No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
195 |
4. Check minimum number of eventsNone |
195 |
5. Include endpointsNone |
195 |
6. Filter based on genotype QC (FinnGen only) |
195 |
Control definitions (FinnGen only)
- Control exclude
- H7_VITREOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H44
- Name in latin
- Degeneratio bulbi oculi
Similar endpoints
↥List of similar endpoints to Degenerative conditions of globe based on the number of shared cases.
Similar with more cases:
- Disorders of globe
- Disorders of vitreous body and globe
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 3241 | 1579 | 1622 |
Only index persons | 2177 | 1098 | 1079 |
Unadjusted period prevalence (%) | |||
Whole population | 0.05 | 0.05 | 0.05 |
Only index persons | 0.04 | 0.04 | 0.04 |
Median age at first event (years) | |||
Whole population | 71.66 | 76.48 | 66.95 |
Only index persons | 69.72 | 76.15 | 63.17 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 195 | 71 | 124 |
Unadjusted period prevalence (%) | 0.04 | 0.02 | 0.05 |
Median age at first event (years) | 65.99 | 65.20 | 66.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 177
- Matched controls
- 1768
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint H7_GLOBEDEGENERATED and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
H7_GLOBEDEGENERATED | 1.333 [1.16, 1.54] | < 0.001 |
Birth year | 0.996 [0.99, 1.0] | 0.296 |
During the follow-up period (1.1.1998 — 31.12.2019), 733 out of 1161 females with H7_GLOBEDEGENERATED died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
H7_GLOBEDEGENERATED | 1.488 [1.24, 1.78] | < 0.001 |
Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 564 out of 1066 males with H7_GLOBEDEGENERATED died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLOBEDEGENERATED.N-year risk | Females | Males |
---|---|---|
1 | 0.104% | 0.31% |
5 | 0.751% | 1.805% |
10 | 1.846% | 4.363% |
15 | 3.805% | 8.382% |
20 | 6.9% | 14.242% |
Relationships between endpoints
↥Index endpoint: H7_GLOBEDEGENERATED – Degenerative conditions of globe
GWS hits: -