Tympanosclerosis

H8_TYMPSCLE

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H74.0 Hospital discharge: ICD-9 — 3850 Cause of death: ICD-10 — H74.0 Cause of death: ICD-9 — 3850 2 out of 7 registries used, show all original rules.	72
4. Check minimum number of events None	72
5. Include endpoints None	72
6. Filter based on genotype QC (FinnGen only)	72

Control definitions (FinnGen only)

Control exclude: H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H74
Name in latin: Tympanosclerosis

NAME	H8_TYMPSCLE
CONTROL_EXCLUDE	H8_MIDDLEMASTOID
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H740
HD_ICD_9	3850
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H740
COD_ICD_9	3850
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Tympanosclerosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	655	366	286
Only index persons	602	343	259
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	39.64	44.87	32.79
Only index persons	38.70	43.91	31.80

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	72	47	25
Unadjusted period prevalence (%)	0.01	0.02	0.01
Median age at first event (years)	45.51	45.56	45.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
69: Matched controls
687

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H74.0

ICD-10 Finland

Tympanosclerosis

+∞

72.0

DCD00

NOMESCO Finland

Myringoplasty

+∞

14.0

H72.0

ICD-10 Finland

Central perforation of tympanic membrane

+∞

14.0

3850A

ICD-9 Finland

Other disorders of middle ear and mastoid, Tympanosclerosis

+∞

14.0

H71

ICD-10 Finland

Cholesteatoma of middle ear

+∞

14.0

UDC00

NOMESCO Finland

Ear microscopy

10.6

9.3

H90.1

ICD-10 Finland

Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side

102.0

8.6

H65.3

ICD-10 Finland

Chronic mucoid otitis media

+∞

8.5

DCD10

NOMESCO Finland

Tympanoplasty

+∞

8.5

DCA20

NOMESCO Finland

Insertion of ventilating tube through tympanic membrane

+∞

8.5

DFF00

NOMESCO Finland

Pure tone audiometry

9.7

7.6

Z01.1

ICD-10 Finland

Examination of ears and hearing

5.1

6.5

H90.0

ICD-10 Finland

Conductive hearing loss, bilateral

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

4.44

2.42

4.6

2.3

—

(3023419) Bacteria identified in Sputum by Culture

6.61

2.41

8.2

3.3

—

(3044290) Cell count panel - Cerebral spinal fluid

4.79

1.97

1.6

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

261

0.54

1.36

5.0

3.8

—

(3000494) Fungus identified in Specimen by Culture

2.02

1.22

1.1

1.5

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.24

1.09

1.3

1.2

—

(3003694) ABO and Rh group [Type] in Blood

155

0.52

1.04

1.1

1.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.99

1.02

1.2

1.4

—

(42870588) Differential panel, method unspecified - Blood

171

1.61

1.01

4.7

5.0

—

(3012516) Albumin [Mass/volume] in Urine

147

1.61

0.94

3.7

3.3

64.8

50.4

mg/l

0.13

(3020682) Albumin/Creatinine [Ratio] in Urine

160

1.54

0.84

4.2

3.8

26.6

7.8

mg/mmol

0.44

100

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.00

0.81

0.0

5.5

—

24.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

397

1.44

0.71

3.2

3.1

—

(3027008) Opiates [Presence] in Urine

1.91

0.70

1.4

2.6

—

(3027944) Amphetamines [Presence] in Urine

1.84

0.67

1.4

2.5

—

(3000764) Benzodiazepines [Presence] in Urine

1.84

0.67

1.4

2.5

—

(3028300) Cannabinoids [Presence] in Urine

1.84

0.67

1.4

2.6

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.71

0.62

12.2

6.0

91.5

93.4

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.7

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.41

0.0

1.7

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.41

0.0

2.3

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.41

0.0

1.1

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.41

0.0

3.7

—

7.8

—

(3019060) Gas panel - Arterial blood

1.50

0.41

1.8

4.9

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.41

0.0

2.4

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.41

0.0

3.6

—

1.4

—

(40768793) Breast Pathology biopsy report

0.00

0.40

0.0

1.1

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.40

0.0

1.2

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.39

0.0

1.0

—

(3007566) Smooth muscle Ab [Titer] in Serum

0.00

0.39

0.0

1.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

132

0.72

0.36

2.9

2.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

223

1.26

0.35

1.8

1.9

97.0

93.0

pmol/l

0.18

116

(40761536) Microorganisms panel - Urine sediment

1.36

0.35

4.7

4.2

—

(3048689) Calprotectin [Mass/mass] in Stool

1.41

0.34

1.5

2.2

228.0

198.1

ug/g

—

(3044640) Blood type and Crossmatch panel - Blood

173

0.76

0.33

2.5

2.2

—

(3022145) Colonoscopy Study observation

1.30

0.31

1.1

1.3

—

(40768804) Tissue Pathology biopsy report

219

1.22

0.27

2.4

1.9

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

624

0.77

0.26

15.1

14.7

79.3

74.8

umol/l

0.56

624

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

573

1.28

0.26

4.6

4.3

4.8

4.6

mmol/l

0.47

533

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

586

0.80

0.25

13.2

14.4

20.7

mg/l

1.62

448

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

533

1.23

0.24

5.7

5.0

1.8

1.9

mu/l

0.05

484

(3011397) Hemoglobin [Presence] in Urine by Test strip

123

0.78

0.22

4.5

3.1

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.29

0.22

1.7

1.5

1.4

—

(3013512) EKG study

175

1.20

0.21

3.8

4.2

—

(4306422)

0.00

0.21

0.0

1.5

—

(4268621)

0.00

0.21

0.0

2.2

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.3

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.3

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.21

0.0

4.3

—

5.0

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.21

0.0

1.8

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.21

0.0

4.3

—

8.8

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.4

—

(40767503) Oxygen content in Capillary blood by calculation

0.00

0.21

0.0

2.9

—

16.4

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.21

0.0

1.4

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

2.6

—

18.6

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.8

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.21

0.0

1.3

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

3.4

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

3.4

—

4.0

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

3.4

—

105.8

—

(3000492) Spirometry study

1.27

0.21

1.3

—

(3021589) Normoblasts [#/volume] in Blood

246

0.85

0.20

9.5

9.1

0.0

e9/l

0.00

203

(40758558) Short blood count panel - Blood

147

1.20

0.20

3.1

7.6

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

0.00

0.20

0.0

1.8

—

25.2

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.20

0.0

1.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.20

0.0

1.4

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.20

0.0

1.4

—

5.8

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.20

0.0

1.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.20

0.0

1.4

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

588

1.24

0.20

5.5

4.7

2.8

2.7

mmol/l

0.26

542

(40761511) CBC panel - Blood by Automated count

619

0.82

0.18

10.7

11.9

—

(3002256) Pathology report gross observation

1.14

0.18

1.3

1.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

111

1.21

0.17

2.0

1.5

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

0.77

0.16

5.0

2.2

2.6

2.4

g/l

—

(3042936) Bacteria identified in Isolate by Culture

0.76

0.16

2.8

1.7

—

(3009542) Hematocrit [Volume Fraction] of Blood

529

1.17

0.16

13.1

13.0

39.8

39.9

0.03

391

(3023368) Bacteria identified in Blood by Culture

139

0.84

0.16

3.7

4.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

0.80

0.15

1.8

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

230

0.88

0.14

5.3

3.9

23.9

25.1

ng/l

0.04

167

(40760892) CBC W Ordered Manual Differential panel - Blood

137

0.85

0.13

6.3

6.1

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

261

1.12

0.12

5.5

6.5

1.2

mmol/l

0.87

220

(3041096) Erythrocytes [Presence] in Urine by Automated

165

1.12

0.10

2.8

3.8

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

546

1.12

0.08

4.3

3.9

1.4

1.3

mmol/l

0.74

508

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

0.77

0.08

1.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.09

0.08

6.9

7.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.84

0.08

1.3

1.4

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

567

1.12

0.08

4.7

4.3

1.5

mmol/l

0.05

522

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.79

0.08

2.2

2.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.04

0.07

2.8

2.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

394

0.92

0.07

3.8

4.1

—

(3018095) Leukocytes [#/volume] in Urine

197

1.09

0.07

2.0

3.4

9.7

51.5

e6/l

1.24

134

(3044889) 12 lead EKG panel

387

1.08

0.06

4.9

3.7

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

569

1.10

0.06

5.8

4.4

6.1

5.9

mmol/l

0.36

526

(3026008) Bacteria identified in Urine by Culture

179

1.08

0.05

2.9

3.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

201

0.93

0.05

2.1

2.9

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

540

0.93

0.04

11.2

12.0

81.9

83.9

ml/min/173m2

0.27

445

(1761868) Lipid panel - Serum or Plasma

200

1.07

0.04

2.4

3.0

—

(36304419) Bacteria [Presence] in Urine

149

0.93

0.04

1.6

2.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

128

1.02

0.00

1.2

1.7

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

229

1.01

0.00

3.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

116

1.04

0.00

1.3

1.4

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

109

1.01

0.00

1.5

1.6

309.5

472.6

pmol/l

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3009466) Valproate [Moles/volume] in Serum or Plasma

0.00

0.0

6.0

—

353.8

—

(3006571) Polymorphonuclear cells/100 leukocytes in Synovial fluid

0.00

0.0

1.4

—

31.4

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

3.6

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3014133) Dog dander IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.6

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

0.0

1.6

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

2.0

—

8.2

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.4

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

5.0

—

215.9

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.4

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.8

—

(43055120) Cytomegalovirus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

1.1

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

5.9

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

341.5

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

0.3

—

(1616796) Gas panel - Central venous blood

0.00

0.0

2.7

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.94

0.00

1.8

2.0

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.0

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

1.4

—

31.0

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

2.6

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3005719) IgG [Mass/volume] in Serum or Plasma

0.92

0.00

1.4

10.4

10.0

g/l

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

14.9

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

0.95

0.00

1.2

1.6

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.1

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.00

0.00

2.3

1.6

435.5

382.0

nmol/l

—

(3026725) Estradiol (E2) [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

0.3

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

2.6

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.7

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.0

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

2.3

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

3.3

—

90.9

—

(4027681)

0.00

0.0

1.0

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.7

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

0.98

0.00

1.0

1.5

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

6.0

—

(40768797) Stomach Pathology biopsy report

0.92

0.00

1.3

1.2

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.3

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

0.85

0.00

3.6

3.2

3.1

13.0

umol/l

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.0

1.5

—

(4281824)

0.00

0.0

1.0

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

1.7

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

25.7

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.2

—

39.3

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_TYMPSCLE and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_TYMPSCLE.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H8_TYMPSCLE – Tympanosclerosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Tympanosclerosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints