No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
81 |
4. Check minimum number of eventsNone |
81 |
5. Include endpointsNone |
81 |
6. Filter based on genotype QC (FinnGen only) |
81 |
Control definitions (FinnGen only)
- Control exclude
- H7_OCUMUSCLE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H50
- Name in latin
- Strabismus mechanicus
Similar endpoints
↥List of similar endpoints to
Mechanical strabismus
based on the number of shared cases.
Similar with more cases:
- Other strabismus
- Strabismus
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 628 | 362 | 266 |
| Only index persons | 526 | 307 | 219 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | - | 33.99 | 31.00 |
| Only index persons | 44.68 | 45.23 | 43.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 81 | 56 | 25 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | 54.61 | 51.62 | 61.29 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 71
- Matched controls
- 709
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H50.6
ICD-10 Finland
Mechanical strabismus
+∞
102.0
71
*
H53.2
ICD-10 Finland
Diplopia
94.3
30.4
32
6
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
150.5
28.1
28
*
CEC00
NOMESCO Finland
Recession of extraocular muscle
+∞
26.8
24
*
CEW99
NOMESCO Finland
Other operation on extraocular muscle
+∞
24.4
22
*
H50.2
ICD-10 Finland
Vertical strabismus
+∞
22.0
20
*
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
+∞
20.8
19
*
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
+∞
20.8
19
*
H50.0
ICD-10 Finland
Convergent concomitant strabismus
+∞
20.8
19
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
24.9
20.3
29
19
XCW99
NOMESCO Finland
Other investigative procedure of eye
14.1
17.8
33
41
H50.8
ICD-10 Finland
Other specified strabismus
+∞
12.9
12
*
H03BB01
ATC
carbimazole; oral
12.7
12.1
22
24
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
142.1
11.8
12
*
CE2W4
NOMESCO Finland
Eye movement mapping
+∞
11.8
11
*
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
+∞
10.7
10
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
13.4
9.4
16
15
H03AA01
ATC
levothyroxine sodium; systemic
5.1
9.2
37
125
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
+∞
8.5
8
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
7.8
8.5
20
34
XCD10
NOMESCO Finland
Electrophysiological examination of eye
38.2
8.3
10
*
WF002
NOMESCO Finland
Radical radiotherapy
14.1
8.0
13
11
ZXA10
NOMESCO Finland
Bilateral
5.1
7.9
28
80
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
8.6
7.9
17
25
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.3
7.7
38
151
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
89.0
7.6
8
*
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
+∞
7.4
7
*
CAC10
NOMESCO Finland
Reconstruction of orbital wall using bone graft or plate
+∞
7.4
7
*
H50.1
ICD-10 Finland
Divergent concomitant strabismus
+∞
7.4
7
*
CAC44
NOMESCO Finland
Combined decompression of orbit
+∞
7.4
7
*
S02.30
ICD-10 Finland
Fracture of orbital floor, closed
76.4
6.5
7
*
CEC30
NOMESCO Finland
Resection of extraocular muscle
+∞
6.3
6
*
ZX050
NOMESCO Finland
Stereotactic radiotherapy
+∞
6.3
6
*
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
14.3
6.3
10
8
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
5.7
6.2
18
40
Mortality – FinRegistry
↥Association
Association between endpoint H7_STRABMECH and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have H7_STRABMECH.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: H7_STRABMECH – Mechanical strabismus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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