amyloidosis: A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
583 |
4. Check minimum number of eventsNone |
583 |
5. Include endpointsNone |
583 |
6. Filter based on genotype QC (FinnGen only) |
583 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Amyloidosis, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Amyloidosis
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5263 | 2849 | 2321 |
| Only index persons | 3048 | 1579 | 1469 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.08 | 0.06 |
| Only index persons | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 67.37 | 66.72 | 68.27 |
| Only index persons | 68.90 | 67.88 | 69.99 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 583 | 282 | 301 |
| Unadjusted period prevalence (%) | 0.12 | 0.10 | 0.13 |
| Median age at first event (years) | 67.40 | 63.33 | 71.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 503
- Matched controls
- 5029
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E85.9
ICD-10 Finland
Amyloidosis, unspecified
+∞
238.0
209
*
E85.80
ICD-10 Finland
Meretoja sick
+∞
102.7
95
*
N08.4*E85.9
ICD-10 Finland
Glomerular disorders in amyloidosis
+∞
100.4
93
*
E85.89
ICD-10 Finland
Other amyloidosis
+∞
91.5
85
*
I43.1*E85.9
ICD-10 Finland
Cardiac amyloidosis
+∞
78.2
73
*
I68.0*E85.9
ICD-10 Finland
Cerebral amyloid angiopathy
+∞
78.2
73
*
H19.8*E85.80
ICD-10 Finland
Reticular keratitis in Meretoja's patients
+∞
70.5
66
*
E85.3
ICD-10 Finland
Secondary systemic amyloidosis
+∞
63.9
60
*
C03CA01
ATC
furosemide; systemic
5.0
61.3
289
1070
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
32.9
57.8
76
27
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
33.9
55.9
73
25
XW000
NOMESCO Finland
Bone marrow biopsy
13.0
49.1
90
83
E85.4
ICD-10 Finland
Organ-limited amyloidosis
+∞
47.7
45
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
10.3
45.9
95
111
A11CC03
ATC
alfacalcidol; systemic
30.7
45.0
60
22
C90.0
ICD-10 Finland
Multiple myeloma
34.3
44.7
58
19
N08.4
ICD-10 Finland
Glomerular disorders in other endocrine, nutritional and metabolic diseases
+∞
44.4
42
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
47.0
38.9
47
11
A12AA04
ATC
calcium carbonate; oral
36.8
37.0
47
14
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
8.1
36.8
87
126
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.3
36.3
304
1577
TK800
NOMESCO Finland
Hemodialysis
18.8
33.1
51
30
2773B
ICD-9 Finland
Other and unspecified disorders of metabolism, Amyloidosis[AMYLOIDOSIS SECUNDARIA]
+∞
31.6
30
*
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
36.0
31.4
40
12
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
26.8
30.6
42
17
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
22.8
30.6
44
21
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
35.1
30.5
39
12
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
18.4
30.3
47
28
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
33.1
28.5
37
12
E85.0
ICD-10 Finland
Non-neuropathic heredofamilial amyloidosis
+∞
28.4
27
*
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
106.1
28.0
30
*
N18.0
ICD-10 Finland
End-stage renal disease
34.0
27.2
35
11
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.2
27.1
116
336
153
Kela drug reimbursment
Lenalidomid
44.0
27.1
33
8
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
102.3
26.9
29
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
4.2
26.6
111
314
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
5.9
26.5
78
151
M04AA01
ATC
allopurinol; systemic
3.8
26.1
124
394
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
26.7
25.6
35
14
I50.9
ICD-10 Finland
Heart failure, unspecified
3.6
25.4
130
439
I68.0
ICD-10 Finland
Cerebral amyloid angiopathy
+∞
25.2
24
*
I43.1
ICD-10 Finland
Cardiomyopathy in metabolic diseases
+∞
25.2
24
*
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
7.7
25.1
60
87
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.2
25.0
164
667
N18.8
ICD-10 Finland
Other chronic renal failure
11.4
24.9
47
45
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
12.2
24.7
45
40
B03XA01
ATC
erythropoietin; parenteral
36.6
24.6
31
9
137
Kela drug reimbursment
Uraemia requiring dialysis
51.1
24.5
29
6
Z49.0
ICD-10 Finland
Preparatory care for dialysis
91.2
23.9
26
*
H16.0
ICD-10 Finland
Corneal ulcer
7.6
23.4
56
81
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.4
22.7
130
472
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.2
22.6
142
553
N19
ICD-10 Finland
Unspecified kidney failure
8.8
22.5
49
61
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
17.0
22.2
35
22
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
65.6
22.0
25
*
H19.8
ICD-10 Finland
Other disorders of sclera and cornea in diseases classified elsewhere
+∞
22.0
21
*
B03XA02
ATC
darbepoetin alfa; parenteral
15.4
22.0
36
25
V03AE01
ATC
polystyrene sulfonate; oral
23.5
22.0
31
14
L01AA03
ATC
melphalan; systemic
120.2
21.7
23
*
L04AA01
ATC
[U] ciclosporin; systemic
15.6
21.5
35
24
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.4
21.3
117
411
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.6
21.1
222
1183
L04AX04
ATC
lenalidomide; oral
34.1
20.4
26
8
C03DA01
ATC
spironolactone; oral
3.8
19.9
93
286
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
8.8
19.9
43
53
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.8
19.8
90
271
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
7.5
19.7
47
68
WW300
NOMESCO Finland
Transfer of autologic stem cells
41.9
19.7
24
6
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.7
19.5
70
168
71239
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD
23.7
19.3
27
12
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
7.1
19.3
48
74
N04.9
ICD-10 Finland
Nephrotic syndrome, unspecified
57.3
19.1
22
*
L99.0*E85.9
ICD-10 Finland
Amyloidosis of skin
+∞
18.9
18
*
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
10.7
18.7
36
36
Z94.0
ICD-10 Finland
Kidney transplant status
31.4
18.5
24
8
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.1
18.4
75
204
L04AA06
ATC
mycophenolic acid; systemic
20.3
18.4
27
14
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
45.8
18.4
22
5
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.5
18.3
93
306
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
14.4
18.0
30
22
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.7
17.9
63
148
E85.8
ICD-10 Finland
Other amyloidosis
+∞
17.8
17
*
AA1AA
NOMESCO Finland
Head X-ray examination
38.2
17.7
22
6
B05DA
ATC
Isotonic solutions
98.5
17.7
19
*
J01MA12
ATC
levofloxacin; systemic
2.8
17.7
131
556
H02AB02
ATC
dexamethasone; systemic
3.4
17.6
91
303
AA1AD
NOMESCO Finland
CT of head and brain
2.6
17.4
154
728
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.8
17.2
78
233
ZXA05
NOMESCO Finland
Left side
2.5
17.2
167
830
WX002
NOMESCO Finland
Sedation and analgesia
2.7
17.1
134
588
329
Kela drug reimbursment
Lenalidomide
51.9
17.1
20
*
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
51.9
17.1
20
*
I50.0
ICD-10 Finland
Congestive heart failure
4.0
17.0
72
202
N17.9
ICD-10 Finland
Acute renal failure, unspecified
6.8
17.0
43
68
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
8.5
16.6
36
45
127
Kela drug reimbursment
Transplant complication
16.4
15.9
25
16
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
7.0
15.7
39
60
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
15.7
182
980
Z49.2
ICD-10 Finland
Other dialysis
164.8
15.6
16
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
39.4
15.5
19
5
J05AB01
ATC
aciclovir; systemic
2.6
15.3
131
602
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.1
15.2
61
163
A04AA01
ATC
ondansetron; systemic, rectal
4.3
15.2
58
148
R06.0
ICD-10 Finland
Dyspnoea
2.4
15.0
155
788
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
58.5
14.9
17
*
I42.2
ICD-10 Finland
Other hypertrophic cardiomyopathy
19.1
14.8
22
12
KA1AE
NOMESCO Finland
Kidney ultrasound examination
7.7
14.7
34
47
V03AE02
ATC
sevelamer; oral
82.5
14.6
16
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
82.5
14.6
16
*
L04AX01
ATC
azathioprine; systemic
5.3
14.6
45
92
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
28.1
14.4
19
7
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.2
14.3
56
146
R80
ICD-10 Finland
Isolated proteinuria
19.8
14.3
21
11
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
14.2
125
579
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
3.3
14.0
73
243
C07AB07
ATC
bisoprolol; oral
2.1
13.8
269
1798
CG2T4
NOMESCO Finland
Topography assessment of cornea
15.3
13.7
22
15
TPX10
NOMESCO Finland
Implantation of vascular injection port
7.1
13.7
33
49
ZXD05
NOMESCO Finland
Urgent procedure
2.2
13.6
173
958
H02.2
ICD-10 Finland
Lagophthalmos
35.1
13.6
17
5
B05DB
ATC
Hypertonic solutions
143.6
13.5
14
*
PBM10
NOMESCO Finland
Closure of arteriovenous fistula of radial artery
143.6
13.5
14
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.1
13.4
242
1560
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.0
13.3
55
151
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.1
13.3
205
1237
ZX120
NOMESCO Finland
Intravenous
3.2
13.1
73
254
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
8.0
13.1
29
38
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
29.2
13.0
17
6
XF404
NOMESCO Finland
Ambulatory ECG
3.1
13.0
75
268
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.9
12.9
85
331
CG2S4
NOMESCO Finland
Photography of cornea
51.4
12.9
15
*
Z2446
NOMESCO Finland
Social worker
4.0
12.9
53
145
CBJ50
NOMESCO Finland
Operation for ptosis of eyebrow
14.5
12.9
21
15
Z3226
NOMESCO Finland
Physiotherapist
2.5
12.8
114
529
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
32.9
12.6
16
5
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
3.0
12.5
76
281
ZX108
NOMESCO Finland
Inhalation
20.7
12.5
18
9
ZXA00
NOMESCO Finland
Right side
2.2
12.5
169
956
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.7
12.4
56
166
9272
FHL
Metatarsophalangeal joint resection
38.5
12.3
15
*
QAJ10
NOMESCO Finland
Browlift
38.5
12.3
15
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.3
12.1
129
655
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.4
12.1
59
187
H02AB06
ATC
prednisolone; systemic
2.0
12.0
253
1708
71200
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Juvenile rheumatoid arthritis
47.8
11.9
14
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
11.8
202
1256
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.1
11.8
169
977
B01AB05
ATC
enoxaparin; parenteral
2.1
11.7
172
1004
L01AA01
ATC
cyclophosphamide; systemic
66.5
11.7
13
*
L04AA13
ATC
leflunomide; oral
7.0
11.6
28
42
QAJ20
NOMESCO Finland
Subperiosteal facelift
+∞
11.5
11
*
2773A
ICD-9 Finland
Other and unspecified disorders of metabolism, Amyloidosis[AMYLOIDOSIS PRIMARIA]
+∞
11.5
11
*
N08.4*E85.80
ICD-10 Finland
Glomerular disease in Meretoja's patients
+∞
11.5
11
*
1XX32
NOMESCO Finland
NA
122.6
11.5
12
*
C10AA05
ATC
atorvastatin; oral
2.0
11.4
205
1297
H04.10
ICD-10 Finland
Dry eye syndrome
3.1
11.4
66
237
R4120
NOMESCO Finland
Occupational therapy
3.7
11.3
50
146
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
3.4
11.1
55
176
ZXA10
NOMESCO Finland
Bilateral
2.3
11.1
119
603
H02.4
ICD-10 Finland
Ptosis of eyelid
5.5
11.1
32
61
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
7.2
11.0
26
38
A46
ICD-10 Finland
Erysipelas
2.6
11.0
87
378
TK810
NOMESCO Finland
Hemofiltration
44.3
11.0
13
*
ZX112
NOMESCO Finland
Subcutaneous
6.7
10.9
27
42
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.6
10.9
88
383
A07AA09
ATC
vancomycin; oral
10.9
10.9
20
19
C09AA05
ATC
ramipril; oral
2.1
10.8
151
858
N39.1
ICD-10 Finland
Persistent proteinuria, unspecified
18.3
10.8
16
9
E87.5
ICD-10 Finland
Hyperkalaemia
28.7
10.8
14
5
9283
FHL
Subtalar joint ossification surgery (or triple)
28.7
10.8
14
5
WX892
NOMESCO Finland
Monitored bed care
3.2
10.6
56
188
Z2221
NOMESCO Finland
Medical doctor
2.1
10.5
148
844
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.0
10.5
42
113
YNB10
NOMESCO Finland
Collection of stem cells for transplant
112.2
10.5
11
*
E85
ICD-10 Finland
Amyloidosis
+∞
10.4
10
*
L01CB
ATC
Podophyllotoxin derivatives
+∞
10.4
10
*
TK820
NOMESCO Finland
Peritoneal dialysis
+∞
10.4
10
*
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
+∞
10.4
10
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
10.4
142
797
ZXE00
NOMESCO Finland
One hour or less
1.9
10.4
207
1349
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.1
10.3
57
196
WW200
NOMESCO Finland
Immunization
5.7
10.1
28
51
Z3231
NOMESCO Finland
Registered nurse
2.0
10.1
153
896
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.7
10.0
73
302
QAJ30
NOMESCO Finland
Other facelift
40.9
10.0
12
*
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
40.9
10.0
12
*
B01AB10
ATC
tinzaparin; parenteral
3.3
10.0
50
162
ZXE20
NOMESCO Finland
More than three and less than five hours
2.4
9.9
90
417
A07EC01
ATC
sulfasalazine; oral, rectal
3.1
9.9
55
189
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
12.5
9.9
17
14
H02.1
ICD-10 Finland
Ectropion of eyelid
9.0
9.9
20
23
TFJ02
NOMESCO Finland
Muscle biopsy of heart
26.6
9.9
13
5
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.9
9.8
31
66
ACC51
NOMESCO Finland
Release of median nerve
3.3
9.7
50
165
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.3
9.7
48
154
S01XA18
ATC
ciclosporin; ophthalmic
56.1
9.7
11
*
R50.9
ICD-10 Finland
Fever, unspecified
2.4
9.6
84
383
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.0
9.6
55
195
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
5.0
9.6
30
63
Z3229
NOMESCO Finland
Other healthcare associate professional
2.9
9.6
62
236
3AC01
NOMESCO Finland
NA
15.4
9.6
15
10
B01AC04
ATC
clopidogrel; oral
2.4
9.5
88
413
CBK11
NOMESCO Finland
Operation for lagophtalmus with implant
101.8
9.4
10
*
ZZC00
NOMESCO Finland
Graft of fascia
+∞
9.4
9
*
27699
ICD-8 Finland
Amyloidosis
+∞
9.4
9
*
E85.2
ICD-10 Finland
Heredofamilial amyloidosis, unspecified
+∞
9.4
9
*
WX2DD
NOMESCO Finland
Low-dose CT of skeleton in whole body
22.2
9.4
13
6
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.8
9.3
61
235
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.9
9.2
37
100
L04AD01
ATC
ciclosporin; systemic
6.5
9.2
23
37
Z31.5
ICD-10 Finland
Genetic counselling
4.4
9.2
32
76
CBB20
NOMESCO Finland
Correction of lax skin of eyelid and resection of herniated fat
8.5
9.1
19
23
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.5
9.1
75
331
9294
FHL
Endoprosthesis replacement of the entire hip joint (eg Charnley)
10.3
9.1
17
17
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
37.4
9.0
11
*
I10
ICD-10 Finland
Essential (primary) hypertension
1.8
9.0
304
2316
R4110
NOMESCO Finland
Physiotherapy
2.0
9.0
142
838
R60.0
ICD-10 Finland
Localized oedema
2.5
9.0
72
314
XCK10
NOMESCO Finland
Photography of fundus of eye
2.6
9.0
66
274
E83.50
ICD-10 Finland
Hypercalcemia
24.5
8.9
12
5
L01AA02
ATC
chlorambucil; oral
24.5
8.9
12
5
9256
FHL
Synovectomy (knee 9311)
24.5
8.9
12
5
NCB20
NOMESCO Finland
Primary total prosthetic replacement of elbow joint
24.5
8.9
12
5
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
8.2
8.9
19
24
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
5.3
8.9
26
51
G51.0
ICD-10 Finland
Bell palsy
5.8
8.8
24
43
H02.3
ICD-10 Finland
Blepharochalasis
2.9
8.8
54
198
N02AX02
ATC
tramadol; systemic, rectal
1.8
8.7
221
1531
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
6.8
8.7
21
32
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
50.9
8.7
10
*
L28
ICPC
Limited function/disability (L)
2.2
8.7
97
496
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.0
8.6
49
173
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
3.1
8.6
48
167
CBF99
NOMESCO Finland
Other operation for ectropion
28.0
8.5
11
*
A12AA12
ATC
[U] calcium acetate anhydrous; systemic
28.0
8.5
11
*
E86
ICD-10 Finland
Volume depletion
28.0
8.5
11
*
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
91.5
8.4
9
*
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
91.5
8.4
9
*
M01CB01
ATC
sodium aurothiomalate; parenteral
8.1
8.4
18
23
TPH07
NOMESCO Finland
Cathetrisation of artery
2.6
8.4
60
246
V03AE03
ATC
lanthanum carbonate; oral
+∞
8.4
8
*
7143C
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Juvenile chronic polyarthritis[POLYARTHRITIS JUVENILIS SERONEGATIVA]
+∞
8.4
8
*
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
6.7
8.3
20
31
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
14.8
8.2
13
9
212
Kela drug reimbursment
Gout
6.2
8.2
21
35
C08CA01
ATC
amlodipine; oral
1.8
8.2
195
1322
I61.1
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, cortical
12.0
8.1
14
12
9314
FHL
Total knee endoprosthesis (also includes patellar part)
17.5
8.1
12
7
L04AA11
ATC
[U] etanercept; parenteral
33.9
8.1
10
*
K65.0
ICD-10 Finland
Acute peritonitis
10.3
8.1
15
15
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.6
8.1
35
102
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.2
8.1
89
451
J01DA01
ATC
[U] cefalexin; systemic
1.7
8.0
303
2352
WX110
NOMESCO Finland
Local anesthesy
1.7
8.0
312
2444
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
8.7
7.9
16
19
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.9
7.9
46
167
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
11.0
7.8
14
13
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
3.4
7.8
37
116
9284
FHL
Wrist ossification surgery
45.7
7.7
9
*
9289
FHL
Other measure in this category
45.7
7.7
9
*
H02AB04
ATC
methylprednisolone; systemic
2.2
7.7
81
403
S97
ICPC
Chronic ulcer skin
3.2
7.7
40
134
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.9
7.7
46
170
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
6.9
7.6
18
27
CBF10
NOMESCO Finland
Shortening of canthal ligaments and tarsal plate for ectropion
25.4
7.6
10
*
201
Kela drug reimbursment
Chronic cardiac insufficiency
3.1
7.6
40
136
CBH25
NOMESCO Finland
Tarsorrhaphy
81.2
7.4
8
*
I42.5
ICD-10 Finland
Other restrictive cardiomyopathy
81.2
7.4
8
*
PG5DE
NOMESCO Finland
Ultrasound examination of injection gate to artery or vein with Doppler method
81.2
7.4
8
*
L88
ICPC
Rheumatoid/seropositive arthritis
3.8
7.4
30
83
XF402
NOMESCO Finland
ECG with work load test
2.3
7.4
67
310
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
3.4
7.3
34
105
RD210
NOMESCO Finland
NA
9.6
7.3
14
15
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
7.3
88
463
H25.1
ICD-10 Finland
Senile nuclear cataract
1.8
7.3
158
1030
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
7.3
97
531
7140B
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SERONEGATIVA]
16.0
7.3
11
7
H26.3
ICD-10 Finland
Drug-induced cataract
16.0
7.3
11
7
JN3AD
NOMESCO Finland
Abdominal CT examination
2.7
7.2
49
193
S18
ICPC
Laceration/cut
1.7
7.2
219
1580
A02BC02
ATC
pantoprazole; systemic
1.7
7.2
317
2533
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
30.5
7.2
9
*
H02AB07
ATC
prednisone; oral
2.1
7.2
81
415
D06BB04
ATC
podophyllotoxin; topical
4.6
7.0
23
52
B01AA03
ATC
warfarin; systemic
1.9
7.0
122
740
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
7.0
80
414
X59
ICD-10 Finland
Exposure to unspecified factor
2.0
7.0
93
510
E000001
ATC
NA
2.0
7.0
100
563
C09CA01
ATC
losartan; oral
1.8
7.0
131
816
H16.9
ICD-10 Finland
Keratitis, unspecified
7.7
6.9
15
20
L04AB01
ATC
etanercept; parenteral
7.7
6.9
15
20
TQW40
NOMESCO Finland
Remowal of suture of skin
2.8
6.9
44
168
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
6.8
101
578
TQW99
NOMESCO Finland
Other minor procedure on skin
2.9
6.8
39
140
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
40.6
6.8
8
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.9
6.8
114
683
B01AB04
ATC
dalteparin; parenteral
3.1
6.8
35
118
N05CF01
ATC
zopiclone; oral
1.7
6.8
170
1157
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
6.7
88
480
WX320
NOMESCO Finland
Spinalanesthesy
1.9
6.7
115
692
E0000UV
ATC
NA
1.7
6.7
181
1253
WW409
NOMESCO Finland
Other aferesis
22.8
6.7
9
*
N17.0
ICD-10 Finland
Acute renal failure with tubular necrosis
22.8
6.7
9
*
L04AC07
ATC
tocilizumab; parenteral
22.8
6.7
9
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.1
6.7
72
363
RS221
NOMESCO Finland
NA
6.0
6.7
17
29
ZZH31
NOMESCO Finland
Bone allograft, small pieces
8.0
6.6
14
18
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
12.5
6.6
11
9
H18.4
ICD-10 Finland
Corneal degeneration
12.5
6.6
11
9
XX9XE
NOMESCO Finland
Other ultrasound examination
8.9
6.6
13
15
M05
ICD-10 Finland
Seropositive rheumatoid arthritis
8.9
6.6
13
15
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
4.3
6.6
23
56
C09CA06
ATC
candesartan; oral
1.9
6.6
109
647
J01FF01
ATC
clindamycin; systemic
1.8
6.5
132
840
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
6.5
192
1360
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
6.3
6.5
16
26
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.8
6.5
41
155
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
3.9
6.5
25
67
NDG77
NOMESCO Finland
Other excision, reconstruction or fusion of joint of first finger
70.7
6.4
7
*
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
70.7
6.4
7
*
QAJ15
NOMESCO Finland
Browlift using video-endoscope
70.7
6.4
7
*
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
70.7
6.4
7
*
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
4.5
6.4
21
48
NHG20
NOMESCO Finland
Fusion of talocrural joint
14.5
6.4
10
7
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.2
6.4
66
327
H02AB09
ATC
hydrocortisone; systemic
5.6
6.3
17
31
CBN30
NOMESCO Finland
Shortening of canthal ligament
11.2
6.3
11
10
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
11.2
6.3
11
10
L03AA02
ATC
filgrastim; parenteral
4.2
6.3
22
54
L99.0
ICD-10 Finland
Amyloidosis of skin
+∞
6.3
6
*
QAJ35
NOMESCO Finland
Other correction of loose or redundant skin of head or neck
+∞
6.3
6
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
6.3
6
*
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
3.2
6.2
31
102
C02AC05
ATC
moxonidine; oral
3.2
6.2
31
102
M05BA04
ATC
alendronic acid; oral
2.3
6.2
57
264
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
6.4
6.2
15
24
P01BA02
ATC
hydroxychloroquine; oral
2.4
6.2
50
221
NF1AA
NOMESCO Finland
Hip X-ray examination
2.3
6.1
54
248
L04AB04
ATC
adalimumab; parenteral
6.1
6.0
15
25
Mortality – FinRegistry
↥Association
Association between endpoint E4_AMYLNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_AMYLNAS | 5.481 [4.42, 6.8] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.681 |
During the follow-up period (1.1.1998 — 31.12.2019), 696 out of 1370 females with E4_AMYLNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_AMYLNAS | 4.06 [3.17, 5.2] | < 0.001 |
| Birth year | 0.985 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 668 out of 1241 males with E4_AMYLNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_AMYLNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.4% | 0.707% |
| 5 | 3.508% | 4.19% |
| 10 | 8.544% | 10.612% |
| 15 | 15.418% | 19.136% |
| 20 | 27.346% | 30.589% |
Relationships between endpoints
↥Index endpoint: E4_AMYLNAS – Amyloidosis, other/unspecified
GWS hits: 12
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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