No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
203 |
4. Check minimum number of eventsNone |
203 |
5. Include endpointsNone |
203 |
6. Filter based on genotype QC (FinnGen only) |
200 |
Control definitions (FinnGen only)
- Control exclude
- H7_VITREOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H44
- Name in latin
- Degeneratio bulbi oculi
Similar endpoints
↥List of similar endpoints to
Degenerative conditions of globe
based on the number of shared cases.
Similar with more cases:
- Disorders of globe
- Disorders of vitreous body and globe
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3241 | 1579 | 1622 |
| Only index persons | 2177 | 1098 | 1079 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.05 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 71.66 | 76.48 | 66.95 |
| Only index persons | 69.72 | 76.15 | 63.17 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 200 | 75 | 125 |
| Unadjusted period prevalence (%) | 0.05 | 0.03 | 0.06 |
| Median age at first event (years) | 66.23 | 65.88 | 66.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 203
- Matched controls
- 2030
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H44.5
ICD-10 Finland
Degenerated conditions of globe
+∞
223.4
171
*
S01ED51
ATC
timolol, combinations; ophthalmic
20.4
102.6
101
94
114
Kela drug reimbursment
Glaucoma
16.7
93.6
111
137
S01ED01
ATC
timolol; ophthalmic
21.9
87.5
75
53
S01EA05
ATC
brimonidine; ophthalmic
41.8
83.9
53
17
S01EC01
ATC
acetazolamide; systemic
27.1
80.4
60
31
S01EX03, ,
ATC
30.1
80.2
57
26
S01EE01
ATC
latanoprost; ophthalmic
10.3
46.5
62
83
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
15.8
45.8
43
34
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
65.5
40.6
46
9
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
10.4
36.2
45
54
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
12.9
31.0
32
29
H33.0
ICD-10 Finland
Retinal detachment with retinal break
13.4
29.8
30
26
H43.1
ICD-10 Finland
Vitreous haemorrhage
296.5
26.3
26
*
S01BA01
ATC
dexamethasone; ophthalmic
10.8
26.0
30
32
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.8
24.5
77
230
H54.4
ICD-10 Finland
Blindness, monocular
141.7
24.2
25
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
141.7
24.2
25
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.3
23.4
126
557
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.9
22.9
64
173
S01EC03
ATC
dorzolamide; ophthalmic
29.1
22.5
30
12
XCK00
NOMESCO Finland
Perimetry
6.9
22.5
39
68
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.1
22.1
124
558
S01EC04
ATC
brinzolamide; ophthalmic
7.5
19.3
30
46
H16.0
ICD-10 Finland
Corneal ulcer
7.3
19.0
30
47
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
7.4
18.5
29
45
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
58.2
18.3
21
*
Z97.0
ICD-10 Finland
Presence of artificial eye
104.3
17.9
19
*
CHF15
NOMESCO Finland
Cryotherapy of ciliary body
+∞
16.9
16
*
37861
ICD-8 Finland
Other diseases of eye, Phthisis et degeneratio bulbi
+∞
16.9
16
*
S01EA03
ATC
apraclonidine; ophthalmic
30.6
16.9
22
8
S01EB01
ATC
pilocarpine; ophthalmic
23.2
15.0
21
10
WX140
NOMESCO Finland
Parabulbar anesthesy
6.5
14.9
26
45
CDC00
NOMESCO Finland
Enucleation of eye
80.7
13.8
15
*
S01FA01
ATC
atropine; ophthalmic
28.0
13.6
18
7
H43.8
ICD-10 Finland
Other disorders of vitreous body
28.0
13.6
18
7
S01EA02
ATC
dipivefrine; ophthalmic
23.1
13.6
19
9
H40.0
ICD-10 Finland
Glaucoma suspect
5.0
13.4
31
70
S01BA07
ATC
fluorometholone; ophthalmic
16.9
12.9
20
13
TCA15
NOMESCO Finland
Retrobulbar therapeutic injection into orbit
+∞
12.6
12
*
25002
ICD-8 Finland
Diabetes mellitus, Retinopathia diabetica
+∞
12.6
12
*
37520
ICD-8 Finland
Glaucoma, Secondary
138.2
12.6
13
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.1
12.6
39
111
H04.10
ICD-10 Finland
Dry eye syndrome
4.4
12.2
34
89
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
11.6
12.1
22
21
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
12.2
11.9
21
19
H3603, E103,
ICD-10 Finland
69.1
11.7
13
*
37514
ICD-8 Finland
Glaucoma, Chronicum absolutum s. fero absolutum dolorosum
+∞
11.6
11
*
H54.0
ICD-10 Finland
Blindness, binocular
126.9
11.5
12
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
37.4
11.4
14
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
12.2
11.3
20
18
A10AB01
ATC
insulin (human); parenteral
5.4
11.0
23
47
A10AA02, ,
ATC
5.0
10.8
25
56
S01BC03
ATC
diclofenac; ophthalmic
11.0
10.8
20
20
S01AX11
ATC
[U] ofloxacin
5.9
10.6
20
37
3604A
ICD-9 Finland
Disorders of the globe, Degenerated conditions of globe
+∞
10.5
10
*
H26.2
ICD-10 Finland
Complicated cataract
34.5
10.5
13
*
XCK10
NOMESCO Finland
Photography of fundus of eye
3.7
10.3
37
116
Z3229
NOMESCO Finland
Other healthcare associate professional
3.8
10.1
34
102
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
42.3
10.1
12
*
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
27.6
9.9
13
5
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
31.7
9.5
12
*
S01BA04
ATC
prednisolone; ophthalmic
9.0
9.3
19
23
XCH00
NOMESCO Finland
Eye pressure measurement
5.2
9.3
20
42
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
25.4
9.0
12
5
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
5.1
8.8
19
40
CKD15
NOMESCO Finland
Injection of vitreous substitute
52.3
8.8
10
*
A10AA01, ,
ATC
7.3
8.6
20
30
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
13.6
8.5
14
11
H18.1
ICD-10 Finland
Bullous keratopathy
93.8
8.5
9
*
H54.1
ICD-10 Finland
Severe visual impairment, binocular
+∞
8.4
8
*
CDC40
NOMESCO Finland
Evisceration of eye with insertion of prosthesis
+∞
8.4
8
*
S01EE05
ATC
tafluprost; ophthalmic
6.8
8.3
20
32
S01FA02
ATC
scopolamine; ophthalmic
23.1
8.1
11
5
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
23.1
8.1
11
5
H3603, E113,
ICD-10 Finland
23.1
8.1
11
5
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
8.3
8.1
17
22
H01.0
ICD-10 Finland
Blepharitis
5.0
8.0
18
39
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
9.0
8.0
16
19
S01EE03
ATC
bimatoprost; ophthalmic
10.0
7.9
15
16
H21.0
ICD-10 Finland
Hyphaema
46.8
7.8
9
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
46.8
7.8
9
*
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
4.4
7.7
20
49
127
Kela drug reimbursment
Transplant complication
26.1
7.6
10
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.5
7.6
28
89
37510
ICD-8 Finland
Glaucoma, Chronicum simplex
83.0
7.5
8
*
H04AA01
ATC
glucagon; nasal, parenteral
8.9
7.5
15
18
3711
FHL
Cyclodiateria or cryocoagulation
+∞
7.3
7
*
S01AA01
ATC
chloramphenicol; ophthalmic
4.8
7.3
17
38
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
16.5
7.3
11
7
C08CA02
ATC
felodipine; oral
3.1
7.3
34
125
A10AB05
ATC
insulin aspart; parenteral
3.3
7.3
29
97
S01ED02
ATC
betaxolol; ophthalmic
9.3
7.2
14
16
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
4.3
7.1
19
48
H26.4
ICD-10 Finland
After-cataract
2.9
7.0
36
140
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
6.1
6.9
18
32
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
11.5
6.9
12
11
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
17.4
6.8
10
6
H40.8
ICD-10 Finland
Other glaucoma
41.5
6.8
8
*
3643
FHL
Vitrectomy through pars Plana
41.5
6.8
8
*
Z94.0
ICD-10 Finland
Kidney transplant status
23.4
6.7
9
*
CKD40
NOMESCO Finland
Endophotocoagulation of retina
12.8
6.7
11
9
S01BC05
ATC
ketorolac; ophthalmic
3.7
6.6
22
65
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.1
6.6
96
599
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.0
6.5
32
121
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
14.9
6.5
10
7
CHD99
NOMESCO Finland
Other filtering operation
72.0
6.5
7
*
3708
FHL
Trabeculectomy or equivalent
72.0
6.5
7
*
H57.1
ICD-10 Finland
Ocular pain
7.4
6.3
14
20
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
18.7
6.3
9
5
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
5.7
6.3
17
32
H05.0
ICD-10 Finland
Acute inflammation of orbit
+∞
6.3
6
*
TCG10
NOMESCO Finland
Removal of sutures from cornea
+∞
6.3
6
*
CKC65
NOMESCO Finland
Removal of buckling implant from sclera
+∞
6.3
6
*
3747
FHL
Combined ablation and vitreous surgery with coagulation
+∞
6.3
6
*
3745
FHL
Hard membrane girding, cerclage with coagulation
+∞
6.3
6
*
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
6.3
6
*
L04AD01
ATC
ciclosporin; systemic
27.6
6.3
8
*
CKC20
NOMESCO Finland
Cryopexy of undetached retina
27.6
6.3
8
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
7.1
6.2
14
21
S01EE04
ATC
travoprost; ophthalmic
7.6
6.0
13
18
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
78
492
1.95
4.84
3.1
2.2
75.13
75.74
nmol/l
0.07
67
418
35
168
2.31
4.40
2.8
6.0
2.19
1.24
mmol/l
0.83
26
135
34
175
2.13
3.61
9.6
9.1
—
—
—
0
0
28
137
2.21
3.36
3.5
2.8
4.04
6.30
ug/l
0.68
19
115
64
420
1.76
3.31
2.2
2.0
204.68
265.63
u/l
0.34
59
388
6
7
8.78
3.28
1.3
2.0
—
—
—
0
0
21
102
2.18
2.58
1.7
1.4
—
—
—
0
0
60
414
1.64
2.50
5.6
3.7
14.34
11.29
mg/mmol
0.20
44
252
81
603
1.57
2.46
6.2
4.4
34.99
34.98
g/l
0.01
72
559
46
297
1.71
2.46
4.5
4.4
1.02
1.02
kg/l
—
10
44
5
8
6.37
2.38
1.0
1.3
—
—
—
0
0
87
665
1.54
2.33
13.6
6.6
1.20
1.21
mmol/l
0.40
77
552
23
124
1.96
2.17
11.0
4.1
5.68
5.74
kpa
0.14
23
117
20
104
2.02
2.09
9.2
2.9
5.05
4.29
kpa
1.02
20
97
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
11
44
2.59
2.05
3.5
2.1
0.32
0.32
u/ml
—
6
24
78
603
1.48
1.90
11.6
5.5
1.20
1.21
mmol/l
0.45
70
544
36
236
1.64
1.81
2.3
1.8
—
—
—
0
0
8
30
2.73
1.74
2.3
1.2
—
—
—
0
0
5
13
3.91
1.72
3.2
2.3
—
—
—
0
0
16
84
1.98
1.65
3.7
3.1
75.33
66.56
ml/min/173m2
—
6
36
71
552
1.44
1.64
2.3
1.9
89.95
93.66
pmol/l
0.31
38
271
5
15
3.39
1.53
1.6
1.3
—
—
—
0
0
5
15
3.39
1.53
1.2
1.5
—
—
—
0
0
5
15
3.39
1.53
1.0
1.6
9.60
16.87
u/l
—
5
15
7
27
2.65
1.53
1.6
1.6
—
—
—
0
0
15
80
1.94
1.49
7.7
3.8
25.53
24.58
mmol/l
0.51
15
80
5
16
3.18
1.44
1.8
1.6
—
—
—
0
0
5
17
2.99
1.36
1.8
1.6
—
—
—
0
0
5
17
2.99
1.36
1.0
1.2
—
—
—
0
0
5
17
2.99
1.36
1.8
1.6
—
—
—
0
0
5
17
2.99
1.36
1.8
1.6
—
—
—
0
0
60
468
1.40
1.33
3.2
3.2
2.32
2.35
mmol/l
0.65
44
402
42
307
1.46
1.32
2.1
1.8
1146.97
1213.80
nmol/l
0.22
34
229
5
18
2.82
1.29
1.8
1.6
—
—
—
0
0
5
18
2.82
1.29
1.8
1.6
—
—
—
0
0
49
372
1.42
1.27
2.8
2.0
3.19
3.44
mg/l
0.32
39
318
12
64
1.93
1.21
2.4
2.0
—
—
—
0
0
62
495
1.36
1.19
5.0
3.1
—
—
—
0
0
75
617
1.34
1.19
4.8
4.3
35.09
52.64
ng/l
1.02
59
462
8
40
2.04
1.13
1.3
1.4
—
—
—
0
0
23
154
1.56
1.09
2.1
1.6
—
—
—
0
0
42
319
1.40
1.08
3.5
2.2
—
—
—
0
0
117
1300
0.76
1.08
6.2
5.0
2.46
2.61
mmol/l
0.82
109
1163
95
818
1.30
1.07
7.1
4.5
7.79
6.85
mmol/l
2.72
88
766
11
60
1.88
1.05
2.4
1.7
—
—
—
0
0
25
349
0.68
1.03
2.8
3.0
0.83
0.80
ug/l
0.07
17
233
27
192
1.47
0.99
4.3
2.4
18.58
21.47
%
0.56
22
165
23
159
1.50
0.96
2.1
1.7
—
—
—
0
0
76
644
1.29
0.94
4.9
4.0
0.00
0.00
estimate
—
10
140
76
645
1.28
0.93
6.9
5.4
0.00
0.00
estimate
—
9
128
6
28
2.18
0.92
1.3
1.7
—
—
—
0
0
77
656
1.28
0.91
4.9
4.0
0.00
0.00
estimate
—
9
125
6
33
1.84
0.79
1.2
1.5
—
0.06
—
0
12
105
940
1.24
0.79
4.4
3.6
15.22
15.04
pmol/l
0.24
89
815
0
26
0.00
0.79
0.0
1.0
—
0.71
—
0
21
14
91
1.58
0.77
1.5
1.3
—
—
—
0
0
114
1036
1.23
0.73
7.9
7.0
90.50
80.07
u/l
0.51
109
969
40
489
0.77
0.72
5.3
4.4
24.18
22.00
%
0.42
26
244
112
1221
0.82
0.72
5.2
4.0
1.44
1.30
mmol/l
1.45
99
1082
46
379
1.28
0.70
4.6
4.0
0.00
0.00
estimate
—
8
120
117
1266
0.82
0.67
5.7
4.5
4.32
4.47
mmol/l
0.74
106
1145
116
1256
0.82
0.67
5.8
4.5
1.34
1.41
mmol/l
0.96
104
1121
5
28
1.80
0.66
1.0
1.4
—
—
—
0
0
12
79
1.55
0.64
1.8
1.8
—
—
—
0
0
8
49
1.66
0.63
1.9
2.6
—
—
—
0
0
54
626
0.81
0.62
4.9
5.1
6.80
2.87
ug/l
0.39
48
543
35
284
1.28
0.61
1.7
1.6
1.73
1.39
mg/l
0.41
28
216
58
501
1.22
0.59
3.3
3.3
2020.97
1775.31
ng/l
0.15
48
410
5
87
0.56
0.57
2.0
1.6
—
—
—
0
0
8
122
0.64
0.56
1.6
1.4
—
—
—
0
0
69
617
1.18
0.48
3.2
2.5
—
—
—
0
0
22
175
1.29
0.45
9.0
5.5
102.73
103.78
mmol/l
0.45
22
175
119
1263
0.86
0.45
5.3
4.7
6.59
6.10
mmol/l
2.04
104
1121
7
51
1.39
0.44
1.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
3.9
—
—
—
0
0
8
61
1.32
0.40
1.6
3.4
—
—
—
0
0
5
35
1.44
0.39
1.6
1.2
—
—
—
0
0
5
36
1.40
0.38
1.2
1.3
—
—
—
0
0
5
36
1.40
0.38
1.0
1.5
—
—
—
0
0
5
36
1.40
0.38
1.6
1.2
—
—
—
0
0
59
531
1.16
0.38
4.9
4.2
—
—
—
0
0
117
1233
0.88
0.37
19.6
15.0
69.86
76.19
ml/min/173m2
1.54
93
1001
26
218
1.22
0.36
3.5
2.7
0.31
1.09
e6/l
2.81
18
120
77
713
1.13
0.33
3.8
5.7
10.82
12.25
umol/l
0.71
69
672
37
328
1.16
0.29
1.6
1.9
364.89
20879550.12
pmol/l
0.50
28
273
75
701
1.11
0.27
23.8
15.4
1.45
1.36
inr
0.25
20
207
101
959
1.11
0.27
4.9
4.0
18.58
13.44
mm/h
1.25
89
871
122
1171
1.10
0.26
5.5
4.3
2.17
2.04
mu/l
0.55
110
1025
57
527
1.11
0.25
3.9
2.6
194.72
146.66
ug/l
0.67
51
472
24
209
1.17
0.24
3.7
2.9
0.86
1.69
e6/l
0.72
16
112
40
363
1.13
0.23
3.0
2.9
24259.15
8628.02
umol/l
0.44
34
301
5
39
1.29
0.23
1.4
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
3.7
—
57.34
—
0
11
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
8
69
1.17
0.16
2.9
2.6
4.55
4.47
pmol/l
—
8
60
73
697
1.07
0.16
3.2
2.7
—
—
—
0
0
135
1317
1.07
0.16
24.2
15.5
27.17
25.45
mg/l
0.21
117
1082
17
150
1.15
0.15
1.2
1.4
—
—
—
0
0
141
1379
1.07
0.15
29.9
18.3
4.03
4.01
mmol/l
0.32
134
1329
136
1390
0.93
0.14
13.1
10.1
29.50
25.02
u/l
0.77
129
1327
41
385
1.08
0.13
4.4
2.9
0.23
0.43
e6/l
0.56
35
294
140
1374
1.06
0.11
29.5
18.2
139.64
139.52
mmol/l
0.21
134
1328
119
1216
0.95
0.11
9.1
6.1
44.97
41.13
mmol/mol
2.73
107
1114
16
176
0.90
0.10
6.9
4.6
33.33
32.52
%
—
9
114
23
213
1.09
0.10
3.3
3.3
0.82
0.83
mmol/l
0.11
23
194
5
47
1.07
0.09
1.4
5.3
—
3.52
—
0
7
5
47
1.07
0.09
1.4
5.4
34.32
32.28
mg/l
—
5
40
5
47
1.07
0.09
1.4
5.4
49.36
220.31
mg/l
—
5
39
6
56
1.07
0.08
1.5
1.3
—
—
—
0
0
7
64
1.10
0.08
1.6
3.3
12.00
3014.39
u/ml
—
7
56
145
1456
0.99
0.00
33.3
22.4
4.38
4.45
e12/l
0.73
140
1402
145
1456
0.99
0.00
33.8
22.5
38.20
39.77
%
1.36
129
1362
16
164
0.97
0.00
2.5
3.3
—
—
—
0
0
75
749
1.00
0.00
8.2
9.1
4.88
4.14
e9/l
1.95
64
654
7
74
0.94
0.00
1.9
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
12.60
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
34
340
1.00
-0.00
1.6
1.5
18.47
20.08
nmol/l
0.24
26
274
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
15.28
—
0
6
16
160
1.00
-0.00
1.0
1.3
1.20
12.43
u/ml
—
8
66
0
6
0.00
-0.00
0.0
3.2
—
219.83
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
85.80
—
0
5
8
86
0.93
-0.00
1.9
2.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
6.51
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLOBEDEGENERATED and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLOBEDEGENERATED | 1.333 [1.16, 1.54] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.296 |
During the follow-up period (1.1.1998 — 31.12.2019), 733 out of 1161 females with H7_GLOBEDEGENERATED died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLOBEDEGENERATED | 1.488 [1.24, 1.78] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 564 out of 1066 males with H7_GLOBEDEGENERATED died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLOBEDEGENERATED.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.104% | 0.31% |
| 5 | 0.751% | 1.805% |
| 10 | 1.846% | 4.363% |
| 15 | 3.805% | 8.382% |
| 20 | 6.9% | 14.242% |
Relationships between endpoints
↥Index endpoint: H7_GLOBEDEGENERATED – Degenerative conditions of globe
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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