Other disorders of skin and subcutaneous tissue in diseases classified elsewhere

L12_SKININOTH

skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters None 0 out of 7 registries used, show all original rules.	0
4. Check minimum number of events None	0
5. Include endpoints L12_AMYLOIDOSISSKIN L12_SKININOTHNAS	39
6. Filter based on genotype QC (FinnGen only)	39

Control definitions (FinnGen only)

Control exclude: L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	L12_SKININOTH
CONTROL_EXCLUDE	L12_OTHERSKINSUBCUTIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	L12_AMYLOIDOSISSKIN\|L12_SKININOTHNAS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other disorders of skin and subcutaneous tissue in diseases classified elsewhere based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	252	125	126
Only index persons	231	118	113
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	57.92	58.77	57.06
Only index persons	57.10	57.14	57.06

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	39	19	20
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	54.74	50.35	58.91

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40760888) Immunoglobulin light chains.free panel - Serum

22.67

6.61

6.7

4.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

5.25

5.83

2.4

1.8

—

(3037756) Immunofixation for Serum or Plasma

13.92

5.03

1.8

1.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

5.50

4.38

4.4

1.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

4.63

4.35

3.4

1.7

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

4.24

3.70

2.4

1.6

—

(3022096) Basophils/100 leukocytes in Blood

147

3.72

3.59

10.4

6.5

0.8

0.7

0.32

133

(3013650) Neutrophils [#/volume] in Blood by Automated count

190

4.07

3.51

10.7

12.0

3.5

4.1

e9/l

1.03

169

(3019198) Lymphocytes [#/volume] in Blood

168

3.83

3.45

8.9

6.9

1.9

1.8

e9/l

0.13

151

(3042936) Bacteria identified in Isolate by Culture

3.72

3.42

3.4

1.6

—

(3006504) Eosinophils/100 leukocytes in Blood

150

3.60

3.42

9.7

6.6

2.9

2.8

0.07

139

(3019069) Monocytes/100 leukocytes in Blood

151

3.56

3.36

11.3

6.8

8.4

9.0

0.69

139

(3018010) Neutrophils/100 leukocytes in Blood

152

3.52

3.31

9.4

6.6

55.7

57.3

0.27

141

(3013115) Eosinophils [#/volume] in Blood

171

3.71

3.29

9.8

6.8

0.2

e9/l

0.05

152

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.98

3.22

2.5

1.6

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

6.83

3.17

2.3

1.5

—

(3001604) Monocytes [#/volume] in Blood

164

3.51

3.16

8.7

6.8

0.5

0.6

e9/l

0.95

139

(3006315) Basophils [#/volume] in Blood

165

3.47

3.11

8.8

6.8

0.0

e9/l

0.12

143

(3002030) Lymphocytes/100 leukocytes in Blood

156

3.38

3.09

10.9

6.7

30.1

27.5

0.58

144

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

5.83

2.87

2.1

1.6

—

(40768443) Skin Pathology biopsy report

6.85

2.81

1.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

227

3.27

2.48

5.8

4.4

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

219

3.02

2.23

6.1

4.6

8.0

6.7

mmol/l

1.06

203

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

5.55

2.14

2.0

2.6

—

(3019225) pH of Specimen

3.35

1.65

6.0

5.8

—

(40758558) Short blood count panel - Blood

2.35

1.65

5.8

8.4

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

3.66

1.57

4.4

3.4

25.5

23.6

mmol/l

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

3.66

1.57

4.8

3.2

53.9

58.4

—

(42870588) Differential panel, method unspecified - Blood

109

2.21

1.55

11.6

6.4

—

(3019060) Gas panel - Arterial blood

2.82

1.53

3.7

3.8

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.62

1.53

18.7

9.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

146

2.16

1.49

6.8

3.9

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

3.21

1.40

4.8

2.5

115.6

121.1

g/l

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

3.21

1.40

10.6

2.6

—

(3023368) Bacteria identified in Blood by Culture

2.13

1.38

4.7

3.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.61

1.36

4.5

2.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

3.03

1.32

11.4

2.9

—

(3024354) Oxygen [Partial pressure] in Venous blood

2.54

1.24

4.0

2.5

5.6

5.0

kpa

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

2.53

1.17

3.6

2.9

5.9

5.7

kpa

—

(1761868) Lipid panel - Serum or Plasma

130

0.44

1.15

3.3

3.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

2.36

1.12

5.7

2.1

—

(3012544) pH of Venous blood

2.36

1.12

3.7

2.8

—

(3031040) Bacteria [#/volume] in Urine by Automated count

207

1.99

1.11

6.8

4.5

—

102.7

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

1.99

1.03

2.2

1.9

28.4

28.5

—

(3002256) Pathology report gross observation

2.15

1.03

1.3

1.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.34

0.96

3.8

4.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.34

0.96

6.2

1.9

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.01

0.94

5.4

2.0

—

(3003694) ABO and Rh group [Type] in Blood

1.88

0.93

1.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.90

0.91

4.3

2.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.78

0.77

8.9

4.9

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.14

0.76

5.8

6.6

1.4

1.1

mmol/l

—

(3020779) Urea [Moles/volume] in Serum or Plasma

2.14

0.76

13.4

6.8

9.9

9.3

mmol/l

—

(3000991) Gas panel - Venous blood

1.97

0.71

5.8

6.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

132

1.51

0.53

5.3

2.7

—

(3013512) EKG study

1.57

0.52

5.7

4.0

—

(3044640) Blood type and Crossmatch panel - Blood

1.51

0.47

4.3

2.5

—

(3033658) Prothrombin time (PT) actual/Normal

1.50

0.45

6.5

3.4

94.3

90.8

0.14

(40761535) Cells panel - Urine sediment

1.64

0.44

6.6

3.6

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.59

0.43

2.0

1.7

—

(40768804) Tissue Pathology biopsy report

127

1.44

0.43

3.6

2.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.54

0.42

3.4

1.9

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.42

0.0

1.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.50

0.42

8.4

3.6

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.44

0.40

2.8

7.6

11.4

umol/l

—

(3020682) Albumin/Creatinine [Ratio] in Urine

102

1.41

0.36

2.9

3.6

3.2

7.0

mg/mmol

—

(3044889) 12 lead EKG panel

230

1.39

0.35

5.3

3.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

123

1.36

0.32

7.5

3.8

—

(3015736) pH of Urine

124

1.34

0.30

6.8

3.4

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

0.66

0.27

2.7

3.0

1.3

0.8

ug/l

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.40

0.25

1.6

2.1

25.4

28.2

u/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.25

0.23

2.0

1.4

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.22

0.0

1.3

—

(3027008) Opiates [Presence] in Urine

0.00

0.22

0.0

1.3

—

(3016879) Cocaine [Presence] in Urine

0.00

0.22

0.0

1.3

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.22

0.0

1.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.22

0.0

1.3

—

(4034850)

0.00

0.22

0.0

4.6

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.22

0.0

1.2

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.22

0.0

3.3

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.22

0.0

1.3

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.21

0.0

1.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

1.6

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.21

0.0

1.3

—

(3000850) Epithelial cells [#/volume] in Urine

1.32

0.21

3.5

2.2

6.0

4.7

e6/l

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.21

0.0

2.3

—

4.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.21

0.20

1.0

1.4

—

(40768800) Prostate Pathology biopsy report

0.00

0.20

0.0

1.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.20

0.0

1.6

—

(36304419) Bacteria [Presence] in Urine

102

1.25

0.18

3.4

2.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

141

1.23

0.17

2.4

1.9

94.6

94.5

pmol/l

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

0.76

0.16

1.4

1.6

1.1

1.4

mmol/l

—

(3026008) Bacteria identified in Urine by Culture

106

1.19

0.11

3.3

2.8

—

(3002582) Erythrocytes [#/volume] in Urine

116

1.18

0.11

3.6

2.7

16.8

36.5

e6/l

0.75

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.16

0.10

3.4

1.8

—

(3002385) Erythrocyte distribution width [Ratio]

277

1.18

0.10

25.3

18.2

13.9

13.8

0.15

271

(3030467) Casts [#/volume] in Urine by Automated count

108

1.16

0.08

3.9

2.5

0.2

0.4

e6/l

0.25

(3009542) Hematocrit [Volume Fraction] of Blood

301

1.15

0.07

27.3

15.4

39.1

39.9

0.24

233

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

192

1.09

0.03

3.3

2.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.09

0.01

3.4

2.8

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.2

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.3

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.2

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

4.5

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.3

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.3

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.3

—

(4094501)

0.00

0.0

1.0

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.0

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

5.0

—

2805.9

—

(4306422)

0.00

0.0

1.0

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.3

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.0

1.3

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.3

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

0.8

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.3

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

4.2

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.0

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

342

0.95

0.00

34.7

16.6

3.9

4.0

mmol/l

0.30

332

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

2.0

—

(40759040) C peptide [Moles/volume] in Serum or Plasma --post meal

0.00

0.0

1.0

—

1.5

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.1

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

4.4

—

107.8

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

2.8

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.8

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

4.4

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

340

1.00

0.00

32.9

16.6

139.1

139.6

mmol/l

0.40

330

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.1

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

1.0

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

101.1

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

4.4

—

4.0

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

0.89

0.00

1.2

1.1

—

1.1

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.0

—

75.4

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.6

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

4.4

—

1.9

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_SKININOTH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_SKININOTH.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_SKININOTH – Other disorders of skin and subcutaneous tissue in diseases classified elsewhere

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other disorders of skin and subcutaneous tissue in diseases classified elsewhere

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints