Abnormalities of ear ossicles

H8_OSSICABN

Otitis media: Inflammation of the anatomical structures of the middle ear, which is most often caused by an infectious process. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H74.3 Cause of death: ICD-10 — H74.3 2 out of 7 registries used, show all original rules.	69
4. Check minimum number of events None	69
5. Include endpoints None	69
6. Filter based on genotype QC (FinnGen only)	69

Control definitions (FinnGen only)

Control exclude: H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H74
Name in latin: Aliae abnormitates acquisitae ossiculorum auditoriorum

NAME	H8_OSSICABN
CONTROL_EXCLUDE	H8_MIDDLEMASTOID
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H743
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H743
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Abnormalities of ear ossicles based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	581	315	265
Only index persons	568	307	261
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	47.99	48.47	47.44
Only index persons	47.28	47.17	47.40

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	69	45	24
Unadjusted period prevalence (%)	0.01	0.02	0.01
Median age at first event (years)	51.41	50.07	53.92

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
60: Matched controls
599

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H74.3

ICD-10 Finland

Other acquired abnormalities of ear ossicles

+∞

86.1

H90.1

ICD-10 Finland

Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side

+∞

24.7

UDC00

NOMESCO Finland

Ear microscopy

19.1

15.4

H90.7

ICD-10 Finland

Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side

195.8

15.2

H80.9

ICD-10 Finland

Otosclerosis, unspecified

+∞

14.1

H80.0

ICD-10 Finland

Otosclerosis involving oval window, nonobliterative

178.8

14.1

H90.6

ICD-10 Finland

Mixed conductive and sensorineural hearing loss, bilateral

65.3

13.6

DDA00

NOMESCO Finland

Stapedotomy

162.6

13.0

H71

ICD-10 Finland

Cholesteatoma of middle ear

+∞

13.0

H74.2

ICD-10 Finland

Discontinuity and dislocation of ear ossicles

+∞

11.8

DDD05

NOMESCO Finland

Plastic repair of ossicular chain

+∞

11.8

DCD10

NOMESCO Finland

Tympanoplasty

+∞

11.8

H90.0

ICD-10 Finland

Conductive hearing loss, bilateral

+∞

9.6

DFF00

NOMESCO Finland

Pure tone audiometry

9.1

9.2

Z01.1

ICD-10 Finland

Examination of ears and hearing

7.6

8.9

DDD10

NOMESCO Finland

Interposition between malleus and stapes

+∞

8.5

ZXC10

NOMESCO Finland

Use of laser

26.4

8.4

DDW99

NOMESCO Finland

Other operation on ossicles of ear

+∞

7.4

DAX00

NOMESCO Finland

Adjustment or review of hearing aid

13.1

6.6

YPA00

NOMESCO Finland

Excision of blood vessel for transplantation

+∞

6.4

H72.0

ICD-10 Finland

Central perforation of tympanic membrane

+∞

6.4

DDD20

NOMESCO Finland

Interposition between eardrum and footplate of stapes

+∞

6.4

H74.1

ICD-10 Finland

Adhesive middle ear disease

+∞

6.4

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

574

0.46

2.08

10.6

12.5

81.9

83.0

ml/min/173m2

0.13

459

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

3.76

1.64

1.6

2.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

167

0.47

1.44

2.2

3.5

—

(3044640) Blood type and Crossmatch panel - Blood

186

0.51

1.19

2.4

2.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

2.08

1.13

1.2

2.0

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

233

0.59

1.00

3.2

3.7

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.00

0.81

0.0

6.4

—

25.4

—

(3003338) MCHC [Mass/volume]

501

1.63

0.78

17.2

17.6

334.1

331.7

g/l

1.46

501

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

166

0.60

0.77

2.8

2.0

135.9

149.0

u/l

0.09

157

(21494755) Public health laboratory ask at order entry panel

1.66

0.75

1.3

1.4

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

216

0.66

0.68

3.6

3.3

26.4

32.7

ng/l

—

150

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.61

0.0

2.3

—

224.4

—

(40768793) Breast Pathology biopsy report

0.00

0.61

0.0

1.3

—

(3036489) Thrombin time

0.00

0.61

0.0

2.2

—

22.5

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.84

0.60

2.8

1.9

164.0

223.4

ng/l

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

220

0.70

0.57

1.4

1.9

87.2

102.3

pmol/l

—

(3021589) Normoblasts [#/volume] in Blood

270

0.73

0.53

6.6

9.3

0.0

e9/l

0.00

217

(3003694) ABO and Rh group [Type] in Blood

156

1.40

0.53

1.3

1.5

—

(3022948) Iron [Moles/volume] in Serum or Plasma

0.58

0.49

2.8

2.4

14.6

13.6

umol/l

—

(3000492) Spirometry study

1.51

0.48

1.7

1.3

—

(3019225) pH of Specimen

1.48

0.47

3.9

5.5

—

(3013512) EKG study

170

0.71

0.45

2.8

3.7

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.55

0.42

17.2

8.7

—

(3050449) Albumin [Mass/time] in Urine collected for unspecified duration

0.00

0.42

0.0

2.9

—

98.8

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.41

0.0

4.2

—

7.3

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.41

0.0

4.2

—

1.3

—

(3000570) Elastase.pancreatic [Mass/mass] in Stool

0.00

0.41

0.0

1.5

—

280.5

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

2.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

135

0.70

0.41

2.4

2.3

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.41

0.0

1.7

—

5.7

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.41

0.0

5.4

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.41

0.0

3.5

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.40

0.0

2.5

—

(3019060) Gas panel - Arterial blood

1.46

0.40

6.4

5.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.42

0.39

1.2

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

535

1.38

0.38

15.6

14.8

40.2

40.1

0.03

395

(3004789) Transferrin [Mass/volume] in Serum or Plasma

0.62

0.38

2.4

g/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

261

1.26

0.37

4.2

—

(36304419) Bacteria [Presence] in Urine

164

0.74

0.36

2.9

3.0

—

(40758558) Short blood count panel - Blood

164

0.74

0.36

3.7

6.6

—

(40768797) Stomach Pathology biopsy report

0.65

0.35

1.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.36

0.32

1.4

1.6

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

463

0.81

0.30

4.1

4.3

14.7

14.9

pmol/l

0.25

411

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.33

0.29

1.4

1.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.26

0.28

6.9

6.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.24

0.28

1.8

1.4

—

(40768804) Tissue Pathology biopsy report

241

0.82

0.27

2.2

1.9

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.23

0.26

2.3

1.6

1.5

1.3

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.34

0.24

1.0

1.7

—

(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood

0.00

0.21

0.0

1.2

—

758.3

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.21

0.0

1.7

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

4.7

—

68.6

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.6

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.21

0.0

1.2

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

3.8

—

106.8

—

(40767503) Oxygen content in Capillary blood by calculation

0.00

0.21

0.0

2.3

—

16.9

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.21

0.0

1.4

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.21

0.0

1.3

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

3.8

—

4.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

3.8

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.21

0.0

1.6

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.21

0.0

1.6

—

4.9

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.21

0.0

2.8

—

8.4

—

(3010421) pH of Blood

0.00

0.21

0.0

3.0

—

7.4

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.21

0.0

1.8

—

58.8

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.21

0.0

2.8

—

4.9

—

(1616796) Gas panel - Central venous blood

0.00

0.21

0.0

1.7

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.25

0.20

1.3

2.0

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.5

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.20

0.0

5.2

—

34.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.19

0.20

1.5

1.8

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

110

1.22

0.19

1.8

1.6

—

(42870588) Differential panel, method unspecified - Blood

197

1.17

0.18

4.9

4.6

—

(40761511) CBC panel - Blood by Automated count

629

0.86

0.18

13.6

12.6

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

560

0.84

0.17

4.4

4.9

2.2

1.9

mu/l

1.05

498

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

198

1.16

0.17

9.5

3.6

30.8

32.2

u/l

0.10

186

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

112

1.20

0.16

3.0

3.3

13.1

24.3

ng/l

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.22

0.15

2.2

2.8

0.8

0.9

e6/l

—

(3031040) Bacteria [#/volume] in Urine by Automated count

382

0.88

0.15

4.0

4.1

—

63.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.22

0.15

1.3

1.7

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

210

0.87

0.14

2.6

2.9

—

(3020682) Albumin/Creatinine [Ratio] in Urine

179

0.86

0.14

2.9

4.0

11.0

mg/mmol

0.00

110

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

136

0.86

0.12

1.8

1.9

2.0

3.2

mg/l

1.22

120

(3012095) Magnesium [Moles/volume] in Serum or Plasma

1.17

0.11

2.3

3.5

0.8

mmol/l

0.20

(3005719) IgG [Mass/volume] in Serum or Plasma

1.15

0.10

6.6

1.8

8.1

10.3

g/l

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.81

0.08

1.8

2.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

0.82

0.08

1.2

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

0.78

0.08

1.4

1.5

—

(3022145) Colonoscopy Study observation

0.76

0.08

1.0

1.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

108

1.13

0.08

1.6

1.7

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.08

0.07

1.6

1.5

—

(1761868) Lipid panel - Serum or Plasma

212

0.92

0.06

1.5

2.9

—

(3026493) Urate [Moles/volume] in Serum or Plasma

161

0.91

0.05

2.3

2.7

353.7

7636.2

umol/l

1.04

132

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

120

0.90

0.05

1.4

1.7

398.7

520.1

pmol/l

0.90

(40760892) CBC W Ordered Manual Differential panel - Blood

140

0.91

0.05

1.9

5.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

101

1.11

0.04

1.2

1.4

—

(3037467) Urinalysis macro (dipstick) panel - Urine

390

0.94

0.04

4.0

4.1

—

(3026008) Bacteria identified in Urine by Culture

179

0.93

0.03

3.6

3.1

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

242

1.05

0.02

2.6

2.7

113.2

110.7

ug/l

0.02

217

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

593

0.97

0.00

12.9

13.6

30.6

21.9

mg/l

0.88

449

(3023368) Bacteria identified in Blood by Culture

133

0.97

0.00

5.4

4.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

133

0.97

0.00

3.6

3.2

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

133

0.97

0.00

5.7

4.5

17.6

22.1

—

(3044889) 12 lead EKG panel

403

0.98

0.00

3.3

3.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

377

1.02

0.00

3.1

—

(3013707) Erythrocyte sedimentation rate by Westergren method

452

0.99

0.00

3.6

4.1

12.7

11.8

mm/h

0.12

407

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

0.92

0.00

5.0

2.6

0.2

g/l

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.0

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(4268621)

0.00

0.0

1.9

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(4281824)

0.00

0.0

1.0

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3000494) Fungus identified in Specimen by Culture

0.93

0.00

1.3

1.4

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.3

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.4

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.0

—

(4146454)

0.00

0.0

2.4

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

22.7

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

1.8

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.6

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.2

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.3

—

103.1

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.2

—

(3042936) Bacteria identified in Isolate by Culture

1.00

0.00

2.1

2.2

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.6

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.4

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

12.3

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

3.3

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

1.5

—

(4306422)

0.00

0.0

1.2

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

3.6

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.2

—

94.5

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.85

0.00

1.8

2.2

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

4.4

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

2.6

—

2.9

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.2

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.2

—

(3003181) Sodium [Moles/volume] in Urine

0.00

-0.00

0.0

1.6

—

62.4

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.1

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

-0.00

0.0

3.1

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

-0.00

0.0

1.6

—

31.9

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

-0.00

0.0

1.7

—

89.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_OSSICABN and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_OSSICABN.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H8_OSSICABN – Abnormalities of ear ossicles

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Abnormalities of ear ossicles

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints