No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
195 |
4. Check minimum number of eventsNone |
195 |
5. Include endpointsNone |
195 |
6. Filter based on genotype QC (FinnGen only) |
195 |
Control definitions (FinnGen only)
- Control exclude
- H7_VITREOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H44
- Name in latin
- Degeneratio bulbi oculi
Similar endpoints
↥List of similar endpoints to
Degenerative conditions of globe
based on the number of shared cases.
Similar with more cases:
- Disorders of globe
- Disorders of vitreous body and globe
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3241 | 1579 | 1622 |
| Only index persons | 2177 | 1098 | 1079 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.05 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 71.66 | 76.48 | 66.95 |
| Only index persons | 69.72 | 76.15 | 63.17 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 195 | 71 | 124 |
| Unadjusted period prevalence (%) | 0.04 | 0.02 | 0.05 |
| Median age at first event (years) | 65.99 | 65.20 | 66.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 177
- Matched controls
- 1768
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H44.5
ICD-10 Finland
Degenerated conditions of globe
+∞
190.9
147
*
114
Kela drug reimbursment
Glaucoma
20.1
59.4
100
107
S01ED51
ATC
timolol, combinations; ophthalmic
21.2
54.6
87
77
S01ED01
ATC
timolol; ophthalmic
21.6
42.7
65
46
S01EC01
ATC
acetazolamide; systemic
39.2
42.1
53
19
S01EX03
ATC
NA
26.7
40.0
56
30
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
39.6
36.0
45
15
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
116.1
35.3
37
*
S01EE01
ATC
latanoprost; ophthalmic
12.0
28.3
55
64
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
23.4
27.2
39
21
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
249.4
22.1
22
*
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
12.1
21.8
41
43
S01EC03
ATC
dorzolamide; ophthalmic
26.3
21.2
29
13
H43.1
ICD-10 Finland
Vitreous haemorrhage
223.9
20.0
20
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.8
19.5
63
153
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.4
19.3
107
457
H54.4
ICD-10 Finland
Blindness, monocular
+∞
19.1
18
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.4
19.0
105
441
37861
ICD-8 Finland
Other diseases of eye, Phthisis et degeneratio bulbi
+∞
15.9
15
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
18.3
15.8
24
15
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.2
15.2
52
131
XCK00
NOMESCO Finland
Perimetry
8.2
14.8
34
50
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
87.5
14.8
16
*
CDC00
NOMESCO Finland
Enucleation of eye
+∞
14.8
14
*
CHF15
NOMESCO Finland
Cryotherapy of ciliary body
+∞
14.8
14
*
S01EA02
ATC
dipivefrine; ophthalmic
30.1
14.6
19
7
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
13.0
14.3
25
22
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
9.9
13.9
28
33
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
20.3
13.7
20
11
37520
ICD-8 Finland
Glaucoma, Secondary
+∞
13.7
13
*
S01EC04
ATC
brinzolamide; ophthalmic
10.7
13.5
26
28
S01FA01
ATC
atropine; ophthalmic
31.1
13.2
17
6
S01EB01
ATC
pilocarpine; ophthalmic
15.7
13.1
21
15
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
10.0
13.0
26
30
Z97.0
ICD-10 Finland
Presence of artificial eye
+∞
12.6
12
*
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
139.4
12.6
13
*
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
29.1
12.3
16
6
H43.8
ICD-10 Finland
Other disorders of vitreous body
32.5
11.8
15
5
A10AA01
ATC
NA
15.0
11.8
19
14
37514
ICD-8 Finland
Glaucoma, Chronicum absolutum s. fero absolutum dolorosum
+∞
11.6
11
*
H3603, E103
ICD-10 Finland
NA
127.9
11.6
12
*
25002
ICD-8 Finland
Diabetes mellitus, Retinopathia diabetica
127.9
11.6
12
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
127.9
11.6
12
*
H54.0
ICD-10 Finland
Blindness, binocular
116.6
10.5
11
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
+∞
10.5
10
*
A10AA02
ATC
NA
8.1
10.4
23
32
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
15.8
10.2
16
11
H16.0
ICD-10 Finland
Corneal ulcer
8.2
10.1
22
30
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
11.6
10.0
18
17
H34.8
ICD-10 Finland
Other retinal vascular occlusions
12.4
9.8
17
15
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
11.6
9.5
17
16
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
105.4
9.5
10
*
TCA15
NOMESCO Finland
Retrobulbar therapeutic injection into orbit
+∞
9.5
9
*
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
+∞
9.5
9
*
3604A
ICD-9 Finland
Disorders of the globe, Degenerated conditions of globe
+∞
9.5
9
*
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
8.5
9.4
20
26
S01EA03
ATC
apraclonidine; ophthalmic
12.4
9.3
16
14
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
38.8
9.1
11
*
H04AA01
ATC
glucagon; nasal, parenteral
15.1
8.8
14
10
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
15.1
8.8
14
10
H40.0
ICD-10 Finland
Glaucoma suspect
5.6
8.7
25
50
CKD15
NOMESCO Finland
Injection of vitreous substitute
94.3
8.5
9
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
13.9
8.0
13
10
H04.10
ICD-10 Finland
Dry eye syndrome
4.7
7.7
26
63
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
19.4
7.7
11
6
H26.2
ICD-10 Finland
Complicated cataract
26.3
7.7
10
*
Z94.0
ICD-10 Finland
Kidney transplant status
83.4
7.5
8
*
H54.1
ICD-10 Finland
Severe visual impairment, binocular
83.4
7.5
8
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
7.9
7.4
16
22
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
7.1
7.3
17
26
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
6.5
7.3
18
30
S01ED02
ATC
betaxolol; ophthalmic
9.4
7.2
14
16
S01EE05
ATC
tafluprost; ophthalmic
8.8
7.0
14
17
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
11.6
6.9
12
11
127
Kela drug reimbursment
Transplant complication
41.7
6.8
8
*
S01FA02
ATC
scopolamine; ophthalmic
23.5
6.7
9
*
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
12.9
6.7
11
9
S01BC03
ATC
diclofenac; ophthalmic
7.0
6.5
15
23
Z49.1
ICD-10 Finland
Extracorporeal dialysis
18.8
6.3
9
5
3651B
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA CAPSULARE (AVOKULMA)]
18.8
6.3
9
5
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
6.3
6
*
CDC40
NOMESCO Finland
Evisceration of eye with insertion of prosthesis
+∞
6.3
6
*
3643
FHL
Vitrectomy through pars Plana
+∞
6.3
6
*
CAW99
NOMESCO Finland
Other operation on orbit
+∞
6.3
6
*
CKC20
NOMESCO Finland
Cryopexy of undetached retina
+∞
6.3
6
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
27.7
6.3
8
*
H3603, E113
ICD-10 Finland
NA
27.7
6.3
8
*
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
8.2
6.2
13
17
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
5.6
6.2
17
33
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLOBEDEGENERATED and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLOBEDEGENERATED | 1.333 [1.16, 1.54] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.296 |
During the follow-up period (1.1.1998 — 31.12.2019), 733 out of 1161 females with H7_GLOBEDEGENERATED died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLOBEDEGENERATED | 1.488 [1.24, 1.78] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 564 out of 1066 males with H7_GLOBEDEGENERATED died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLOBEDEGENERATED.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.104% | 0.31% |
| 5 | 0.751% | 1.805% |
| 10 | 1.846% | 4.363% |
| 15 | 3.805% | 8.382% |
| 20 | 6.9% | 14.242% |
Relationships between endpoints
↥Index endpoint: H7_GLOBEDEGENERATED – Degenerative conditions of globe
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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