eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
68 |
4. Check minimum number of eventsNone |
68 |
5. Include endpointsNone |
68 |
6. Filter based on genotype QC (FinnGen only) |
68 |
Control definitions (FinnGen only)
- Control exclude
- H7_VITREOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified disorders of globe
based on the number of shared cases.
Similar with more cases:
- Disorders of globe
- Disorders of vitreous body and globe
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 657 | 254 | 394 |
| Only index persons | 443 | 195 | 248 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 63.29 | 62.09 | 63.90 |
| Only index persons | 54.96 | 56.97 | 53.37 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 68 | 33 | 35 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | 61.13 | 56.97 | 65.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 61
- Matched controls
- 612
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H44.8
ICD-10 Finland
Other disorders of globe
+∞
32.1
28
*
H44.9
ICD-10 Finland
Disorder of globe, unspecified
+∞
21.0
19
*
3608A
ICD-9 Finland
Disorders of the globe, Other disorders of globe[ANOPHTALMIA ARTEFACTA]
+∞
16.4
15
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
+∞
8.5
8
*
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLOBENAS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLOBENAS | 1.845 [1.24, 2.76] | 0.003 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 175 males with H7_GLOBENAS died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLOBENAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.327% |
| 5 | No data | 1.96% |
| 10 | No data | 5.069% |
| 15 | No data | 9.458% |
| 20 | No data | 15.972% |
Relationships between endpoints
↥Index endpoint: H7_GLOBENAS – Other and unspecified disorders of globe
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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