Colorectal squamous cell carcinoma

C3_COLORECTAL_SQUAM

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Cancer registry: Topography ICD-O-3 — C1[8-9]\|C20 Cancer registry: Morphology ICD-O-3 — 8070 Cancer registry: Behaviour codes — 3 1 out of 7 registries used, show all original rules.	38
4. Check minimum number of events None	38
5. Include endpoints None	38
6. Filter based on genotype QC (FinnGen only)	38

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF9

NAME	C3_COLORECTAL_SQUAM
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO	C1[8-9]\|C20
CANC_TOPO_EXCL
CANC_MORPH	8070
CANC_MORPH_EXCL
CANC_BEHAV	3

Similar endpoints

↥

List of similar endpoints to Colorectal squamous cell carcinoma based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Colorectal squamous cell carcinoma, excluding all cancers (controls excluding all cancers)

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	38	31	7
Unadjusted period prevalence (%)	0.01	0.01	0.00
Median age at first event (years)	62.06	59.94	71.42

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

21.94

20.83

3.4

5.5

2.1

12.0

ug/l

1.17

(3022145) Colonoscopy Study observation

17.31

18.36

2.8

1.1

—

(4035726)

11.31

12.35

1.4

1.2

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

140

5.50

9.0

5.4

35.3

35.1

g/l

0.09

132

(3012095) Magnesium [Moles/volume] in Serum or Plasma

4.89

5.27

2.3

2.8

0.8

mmol/l

0.81

(3023368) Bacteria identified in Blood by Culture

4.37

4.78

6.3

4.8

—

(40768804) Tissue Pathology biopsy report

144

4.59

4.39

3.5

1.8

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

113

3.25

3.10

8.4

4.6

2.3

mmol/l

0.30

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.79

3.00

1.2

1.4

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

5.86

2.88

6.1

5.5

24.7

25.8

mmol/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

3.17

2.83

2.6

2.0

—

(40758558) Short blood count panel - Blood

3.08

2.81

10.1

9.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

112

2.96

2.67

3.6

3.0

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

3.07

2.45

2.5

2.8

2.7

4.1

e6/l

—

(3033658) Prothrombin time (PT) actual/Normal

2.85

2.44

3.2

3.9

101.1

93.0

0.60

(3002256) Pathology report gross observation

3.28

2.44

2.0

1.2

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

202

2.83

2.21

11.4

7.4

8.0

9.8

umol/l

2.02

189

(3025941) Bacteria identified in Stool by Culture

4.53

2.13

1.0

1.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

214

2.90

2.05

5.6

4.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

142

2.57

2.04

5.8

4.2

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

5.05

2.00

6.0

9.9

0.9

1.4

—

(3014007) Fractional oxyhemoglobin in Arterial blood

5.05

2.00

6.0

10.3

97.4

94.7

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

5.05

2.00

6.0

9.9

0.4

0.8

—

(3044640) Blood type and Crossmatch panel - Blood

2.46

1.87

3.1

2.2

—

(36304419) Bacteria [Presence] in Urine

2.43

1.82

3.7

3.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

3.94

1.67

1.0

—

(3032080) INR in Blood by Coagulation assay

124

2.29

1.66

5.7

6.8

1.0

1.2

inr

—

(42870588) Differential panel, method unspecified - Blood

108

2.27

1.60

5.0

5.4

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

2.46

1.59

5.0

3.9

2.5

mmol/l

0.18

(3000492) Spirometry study

3.04

1.50

1.0

1.7

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.43

1.49

9.4

9.2

—

(3001604) Monocytes [#/volume] in Blood

157

2.18

1.46

3.4

5.7

0.5

0.6

e9/l

0.04

144

(3006315) Basophils [#/volume] in Blood

157

2.18

1.46

3.5

5.8

0.0

e9/l

1.44

144

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.32

1.42

2.1

2.6

0.2

1.0

e6/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

2.26

1.41

1.9

1.3

—

(3001019) Free T4 and TSH panel - Serum or Plasma

3.22

1.40

1.8

1.6

—

(3019198) Lymphocytes [#/volume] in Blood

160

2.11

1.35

3.8

5.9

1.3

1.8

e9/l

2.37

148

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.04

1.33

2.4

1.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

124

2.06

1.31

2.2

1.9

87.1

99.5

pmol/l

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

2.65

1.30

8.3

8.0

112.7

119.0

g/l

—

(3000991) Gas panel - Venous blood

2.87

1.25

6.4

8.1

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.87

1.25

1.6

2.2

—

(3013115) Eosinophils [#/volume] in Blood

164

2.02

1.22

4.3

5.8

0.2

e9/l

0.37

150

(3021589) Normoblasts [#/volume] in Blood

127

1.99

1.21

17.2

10.7

0.0

e9/l

0.00

102

(3007853) Bacteria identified in Skin by Aerobe culture

2.63

1.20

1.3

1.5

—

(3048689) Calprotectin [Mass/mass] in Stool

2.37

1.12

1.3

1.7

92.9

96.8

ug/g

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.29

1.09

1.1

1.6

—

(3016502) Oxygen saturation in Arterial blood

2.44

0.98

8.3

7.6

98.3

95.6

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

107

1.86

0.97

4.7

2.6

57.4

54.9

u/l

0.12

(21494755) Public health laboratory ask at order entry panel

2.26

0.94

1.0

1.3

—

(36660697) Celiac disease serology panel - Serum

0.00

0.81

0.0

1.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.72

0.77

2.8

1.6

—

(3003694) ABO and Rh group [Type] in Blood

1.77

0.72

1.3

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

308

0.57

0.68

3.7

5.8

37.0

39.9

mmol/mol

1.81

286

(40760892) CBC W Ordered Manual Differential panel - Blood

1.76

0.66

4.6

4.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.68

0.53

1.7

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.68

0.53

1.7

1.5

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.70

0.45

1.4

2.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

0.42

0.0

1.2

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

1.42

0.42

1.4

1.7

3.6

0.8

mg/l

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.41

0.0

1.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

0.41

0.0

1.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

301

1.73

0.40

22.7

15.3

37.9

39.6

1.29

219

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

101

1.44

0.38

1.4

2.1

95.8

112.7

u/l

0.21

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

121

1.40

0.36

2.5

3.5

24.3

29.8

u/l

0.88

113

(3002385) Erythrocyte distribution width [Ratio]

266

1.38

0.34

33.6

18.2

13.8

13.7

0.17

261

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

181

1.36

0.33

3.1

2.7

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

324

0.77

0.31

3.9

4.6

5.7

5.8

mmol/l

0.47

299

(3041096) Erythrocytes [Presence] in Urine by Automated

1.39

0.30

3.9

3.6

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

305

0.79

0.28

4.6

4.8

2.0

1.8

mu/l

0.30

276

(3015171) Extractable nuclear Ab [Units/volume] in Serum

0.00

0.22

0.0

1.3

—

(40768443) Skin Pathology biopsy report

0.00

0.22

0.0

1.4

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.22

0.0

1.7

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

0.00

0.22

0.0

4.4

—

24.6

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.22

0.0

1.8

—

93.3

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

0.00

0.22

0.0

2.6

—

(3020891) Body temperature

0.00

0.22

0.0

4.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

0.22

0.0

1.3

—

(3022313) Gas panel - Capillary blood

0.00

0.22

0.0

4.4

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3013512) EKG study

1.29

0.20

3.6

3.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.23

0.19

1.6

1.3

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

181

1.22

0.17

6.9

4.5

6.6

6.5

mmol/l

0.04

171

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

115

1.20

0.13

3.5

4.0

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

134

0.85

0.11

2.6

2.3

74.7

76.0

nmol/l

0.05

119

(3011397) Hemoglobin [Presence] in Urine by Test strip

0.85

0.08

2.7

3.3

—

(1761868) Lipid panel - Serum or Plasma

109

0.89

0.04

1.9

3.0

—

(3026008) Bacteria identified in Urine by Culture

106

0.92

0.01

4.4

2.7

—

(3015736) pH of Urine

113

0.96

0.00

2.5

3.4

—

(3044889) 12 lead EKG panel

237

1.03

0.00

4.0

3.9

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

5.5

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

283.2

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

0.91

0.00

1.3

1.4

2.0

2.3

g/l

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

0.00

0.0

1.4

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.8

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.0

1.1

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.0

4.7

—

1.8

—

(3026493) Urate [Moles/volume] in Serum or Plasma

0.93

0.00

1.4

2.4

30991.3

6172.9

umol/l

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.0

1.0

—

(3010130) Cytomegalovirus IgG Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.2

—

(1002224) Polysomnography panel

0.00

0.0

1.1

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

2.2

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.0

1.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.1

—

(3037522) Nuclear Ab [Titer] in Serum

0.98

0.00

1.2

1.4

—

805.0

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

3.1

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: C3_COLORECTAL_SQUAM – Colorectal squamous cell carcinoma

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Colorectal squamous cell carcinoma

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Case counts by code for Colorectal squamous cell carcinoma (C3_COLORECTAL_SQUAM)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints