Cutaneous autosensitization

L12_CUT_AUTOSENS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L30.2 Cause of death: ICD-10 — L30.2 2 out of 7 registries used, show all original rules.	49
4. Check minimum number of events None	49
5. Include endpoints None	49
6. Filter based on genotype QC (FinnGen only)	49

Control definitions (FinnGen only)

Control exclude: L12_DERMATITISECZEMA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L30
Name in latin: Reactio "id"

NAME	L12_CUT_AUTOSENS
CONTROL_EXCLUDE	L12_DERMATITISECZEMA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L302
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L302
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Cutaneous autosensitization based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	378	203	172
Only index persons	355	197	158
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	45.42	45.51	45.03
Only index persons	45.42	46.08	44.60

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	49	32	17
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	49.89	49.61	50.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3000494) Fungus identified in Specimen by Culture

4.06

3.96

1.8

1.3

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

9.09

2.81

1.4

1.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.70

2.67

2.1

1.9

—

(40760892) CBC W Ordered Manual Differential panel - Blood

2.48

2.22

3.4

4.7

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

3.33

2.04

2.5

7.3

1.0

mmol/l

—

(40768443) Skin Pathology biopsy report

4.92

1.99

1.4

1.2

—

(3023368) Bacteria identified in Blood by Culture

2.40

1.89

4.5

4.4

—

(3032080) INR in Blood by Coagulation assay

117

2.20

1.81

3.5

7.2

1.3

1.2

inr

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.61

1.79

1.5

1.3

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

3.85

1.66

1.4

1.1

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

3.58

1.56

6.0

3.8

0.5

0.8

—

(3021960) Folate [Moles/volume] in Serum or Plasma

2.28

1.56

1.2

1.5

19.6

21.1

nmol/l

0.21

(3014007) Fractional oxyhemoglobin in Arterial blood

3.35

1.47

6.0

3.7

94.8

90.6

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

3.35

1.47

6.0

3.7

1.8

2.5

—

(3022096) Basophils/100 leukocytes in Blood

181

1.93

1.40

6.8

5.0

0.5

0.7

0.90

162

(3013826) Glucose [Moles/volume] in Serum or Plasma

212

1.90

1.33

6.7

4.1

6.8

6.7

mmol/l

0.15

188

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.20

1.29

2.7

2.3

0.6

0.4

e6/l

—

(3006504) Eosinophils/100 leukocytes in Blood

186

1.85

1.25

6.8

4.9

2.9

2.7

0.18

167

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

134

1.83

1.17

2.0

1.7

104.1

100.8

pmol/l

—

(3019069) Monocytes/100 leukocytes in Blood

189

1.80

1.16

6.9

5.2

8.0

8.2

0.14

173

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

199

1.79

1.15

7.2

5.7

8.3

10.0

umol/l

1.09

190

(3018010) Neutrophils/100 leukocytes in Blood

191

1.77

1.11

6.5

4.7

57.1

0.01

174

(3042936) Bacteria identified in Isolate by Culture

2.11

1.11

1.6

1.7

—

(40761535) Cells panel - Urine sediment

2.23

1.08

2.1

3.7

—

(3023520) Reticulocytes [#/volume] in Blood

2.41

1.06

1.0

3.2

87.0

78.2

e9/l

—

(3044640) Blood type and Crossmatch panel - Blood

129

1.77

1.04

2.4

1.8

—

(3002030) Lymphocytes/100 leukocytes in Blood

195

1.71

1.00

6.9

5.0

28.9

28.4

0.09

176

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

122

1.75

0.99

3.0

2.4

—

(3003396) Base excess in Arterial blood by calculation

2.39

0.97

15.0

8.9

1.1

0.8

mmol/l

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

1.82

0.93

1.5

1.2

1.1

0.6

u/ml

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

1.89

0.91

1.7

1.2

1.1

18.4

u/ml

—

(40768804) Tissue Pathology biopsy report

154

1.64

0.85

2.2

1.9

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

1.87

0.68

5.6

2.9

2.5

1.3

mmol/l

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.87

0.68

2.2

1.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

182

1.50

0.63

4.3

3.7

—

(3019225) pH of Specimen

1.74

0.63

2.6

4.5

—

(3003694) ABO and Rh group [Type] in Blood

117

1.55

0.63

1.2

1.6

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.62

0.0

1.7

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.62

0.0

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.62

0.0

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.62

0.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.62

0.0

1.5

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.61

0.0

1.5

—

(36660697) Celiac disease serology panel - Serum

1.87

0.61

1.2

1.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.60

0.56

1.6

2.2

—

(3000492) Spirometry study

1.61

0.55

1.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

361

1.59

0.52

5.2

4.8

2.0

1.8

mu/l

0.37

333

(3012095) Magnesium [Moles/volume] in Serum or Plasma

1.57

0.50

4.4

3.0

0.9

0.8

mmol/l

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.50

0.48

3.1

2.1

—

(3044889) 12 lead EKG panel

270

0.72

0.46

2.6

3.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.48

0.45

3.1

2.2

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

116

1.42

0.44

5.8

2.0

53.3

54.0

u/l

0.04

107

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

378

1.52

0.43

14.0

9.5

89.5

85.7

ml/min/173m2

0.88

305

(3005033) Fetal Nuchal fold Thickness US

0.00

0.41

0.0

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.41

0.0

1.4

—

(3026008) Bacteria identified in Urine by Culture

1.43

0.41

2.5

2.7

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.40

0.0

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.48

0.40

1.6

2.2

—

(3010813) Leukocytes [#/volume] in Blood

454

0.70

0.39

29.6

17.1

7.2

6.6

e9/l

0.98

444

(3026361) Erythrocytes [#/volume] in Blood

454

0.70

0.39

29.5

17.0

4.5

e12/l

0.17

443

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.43

0.39

1.6

2.1

—

(3033658) Prothrombin time (PT) actual/Normal

1.40

0.33

8.1

3.0

98.1

97.9

0.01

(36304419) Bacteria [Presence] in Urine

1.37

0.32

2.6

2.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.32

0.31

1.4

2.1

—

(40761511) CBC panel - Blood by Automated count

427

0.76

0.30

18.7

10.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

261

1.27

0.28

4.8

3.9

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

400

1.35

0.25

19.0

12.1

139.5

139.7

mmol/l

0.22

394

(3007461) Platelets [#/volume] in Blood

453

0.72

0.24

29.4

17.0

272.6

252.7

e9/l

0.95

446

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.39

0.24

3.2

1.9

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.28

0.23

6.4

5.4

103.2

104.3

mmol/l

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.21

0.0

1.2

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.21

0.0

4.4

—

(1761868) Lipid panel - Serum or Plasma

152

0.80

0.20

1.8

2.4

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.20

0.0

3.5

—

15.6

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.6

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

424

1.37

0.18

18.2

12.6

69.2

72.7

umol/l

1.42

424

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.77

0.17

2.7

1.8

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.77

0.17

1.3

1.4

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

402

1.31

0.16

19.0

12.1

3.9

4.0

mmol/l

1.25

395

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

281

1.17

0.15

4.0

3.9

—

(3009542) Hematocrit [Volume Fraction] of Blood

375

1.20

0.12

19.3

11.9

41.2

39.8

1.19

283

(42870588) Differential panel, method unspecified - Blood

135

1.16

0.11

8.8

4.8

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.12

0.10

3.4

5.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.12

0.10

1.2

1.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

0.78

0.09

1.4

1.9

—

(3015736) pH of Urine

147

1.13

0.08

5.4

3.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.16

0.07

3.8

3.6

—

(3013512) EKG study

111

0.88

0.07

2.7

3.0

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

151

1.09

0.04

3.4

3.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

107

0.92

0.02

2.6

—

(40758558) Short blood count panel - Blood

106

1.05

0.00

11.2

5.9

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.0

1.1

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

3.2

—

105.2

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

2.7

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

3.2

—

4.2

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.02

0.00

1.2

1.6

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

5.0

—

55.2

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.2

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

3.2

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.2

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.0

3.6

—

57.6

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

2.4

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3048689) Calprotectin [Mass/mass] in Stool

0.88

0.00

2.2

2.0

268.4

77.3

ug/g

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.3

—

(1616796) Gas panel - Central venous blood

0.00

0.0

1.6

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

1.7

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.0

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

0.0

1.4

—

0.8

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.2

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

3.3

—

10.4

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

4.0

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

4.1

—

1.9

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

3.3

—

1.6

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

2.0

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_CUT_AUTOSENS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_CUT_AUTOSENS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_CUT_AUTOSENS – Cutaneous autosensitization

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Cutaneous autosensitization

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints