No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
177 |
4. Check minimum number of eventsNone |
177 |
5. Include endpointsNone |
177 |
6. Filter based on genotype QC (FinnGen only) |
177 |
Control definitions (FinnGen only)
- Control exclude
- H7_VITREOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF6
Similar endpoints
↥List of similar endpoints to
Other endophthalmitis
based on the number of shared cases.
Similar with more cases:
- Disorders of globe
- Disorders of vitreous body and globe
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1770 | 938 | 814 |
| Only index persons | 1405 | 776 | 629 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 66.80 | 71.11 | 61.85 |
| Only index persons | 65.42 | 70.24 | 59.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 177 | 96 | 81 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | 60.99 | 60.01 | 62.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 159
- Matched controls
- 1591
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H44.1
ICD-10 Finland
Other endophthalmitis
+∞
166.1
129
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
45.2
56.9
70
27
H44.0
ICD-10 Finland
Purulent endophthalmitis
+∞
41.5
38
*
CKA10
NOMESCO Finland
Biopsy of vitreous body
+∞
38.0
35
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
46.1
36.4
44
13
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
21.8
30.9
46
29
WX140
NOMESCO Finland
Parabulbar anesthesy
21.6
27.7
41
25
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
5.0
20.4
101
410
Z96.1
ICD-10 Finland
Presence of intraocular lens
6.1
20.4
66
166
H43.1
ICD-10 Finland
Vitreous haemorrhage
201.4
17.9
18
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
8.5
17.9
41
62
H20.1
ICD-10 Finland
Chronic iridocyclitis
39.9
17.1
21
6
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.9
16.7
45
86
S01ED51
ATC
timolol, combinations; ophthalmic
6.6
15.3
42
82
H33.0
ICD-10 Finland
Retinal detachment with retinal break
19.4
14.8
22
13
XCK10
NOMESCO Finland
Photography of fundus of eye
5.8
14.0
43
96
36609
ICD-8 Finland
Other inflammation of uveal tract, Unspecified
+∞
13.7
13
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.6
13.3
53
157
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.5
12.8
91
437
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
26.9
12.8
17
7
TCK20
NOMESCO Finland
Needle biopsy of vitreous body
+∞
12.7
12
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
9.1
11.9
25
32
S01ED01
ATC
timolol; ophthalmic
7.3
11.2
27
43
H3603, E103
ICD-10 Finland
NA
+∞
10.5
10
*
XCK00
NOMESCO Finland
Perimetry
6.8
10.4
26
44
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
13.4
10.1
17
14
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.8
9.9
34
85
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
19.0
9.6
14
8
H43.8
ICD-10 Finland
Other disorders of vitreous body
32.2
9.5
12
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
23.4
9.5
13
6
36402
ICD-8 Finland
Iritis, Iridocyclitis, uveitis chronica
+∞
9.5
9
*
XCD20
NOMESCO Finland
Photoangiography of eye
14.9
9.4
15
11
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
25.7
9.0
12
5
H26.4
ICD-10 Finland
After-cataract
4.1
8.9
36
105
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
9.4
8.6
17
20
S01BC03
ATC
diclofenac; ophthalmic
13.8
8.5
14
11
ZXA00
NOMESCO Finland
Right side
2.9
8.4
62
284
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
+∞
8.4
8
*
3641A
ICD-9 Finland
Disorders of iris and ciliary body, Chronic iridocyclitis
+∞
8.4
8
*
S01EC01
ATC
acetazolamide; systemic
8.9
8.3
17
21
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.6
7.9
84
474
H02AB06
ATC
prednisolone; systemic
2.6
7.9
87
502
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
8.1
7.9
17
23
114
Kela drug reimbursment
Glaucoma
3.8
7.9
34
105
H25.1
ICD-10 Finland
Senile nuclear cataract
2.7
7.8
69
349
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
16.1
7.8
12
8
CKC15
NOMESCO Finland
Panretinal photocoagulation
47.3
7.8
9
*
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
19.5
7.7
11
6
WX002
NOMESCO Finland
Sedation and analgesia
3.1
7.6
45
177
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
14.3
7.5
12
9
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
83.8
7.5
8
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
83.8
7.5
8
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
83.8
7.5
8
*
ZX198
NOMESCO Finland
Other local administration
83.8
7.5
8
*
H16.0
ICD-10 Finland
Corneal ulcer
8.0
7.4
16
22
36608
ICD-8 Finland
Other inflammation of uveal tract, Alia definita
+∞
7.3
7
*
S01EA03
ATC
apraclonidine; ophthalmic
21.2
7.2
10
5
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
21.2
7.2
10
5
H26.2
ICD-10 Finland
Complicated cataract
17.6
6.8
10
6
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
23.7
6.7
9
*
ZXA05
NOMESCO Finland
Left side
2.6
6.7
57
278
S01EE01
ATC
latanoprost; ophthalmic
4.3
6.6
24
63
S01BC05
ATC
ketorolac; ophthalmic
7.1
6.5
15
23
TCH12
NOMESCO Finland
Sample aspiration from anterior chambre
72.6
6.5
7
*
H30.2
ICD-10 Finland
Posterior cyclitis
72.6
6.5
7
*
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
7.6
6.4
14
20
CKD40
NOMESCO Finland
Endophotocoagulation of retina
18.9
6.3
9
5
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
6.8
6.3
15
24
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
+∞
6.3
6
*
TCH10
NOMESCO Finland
Needle aspiration of aqueous from anterior chamber
+∞
6.3
6
*
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
+∞
6.3
6
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
10.6
6.1
11
11
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
7.8
6.1
13
18
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
15
30
5.37
7.32
1.9
1.6
—
—
—
0
0
10
15
7.01
6.38
1.2
1.3
—
—
—
0
0
15
38
4.22
5.56
1.8
1.5
—
—
—
0
0
8
9
9.24
4.32
1.3
1.2
—
—
—
0
0
7
6
12.07
4.31
3.0
1.8
535.3
1203.8
u/ml
—
7
6
32
166
2.13
3.37
7.5
5.6
1.0
1.0
mmol/l
0.05
32
151
8
18
4.60
2.83
1.3
1.1
—
—
—
0
0
5
9
5.68
2.23
1.0
1.2
—
—
—
0
0
6
14
4.40
2.17
1.7
1.1
—
—
—
0
0
75
580
1.51
1.90
2.0
2.0
92.2
96.1
pmol/l
0.25
42
280
8
28
2.94
1.88
1.1
1.9
4.3
3.9
mmol/l
—
8
28
9
35
2.65
1.83
1.2
1.8
461.8
448.0
mg/l
—
9
35
78
613
1.49
1.81
5.7
4.3
34.4
35.3
g/l
0.78
72
568
77
605
1.48
1.78
5.2
4.4
—
—
—
0
0
15
79
1.98
1.54
1.1
1.6
—
—
—
0
0
5
15
3.40
1.53
3.6
1.5
—
—
—
0
0
9
41
2.26
1.39
6.4
3.8
—
3.8
—
0
6
9
41
2.26
1.39
1.3
1.2
—
—
—
0
0
10
47
2.20
1.36
1.4
1.9
—
—
—
0
0
9
42
2.20
1.36
1.3
1.2
—
—
—
0
0
83
692
1.38
1.28
7.9
6.0
1.2
1.2
mmol/l
0.18
74
575
6
25
2.45
1.25
3.7
1.7
—
—
—
0
0
27
184
1.55
1.20
9.0
9.2
—
—
—
0
0
10
50
2.06
1.19
1.8
2.1
—
—
—
0
0
18
111
1.69
1.17
2.7
3.2
69.4
61.5
ml/min/173m2
—
5
47
37
273
1.45
1.14
4.2
3.3
48.2
126.3
ng/l
1.05
28
222
7
32
2.24
1.09
1.1
1.9
766.6
186.2
e6/l
—
7
26
7
32
2.24
1.09
1.1
1.7
3.3
23.5
e6/l
—
7
25
17
106
1.67
1.07
2.2
2.2
0.2
0.2
g/l
0.20
17
97
11
60
1.89
1.05
1.3
1.3
—
—
—
0
0
17
107
1.65
1.04
3.3
2.7
255.3
214.1
ng/l
0.10
17
90
31
225
1.46
1.04
2.1
1.8
—
—
—
0
0
30
217
1.46
1.02
3.1
2.2
14.8
12.7
umol/l
0.84
30
193
0
29
0.00
0.98
0.0
1.4
—
—
—
0
0
7
36
1.98
0.98
3.3
1.7
—
—
—
0
0
23
159
1.51
0.97
2.0
1.6
—
—
—
0
0
6
28
2.18
0.92
2.5
2.4
386.7
72.5
ug/min
—
6
19
39
302
1.37
0.92
3.1
2.3
—
—
—
0
0
6
29
2.11
0.90
2.0
1.3
—
—
—
0
0
17
112
1.57
0.88
4.7
3.1
68.7
66.2
g/l
0.65
17
98
111
1002
1.29
0.86
4.4
3.9
15.0
14.9
pmol/l
0.18
99
875
65
755
0.78
0.83
2.3
2.8
—
—
—
0
0
70
599
1.28
0.83
4.6
4.1
42.6
47.0
ng/l
0.11
51
443
79
690
1.26
0.78
5.9
3.9
0.0
0.0
estimate
0.00
15
131
16
108
1.53
0.76
1.2
1.7
—
—
—
0
0
7
38
1.88
0.74
3.3
1.7
—
—
—
0
0
13
84
1.59
0.74
6.9
3.1
1.0
1.2
%
0.70
13
84
5
25
2.03
0.73
1.6
1.2
—
—
—
0
0
7
40
1.78
0.72
1.1
1.5
—
—
—
0
0
88
787
1.24
0.68
12.6
9.0
3.9
4.3
e9/l
1.01
81
692
5
29
1.74
0.64
2.6
1.7
—
—
—
0
0
142
1345
1.28
0.62
20.6
15.1
27.4
25.0
mg/l
0.29
114
1071
5
30
1.69
0.62
1.8
1.5
—
—
—
0
0
8
51
1.60
0.61
4.1
2.5
24.2
24.9
mmol/l
—
8
46
0
20
0.00
0.60
0.0
1.2
—
1.3
—
0
6
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
1.9
—
0
8
8
52
1.56
0.60
6.9
3.5
—
—
—
0
0
37
309
1.25
0.53
1.6
1.8
1.4
1.4
mg/l
0.02
29
244
110
1024
1.20
0.51
4.9
3.9
13.6
13.6
mm/h
0.00
104
925
21
163
1.33
0.51
2.1
1.7
—
—
—
0
0
77
696
1.19
0.50
6.1
3.9
0.0
0.0
estimate
0.00
14
123
12
85
1.44
0.48
3.3
2.6
2.1
1.6
mmol/l
—
6
62
13
94
1.41
0.47
1.5
1.3
—
—
—
0
0
12
86
1.42
0.46
9.9
3.8
54.1
44.8
%
0.60
12
86
36
305
1.23
0.46
1.8
1.9
422.8
463.8
pmol/l
0.28
29
250
5
32
1.58
0.42
1.2
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.8
—
4.4
—
0
5
0
17
0.00
0.41
0.0
4.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
5
34
1.48
0.40
1.2
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
110.7
—
0
18
127
1212
1.17
0.38
5.5
4.7
2.0
2.0
mu/l
0.15
118
1065
6
87
0.68
0.34
1.8
1.6
—
—
—
0
0
6
46
1.31
0.33
1.3
2.3
—
—
—
0
0
10
75
1.35
0.31
2.8
2.6
4.4
4.6
pmol/l
—
10
65
74
688
1.13
0.31
7.9
5.3
0.0
0.0
estimate
0.00
16
130
26
224
1.19
0.29
4.2
2.9
2.2
2.5
e6/l
0.13
18
133
12
95
1.28
0.27
3.5
2.4
4.9
5.0
kpa
0.07
12
81
130
1257
1.13
0.26
7.4
6.1
42.1
40.7
mmol/mol
0.76
123
1155
5
37
1.36
0.23
2.2
1.9
—
—
—
0
0
5
42
1.20
0.21
2.6
1.9
0.0
0.0
g/l
—
5
37
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
95.4
—
0
14
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
17
147
1.17
0.19
1.7
2.5
7.2
5.7
ug/l
0.27
17
127
122
1186
1.09
0.18
20.7
16.4
38.8
39.4
%
0.31
73
798
26
236
1.12
0.16
4.2
2.8
0.7
1.1
e6/l
0.74
19
144
128
1306
0.93
0.13
5.2
4.7
6.2
6.0
mmol/l
0.66
120
1168
41
387
1.08
0.12
4.4
3.9
0.0
0.0
estimate
0.00
14
127
23
211
1.10
0.12
1.4
1.3
69.7
43.0
iu/ml
—
9
63
10
86
1.17
0.11
11.0
3.6
24.2
25.0
mmol/l
—
10
86
5
44
1.14
0.10
2.0
2.0
—
—
—
0
0
5
46
1.09
0.09
2.6
1.8
0.0
0.0
g/l
—
5
41
5
48
1.04
0.09
2.6
1.8
40.6
38.5
g/l
—
5
39
50
480
1.06
0.09
4.0
3.2
2.3
2.3
mmol/l
0.90
42
417
124
1260
0.95
0.09
4.2
4.1
1.2
1.3
mmol/l
0.15
114
1124
15
137
1.10
0.08
1.3
1.9
423.1
361.4
nmol/l
1.06
15
122
8
77
1.04
0.07
6.9
5.1
22.3
24.9
mmol/l
—
8
77
9
85
1.06
0.07
1.9
2.1
—
—
—
0
0
18
168
1.08
0.06
1.4
1.4
—
—
—
0
0
45
436
1.04
0.05
3.9
4.9
2.3
2.9
ug/l
0.25
39
383
128
1291
0.97
0.03
4.7
4.5
1.4
1.5
mmol/l
0.27
119
1158
27
261
1.04
0.03
2.9
3.0
0.6
0.8
ug/l
1.04
20
169
14
148
0.94
0.02
2.9
4.1
2.5
9.0
ug/l
—
9
119
38
371
1.03
0.02
3.8
2.9
376.9
8760.5
umol/l
2.27
31
297
127
1261
1.03
0.02
18.1
14.4
75.8
76.8
ml/min/173m2
0.19
106
1030
51
519
0.98
0.02
5.9
3.2
—
—
—
0
0
55
558
0.98
0.01
5.9
4.0
—
—
—
0
0
16
167
0.95
0.01
5.0
5.7
-1.0
1.5
mmol/l
0.87
11
129
17
177
0.96
0.01
1.1
1.6
—
—
—
0
0
15
149
1.01
0.00
3.3
3.6
—
—
—
0
0
17
169
1.01
0.00
2.5
2.4
7.0
8.9
umol/l
0.29
17
143
130
1303
0.99
0.00
4.8
4.6
4.3
4.5
mmol/l
2.99
123
1182
133
1335
0.98
0.00
5.5
5.1
2.4
2.7
mmol/l
3.77
125
1201
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
10
100
1.00
0.00
2.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
20
200
1.00
0.00
9.8
5.4
105.1
103.9
mmol/l
0.54
20
193
5
55
0.91
0.00
2.6
1.7
2.7
3.0
g/l
—
5
43
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
3.9
—
—
—
0
0
6
59
1.02
0.00
2.3
1.7
10.8
9.2
g/l
—
6
50
0
5
0.00
0.00
0.0
1.0
—
9.3
—
0
5
0
7
0.00
0.00
0.0
1.1
—
11.7
—
0
7
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
35
350
1.00
0.00
3.3
4.3
19.6
21.7
%
0.56
15
168
5
50
1.00
0.00
2.6
1.8
5.7
0.5
g/l
—
5
43
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
3.9
—
—
—
0
0
0
9
0.00
0.00
0.0
2.2
—
13.6
—
0
9
6
63
0.95
0.00
2.3
1.7
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_OTHENDOPHTHALMITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OTHENDOPHTHALMITIS | 1.387 [1.15, 1.67] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.049 |
During the follow-up period (1.1.1998 — 31.12.2019), 280 out of 691 females with H7_OTHENDOPHTHALMITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OTHENDOPHTHALMITIS | 1.786 [1.39, 2.3] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 230 out of 557 males with H7_OTHENDOPHTHALMITIS died.
Mortality risk
Mortality risk for people of age
years, who have H7_OTHENDOPHTHALMITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.091% | 0.253% |
| 5 | 0.739% | 1.803% |
| 10 | 1.913% | 4.433% |
| 15 | 3.556% | 8.403% |
| 20 | 6.099% | 13.372% |
Relationships between endpoints
↥Index endpoint: H7_OTHENDOPHTHALMITIS – Other endophthalmitis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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