pathological myopia: ['Excessive axial myopia associated with complications (especially posterior staphyloma and CHOROIDAL NEOVASCULARIZATION) that can lead to BLINDNESS.']
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
262 |
4. Check minimum number of eventsNone |
262 |
5. Include endpointsNone |
262 |
6. Filter based on genotype QC (FinnGen only) |
246 |
Control definitions (FinnGen only)
- Control exclude
- H7_VITREOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H44
- Name in latin
- Myopia degenerativa
Similar endpoints
↥List of similar endpoints to
Degenerative myopia
based on the number of shared cases.
Similar with more cases:
- Disorders of globe
- Disorders of vitreous body and globe
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2133 | 1513 | 608 |
| Only index persons | 1912 | 1363 | 549 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.02 |
| Only index persons | 0.04 | 0.05 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 59.30 | 62.03 | 52.35 |
| Only index persons | 57.27 | 59.91 | 50.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 246 | 184 | 62 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.03 |
| Median age at first event (years) | 57.18 | 57.05 | 57.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 262
- Matched controls
- 2620
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H44.2
ICD-10 Finland
Degenerative myopia
+∞
307.7
250
*
H52.1
ICD-10 Finland
Myopia
37.6
144.5
98
41
H26.4
ICD-10 Finland
After-cataract
10.6
68.4
93
129
Z96.1
ICD-10 Finland
Presence of intraocular lens
7.6
56.9
113
237
CJB10
NOMESCO Finland
Laser discission of secondary cataract
9.6
54.4
76
107
H26.02
ICD-10 Finland
Presenil cataract
19.7
48.0
39
23
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
15.4
45.3
42
32
XCW99
NOMESCO Finland
Other investigative procedure of eye
7.2
43.9
80
150
H33.0
ICD-10 Finland
Retinal detachment with retinal break
17.1
42.5
37
25
H43.8
ICD-10 Finland
Other disorders of vitreous body
14.4
33.8
32
25
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.0
30.9
65
137
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
7.9
30.4
46
69
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.6
29.3
94
283
S01ED51
ATC
timolol, combinations; ophthalmic
6.5
29.3
54
100
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
8.5
26.1
36
48
114
Kela drug reimbursment
Glaucoma
5.4
23.9
54
120
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.6
23.1
136
607
S01EC04
ATC
brinzolamide; ophthalmic
7.5
22.3
34
51
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
3.4
21.7
144
685
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
5.5
19.7
42
88
XCK00
NOMESCO Finland
Perimetry
5.8
19.5
39
77
CKC12
NOMESCO Finland
Photocoagulation of retina
8.1
18.6
26
35
S01EE01
ATC
latanoprost; ophthalmic
5.4
18.5
40
85
H33.3
ICD-10 Finland
Retinal breaks without detachment
7.3
18.2
28
42
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
6.5
17.9
31
53
XCH00
NOMESCO Finland
Eye pressure measurement
6.6
17.7
30
50
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
6.1
17.4
32
58
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
27.8
17.2
23
9
3602A
ICD-9 Finland
Disorders of the globe, Degenerative disorders of globe[MYOPIA MALIGNA]
+∞
16.8
16
*
H40.0
ICD-10 Finland
Glaucoma suspect
4.4
16.1
45
118
Z3229
NOMESCO Finland
Other healthcare associate professional
4.2
14.6
43
117
H35.4
ICD-10 Finland
Peripheral retinal degeneration
45.2
14.3
17
*
S01ED01
ATC
timolol; ophthalmic
6.2
13.0
23
40
XCK10
NOMESCO Finland
Photography of fundus of eye
3.7
12.7
44
134
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
39.6
12.3
15
*
H25.1
ICD-10 Finland
Senile nuclear cataract
2.6
12.2
102
514
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
16.0
11.5
18
12
ZXA10
NOMESCO Finland
Bilateral
2.7
11.4
75
334
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.4
11.4
149
917
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
5.5
11.0
22
43
37002
ICD-8 Finland
Refractive errors, Myopia
+∞
10.5
10
*
H53.0
ICD-10 Finland
Amblyopia ex anopsia
24.5
10.4
14
6
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.1
10.2
48
177
H25.0
ICD-10 Finland
Senile incipient cataract
3.9
9.5
30
85
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
18.4
9.5
14
8
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
22.7
9.4
13
6
H44.3
ICD-10 Finland
Other degenerative disorders of globe
+∞
9.4
9
*
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
+∞
9.4
9
*
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
4.9
9.2
21
46
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.9
9.1
50
200
H26.2
ICD-10 Finland
Complicated cataract
16.3
9.1
14
9
CKC30
NOMESCO Finland
Cryopexy of detached retina
51.8
8.7
10
*
S01EE04
ATC
travoprost; ophthalmic
8.7
8.7
18
22
CKD40
NOMESCO Finland
Endophotocoagulation of retina
20.9
8.5
12
6
CS494
NOMESCO Finland
Other visual field testing
8.3
8.5
18
23
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
9.9
8.4
16
17
H43.1
ICD-10 Finland
Vitreous haemorrhage
+∞
8.4
8
*
S01EA05
ATC
brimonidine; ophthalmic
8.6
8.2
17
21
H27.0
ICD-10 Finland
Aphakia
46.4
7.8
9
*
CKC60
NOMESCO Finland
Local buckling of sclera using implant
46.4
7.8
9
*
S01EC03
ATC
dorzolamide; ophthalmic
19.1
7.7
11
6
S01EE03
ATC
bimatoprost; ophthalmic
8.0
7.5
16
21
CKC70
NOMESCO Finland
Circular buckling of sclera
82.3
7.5
8
*
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
82.3
7.5
8
*
CKC65
NOMESCO Finland
Removal of buckling implant from sclera
+∞
7.3
7
*
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
30.9
7.2
9
*
ZXA05
NOMESCO Finland
Left side
2.1
6.8
78
435
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
71.5
6.5
7
*
CKC10
NOMESCO Finland
Local photocoagulation of retina
6.8
6.4
15
23
3745
FHL
Hard membrane girding, cerclage with coagulation
+∞
6.3
6
*
ZXA00
NOMESCO Finland
Right side
2.0
6.3
82
478
H53.1
ICD-10 Finland
Subjective visual disturbances
3.2
6.3
25
83
XCD20
NOMESCO Finland
Photoangiography of eye
8.0
6.2
13
17
S01EE05
ATC
tafluprost; ophthalmic
3.9
6.0
18
49
WX140
NOMESCO Finland
Parabulbar anesthesy
3.7
6.0
19
54
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
196
1670
1.69
3.34
4.3
4.1
14.71
14.81
pmol/l
0.23
180
1502
17
81
2.18
2.18
1.4
1.4
—
—
—
0
0
7
19
3.75
2.16
1.4
1.2
—
—
—
0
0
56
390
1.55
2.13
1.4
1.7
1378.53
1201.35
nmol/l
0.81
38
284
34
210
1.71
2.07
1.4
1.9
—
—
—
0
0
45
302
1.59
2.00
1.6
1.9
—
—
—
0
0
109
883
1.40
1.90
2.6
2.3
75.46
79.34
nmol/l
0.74
91
785
33
212
1.64
1.76
1.5
1.9
—
—
—
0
0
55
403
1.46
1.65
1.4
1.4
—
—
—
0
0
114
960
1.33
1.47
5.2
5.5
1.22
1.22
mmol/l
0.01
100
870
62
477
1.39
1.42
2.5
2.1
2.97
3.17
mg/l
0.26
55
411
38
267
1.50
1.40
6.3
6.3
—
—
—
0
0
123
1055
1.31
1.37
6.2
6.3
1.22
1.22
mmol/l
0.14
103
888
100
835
1.32
1.35
1.9
1.9
96.25
96.15
pmol/l
0.01
42
408
24
155
1.60
1.28
4.6
3.4
80.18
80.76
ng/l
0.02
17
136
11
58
1.94
1.14
3.7
4.4
3.55
3.89
mmol/l
1.44
11
58
211
1975
1.35
1.13
5.6
5.4
39.11
39.51
mmol/mol
0.30
197
1826
23
153
1.55
1.10
3.0
3.1
263.22
184.15
ng/l
0.42
23
136
56
443
1.34
1.08
1.9
1.8
475.74
20391514.59
pmol/l
0.50
43
358
73
603
1.29
1.04
2.6
3.0
893.95
1083.85
ng/l
0.43
64
502
213
2004
1.34
1.04
5.3
4.9
2.06
2.50
mu/l
0.30
197
1800
221
2093
1.36
1.01
4.6
4.5
5.77
5.90
mmol/l
1.21
205
1899
93
796
1.26
0.99
3.5
3.5
16.34
30.73
ng/l
1.77
66
540
0
29
0.00
0.98
0.0
2.2
—
13.38
—
0
29
44
341
1.35
0.98
2.8
2.5
1.73
1.13
e6/l
0.25
25
187
8
43
1.89
0.88
2.0
1.1
—
—
—
0
0
40
316
1.31
0.80
2.8
2.7
2.11
3.85
e6/l
0.81
22
164
0
24
0.00
0.79
0.0
1.0
—
—
—
0
0
50
408
1.28
0.79
2.8
2.6
2.46
2.46
mmol/l
0.02
39
357
0
26
0.00
0.79
0.0
1.6
—
—
—
0
0
24
175
1.41
0.78
1.6
2.5
74.00
64.00
ml/min/173m2
0.70
11
64
9
54
1.69
0.75
1.4
1.3
—
—
—
0
0
5
25
2.02
0.73
1.4
1.7
—
—
—
0
0
68
582
1.23
0.72
3.0
2.9
0.69
0.46
e6/l
0.31
52
432
7
40
1.77
0.72
1.1
1.5
—
—
—
0
0
230
2216
1.31
0.71
17.6
15.3
3.96
3.96
mmol/l
0.10
224
2147
5
28
1.80
0.66
1.6
1.6
—
—
—
0
0
229
2209
1.29
0.66
17.5
15.3
139.58
139.74
mmol/l
0.43
223
2143
13
87
1.52
0.64
1.8
1.9
—
—
—
0
0
66
572
1.21
0.62
4.7
4.0
0.00
0.00
estimate
-0.00
25
207
16
114
1.43
0.60
4.5
8.6
0.63
0.68
%
0.23
16
114
0
21
0.00
0.60
0.0
1.6
—
—
—
0
0
0
21
0.00
0.60
0.0
1.4
—
—
—
0
0
45
533
0.81
0.59
2.4
2.6
349.64
6593.96
umol/l
2.70
39
458
16
115
1.42
0.58
4.5
8.3
1.20
1.38
%
0.42
16
115
30
371
0.78
0.58
1.5
1.3
18.53
13.07
u/ml
0.12
13
143
220
2121
1.23
0.57
4.6
4.4
4.73
4.79
mmol/l
0.40
201
1947
219
2111
1.23
0.57
4.4
4.3
1.56
1.54
mmol/l
0.20
201
1922
31
378
0.80
0.54
1.5
1.3
30.63
33.00
iu/ml
—
8
142
140
1309
1.15
0.50
2.7
3.0
—
—
—
0
0
82
739
1.16
0.49
3.7
3.0
—
—
—
0
0
16
121
1.34
0.45
5.6
7.0
25.06
25.14
mmol/l
0.03
16
116
19
149
1.30
0.43
1.5
1.6
—
—
—
0
0
84
767
1.14
0.42
2.7
3.3
2.37
2.36
mmol/l
0.45
69
677
5
33
1.52
0.41
1.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
209
2024
1.16
0.40
4.0
3.9
1.25
1.25
mmol/l
0.01
192
1830
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
221
2150
1.18
0.40
14.6
13.3
24.85
23.34
mg/l
0.22
166
1664
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
9
68
1.33
0.38
2.1
1.7
—
—
—
0
0
9
121
0.73
0.36
4.6
6.2
26.66
24.87
mmol/l
—
9
121
222
2165
1.17
0.36
5.1
4.9
2.77
2.82
mmol/l
0.49
203
1976
6
43
1.40
0.35
1.5
1.3
—
—
—
0
0
6
43
1.40
0.35
1.5
1.3
—
—
—
0
0
10
73
1.38
0.35
2.0
1.9
—
—
—
0
0
32
369
0.85
0.34
1.2
1.4
—
—
—
0
0
30
257
1.19
0.34
4.6
4.2
34.36
33.18
%
0.33
22
157
6
86
0.69
0.33
1.8
1.4
—
—
—
0
0
72
661
1.12
0.33
2.2
2.2
59.22
55.65
u/l
0.38
67
607
10
74
1.37
0.33
1.5
1.6
5.07
4.81
ug/l
—
10
68
14
110
1.29
0.32
1.4
1.7
—
—
—
0
0
55
497
1.13
0.32
1.3
1.2
3.28
2.46
u/ml
0.11
11
150
77
831
0.90
0.32
4.8
3.8
—
—
—
0
0
7
55
1.28
0.30
3.4
2.6
25.07
25.29
mmol/l
—
7
55
118
1237
0.92
0.26
7.9
9.5
4.27
4.01
e9/l
0.46
107
1089
167
1615
1.09
0.26
3.6
4.0
11.35
12.08
mm/h
0.35
151
1476
9
72
1.26
0.26
1.8
1.9
—
—
—
0
0
25
217
1.17
0.25
4.0
6.8
1.17
1.45
mmol/l
0.13
20
177
55
506
1.11
0.25
1.5
1.5
24.95
21.44
nmol/l
0.66
42
420
26
227
1.16
0.25
3.8
3.4
—
—
—
0
0
109
1040
1.08
0.23
4.3
3.7
0.00
0.00
estimate
-0.00
26
218
5
42
1.19
0.21
1.6
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.7
—
95.31
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.7
—
—
—
0
0
0
10
0.00
0.21
0.0
2.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.7
—
—
—
0
0
8
104
0.76
0.21
2.5
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
—
—
0
0
0
12
0.00
0.21
0.0
4.5
—
169.50
—
0
12
0
12
0.00
0.21
0.0
1.1
—
206.08
—
0
12
0
13
0.00
0.21
0.0
7.6
—
39.20
—
0
5
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
15
176
0.84
0.20
2.5
1.7
—
—
—
0
0
9
114
0.78
0.20
1.0
1.3
—
—
—
0
0
101
965
1.08
0.20
20.5
12.0
1.22
1.18
inr
0.18
34
297
0
14
0.00
0.20
0.0
3.8
—
—
—
0
0
0
14
0.00
0.20
0.0
2.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
2.2
—
—
—
0
0
0
14
0.00
0.20
0.0
2.3
—
—
—
0
0
6
51
1.18
0.19
2.0
1.4
—
—
—
0
0
13
153
0.84
0.18
7.8
6.7
9.99
8.94
mmol/l
0.24
13
147
7
60
1.17
0.18
1.4
1.3
—
—
—
0
0
232
2292
1.11
0.16
10.0
10.2
24.81
25.38
u/l
0.23
226
2198
95
912
1.07
0.16
4.6
4.1
35.95
35.63
g/l
0.25
80
850
125
1212
1.06
0.15
4.0
4.6
6.46
6.57
mmol/l
0.29
119
1119
9
78
1.16
0.15
1.3
2.5
—
—
—
0
0
18
159
1.14
0.15
2.4
3.0
25.83
37.43
u/ml
0.56
18
153
44
411
1.08
0.15
3.7
3.6
315.30
161.76
ng/l
0.33
34
321
108
1043
1.06
0.15
5.3
5.0
0.00
0.00
estimate
-0.00
25
204
24
217
1.12
0.15
4.0
6.7
5.32
5.17
kpa
0.16
24
210
24
217
1.12
0.15
4.0
6.7
10.97
11.92
kpa
0.49
24
210
11
93
1.19
0.14
4.6
3.4
25.77
24.78
mmol/l
0.83
11
93
64
609
1.07
0.14
1.5
1.6
1.29
1.36
mmol/l
0.27
52
509
92
886
1.06
0.14
3.6
2.7
84.87
104.60
ug/l
0.82
84
809
239
2367
1.11
0.14
22.0
20.1
40.25
39.88
%
0.82
218
2219
93
963
0.95
0.13
2.5
2.5
—
—
—
0
0
239
2368
1.11
0.13
22.5
20.1
4.45
4.44
e12/l
0.10
233
2302
239
2368
1.11
0.13
22.4
20.0
251.65
252.88
e9/l
0.11
232
2307
18
161
1.13
0.13
1.2
1.2
93.50
177.80
iu/ml
—
6
72
207
2042
1.07
0.13
14.2
12.9
82.46
80.39
ml/min/173m2
0.69
176
1663
23
210
1.10
0.12
1.7
2.2
26.61
30.23
u/l
0.61
18
179
11
95
1.16
0.12
3.8
3.6
36.33
47.26
%
0.74
11
95
51
485
1.06
0.11
2.4
2.3
—
—
—
0
0
172
1691
1.05
0.11
6.7
7.2
81.61
79.31
u/l
0.23
160
1568
45
473
0.94
0.10
1.6
1.7
0.77
1.08
mg/l
1.04
34
377
119
1163
1.04
0.10
4.9
6.0
9.50
10.38
umol/l
0.96
111
1099
16
145
1.11
0.09
1.0
1.3
—
38.79
—
0
11
229
2271
1.07
0.09
16.9
15.8
73.09
73.64
umol/l
0.13
229
2271
108
1055
1.04
0.09
4.1
3.7
0.00
0.01
estimate
0.50
24
201
29
273
1.07
0.08
3.0
2.2
2.45
2.37
g/l
0.37
24
248
143
1406
1.04
0.08
3.2
2.8
51.27
45.61
u/l
0.30
128
1306
30
283
1.07
0.08
4.7
4.5
20.85
21.67
%
0.10
11
141
7
68
1.03
0.08
1.0
1.7
—
—
—
0
0
6
73
0.82
0.07
1.0
1.6
—
—
—
0
0
25
265
0.94
0.07
3.3
2.2
18.08
22.02
%
1.30
19
218
63
612
1.04
0.06
3.4
3.7
7.59
6.94
mg/mmol
0.05
40
373
17
183
0.92
0.06
1.6
1.8
—
—
—
0
0
15
161
0.93
0.05
1.6
1.8
—
—
—
0
0
22
211
1.05
0.03
2.8
3.0
0.60
0.76
ug/l
0.76
17
137
70
690
1.02
0.02
2.5
2.8
32.55
31.37
u/l
0.09
64
658
10
106
0.94
0.01
3.9
3.6
1.13
1.19
%
—
10
106
31
304
1.02
0.00
3.1
2.2
11.66
12.78
umol/l
0.52
26
279
25
248
1.01
0.00
5.6
6.5
103.12
104.24
mmol/l
0.59
25
248
10
103
0.97
0.00
3.9
3.6
0.66
0.66
%
—
10
103
12
115
1.05
0.00
1.2
1.0
—
—
—
0
0
6
65
0.92
0.00
2.0
2.0
206.83
336.68
ug/l
—
6
58
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
6.63
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
71
0.99
-0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
59
0.84
-0.00
1.0
1.3
—
1.89
—
0
11
5
57
0.87
-0.00
1.2
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.1
—
218.89
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
107.29
—
0
7
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
-0.00
2.2
2.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1923.60
—
0
5
7
71
0.99
-0.00
1.0
1.2
—
—
—
0
0
7
71
0.99
-0.00
2.4
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_DEGENMYOPIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_DEGENMYOPIA | 0.986 [0.85, 1.15] | 0.861 |
| Birth year | 0.991 [0.98, 1.0] | 0.057 |
During the follow-up period (1.1.1998 — 31.12.2019), 268 out of 1168 females with H7_DEGENMYOPIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_DEGENMYOPIA | 0.96 [0.72, 1.27] | 0.776 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 478 males with H7_DEGENMYOPIA died.
Mortality risk
Mortality risk for people of age
years, who have H7_DEGENMYOPIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.071% | 0.19% |
| 5 | 0.463% | 1.034% |
| 10 | 1.237% | 2.553% |
| 15 | 2.487% | 4.715% |
| 20 | 4.421% | 8.143% |
Relationships between endpoints
↥Index endpoint: H7_DEGENMYOPIA – Degenerative myopia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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