Other and unspecified disorders of globe

H7_GLOBENAS

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H44.8, H44.9 Hospital discharge: ICD-9 — 360[8-9] Cause of death: ICD-10 — H44.8, H44.9 Cause of death: ICD-9 — 360[8-9] 2 out of 7 registries used, show all original rules.	72
4. Check minimum number of events None	72
5. Include endpoints None	72
6. Filter based on genotype QC (FinnGen only)	70

Control definitions (FinnGen only)

Control exclude: H7_VITREOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	H7_GLOBENAS
CONTROL_EXCLUDE	H7_VITREOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H44[8-9]
HD_ICD_9	360[8-9]
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H44[8-9]
COD_ICD_9	360[8-9]
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other and unspecified disorders of globe based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	657	254	394
Only index persons	443	195	248
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	63.29	62.09	63.90
Only index persons	54.96	56.97	53.37

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	70	35	35
Unadjusted period prevalence (%)	0.01	0.01	0.02
Median age at first event (years)	59.69	54.32	65.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
72: Matched controls
720

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H44.8

ICD-10 Finland

Other disorders of globe

+∞

44.4

H44.9

ICD-10 Finland

Disorder of globe, unspecified

+∞

20.8

3608A

ICD-9 Finland

Disorders of the globe, Other disorders of globe[ANOPHTALMIA ARTEFACTA]

+∞

17.4

Z90.0

ICD-10 Finland

Acquired absence of part of head and neck

101.4

8.6

H43.8

ICD-10 Finland

Other disorders of vitreous body

25.3

6.9

N17.9

ICD-10 Finland

Acute renal failure, unspecified

12.7

6.6

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.96

3.34

6.3

7.2

1.12

1.05

mmol/l

0.24

(40758558) Short blood count panel - Blood

134

2.47

3.13

10.9

8.4

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

2.98

2.91

1.8

3.2

4.22

9.38

umol/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

236

2.17

2.62

10.8

6.9

—

(3022313) Gas panel - Capillary blood

4.72

2.54

5.9

1.5

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

5.34

2.45

7.3

1.8

23.87

24.56

mmol/l

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

2.47

2.42

4.1

4.0

0.79

0.80

mmol/l

0.08

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

4.57

2.20

1.5

2.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.30

2.19

1.8

1.7

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.41

2.10

1.7

1.5

—

(3045414) Leukocytes [Presence] in Urine

4.26

2.08

2.5

1.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.39

1.97

2.6

1.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

194

1.94

1.92

3.9

3.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

213

1.90

1.87

1.9

2.0

115.11

94.36

pmol/l

3.00

(3037522) Nuclear Ab [Titer] in Serum

2.38

1.85

1.1

1.5

896.00

375.00

titre

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

233

1.87

1.80

10.3

8.1

1.21

mmol/l

0.18

209

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.28

1.79

1.8

1.6

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

4.05

1.74

1.0

1.4

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.75

1.64

5.0

2.4

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

3.17

1.62

1.5

1.3

1.20

1.16

g/l

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

3.28

1.46

1.2

—

(3018095) Leukocytes [#/volume] in Urine

193

1.74

1.39

4.3

3.7

23.60

29.27

e6/l

0.17

135

(4035726) Immunohistochemistry procedure

2.19

1.32

1.9

1.2

—

(3000330) Specific gravity of Urine by Test strip

2.52

1.27

3.8

4.7

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.61

1.17

1.6

1.3

0.26

0.23

g/l

—

(3027945) Reticulocytes/100 erythrocytes in Blood

1.91

0.93

2.3

3.5

1.96

1.77

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

2.02

0.92

3.1

1.9

109.13

142.64

ng/l

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.16

0.91

1.7

1.4

—

(3002256) Pathology report gross observation

1.82

0.88

1.3

—

(3000991) Gas panel - Venous blood

1.79

0.84

14.5

8.6

—

(3022621) pH of Urine by Test strip

1.79

0.84

3.1

2.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.95

0.84

1.0

—

(36304419) Bacteria [Presence] in Urine

143

1.55

0.82

3.7

2.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

118

1.58

0.78

3.7

2.2

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.26

0.78

1.6

2.0

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

219

1.46

0.75

2.4

75.86

76.97

nmol/l

0.09

190

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.74

0.71

2.3

1.4

—

(3023368) Bacteria identified in Blood by Culture

150

1.46

0.65

7.0

4.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.71

0.62

1.2

1.6

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.73

0.58

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

296

1.36

0.57

3.5

2.9

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.59

0.54

2.0

1.7

—

(3042936) Bacteria identified in Isolate by Culture

1.57

0.53

2.7

2.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

129

1.42

0.52

4.1

3.6

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

528

1.38

0.46

25.2

15.0

23.33

22.69

mg/l

0.06

410

(3004588) Protein electrophoresis panel - Serum or Plasma

1.50

0.41

2.4

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.50

0.41

4.6

5.2

28.82

25.44

mmol/l

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.42

0.39

1.4

1.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

379

1.26

0.37

5.5

4.2

—

(3017732) Neutrophils [#/volume] in Blood

1.40

0.35

4.5

3.6

5.30

4.87

e9/l

—

(3031040) Bacteria [#/volume] in Urine by Automated count

361

1.24

0.35

5.9

4.3

—

68.00

—

(40761535) Cells panel - Urine sediment

1.33

0.34

3.5

2.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

246

1.23

0.30

3.3

2.7

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.28

0.29

15.4

7.3

102.50

104.61

mmol/l

—

(3026008) Bacteria identified in Urine by Culture

180

1.24

0.28

4.5

2.9

—

(40768804) Tissue Pathology biopsy report

239

1.21

0.26

3.2

2.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

155

1.22

0.22

3.9

3.7

—

(3022217) INR in Platelet poor plasma by Coagulation assay

272

1.18

0.22

12.6

13.2

1.30

1.25

inr

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

2.5

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

2.68

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.20

0.0

1.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.22

0.20

1.3

2.0

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

168

1.18

0.18

2.8

2.2

157.68

259.72

u/l

0.45

162

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.13

0.16

1.7

1.9

—

(3013512) EKG study

159

0.85

0.15

5.9

4.0

—

(40761511) CBC panel - Blood by Automated count

551

1.17

0.14

19.9

13.1

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

138

0.84

0.14

4.8

4.3

27.14

23.04

—

(3044640) Blood type and Crossmatch panel - Blood

162

1.15

0.13

4.2

2.2

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.17

0.10

2.0

4.9

1.20

1.21

mmol/l

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.10

0.09

2.3

1.7

—

(3044889) 12 lead EKG panel

367

1.08

0.06

3.6

3.8

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

232

0.93

0.06

5.3

4.2

19.71

31.55

ng/l

0.97

169

(1761868) Lipid panel - Serum or Plasma

161

1.07

0.03

2.1

2.9

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

219

0.94

0.03

5.4

4.1

—

(3003694) ABO and Rh group [Type] in Blood

128

0.93

0.03

1.2

1.4

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

106

0.93

0.01

2.6

2.8

0.60

0.73

ug/l

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

496

1.03

0.00

3.8

4.0

1.32

1.23

mmol/l

0.34

443

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.6

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

0.0

1.3

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.2

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.2

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.6

—

5.39

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.87

0.00

1.4

1.6

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.1

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.8

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.5

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

0.0

1.2

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.2

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

2.0

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

4.08

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.3

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

-0.00

0.0

1.3

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.2

—

(3011288) Drugs identified in Urine by Screen method

0.00

-0.00

0.0

1.9

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

0.98

-0.00

1.7

1.6

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

-0.00

0.0

1.3

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

-0.00

0.0

1.3

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.4

—

(3022756) Ceruloplasmin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

255.60

—

(3011648) Oxygen content in Venous blood

0.00

-0.00

0.0

1.0

—

11.16

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.4

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

-0.00

0.0

1.3

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.3

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.4

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

4.4

—

16.67

—

(21494434) Karyotype in Bone marrow

0.00

-0.00

0.0

1.0

—

(3004809) Band form neutrophils/100 leukocytes in Blood

0.00

-0.00

0.0

3.5

—

2.00

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

51.60

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

-0.00

0.0

4.6

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.4

—

(3000494) Fungus identified in Specimen by Culture

1.02

-0.00

1.1

1.8

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

-0.00

0.0

1.0

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

3.9

—

99.50

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

1.4

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.93

-0.00

1.9

1.3

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

-0.00

0.0

1.7

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

-0.00

0.0

1.5

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

-0.00

0.0

1.6

—

62.31

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

520

1.00

-0.00

4.4

4.43

4.56

mmol/l

0.45

470

(3005715) Vancomycin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

13.4

—

11.88

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_GLOBENAS and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
H7_GLOBENAS	1.845 [1.24, 2.76]	0.003
Birth year	0.986 [0.98, 1.0]	0.005

During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 175 males with H7_GLOBENAS died.

Mortality risk

Mortality risk for people of age

years, who have H7_GLOBENAS.

N-year risk	Females	Males
1	No data	0.327%
5	No data	1.96%
10	No data	5.069%
15	No data	9.458%
20	No data	15.972%

Relationships between endpoints

↥

Index endpoint: H7_GLOBENAS – Other and unspecified disorders of globe

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other and unspecified disorders of globe

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints