
680
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
6.4
13.3
22
35
3661A
ICD-9 Finland
Cataract, Senile cataract
4.2
13.3
35
85
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
14.0
13.3
22
16
H35.4
ICD-10 Finland
Peripheral retinal degeneration
12.4
13.1
23
19
TCG10
NOMESCO Finland
Removal of sutures from cornea
15.3
13.1
21
14
H01.0
ICD-10 Finland
Blepharitis
2.8
13.1
68
256
H25.0
ICD-10 Finland
Senile incipient cataract
2.5
13.0
82
340
S01FA02
ATC
scopolamine; ophthalmic
10.2
13.0
25
25
25002
ICD-8 Finland
Diabetes mellitus, Retinopathia diabetica
50.7
12.9
15
*
H53.1
ICD-10 Finland
Subjective visual disturbances
2.7
12.7
69
266
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
15.7
12.6
20
13
CKC30
NOMESCO Finland
Cryopexy of detached retina
12.5
12.6
22
18
H21.1
ICD-10 Finland
Other vascular disorders of iris and ciliary body
70.8
12.6
14
*
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
32.5
12.6
16
5
36402
ICD-8 Finland
Iritis, Iridocyclitis, uveitis chronica
32.5
12.6
16
5
H33.4
ICD-10 Finland
Traction detachment of retina
32.5
12.6
16
5
CHD35
NOMESCO Finland
Laser goniopuncture
17.6
12.5
19
11
3656X
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA SECUNDARIA ALIA SEU NUD]
+∞
12.5
12
*
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
3.5
12.3
42
123
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
14.6
12.3
20
14
H21.0
ICD-10 Finland
Hyphaema
16.1
12.2
19
12
CFW99
NOMESCO Finland
Other operation on conjunctiva
21.6
12.0
17
8
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
12.0
225
1405
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
3.5
11.9
41
121
H3603, E113,
ICD-10 Finland
11.9
11.9
21
18
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
11.9
11.9
21
18
CKC15
NOMESCO Finland
Panretinal photocoagulation
9.8
11.8
23
24
3708
FHL
Trabeculectomy or equivalent
30.4
11.7
15
5
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
12.7
11.7
20
16
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
10.2
11.5
22
22
3711
FHL
Cyclodiateria or cryocoagulation
+∞
11.5
11
*
37514
ICD-8 Finland
Glaucoma, Chronicum absolutum s. fero absolutum dolorosum
+∞
11.5
11
*
H44.7
ICD-10 Finland
Retained (old) intraocular foreign body, nonmagnetic
+∞
11.5
11
*
H40.11
ICD-10 Finland
Low pressure glaucoma
3.8
11.4
34
91
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
4.3
11.3
29
69
H20.8
ICD-10 Finland
Other iridocyclitis
15.2
11.3
18
12
CK2M4
NOMESCO Finland
Macular light layer imaging (OCT)
10.7
11.3
21
20
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
3.9
11.3
33
87
3660C
ICD-9 Finland
Cataract, Infantile, juvenile and presenile cataract[CATARACTA PRAESENILIS]
17.3
11.2
17
10
A10AB05
ATC
insulin aspart; parenteral
2.3
11.2
85
384
CM2S4
NOMESCO Finland
Follow-up photography of age-related macular degeneration lesions
12.9
11.2
19
15
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
25.3
11.2
15
6
CKC60
NOMESCO Finland
Local buckling of sclera using implant
10.2
11.0
21
21
ZXE00
NOMESCO Finland
One hour or less
1.6
11.0
367
2660
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
43.8
10.9
13
*
H35.6
ICD-10 Finland
Retinal haemorrhage
9.0
10.8
22
25
3663A
ICD-9 Finland
Cataract secondary to ocular disorders
28.4
10.7
14
5
37510
ICD-8 Finland
Glaucoma, Chronicum simplex
21.7
10.7
15
7
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
9.3
10.5
21
23
A10AC01
ATC
insulin (human); parenteral
2.2
10.5
92
442
CDC40
NOMESCO Finland
Evisceration of eye with insertion of prosthesis
111.2
10.4
11
*
3604
FHL
Penetration of the cornea
111.2
10.4
11
*
3747
FHL
Combined ablation and vitreous surgery with coagulation
111.2
10.4
11
*
CAE10
NOMESCO Finland
Revision and secondary implant in orbit
+∞
10.4
10
*
3604A
ICD-9 Finland
Disorders of the globe, Degenerated conditions of globe
+∞
10.4
10
*
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
32.9
10.3
13
*
H43.3
ICD-10 Finland
Other vitreous opacities
19.0
10.3
15
8
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
19.0
10.3
15
8
37002
ICD-8 Finland
Refractive errors, Myopia
23.6
10.3
14
6
Z3231
NOMESCO Finland
Registered nurse
1.6
10.2
264
1792
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.7
9.9
31
86
H35.8
ICD-10 Finland
Other specified retinal disorders
12.3
9.9
17
14
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
9.8
362
2668
H30.2
ICD-10 Finland
Posterior cyclitis
20.3
9.8
14
7
S01AD03
ATC
aciclovir; ophthalmic
2.9
9.7
46
165
S01AA01
ATC
chloramphenicol; ophthalmic
2.6
9.7
57
229
S05.6
ICD-10 Finland
Penetrating wound of eyeball without foreign body
55.6
9.7
11
*
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
2.5
9.6
60
248
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
10.2
9.5
18
18
3102
FHL
Enucleation
101.0
9.4
10
*
CAW99
NOMESCO Finland
Other operation on orbit
101.0
9.4
10
*
A10AD01
ATC
insulin (human); parenteral
3.6
9.4
31
89
A12AA04
ATC
calcium carbonate; oral
4.4
9.4
23
53
ZX198
NOMESCO Finland
Other local administration
8.1
9.4
20
25
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
9.2
340
2498
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
2.3
9.2
67
298
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
7.1
9.1
21
30
37600
ICD-8 Finland
Detachment of retina, Primaria
37.0
9.0
11
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.2
9.0
77
367
CKC70
NOMESCO Finland
Circular buckling of sclera
12.7
8.9
15
12
H53.0
ICD-10 Finland
Amblyopia ex anopsia
9.6
8.8
17
18
CG2T4
NOMESCO Finland
Topography assessment of cornea
7.0
8.6
20
29
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.3
8.5
64
289
E913A
ICD-9 Finland
Accidental mechanical suffocation
90.8
8.4
9
*
ZXD20
NOMESCO Finland
Day surgery
1.8
8.4
125
724
S05.1
ICD-10 Finland
Contusion of eyeball and orbital tissues
4.7
8.4
19
41
3852
FHL
Reoperation for another reason
+∞
8.3
8
*
H40.8
ICD-10 Finland
Other glaucoma
10.9
8.3
15
14
H40.20
ICD-10 Finland
Acute glaucoma with closed ventricular angle
9.5
8.3
16
17
S01AX12
ATC
[U] norfloxacin
9.5
8.3
16
17
H35.9
ICD-10 Finland
Retinal disorder, unspecified
14.6
8.2
13
9
H3600, E113,
ICD-10 Finland
4.8
8.1
18
38
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
10.1
8.0
15
15
A10AE04
ATC
insulin glargine; parenteral
1.9
8.0
99
540
CHD00
NOMESCO Finland
Laser trabeculoplasty
4.0
7.9
22
56
H35.37
ICD-10 Finland
Macular holes
4.0
7.9
22
56
CKD95
NOMESCO Finland
Extended combined vitectomy and lens procedure through pars plana
13.2
7.9
13
10
CK2P4
NOMESCO Finland
Optic nerve head light layer imaging (OCT)
13.2
7.9
13
10
H18.6
ICD-10 Finland
Keratoconus
10.9
7.8
14
13
V03AE01
ATC
polystyrene sulfonate; oral
4.2
7.8
20
48
L04AA06
ATC
mycophenolic acid; systemic
4.2
7.8
20
48
3718X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Other corneal disorders
45.3
7.7
9
*
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
18.5
7.6
11
6
CA1AD
NOMESCO Finland
Orbita CT
25.2
7.6
10
*
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
25.2
7.6
10
*
H27.1
ICD-10 Finland
Dislocation of lens
10.1
7.5
14
14
H25.8
ICD-10 Finland
Other senile cataract
1.8
7.5
127
764
Z49.1
ICD-10 Finland
Extracorporeal dialysis
4.3
7.5
19
45
T89
ICPC
Diabetes insulin dependent
2.6
7.4
41
160
CJE00
NOMESCO Finland
Phakoemulsification
80.7
7.4
8
*
ZZL00
NOMESCO Finland
Free graft of amniotic membrane
80.7
7.4
8
*
TK800
NOMESCO Finland
Hemodialysis
3.4
7.4
26
78
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
7.4
226
1580
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
7.7
7.4
16
21
A46
ICD-10 Finland
Erysipelas
1.7
7.3
143
895
36600
ICD-8 Finland
Other inflammation of uveal tract, Abscessus oculi. Uveitis suppurativa. Panophthalmitis
+∞
7.3
7
*
36608
ICD-8 Finland
Other inflammation of uveal tract, Alia definita
+∞
7.3
7
*
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
7.3
7
*
N0830, E102,
ICD-10 Finland
+∞
7.3
7
*
3649
FHL
Other measure in this category
+∞
7.3
7
*
H3603, E107,
ICD-10 Finland
+∞
7.3
7
*
CBH30
NOMESCO Finland
Tarsorraphy
+∞
7.3
7
*
3700A
ICD-9 Finland
Keratitis, Corneal ulcer
+∞
7.3
7
*
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
15.9
7.2
11
7
F99
ICPC
Eye/adnexa disease other
7.4
7.2
16
22
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.7
7.2
143
900
CFB00
NOMESCO Finland
Suture of conjunctiva
20.2
7.1
10
5
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
7.1
76
394
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
8.0
7.1
15
19
B03XA02
ATC
darbepoetin alfa; parenteral
3.1
7.1
29
96
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
2.3
7.0
52
233
Z94.0
ICD-10 Finland
Kidney transplant status
7.1
7.0
16
23
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
3.0
6.9
30
103
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.9
6.9
93
523
R42
ICD-10 Finland
Dizziness and giddiness
1.5
6.8
214
1503
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
3.1
6.8
28
93
3793C
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[PSEUDOPHAKIA]
11.0
6.8
12
11
L01BA01
ATC
methotrexate; systemic
2.7
6.8
36
138
ZYC01
NOMESCO Finland
Remote contact by phone
2.3
6.8
52
237
A10AE05
ATC
insulin detemir; parenteral
2.2
6.7
53
245
N18.8
ICD-10 Finland
Other chronic renal failure
2.9
6.7
30
105
SPAT1301
SPAT
No procedures
1.5
6.6
282
2111
H40.1
ICD-10 Finland
Primary open-angle glaucoma
12.3
6.6
11
9
3744
FHL
Pericardial identification surgery with coagulation (includes epi- and intrascleral indications and eg Lincoff catheter)
12.3
6.6
11
9
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
12.3
6.6
11
9
H26.1
ICD-10 Finland
Traumatic cataract
10.1
6.5
12
12
E10
ICD-10 Finland
Type 1 diabetes mellitus
3.6
6.5
21
60
CDC30
NOMESCO Finland
Evisceration of eye
70.3
6.4
7
*
3665A
ICD-9 Finland
Cataract, After-cataract
70.3
6.4
7
*
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
5.2
6.3
18
35
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
11.1
6.3
11
10
R3120
NOMESCO Finland
Training in mobility skills
9.3
6.3
12
13
H26.3
ICD-10 Finland
Drug-induced cataract
9.3
6.3
12
13
CK2Y4
NOMESCO Finland
OCT video recording of ocular fundus
9.3
6.3
12
13
CJF45
NOMESCO Finland
Removal and implantation of artificial lens in anterior chamber with iridectomy or iridotomy
18.1
6.3
9
5
CAE00
NOMESCO Finland
Removal of implant from orbit
+∞
6.3
6
*
3620B
ICD-9 Finland
Other retinal disorders, Diabetic retinopathy[RETINOPATHIA DIABETICA PROLIFERATIVA]
+∞
6.3
6
*
CDC10
NOMESCO Finland
Enucleation of eye with insertion of prosthesis
+∞
6.3
6
*
CAE20
NOMESCO Finland
Revision of conjunctival sac with graft
+∞
6.3
6
*
37601
ICD-8 Finland
Detachment of retina, Secundaria
+∞
6.3
6
*
3792A
ICD-9 Finland
Other disorders of eye, Disorders of vitreous body
+∞
6.3
6
*
CJF20
NOMESCO Finland
Removal of artificial lens
26.9
6.2
8
*
CHB99
NOMESCO Finland
Other operation on anterior chamber and anterior chamber angle
26.9
6.2
8
*
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
26.9
6.2
8
*
A10AA03, ,
ATC
4.0
6.2
17
43
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.6
6.2
149
984
R51.80
ICD-10 Finland
Headache
1.7
6.2
125
790
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.0
6.2
63
322
S01AA12
ATC
tobramycin; ophthalmic
6.7
6.0
14
21
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
6.1
6.0
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
98
227
4.68
39.71
1.6
1.6
—
—
—
0
0
79
163
5.18
36.66
1.7
1.6
—
—
—
0
0
27
59
4.68
11.70
1.5
1.2
—
—
—
0
0
26
60
4.42
10.56
1.2
1.2
—
—
—
0
0
19
36
5.36
9.66
1.4
1.3
—
—
—
0
0
166
1016
1.76
9.31
8.6
5.0
1.09
1.03
mmol/l
1.38
155
927
14
14
10.13
7.54
1.1
1.0
—
—
—
0
0
478
3902
1.44
7.18
9.1
6.5
1.21
1.21
mmol/l
0.52
414
3280
179
1205
1.59
6.88
1.8
1.9
30.40
29.72
s
0.78
170
1165
438
3561
1.41
6.52
7.7
5.7
1.21
1.21
mmol/l
0.89
405
3212
33
129
2.61
6.01
7.8
5.0
180.33
405.82
iu/ml
—
9
17
28
102
2.80
5.83
1.8
1.4
130.75
115.05
u/ml
—
8
19
141
960
1.55
5.11
1.8
1.8
—
—
—
0
0
97
603
1.68
5.10
1.6
1.6
—
—
—
0
0
186
1355
1.46
4.86
1.9
1.8
—
—
—
0
0
341
2764
1.36
4.77
5.0
3.7
159.17
131.64
e6/l
0.14
249
1995
374
3086
1.34
4.62
4.6
3.8
37.18
48.81
ng/l
0.47
278
2238
131
898
1.53
4.60
3.7
3.7
241.94
258.36
u/l
0.53
119
848
300
2408
1.35
4.41
2.4
2.1
217.12
262.39
u/l
0.45
282
2253
15
38
3.99
4.31
1.2
1.2
—
—
—
0
0
11
20
5.55
4.29
1.1
1.0
2261.45
1762.30
miu/ml
0.58
11
20
218
1670
1.39
4.27
5.4
4.3
1.02
1.02
kg/l
0.23
39
240
113
764
1.54
4.23
8.0
3.5
1.74
1.89
mmol/l
0.18
97
622
134
942
1.49
4.17
4.9
7.1
1.80
1.29
mmol/l
0.63
100
743
13
30
4.38
4.13
2.2
2.6
531.54
920.87
u/ml
1.42
13
30
136
964
1.48
4.07
1.8
1.8
—
—
—
0
0
297
2406
1.34
4.05
4.1
3.3
39.95
94.23
e6/l
1.13
238
1865
107
722
1.54
4.04
2.5
2.4
6.29
6.59
ug/l
0.09
88
617
341
2822
1.32
4.00
4.3
3.2
—
—
—
0
0
133
942
1.48
3.99
4.9
7.0
5.11
5.07
kpa
0.13
127
899
133
943
1.47
3.97
4.9
7.0
11.72
11.94
kpa
0.18
127
902
624
5620
1.30
3.80
4.4
3.8
15.00
14.93
pmol/l
0.27
550
5037
55
318
1.77
3.79
1.8
2.1
36.72
39.53
u/l
0.57
47
277
433
3721
1.29
3.79
5.1
3.9
0.00
0.00
estimate
0.50
83
757
134
964
1.45
3.72
9.3
7.7
—
—
—
0
0
96
645
1.54
3.71
7.1
2.9
4.48
4.38
kpa
0.20
96
624
293
2402
1.31
3.62
4.3
3.7
17.72
8.55
mg/mmol
1.37
206
1490
381
3243
1.29
3.52
2.0
2.1
95.18
93.67
pmol/l
0.25
197
1663
165
1245
1.39
3.51
3.4
3.0
1.38
2.42
e6/l
2.08
100
685
468
4091
1.27
3.48
5.6
5.9
10.27
11.61
umol/l
3.31
440
3864
270
2202
1.31
3.44
3.9
3.2
0.42
0.47
e6/l
0.17
213
1688
254
2055
1.32
3.43
2.4
2.2
3.06
3.10
mg/l
0.08
223
1738
57
344
1.70
3.41
2.4
1.8
2.67
2.31
ug/l
0.10
50
294
91
619
1.52
3.34
6.5
3.5
119.97
85.38
ng/l
2.22
74
535
173
1333
1.36
3.23
3.4
2.8
1.10
1.16
e6/l
0.08
108
769
363
3098
1.27
3.22
2.7
2.2
75.38
77.67
nmol/l
0.86
317
2712
304
2538
1.29
3.22
3.3
3.0
2213.63
1596.63
ng/l
1.06
274
2185
508
4512
1.26
3.21
6.0
4.8
7.00
6.77
mmol/l
1.40
485
4230
87
592
1.52
3.20
2.8
2.7
67.00
64.12
ml/min/173m2
0.22
31
249
399
3449
1.26
3.17
5.7
4.5
34.68
35.13
g/l
0.84
354
3200
431
3760
1.26
3.17
5.1
3.9
0.00
0.00
estimate
0.50
75
681
20
85
2.38
3.16
2.5
2.2
—
—
—
0
0
426
3713
1.26
3.15
6.7
5.3
0.00
0.00
estimate
-0.00
78
695
6
8
7.54
3.06
5.8
5.3
—
—
—
0
0
288
2405
1.28
3.02
2.9
2.5
54.30
59.28
u/l
1.09
268
2220
285
2377
1.28
3.01
4.0
3.1
6.69
7.28
mmol/l
1.53
243
1982
12
37
3.27
2.94
1.3
1.2
—
—
—
0
0
159
1228
1.35
2.93
3.1
3.1
0.81
0.82
mmol/l
0.39
153
1144
566
5125
1.25
2.89
5.8
4.7
15041.60
3039.20
e6/l
—
10
95
211
1705
1.30
2.83
3.1
2.6
4.19
5.74
e6/l
1.33
195
1530
96
684
1.45
2.83
2.8
2.9
66.52
66.40
g/l
0.05
86
615
65
427
1.56
2.82
3.1
2.8
0.23
0.26
e6/l
0.12
65
412
643
5923
1.25
2.74
8.5
7.2
81.57
79.01
u/l
0.51
609
5533
6
10
6.03
2.70
2.0
1.3
196.67
100.80
ng/l
—
6
10
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
46
281
1.67
2.69
2.5
2.6
0.35
0.36
u/ml
0.07
26
169
192
1544
1.30
2.67
4.3
4.0
140.55
302.60
ng/l
1.59
160
1256
609
5589
1.23
2.63
4.6
4.0
14.72
13.26
mm/h
1.24
552
5111
41
248
1.68
2.50
3.7
3.3
3.72
3.96
mmol/l
2.77
41
243
243
2030
1.26
2.49
5.1
4.2
0.00
0.01
estimate
0.69
72
681
9
26
3.48
2.48
1.0
1.1
—
—
—
0
0
27
144
1.90
2.48
1.6
1.3
176.68
16.37
e6/l
0.76
22
115
31
175
1.80
2.40
1.9
1.3
—
—
—
0
0
424
3775
1.22
2.38
19.9
16.6
1.34
1.30
inr
0.34
121
1088
5
8
6.27
2.37
1.0
2.8
—
—
—
0
0
723
6796
1.24
2.32
5.3
4.7
2.11
2.13
mu/l
0.05
660
6129
21
105
2.02
2.32
1.7
1.6
—
—
—
0
0
228
1907
1.25
2.30
4.2
3.8
89.79
88.10
%
0.41
220
1859
6
13
4.64
2.27
1.2
1.2
99.00
96.15
%
—
6
13
8
23
3.50
2.27
2.3
1.4
—
—
—
0
0
23
120
1.94
2.27
1.3
1.1
—
—
—
0
0
71
500
1.45
2.27
4.9
3.3
2.22
1.96
mmol/l
0.17
54
375
37
226
1.66
2.20
1.5
1.6
0.11
0.08
iu/ml
—
10
46
145
1153
1.30
2.19
3.5
2.3
2.26
2.32
g/l
0.61
132
1058
809
7718
1.27
2.18
24.7
18.1
3.98
3.98
mmol/l
0.02
786
7477
56
379
1.51
2.18
6.8
3.8
23.49
24.15
mmol/l
0.82
56
369
807
7700
1.27
2.15
24.5
18.0
139.49
139.59
mmol/l
0.47
786
7473
45
291
1.57
2.15
3.5
3.4
1.15
1.39
mmol/l
1.33
45
283
232
1959
1.24
2.14
1.7
1.6
1.40
1.37
mmol/l
0.29
201
1625
69
491
1.44
2.10
6.3
8.0
94.52
94.09
%
0.51
69
486
11
43
2.58
2.08
2.0
1.7
—
—
—
0
0
397
3547
1.20
2.08
7.7
5.7
58.23
58.12
%
0.06
377
3325
5
10
5.02
2.07
1.2
1.0
—
—
—
0
0
72
519
1.42
2.05
1.5
1.6
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
10
38
2.65
2.00
1.0
1.2
—
—
—
0
0
24
134
1.81
1.96
1.6
1.5
—
—
—
0
0
10
39
2.58
1.94
2.4
1.5
14.10
21.16
nmol/l
—
10
33
154
1256
1.27
1.92
3.5
2.3
12.16
12.37
umol/l
0.12
142
1156
15
72
2.10
1.87
3.5
2.3
—
—
—
0
0
672
6329
1.19
1.84
23.9
18.3
14.96
15.08
%
0.21
663
6212
135
1090
1.28
1.83
3.7
2.4
20.61
21.80
%
0.54
111
916
399
3602
1.18
1.79
8.0
5.9
26.56
26.88
%
0.21
380
3377
276
2420
1.20
1.73
3.4
3.0
33.61
33.13
u/l
0.08
258
2295
21
118
1.80
1.71
1.3
1.6
—
—
—
0
0
472
4333
1.17
1.71
10.3
8.7
4.41
4.20
e9/l
1.10
425
3783
118
946
1.28
1.71
3.2
2.4
1.71
1.83
%
1.00
107
842
193
1638
1.22
1.69
1.7
1.8
1291.78
1203.30
nmol/l
0.62
149
1229
19
104
1.84
1.68
5.2
4.2
373.50
371.02
umol/l
0.03
14
90
30
188
1.61
1.67
1.4
1.4
—
—
—
0
0
20
113
1.79
1.61
1.5
1.2
174.95
286.19
u/ml
1.49
11
59
19
106
1.81
1.59
1.3
1.6
—
—
—
0
0
67
502
1.36
1.57
6.4
7.6
1.35
1.39
%
0.14
67
497
6
21
2.87
1.50
1.0
1.1
—
—
—
0
0
6
21
2.87
1.50
1.0
1.1
—
—
—
0
0
6
21
2.87
1.50
1.0
1.1
—
—
—
0
0
776
7453
1.19
1.49
20.8
15.2
26.27
25.14
mg/l
0.37
627
5974
188
1614
1.20
1.47
1.6
1.7
1.24
1.26
mg/l
0.06
147
1246
718
6856
1.17
1.46
7.0
5.9
41.83
40.32
mmol/mol
3.10
664
6284
6
22
2.74
1.43
1.0
1.1
—
—
—
0
0
26
165
1.59
1.41
2.2
1.7
6.64
6.13
iu/l
—
9
48
301
2701
1.16
1.40
3.2
3.3
2.34
2.35
mmol/l
0.73
249
2354
6
23
2.62
1.37
1.0
1.2
—
—
—
0
0
85
675
1.28
1.36
2.1
2.0
360.03
378.67
nmol/l
0.43
79
610
65
498
1.33
1.35
6.5
7.8
0.68
0.68
%
0.00
65
493
10
47
2.14
1.34
1.2
1.2
—
—
—
0
0
9
43
2.10
1.30
1.2
1.1
—
—
—
0
0
9
43
2.10
1.30
1.2
1.1
—
—
—
0
0
9
43
2.10
1.30
1.1
1.2
3.18
1.87
mmol/l
—
9
43
447
4146
1.14
1.30
2.8
2.8
—
—
—
0
0
10
48
2.09
1.28
2.1
2.1
—
—
—
0
0
9
44
2.05
1.27
1.2
1.1
—
—
—
0
0
9
44
2.05
1.27
1.2
1.1
—
—
—
0
0
9
44
2.05
1.27
1.2
1.1
—
—
—
0
0
16
93
1.73
1.21
1.3
1.5
71.00
63.16
%
—
9
64
113
942
1.23
1.21
1.4
1.4
—
—
—
0
0
26
174
1.51
1.16
1.8
1.6
—
—
—
0
0
220
1956
1.16
1.15
3.2
2.6
6477.04
9031.21
umol/l
0.30
187
1679
8
39
2.06
1.15
18.0
19.5
950.00
1472.08
nmol/l
—
8
39
39
285
1.38
1.12
3.7
3.0
—
—
—
0
0
27
184
1.48
1.11
1.8
1.6
—
—
—
0
0
81
661
1.25
1.07
4.7
3.8
1.22
1.23
mmol/l
0.56
66
569
13
74
1.77
1.07
1.4
1.9
—
—
—
0
0
10
52
1.93
1.06
1.4
1.6
—
—
—
0
0
30
213
1.42
1.02
2.2
1.7
—
—
—
0
0
12
68
1.77
1.00
1.0
1.2
1.70
1.42
nmol/l
0.38
12
61
20
131
1.54
1.00
1.9
1.7
—
—
—
0
0
17
107
1.60
1.00
1.2
1.1
—
—
—
0
0
380
3535
1.12
1.00
3.0
2.7
—
—
—
0
0
5
23
2.18
0.98
1.0
1.2
—
—
—
0
0
7
36
1.95
0.97
2.0
1.2
—
—
—
0
0
7
36
1.95
0.97
2.0
1.2
—
—
—
0
0
173
1533
1.16
0.96
1.3
1.2
2.68
1.73
u/ml
0.29
36
411
13
77
1.70
0.95
2.1
1.5
—
—
—
0
0
13
77
1.70
0.95
2.1
1.5
—
—
—
0
0
14
85
1.66
0.94
2.0
1.6
—
—
—
0
0
25
175
1.44
0.93
1.5
1.3
—
—
—
0
0
807
7861
1.15
0.91
12.7
10.4
26.79
25.46
u/l
0.67
779
7538
213
1925
1.14
0.89
1.6
1.6
22.75
20.80
nmol/l
0.60
181
1620
43
333
1.30
0.89
2.4
2.6
4.56
3.54
g/l
0.73
38
297
39
298
1.32
0.89
2.1
1.7
—
—
—
0
0
43
334
1.30
0.87
2.4
2.6
7.76
7.36
g/l
0.73
38
297
43
334
1.30
0.87
2.4
2.6
—
—
—
0
0
339
3155
1.11
0.87
3.5
2.7
140.49
133.48
ug/l
0.20
308
2870
42
326
1.30
0.86
2.3
1.8
—
—
—
0
0
84
709
1.20
0.84
2.5
2.3
28.56
32.25
u/l
0.93
64
595
15
96
1.57
0.84
2.2
1.3
—
—
—
0
0
31
231
1.35
0.84
1.2
1.1
—
—
—
0
0
40
310
1.30
0.83
2.3
2.6
10.47
10.33
g/l
0.07
35
272
192
1732
1.13
0.83
1.8
1.7
434.14
16382193.88
pmol/l
1.30
149
1404
36
275
1.32
0.83
3.6
3.6
55.39
76.94
mg/l
0.42
30
228
18
121
1.50
0.83
2.1
1.6
—
—
—
0
0
18
121
1.50
0.83
2.1
1.6
—
—
—
0
0
31
232
1.35
0.82
1.2
1.1
—
—
—
0
0
311
2890
1.11
0.81
5.2
4.2
—
—
—
0
0
36
276
1.32
0.81
3.6
3.7
34.35
36.97
mg/l
0.15
30
229
203
1841
1.13
0.81
3.2
2.4
—
—
—
0
0
8
47
1.71
0.80
2.0
1.2
—
—
—
0
0
8
47
1.71
0.80
2.0
1.2
—
—
—
0
0
9
149
0.60
0.79
5.3
3.6
8.68
1990.16
u/ml
—
9
138
0
28
0.00
0.76
0.0
1.9
—
—
—
0
0
11
67
1.65
0.75
1.5
1.9
—
—
—
0
0
15
100
1.51
0.73
4.1
1.7
32.60
32.74
pg
0.03
15
100
14
92
1.53
0.72
1.1
1.3
24851.33
111213.83
e6/l
—
6
52
39
311
1.26
0.68
2.6
2.7
3.07
2.94
g/l
0.27
32
274
5
27
1.86
0.68
1.6
2.8
—
—
—
0
0
5
27
1.86
0.68
1.6
2.8
—
—
—
0
0
7
42
1.67
0.68
3.1
1.5
—
—
—
0
0
7
42
1.67
0.68
3.1
1.5
—
—
—
0
0
7
42
1.67
0.68
1.4
1.7
—
—
—
0
0
7
43
1.63
0.67
1.4
1.7
—
—
—
0
0
835
8193
1.13
0.66
29.9
22.5
132.38
133.78
g/l
1.80
821
8032
10
62
1.62
0.65
1.3
1.3
—
—
—
0
0
15
103
1.46
0.65
1.9
1.5
—
—
—
0
0
10
154
0.65
0.64
1.2
1.5
—
—
—
0
0
26
198
1.32
0.64
2.1
2.2
183.04
99.04
ug/min
0.55
16
117
5
29
1.73
0.64
1.0
1.0
—
—
—
0
0
85
971
0.86
0.63
5.3
4.5
33.47
32.39
%
0.47
60
631
23
173
1.34
0.62
3.0
2.5
15.60
15.76
%
—
10
90
34
271
1.26
0.61
3.7
3.6
—
1.95
—
0
26
25
192
1.31
0.59
1.6
1.7
8439.92
18287.35
e6/l
1.30
13
139
0
22
0.00
0.59
0.0
1.6
—
—
—
0
0
833
8186
1.11
0.59
29.7
22.5
39.27
39.62
%
0.78
760
7572
33
264
1.26
0.58
1.8
2.6
38.31
37.58
g/l
0.32
27
227
833
8187
1.11
0.58
29.8
22.4
246.78
247.21
e9/l
0.07
814
7935
96
851
1.14
0.58
3.9
3.5
—
—
—
0
0
833
8190
1.11
0.56
29.8
22.4
4.40
4.44
e12/l
1.31
810
7911
27
212
1.28
0.56
1.6
1.3
26.78
27.53
iu/l
0.03
21
176
6
37
1.63
0.55
1.5
1.5
—
—
—
0
0
713
6965
1.09
0.54
18.9
14.4
76.24
77.57
ml/min/173m2
0.74
597
5723
6
38
1.58
0.54
1.0
1.3
—
—
—
0
0
19
143
1.34
0.52
3.6
1.3
0.82
0.85
nmol/l
0.07
14
117
9
63
1.43
0.52
1.1
1.0
—
—
—
0
0
23
179
1.29
0.51
1.6
1.3
—
—
—
0
0
9
65
1.39
0.50
1.1
1.6
—
—
—
0
0
16
118
1.36
0.50
1.3
1.2
—
—
—
0
0
12
84
1.43
0.49
1.8
1.7
—
1744.00
—
0
5
13
178
0.73
0.49
1.7
1.4
—
—
—
0
0
13
93
1.40
0.48
1.5
1.4
0.61
0.68
nmol/l
0.33
13
84
44
515
0.85
0.47
2.1
1.8
—
—
—
0
0
27
218
1.25
0.47
1.6
2.0
—
—
—
0
0
11
77
1.43
0.45
1.5
1.4
1095.83
148735.35
e6/l
—
6
57
23
184
1.26
0.43
2.7
2.2
127.75
125.75
g/l
0.10
16
135
5
31
1.62
0.43
1.4
1.1
335.80
174.12
iu/ml
—
5
31
5
34
1.47
0.40
2.0
5.0
—
—
—
0
0
54
476
1.14
0.39
1.6
1.5
—
—
—
0
0
9
66
1.37
0.38
1.0
1.1
—
—
—
0
0
5
36
1.39
0.38
1.2
1.1
—
—
—
0
0
105
1137
0.91
0.36
1.3
1.2
21.06
12.07
u/ml
0.36
36
414
735
7232
1.06
0.36
5.0
4.5
4.45
4.59
mmol/l
3.15
670
6604
53
470
1.13
0.36
2.1
2.2
14.36
12.93
nmol/l
0.58
44
419
6
43
1.40
0.35
1.0
1.0
—
—
—
0
0
6
43
1.40
0.35
1.8
2.1
—
—
—
0
0
14
109
1.29
0.33
1.6
1.6
—
—
—
0
0
6
89
0.67
0.33
1.0
1.1
—
—
—
0
0
10
74
1.35
0.32
1.2
1.1
—
—
—
0
0
6
47
1.28
0.32
1.0
1.4
0.91
0.97
g/l
—
6
47
728
7174
1.06
0.31
4.9
4.4
1.45
1.46
mmol/l
0.43
663
6500
18
147
1.23
0.31
1.1
1.2
—
—
—
0
0
7
100
0.70
0.30
1.1
1.1
—
—
—
0
0
22
184
1.20
0.30
1.5
1.3
—
—
—
0
0
22
184
1.20
0.30
1.5
1.3
—
—
—
0
0
13
102
1.28
0.30
1.0
1.1
—
82.14
—
0
21
12
93
1.29
0.30
1.0
1.0
0.82
1.78
u/ml
—
5
38
27
313
0.86
0.29
1.9
3.1
22.27
4617.18
u/ml
0.83
22
270
39
345
1.14
0.29
1.2
1.3
—
—
—
0
0
93
865
1.08
0.28
2.5
2.5
6.66
8.33
umol/l
0.72
83
759
31
271
1.15
0.27
1.5
1.2
—
—
—
0
0
12
95
1.27
0.26
1.4
1.7
—
—
—
0
0
9
72
1.25
0.25
1.0
1.1
—
—
—
0
0
17
143
1.19
0.23
4.3
3.3
4.16
4.45
e9/l
0.26
17
143
5
38
1.32
0.23
1.0
1.3
1.54
1.55
g/l
—
5
38
729
7207
1.04
0.23
5.1
4.7
6.18
6.00
mmol/l
2.10
664
6465
37
333
1.12
0.22
1.1
1.0
—
—
—
0
0
80
854
0.93
0.22
3.5
3.9
2.86
29.88
ug/l
1.96
60
705
5
42
1.19
0.21
1.8
4.3
—
—
—
0
0
161
1544
1.05
0.21
2.9
3.0
2.46
2.46
mmol/l
0.04
138
1353
0
11
0.00
0.21
0.0
2.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
98
1033
0.94
0.20
1.2
1.4
—
—
—
0
0
247
2399
1.04
0.19
4.9
5.1
5.09
2.80
ug/l
0.72
221
2134
12
100
1.20
0.18
1.8
1.4
—
—
—
0
0
12
100
1.20
0.18
1.8
1.4
—
—
—
0
0
12
100
1.20
0.18
1.8
1.4
—
—
—
0
0
747
7403
1.04
0.18
5.6
5.0
2.55
2.69
mmol/l
4.27
687
6728
699
6921
1.03
0.17
4.4
4.0
1.30
1.28
mmol/l
0.32
632
6212
7
62
1.13
0.17
1.0
1.1
—
—
—
0
0
7
63
1.11
0.17
2.7
1.6
—
—
—
0
0
19
167
1.14
0.17
2.2
1.8
44.74
40.44
nmol/l
0.31
19
158
12
101
1.19
0.16
1.8
1.4
—
—
—
0
0
12
101
1.19
0.16
1.8
1.4
—
—
—
0
0
8
69
1.16
0.16
1.8
1.6
—
—
—
0
0
8
69
1.16
0.16
1.8
1.6
—
—
—
0
0
8
69
1.16
0.16
1.8
1.6
—
—
—
0
0
71
749
0.94
0.15
2.2
1.8
1.56
1.50
%
0.40
62
658
12
102
1.18
0.15
1.8
1.4
—
—
—
0
0
24
217
1.11
0.14
1.4
1.4
—
—
—
0
0
17
150
1.14
0.14
4.8
3.6
60.29
60.13
%
0.02
17
150
27
251
1.08
0.10
1.9
1.9
—
—
—
0
0
5
44
1.14
0.10
2.2
1.8
—
—
—
0
0
5
44
1.14
0.10
1.2
1.6
101.80
79.07
umol/l
—
5
44
5
44
1.14
0.10
2.2
1.8
—
—
—
0
0
477
4724
1.02
0.09
3.4
3.1
51.01
50.80
u/l
0.02
438
4357
116
1190
0.97
0.09
1.4
1.2
49.39
35.21
iu/ml
0.59
38
390
5
63
0.79
0.08
1.2
1.2
—
—
—
0
0
194
1907
1.02
0.08
4.6
4.4
22.51
21.23
%
0.60
106
940
22
206
1.07
0.07
1.8
1.7
—
—
—
0
0
8
94
0.85
0.06
1.3
1.4
—
—
—
0
0
8
94
0.85
0.06
1.3
1.4
—
—
—
0
0
8
94
0.85
0.06
1.3
1.4
—
—
—
0
0
9
100
0.90
0.06
1.2
1.5
—
—
—
0
0
15
162
0.92
0.06
1.3
1.3
—
—
—
0
0
21
198
1.06
0.05
1.3
1.2
—
—
—
0
0
46
474
0.97
0.04
1.8
1.8
—
—
—
0
0
23
219
1.05
0.04
1.3
1.4
283.29
290.18
ug/g
0.06
12
125
24
229
1.05
0.04
1.5
1.8
—
—
—
0
0
137
1352
1.02
0.04
3.1
3.0
0.78
0.81
ug/l
0.14
105
894
52
532
0.98
0.03
1.7
1.9
—
—
—
0
0
19
198
0.96
0.02
2.1
1.9
—
—
—
0
0
10
94
1.06
0.01
1.2
1.2
1.80
8.21
u/ml
—
5
43
17
166
1.02
0.00
1.1
1.1
—
—
—
0
0
11
108
1.02
0.00
1.0
1.1
—
—
—
0
0
43
433
0.99
0.00
1.1
1.2
132.07
141.59
iu/ml
0.04
14
165
5
51
0.98
0.00
1.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
97
0.93
-0.00
1.0
1.0
—
—
—
0
0
8
87
0.92
-0.00
2.5
3.8
—
—
—
0
0
6
69
0.87
-0.00
1.3
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
-0.00
1.8
2.2
—
—
—
0
0
5
53
0.94
-0.00
1.2
1.4
—
57.14
—
0
7
5
57
0.88
-0.00
1.2
1.4
—
391.25
—
0
8
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLOBE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLOBE | 1.188 [1.07, 1.32] | 0.002 |
| Birth year | 0.998 [0.99, 1.01] | 0.557 |
During the follow-up period (1.1.1998 — 31.12.2019), 1511 out of 3733 females with H7_GLOBE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLOBE | 1.391 [1.21, 1.59] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.047 |
During the follow-up period (1.1.1998 — 31.12.2019), 1101 out of 2981 males with H7_GLOBE died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLOBE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.145% | 0.279% |
| 5 | 0.882% | 1.903% |
| 10 | 1.939% | 4.507% |
| 15 | 3.542% | 8.496% |
| 20 | 6.097% | 13.929% |
Relationships between endpoints
↥Index endpoint: H7_GLOBE – Disorders of globe
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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