Other disorders of skin and subcutaneous tissue in diseases classified elsewhere

L12_SKININOTH

skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.

Suggest a new description

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters None 0 out of 7 registries used, show all original rules.	0
4. Check minimum number of events None	0
5. Include endpoints L12_AMYLOIDOSISSKIN L12_SKININOTHNAS	44
6. Filter based on genotype QC (FinnGen only)	42

Control definitions (FinnGen only)

Control exclude: L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	L12_SKININOTH
CONTROL_EXCLUDE	L12_OTHERSKINSUBCUTIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	L12_AMYLOIDOSISSKIN\|L12_SKININOTHNAS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Other disorders of skin and subcutaneous tissue in diseases classified elsewhere based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	252	125	126
Only index persons	231	118	113
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	57.92	58.77	57.06
Only index persons	57.10	57.14	57.06

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	42	19	23
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	56.20	50.35	61.03

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

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N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3037756) Immunofixation for Serum or Plasma

20.30

7.70

1.6

1.1

—

(40760888) Immunoglobulin light chains.free panel - Serum

25.16

7.52

6.1

4.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

5.32

6.64

2.3

1.7

—

(3004588) Protein electrophoresis panel - Serum or Plasma

6.91

5.29

3.7

1.6

—

(3006504) Eosinophils/100 leukocytes in Blood

167

4.36

4.78

9.5

5.9

2.87

2.74

0.15

155

(3019069) Monocytes/100 leukocytes in Blood

168

4.32

4.72

11.7

6.2

8.06

8.71

0.70

155

(3007853) Bacteria identified in Skin by Aerobe culture

4.54

4.64

3.2

1.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

4.54

4.64

2.2

1.6

—

(3018010) Neutrophils/100 leukocytes in Blood

170

4.24

4.60

9.1

5.9

55.84

57.00

0.21

158

(3022096) Basophils/100 leukocytes in Blood

162

4.09

4.54

9.7

5.8

0.77

0.65

0.63

147

(40760892) CBC W Ordered Manual Differential panel - Blood

171

4.19

4.54

11.8

6.2

—

(3002030) Lymphocytes/100 leukocytes in Blood

174

4.08

4.35

10.6

6.0

30.16

27.60

0.66

162

(3042936) Bacteria identified in Isolate by Culture

3.70

3.2

1.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

4.29

3.62

2.3

1.6

—

(40768443) Skin Pathology biopsy report

8.06

3.51

1.1

1.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

6.17

3.00

2.3

1.5

—

(3037467) Urinalysis macro (dipstick) panel - Urine

255

3.26

2.72

5.6

4.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

4.98

2.59

2.1

1.5

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

4.78

2.23

2.8

1.0

2.28

3.26

g/l

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

4.45

2.12

2.8

1.0

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

4.45

2.12

2.8

1.0

2.82

3.85

g/l

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

4.45

2.12

2.8

1.0

6.52

8.42

g/l

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

4.16

2.01

4.2

3.3

23.90

23.87

mmol/l

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

4.97

1.99

2.0

2.5

—

(3019060) Gas panel - Arterial blood

3.14

1.90

3.5

3.8

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

3.69

1.81

4.5

2.4

120.33

123.39

g/l

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.69

1.81

4.7

7.4

—

(3019225) pH of Specimen

3.27

1.81

5.3

5.2

—

(1761868) Lipid panel - Serum or Plasma

148

0.37

1.77

3.3

3.0

—

(3007164) IgA [Mass/volume] in Serum or Plasma

2.46

1.76

2.5

1.2

2.90

2.45

g/l

—

(36660697) Celiac disease serology panel - Serum

3.13

1.73

1.3

1.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

3.48

1.72

9.0

2.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

167

2.15

1.64

4.2

2.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.58

1.60

16.9

9.1

—

(3023368) Bacteria identified in Blood by Culture

107

2.15

1.57

4.3

3.6

—

(3003694) ABO and Rh group [Type] in Blood

2.19

1.56

1.3

1.5

—

(3022217) INR in Platelet poor plasma by Coagulation assay

179

2.11

1.55

7.0

12.0

1.23

1.17

inr

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.99

1.49

9.3

2.4

—

(40758558) Short blood count panel - Blood

2.13

1.41

5.8

7.8

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

3.18

1.40

4.8

3.0

53.90

58.18

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

2.65

1.38

3.6

2.7

5.75

5.63

kpa

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.41

1.29

4.5

2.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.09

1.19

4.8

1.8

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

2.68

1.18

8.2

2.6

106.40

60.84

ng/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.98

1.15

3.8

2.0

—

(3031040) Bacteria [#/volume] in Urine by Automated count

234

1.89

1.09

6.5

4.4

—

88.43

—

(3024354) Oxygen [Partial pressure] in Venous blood

2.41

0.98

4.0

2.5

5.60

4.96

kpa

—

(3020779) Urea [Moles/volume] in Serum or Plasma

2.23

0.93

11.3

6.1

10.77

9.03

mmol/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.08

0.88

3.8

4.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

2.01

0.85

2.2

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.01

0.85

6.2

1.8

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

1.80

0.80

2.2

1.9

28.44

28.42

—

(40768804) Tissue Pathology biopsy report

139

1.65

0.79

3.2

2.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

2.00

0.78

5.7

1.9

—

(3002256) Pathology report gross observation

2.00

0.78

1.3

1.1

—

(3021589) Normoblasts [#/volume] in Blood

149

1.63

0.77

9.1

10.2

0.00

e9/l

-0.00

121

(3019832) Treponema pallidum Ab [Presence] in Serum

1.89

0.76

2.9

1.9

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.04

0.73

5.8

6.8

1.38

1.12

mmol/l

—

(3000991) Gas panel - Venous blood

1.75

0.63

5.8

6.5

—

(3044640) Blood type and Crossmatch panel - Blood

109

1.57

0.62

3.9

2.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.82

0.61

1.8

1.7

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

0.57

0.60

2.7

3.0

1.25

0.80

ug/l

—

(3033658) Prothrombin time (PT) actual/Normal

1.56

0.56

6.1

3.3

93.38

90.53

0.12

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.62

0.55

3.3

2.7

7.00

13.38

umol/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

132

1.47

0.51

6.8

3.7

—

(3013512) EKG study

1.48

0.46

5.6

3.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

144

1.42

0.45

4.9

2.7

—

(40761535) Cells panel - Urine sediment

1.58

0.43

6.6

3.5

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.42

0.0

1.3

—

(3015736) pH of Urine

138

1.38

0.38

6.1

3.4

—

5.89

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.41

0.34

8.4

3.6

—

(3044889) 12 lead EKG panel

250

1.33

0.32

5.5

3.6

—

(3026008) Bacteria identified in Urine by Culture

123

1.33

0.31

2.9

2.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

153

1.30

0.29

2.4

1.9

89.03

93.25

pmol/l

0.13

(3000850) Epithelial cells [#/volume] in Urine

1.33

0.25

3.3

2.2

5.56

4.98

e6/l

0.05

(3020682) Albumin/Creatinine [Ratio] in Urine

117

1.29

0.24

2.8

3.5

2.90

6.21

mg/mmol

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.21

0.22

1.6

2.0

25.40

27.57

u/l

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.9

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.21

0.0

1.3

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.21

0.0

4.1

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

3.3

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

5.5

—

2351.51

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

1.6

—

(4034850) Laboratory test

0.00

0.21

0.0

4.8

—

(3027008) Opiates [Presence] in Urine

0.00

0.21

0.0

1.2

—

(3016879) Cocaine [Presence] in Urine

0.00

0.21

0.0

1.2

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.21

0.0

1.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.23

0.21

3.2

1.8

—

(40768800) Prostate Pathology biopsy report

0.00

0.20

0.0

1.1

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.20

0.0

1.2

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.20

0.0

2.2

—

4.60

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.20

0.0

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

101

1.26

0.19

3.0

2.8

—

(36304419) Bacteria [Presence] in Urine

112

1.23

0.17

3.2

2.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

225

1.15

0.11

3.6

2.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.13

0.10

2.0

1.4

—

(3000494) Fungus identified in Specimen by Culture

1.13

0.10

2.2

1.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.13

0.09

2.0

1.4

—

(3002385) Erythrocyte distribution width [Ratio]

319

1.14

0.07

26.2

17.1

14.32

14.79

0.35

314

(3002582) Erythrocytes [#/volume] in Urine

129

1.13

0.06

3.4

2.7

15.78

33.85

e6/l

0.77

100

(3030467) Casts [#/volume] in Urine by Automated count

119

1.01

0.00

3.9

2.5

0.25

0.40

e6/l

0.22

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

3.4

—

1.90

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

0.0

1.0

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.1

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.6

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.1

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

2.6

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.9

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

0.98

0.00

10.8

5.4

101.60

104.18

mmol/l

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.1

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.3

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

1.56

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

0.95

-0.00

1.4

1.6

1.00

1.37

mmol/l

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

2.0

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

383

1.16

-0.00

31.7

16.0

139.33

139.51

mmol/l

0.15

372

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

-0.00

0.0

4.4

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.0

—

96.83

—

(40759040) C peptide [Moles/volume] in Serum or Plasma --post meal

0.00

-0.00

0.0

1.0

—

1.50

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

-0.00

0.0

1.0

—

11.02

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3023419) Bacteria identified in Sputum by Culture

0.00

-0.00

0.0

4.5

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

(40768793) Breast Pathology biopsy report

0.00

-0.00

0.0

1.3

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

-0.00

0.0

1.2

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

-0.00

0.0

1.0

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(3020491) Glucose [Moles/volume] in Blood

0.00

-0.00

0.0

1.3

—

5.98

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

-0.00

0.0

1.0

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

-0.00

0.0

4.4

—

3.98

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

0.78

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

-0.00

0.0

1.8

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

-0.00

0.0

1.3

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

-0.00

0.0

4.4

—

107.80

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3011288) Drugs identified in Urine by Screen method

0.00

-0.00

0.0

1.4

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

385

1.11

-0.00

33.4

15.9

3.96

3.98

mmol/l

0.22

374

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.8

—

5.37

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

-0.00

0.0

2.3

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

-0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_SKININOTH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_SKININOTH.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: L12_SKININOTH – Other disorders of skin and subcutaneous tissue in diseases classified elsewhere

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other disorders of skin and subcutaneous tissue in diseases classified elsewhere

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints