Degenerative conditions of globe

H7_GLOBEDEGENERATED

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H44.5
  • Hospital discharge: ICD-9 3604
  • Hospital discharge: ICD-8 37861|37514
  • Cause of death: ICD-10 H44.5
  • Cause of death: ICD-9 3604
  • Cause of death: ICD-8 37861|37514

2 out of 7 registries used, show all original rules.

195

4. Check minimum number of events

None

195

5. Include endpoints

None

195

6. Filter based on genotype QC (FinnGen only)

195

Control definitions (FinnGen only)

Control exclude
H7_VITREOUS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H44
Name in latin
Degeneratio bulbi oculi

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3241 1579 1622
Only index persons 2177 1098 1079
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.05
Only index persons 0.04 0.04 0.04
Median age at first event (years)
Whole population 71.66 76.48 66.95
Only index persons 69.72 76.15 63.17

-FinnGen-

Key figures

All Female Male
Number of individuals 195 71 124
Unadjusted period prevalence (%) 0.04 0.02 0.05
Median age at first event (years) 65.99 65.20 66.44

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
177
Matched controls
1768
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H44.5
ICD-10 Finland
Degenerated conditions of globe
+∞
190.9
147
*
114
Kela drug reimbursment
Glaucoma
20.1
59.4
100
107
S01ED51
ATC
timolol, combinations; ophthalmic
21.2
54.6
87
77
S01ED01
ATC
timolol; ophthalmic
21.6
42.7
65
46
S01EC01
ATC
acetazolamide; systemic
39.2
42.1
53
19
S01EX03
ATC
NA
26.7
40.0
56
30
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
39.6
36.0
45
15
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
116.1
35.3
37
*
S01EE01
ATC
latanoprost; ophthalmic
12.0
28.3
55
64
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
23.4
27.2
39
21
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
249.4
22.1
22
*
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
12.1
21.8
41
43
S01EC03
ATC
dorzolamide; ophthalmic
26.3
21.2
29
13
H43.1
ICD-10 Finland
Vitreous haemorrhage
223.9
20.0
20
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.8
19.5
63
153
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.4
19.3
107
457
H54.4
ICD-10 Finland
Blindness, monocular
+∞
19.1
18
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.4
19.0
105
441
37861
ICD-8 Finland
Other diseases of eye, Phthisis et degeneratio bulbi
+∞
15.9
15
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
18.3
15.8
24
15
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.2
15.2
52
131
XCK00
NOMESCO Finland
Perimetry
8.2
14.8
34
50
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
87.5
14.8
16
*
CHF15
NOMESCO Finland
Cryotherapy of ciliary body
+∞
14.8
14
*
CDC00
NOMESCO Finland
Enucleation of eye
+∞
14.8
14
*
S01EA02
ATC
dipivefrine; ophthalmic
30.1
14.6
19
7
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
13.0
14.3
25
22
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
9.9
13.9
28
33
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
20.3
13.7
20
11
37520
ICD-8 Finland
Glaucoma, Secondary
+∞
13.7
13
*
S01EC04
ATC
brinzolamide; ophthalmic
10.7
13.5
26
28
S01FA01
ATC
atropine; ophthalmic
31.1
13.2
17
6
S01EB01
ATC
pilocarpine; ophthalmic
15.7
13.1
21
15
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
10.0
13.0
26
30
Z97.0
ICD-10 Finland
Presence of artificial eye
+∞
12.6
12
*
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
139.4
12.6
13
*
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
29.1
12.3
16
6
H43.8
ICD-10 Finland
Other disorders of vitreous body
32.5
11.8
15
5
A10AA01
ATC
NA
15.0
11.8
19
14
37514
ICD-8 Finland
Glaucoma, Chronicum absolutum s. fero absolutum dolorosum
+∞
11.6
11
*
H3603, E103
ICD-10 Finland
NA
127.9
11.6
12
*
25002
ICD-8 Finland
Diabetes mellitus, Retinopathia diabetica
127.9
11.6
12
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
127.9
11.6
12
*
H54.0
ICD-10 Finland
Blindness, binocular
116.6
10.5
11
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
+∞
10.5
10
*
A10AA02
ATC
NA
8.1
10.4
23
32
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
15.8
10.2
16
11
H16.0
ICD-10 Finland
Corneal ulcer
8.2
10.1
22
30
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
11.6
10.0
18
17
H34.8
ICD-10 Finland
Other retinal vascular occlusions
12.4
9.8
17
15
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
11.6
9.5
17
16
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
105.4
9.5
10
*
TCA15
NOMESCO Finland
Retrobulbar therapeutic injection into orbit
+∞
9.5
9
*
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
+∞
9.5
9
*
3604A
ICD-9 Finland
Disorders of the globe, Degenerated conditions of globe
+∞
9.5
9
*
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
8.5
9.4
20
26
S01EA03
ATC
apraclonidine; ophthalmic
12.4
9.3
16
14
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
38.8
9.1
11
*
H04AA01
ATC
glucagon; nasal, parenteral
15.1
8.8
14
10
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
15.1
8.8
14
10
H40.0
ICD-10 Finland
Glaucoma suspect
5.6
8.7
25
50
CKD15
NOMESCO Finland
Injection of vitreous substitute
94.3
8.5
9
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
13.9
8.0
13
10
H04.10
ICD-10 Finland
Dry eye syndrome
4.7
7.7
26
63
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
19.4
7.7
11
6
H26.2
ICD-10 Finland
Complicated cataract
26.3
7.7
10
*
Z94.0
ICD-10 Finland
Kidney transplant status
83.4
7.5
8
*
H54.1
ICD-10 Finland
Severe visual impairment, binocular
83.4
7.5
8
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
7.9
7.4
16
22
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
7.1
7.3
17
26
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
6.5
7.3
18
30
S01ED02
ATC
betaxolol; ophthalmic
9.4
7.2
14
16
S01EE05
ATC
tafluprost; ophthalmic
8.8
7.0
14
17
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
11.6
6.9
12
11
127
Kela drug reimbursment
Transplant complication
41.7
6.8
8
*
S01FA02
ATC
scopolamine; ophthalmic
23.5
6.7
9
*
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
12.9
6.7
11
9
S01BC03
ATC
diclofenac; ophthalmic
7.0
6.5
15
23
Z49.1
ICD-10 Finland
Extracorporeal dialysis
18.8
6.3
9
5
3651B
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA CAPSULARE (AVOKULMA)]
18.8
6.3
9
5
CDC40
NOMESCO Finland
Evisceration of eye with insertion of prosthesis
+∞
6.3
6
*
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
6.3
6
*
CKC20
NOMESCO Finland
Cryopexy of undetached retina
+∞
6.3
6
*
3643
FHL
Vitrectomy through pars Plana
+∞
6.3
6
*
CAW99
NOMESCO Finland
Other operation on orbit
+∞
6.3
6
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
27.7
6.3
8
*
H3603, E113
ICD-10 Finland
NA
27.7
6.3
8
*
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
8.2
6.2
13
17
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
5.6
6.2
17
33

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
41
156
3.06
8.37
2.4
1.8
—
—
—
0
0
35
158
2.48
5.07
2.8
6.1
2.1
1.3
mmol/l
0.63
25
124
24
93
2.80
4.68
5.5
3.8
—
—
—
0
0
45
262
1.93
3.43
5.2
4.0
—
—
—
0
0
21
91
2.47
3.31
3.5
6.9
25.2
24.1
mmol/l
0.67
21
86
27
132
2.21
3.26
3.6
2.8
4.2
6.5
ug/l
0.65
18
111
60
392
1.77
3.16
2.3
2.1
212.1
276.7
u/l
0.34
55
361
7
13
5.54
2.89
3.1
1.6
—
—
—
0
0
21
97
2.31
2.89
3.5
4.0
—
—
—
0
0
24
120
2.14
2.75
10.5
4.2
—
—
—
0
0
78
566
1.63
2.72
6.3
4.4
34.8
34.9
g/l
0.06
69
524
34
195
1.90
2.69
2.9
1.8
—
—
—
0
0
58
391
1.69
2.68
5.8
4.0
14.9
11.5
mg/mmol
0.21
42
242
23
116
2.11
2.58
10.7
4.1
0.6
1.8
mmol/l
1.12
17
85
23
118
2.08
2.48
11.0
4.1
5.7
5.7
kpa
0.11
23
111
0
64
0.00
2.47
0.0
1.1
—
99.4
—
0
21
15
66
2.38
2.31
2.9
7.4
—
—
—
0
0
20
100
2.11
2.30
9.2
2.9
5.0
4.3
kpa
0.95
20
93
43
278
1.70
2.30
4.5
4.5
1.0
1.0
kg/l
—
10
40
54
374
1.61
2.21
8.6
3.9
7.4
7.4
ph
—
9
81
56
393
1.60
2.17
4.9
3.0
6.0
7.6
mmol/l
2.64
45
311
26
426
0.55
2.14
3.6
3.0
—
—
—
0
0
52
374
1.53
1.79
5.2
3.1
38.3
242.8
mg/l
0.64
37
241
15
75
2.08
1.75
7.7
3.9
25.5
24.6
mmol/l
0.49
15
75
73
568
1.46
1.71
12.2
5.5
1.2
1.2
mmol/l
0.59
65
512
5
16
3.18
1.44
1.0
1.5
—
—
—
0
0
66
520
1.41
1.41
2.3
1.9
89.2
92.9
pmol/l
0.29
36
250
7
29
2.46
1.40
2.7
2.3
8.5
7.7
kpa
—
7
24
54
414
1.42
1.33
4.5
4.1
—
—
—
0
0
6
24
2.55
1.31
1.5
1.4
—
—
—
0
0
17
100
1.77
1.28
12.0
7.1
—
—
—
0
0
109
1232
0.74
1.27
6.1
5.0
2.4
2.6
mmol/l
1.02
103
1102
10
50
2.05
1.18
3.8
4.3
—
—
—
0
0
71
581
1.35
1.18
4.8
4.3
36.5
55.0
ng/l
1.00
55
431
14
80
1.81
1.16
2.8
2.5
4.4
3.8
e9/l
—
7
60
5
20
2.54
1.16
1.0
1.5
—
—
—
0
0
7
31
2.30
1.11
1.0
1.4
—
—
—
0
0
19
121
1.63
1.10
2.9
1.6
—
—
—
0
0
26
180
1.51
1.07
4.4
2.4
17.1
21.4
%
1.19
21
156
24
340
0.66
1.07
2.5
2.9
0.8
0.8
ug/l
0.11
16
227
46
357
1.38
1.05
2.8
2.0
3.1
3.4
mg/l
0.62
37
304
51
403
1.36
1.05
2.9
3.1
—
—
—
0
0
38
286
1.41
1.04
2.2
1.8
1160.3
1214.7
nmol/l
0.16
32
215
90
774
1.30
1.03
7.3
4.5
7.8
6.8
mmol/l
2.60
83
722
72
602
1.31
1.01
4.7
3.9
0.0
0.0
estimate
—
9
121
55
443
1.34
1.00
3.2
3.1
2.3
2.3
mmol/l
0.53
42
374
72
606
1.30
0.95
6.9
5.2
0.0
0.0
estimate
—
9
119
104
1160
0.78
0.95
5.2
4.0
1.4
1.3
mmol/l
1.42
93
1029
10
55
1.86
0.94
1.6
2.5
—
—
—
0
0
73
617
1.29
0.94
4.9
3.9
0.0
0.0
estimate
—
9
116
6
115
0.51
0.85
5.7
3.8
—
—
—
0
0
6
31
1.96
0.85
2.8
2.0
—
—
—
0
0
108
1190
0.79
0.84
5.7
4.4
1.3
1.4
mmol/l
1.20
97
1061
119
1080
1.26
0.82
25.7
16.1
36.9
39.6
%
1.10
64
720
109
1198
0.80
0.82
5.7
4.5
4.3
4.5
mmol/l
0.90
99
1082
111
1001
1.25
0.80
29.2
20.1
332.4
332.3
g/l
0.05
111
990
0
26
0.00
0.79
0.0
3.0
—
4.4
—
0
26
0
27
0.00
0.78
0.0
3.6
—
58.6
—
0
27
28
363
0.73
0.77
4.0
3.5
—
—
—
0
0
99
886
1.24
0.75
4.2
3.6
15.2
15.0
pmol/l
0.19
87
766
108
976
1.24
0.75
8.0
7.0
91.0
79.9
u/l
0.51
103
911
10
60
1.70
0.73
4.4
4.6
—
—
—
0
0
5
25
2.03
0.73
3.4
2.5
—
—
—
0
0
11
70
1.61
0.66
8.9
3.1
—
—
—
0
0
34
272
1.30
0.65
1.7
1.6
1.7
1.4
mg/l
0.42
27
205
6
104
0.56
0.64
1.3
1.5
—
—
—
0
0
52
606
0.81
0.63
4.6
5.0
7.0
2.8
ug/l
0.40
46
526
111
1200
0.83
0.63
5.3
4.6
6.6
6.1
mmol/l
1.93
97
1063
43
357
1.26
0.63
4.6
4.1
0.0
0.0
estimate
—
8
112
54
463
1.23
0.60
5.1
3.6
47.5
94.2
e6/l
0.70
42
341
24
185
1.34
0.59
33.9
24.8
1.9
1.2
inr
—
5
19
14
100
1.43
0.53
1.4
2.4
—
—
—
0
0
47
544
0.82
0.53
10.7
10.0
0.0
0.0
e9/l
0.54
38
451
17
127
1.37
0.51
12.6
4.4
—
—
—
0
0
18
136
1.36
0.51
3.1
1.6
—
—
—
0
0
7
46
1.54
0.49
4.4
4.9
—
—
—
0
0
7
48
1.48
0.47
2.4
3.4
4.0
4.1
mmol/l
—
7
43
41
475
0.83
0.47
2.6
2.1
—
—
—
0
0
15
113
1.35
0.44
1.4
2.4
151.6
153.8
ug/g
—
7
92
5
31
1.63
0.43
1.6
1.1
—
—
—
0
0
13
96
1.38
0.43
3.2
2.8
—
—
—
0
0
18
141
1.30
0.42
2.0
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.9
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
21
170
1.26
0.39
5.4
2.7
1.6
1.8
%
0.55
16
149
5
36
1.40
0.38
1.4
1.6
—
—
—
0
0
21
171
1.26
0.37
3.2
1.9
—
—
—
0
0
68
622
1.14
0.35
6.1
5.7
0.2
0.2
e9/l
0.29
60
555
93
870
1.13
0.34
6.5
4.2
—
—
—
0
0
40
353
1.17
0.33
4.2
2.9
—
—
—
0
0
11
143
0.76
0.33
1.3
1.3
—
—
—
0
0
44
392
1.16
0.33
5.5
4.2
—
—
—
0
0
10
75
1.35
0.31
2.1
1.5
—
—
—
0
0
46
414
1.15
0.30
4.3
3.1
15.4
63.1
e6/l
1.46
41
322
72
671
1.12
0.27
3.9
5.7
10.6
12.3
umol/l
0.84
64
633
66
614
1.11
0.26
6.1
5.6
1.7
1.8
e9/l
0.16
59
552
45
410
1.13
0.25
3.6
2.3
—
—
—
0
0
64
596
1.11
0.24
6.1
5.5
0.7
0.6
e9/l
2.05
57
530
40
364
1.12
0.23
4.4
2.9
0.2
0.4
e6/l
0.37
34
275
10
79
1.28
0.23
1.3
1.3
—
—
—
0
0
32
287
1.14
0.22
3.5
2.5
2.4
4.0
e6/l
1.31
32
258
64
599
1.10
0.22
6.1
5.5
0.0
0.0
e9/l
0.89
57
535
128
1321
0.91
0.22
13.0
10.0
29.7
25.0
u/l
0.76
122
1260
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
14
166
0.83
0.21
1.4
1.2
—
—
—
0
0
61
571
1.10
0.21
13.9
9.7
1.3
1.4
inr
0.13
15
171
0
12
0.00
0.21
0.0
2.2
—
32.3
—
0
12
5
43
1.17
0.21
1.4
4.7
49.4
241.4
mg/l
—
5
35
5
43
1.17
0.21
1.4
4.7
34.3
33.6
mg/l
—
5
36
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
2.4
—
64.2
—
0
14
0
14
0.00
0.20
0.0
1.1
—
270.9
—
0
9
15
127
1.20
0.20
1.1
1.3
—
—
—
0
0
111
1149
0.92
0.19
9.2
6.1
44.7
41.2
mmol/mol
2.22
101
1053
114
1101
1.09
0.19
5.3
4.3
2.1
2.0
mu/l
0.39
105
960
10
81
1.25
0.19
1.2
1.1
—
—
—
0
0
44
408
1.10
0.18
6.8
4.8
—
—
—
0
0
11
91
1.22
0.18
1.0
1.8
—
—
—
0
0
7
62
1.13
0.17
1.6
3.3
12.0
3125.7
u/ml
—
7
54
5
68
0.73
0.17
2.0
1.5
1.2
1.0
g/l
—
5
63
8
68
1.18
0.17
3.8
1.7
1.8
1.5
g/l
—
8
58
8
71
1.13
0.16
2.1
1.7
—
—
—
0
0
10
119
0.83
0.16
1.8
2.0
303.7
394.5
nmol/l
—
10
104
37
343
1.10
0.15
3.2
2.9
26576.0
8005.5
umol/l
0.49
31
281
128
1251
1.07
0.13
24.8
15.6
27.8
25.8
mg/l
0.25
111
1030
33
307
1.09
0.13
1.7
1.9
378.2
430.3
pmol/l
0.42
26
254
22
200
1.11
0.13
3.4
3.2
0.8
0.8
mmol/l
0.00
22
180
28
301
0.92
0.11
1.5
1.4
—
—
—
0
0
22
202
1.10
0.11
1.5
1.4
2.8
2.8
g/l
—
9
122
133
1308
1.05
0.09
30.5
18.2
4.0
4.0
mmol/l
0.43
126
1257
5
60
0.83
0.08
1.2
1.2
—
—
—
0
0
7
64
1.10
0.08
3.1
2.6
4.0
4.5
pmol/l
—
7
55
93
911
1.04
0.07
5.1
4.0
19.6
13.4
mm/h
1.47
81
825
132
1303
1.04
0.06
30.2
18.2
139.7
139.5
mmol/l
0.42
126
1256
129
1306
0.96
0.06
24.4
14.9
—
—
—
0
0
137
1385
0.96
0.05
33.5
22.4
4.4
4.5
e12/l
0.60
132
1332
137
1385
0.96
0.05
33.7
22.4
7.3
6.8
e9/l
2.10
132
1334
11
120
0.91
0.05
1.5
1.3
—
—
—
0
0
25
258
0.96
0.02
3.9
6.1
—
—
—
0
0
87
878
0.98
0.01
4.2
4.1
—
—
—
0
0
29
297
0.97
0.01
9.3
6.4
—
—
—
0
0
71
711
1.00
0.00
8.4
9.0
5.0
4.2
e9/l
2.13
62
618
11
113
0.97
0.00
2.2
4.5
0.6
1.0
%
—
5
45
15
152
0.99
0.00
1.0
1.3
1.3
12.4
u/ml
—
7
66
32
318
1.01
0.00
1.6
1.5
18.6
20.6
nmol/l
0.29
25
256
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
107.2
—
0
6
0
6
0.00
0.00
0.0
1.0
—
19.9
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
2550.0
—
0
7
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
20.0
—
0
5
0
9
0.00
0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.3
—
4.1
—
0
9
0
5
0.00
0.00
0.0
1.4
—
13.0
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
257.2
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
102.4
—
0
5
6
60
1.00
0.00
1.3
1.2
31.4
280.3
u/ml
—
6
55
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_GLOBEDEGENERATED and mortality.

Females

Parameter HR [95% CI] p-value
H7_GLOBEDEGENERATED 1.333 [1.16, 1.54] < 0.001
Birth year 0.996 [0.99, 1.0] 0.296

During the follow-up period (1.1.1998 — 31.12.2019), 733 out of 1161 females with H7_GLOBEDEGENERATED died.

Males

Parameter HR [95% CI] p-value
H7_GLOBEDEGENERATED 1.488 [1.24, 1.78] < 0.001
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 564 out of 1066 males with H7_GLOBEDEGENERATED died.

Mortality risk

Mortality risk for people of age

years, who have H7_GLOBEDEGENERATED.

N-year risk Females Males
1 0.104% 0.31%
5 0.751% 1.805%
10 1.846% 4.363%
15 3.805% 8.382%
20 6.9% 14.242%

Relationships between endpoints

Index endpoint: H7_GLOBEDEGENERATED – Degenerative conditions of globe

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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