No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
198 |
4. Check minimum number of eventsNone |
198 |
5. Include endpointsNone |
198 |
6. Filter based on genotype QC (FinnGen only) |
198 |
Control definitions (FinnGen only)
- Control exclude
- H7_VITREOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF6
- Parent code in ICD-10
- H44
- Name in latin
- Endophthalmitis purulenta
Similar endpoints
↥List of similar endpoints to
Purulent endophthalmitis
based on the number of shared cases.
Similar with more cases:
- Disorders of globe
- Disorders of vitreous body and globe
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1886 | 976 | 889 |
| Only index persons | 1367 | 724 | 643 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 70.38 | 74.48 | 66.01 |
| Only index persons | 69.64 | 74.44 | 64.23 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 198 | 87 | 111 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.05 |
| Median age at first event (years) | 71.02 | 72.48 | 69.88 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 174
- Matched controls
- 1741
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H44.0
ICD-10 Finland
Purulent endophthalmitis
+∞
190.3
146
*
CKA10
NOMESCO Finland
Biopsy of vitreous body
+∞
88.2
77
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
39.3
79.7
106
66
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
66.0
48.7
55
12
WX140
NOMESCO Finland
Parabulbar anesthesy
23.4
42.0
62
40
H44.1
ICD-10 Finland
Other endophthalmitis
+∞
41.3
38
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
7.4
32.3
129
484
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
82.7
25.6
28
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
9.0
25.2
58
91
Z96.1
ICD-10 Finland
Presence of intraocular lens
6.3
24.1
78
199
TCH12
NOMESCO Finland
Sample aspiration from anterior chambre
+∞
23.5
22
*
3600A
ICD-9 Finland
Disorders of the globe, Purulent endophthalmitis
+∞
20.2
19
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
18.6
20.2
31
20
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
8.6
19.2
44
66
H43.1
ICD-10 Finland
Vitreous haemorrhage
+∞
19.1
18
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
112.2
19.0
20
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.9
16.9
52
117
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
13.1
16.5
29
26
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.9
16.2
107
507
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.8
15.6
108
526
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
58.3
14.1
16
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
28.4
13.7
18
7
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
10.7
13.5
26
28
H25.1
ICD-10 Finland
Senile nuclear cataract
3.4
13.2
91
422
S01ED51
ATC
timolol, combinations; ophthalmic
5.4
13.0
41
93
WX100
NOMESCO Finland
Conjunctival surface anesthesia
4.3
11.8
48
142
3643
FHL
Vitrectomy through pars Plana
+∞
11.6
11
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
6.5
11.4
30
54
XCK10
NOMESCO Finland
Photography of fundus of eye
4.7
11.2
40
103
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
10.6
10.6
20
21
S01ED01
ATC
timolol; ophthalmic
6.5
10.3
27
48
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
18.1
10.1
15
9
H16.0
ICD-10 Finland
Corneal ulcer
8.9
9.7
20
25
H20.1
ICD-10 Finland
Chronic iridocyclitis
32.0
9.5
12
*
H02AB06
ATC
prednisolone; systemic
2.7
9.1
100
580
H43.8
ICD-10 Finland
Other disorders of vitreous body
19.9
9.1
13
7
S01EC01
ATC
acetazolamide; systemic
10.3
9.0
17
18
S01EE01
ATC
latanoprost; ophthalmic
5.4
8.7
26
55
CKD40
NOMESCO Finland
Endophotocoagulation of retina
29.1
8.6
11
*
TCK20
NOMESCO Finland
Needle biopsy of vitreous body
+∞
8.4
8
*
H26.2
ICD-10 Finland
Complicated cataract
23.3
8.1
11
5
114
Kela drug reimbursment
Glaucoma
3.7
8.1
37
119
XCK00
NOMESCO Finland
Perimetry
5.0
8.0
25
56
CKC12
NOMESCO Finland
Photocoagulation of retina
8.1
7.9
17
23
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
16.0
7.8
12
8
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.2
7.8
43
160
CKD60
NOMESCO Finland
Anterior vitrectomy
26.3
7.7
10
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
26.3
7.7
10
*
ZXD05
NOMESCO Finland
Urgent procedure
2.6
7.5
70
358
S01EA03
ATC
apraclonidine; ophthalmic
14.2
7.5
12
9
WX002
NOMESCO Finland
Sedation and analgesia
2.8
7.3
52
228
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
4.1
6.9
26
71
Z94.7
ICD-10 Finland
Corneal transplant status
41.7
6.8
8
*
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
41.7
6.8
8
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
8.3
6.8
14
18
WX142
NOMESCO Finland
Sub-tenon anesthesy
23.6
6.7
9
*
H26.4
ICD-10 Finland
After-cataract
3.4
6.6
32
108
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
72.4
6.5
7
*
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
7.5
6.4
14
20
36600
ICD-8 Finland
Other inflammation of uveal tract, Abscessus oculi. Uveitis suppurativa. Panophthalmitis
+∞
6.3
6
*
S01AA12
ATC
tobramycin; ophthalmic
+∞
6.3
6
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
8.2
6.2
13
17
A10AA02
ATC
NA
6.0
6.2
16
29
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
13.2
6.2
10
8
A10AA01
ATC
NA
13.2
6.2
10
8
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
7.7
6.0
13
18
Mortality – FinRegistry
↥Association
Association between endpoint H7_PURENDOPHTHALMITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PURENDOPHTHALMITIS | 1.168 [0.94, 1.45] | 0.163 |
| Birth year | 0.996 [0.99, 1.0] | 0.398 |
During the follow-up period (1.1.1998 — 31.12.2019), 234 out of 595 females with H7_PURENDOPHTHALMITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PURENDOPHTHALMITIS | 1.545 [1.18, 2.02] | 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 168 out of 486 males with H7_PURENDOPHTHALMITIS died.
Mortality risk
Mortality risk for people of age
years, who have H7_PURENDOPHTHALMITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.127% | 0.329% |
| 5 | 0.731% | 1.799% |
| 10 | 1.797% | 4.371% |
| 15 | 3.428% | 8.472% |
| 20 | 5.99% | 13.724% |
Relationships between endpoints
↥Index endpoint: H7_PURENDOPHTHALMITIS – Purulent endophthalmitis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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