Poikiloderma of Civatte

L12_POIKOLOCIVAT

photosensitivity disease: Photosensitivity refers to various symptoms, diseases and conditions caused or aggravated by exposure to sunlight.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L57.3 Cause of death: ICD-10 — L57.3 2 out of 7 registries used, show all original rules.	59
4. Check minimum number of events None	59
5. Include endpoints None	59
6. Filter based on genotype QC (FinnGen only)	59

Control definitions (FinnGen only)

Control exclude: L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L57
Name in latin: Poikiloderm[i]a Civatte

NAME	L12_POIKOLOCIVAT
CONTROL_EXCLUDE	L12_RADIATIONRELATEDSKIN
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L573
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L573
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Poikiloderma of Civatte based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	307	186	121
Only index persons	294	181	113
Unadjusted period prevalence (%)
Whole population	0.00	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	-	54.65	53.29
Only index persons	53.91	54.48	52.99

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	59	43	16
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	53.98	53.01	56.57

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
53: Matched controls
531

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L57.3

ICD-10 Finland

Poikiloderma of Civatte

+∞

75.9

L57.0

ICD-10 Finland

Actinic keratosis

17.2

6.7

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

5.53

4.72

1.4

—

(3045414) Leukocytes [Presence] in Urine

8.20

4.00

3.4

1.4

—

(3019150) Specific gravity of Urine by Refractometry

111

2.96

3.80

4.8

4.4

—

1.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

2.95

3.63

1.5

—

(3037522) Nuclear Ab [Titer] in Serum

3.06

3.46

1.3

1.4

186.7

794.3

titre

—

(3000494) Fungus identified in Specimen by Culture

3.29

3.26

1.4

1.3

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

3.95

3.21

1.6

1.5

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

10.75

3.03

1.4

1.0

—

(3002256) Pathology report gross observation

2.85

2.73

1.5

1.1

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

7.66

2.60

1.2

1.1

—

(40761535) Cells panel - Urine sediment

3.14

2.33

4.7

3.6

—

(3023368) Bacteria identified in Blood by Culture

121

2.30

2.29

3.1

3.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

165

2.17

3.5

2.8

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.88

2.04

1.6

1.7

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.41

2.02

1.4

1.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

322

2.24

1.99

2.5

2.9

—

(42529406) Shigella sp [Presence] in Stool by Culture

3.80

1.89

1.7

1.3

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

3.80

1.89

1.7

1.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

3.80

1.89

1.7

1.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

2.66

1.79

1.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.53

1.76

1.3

1.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

101

2.13

1.74

4.2

3.8

—

(3032080) INR in Blood by Coagulation assay

169

1.96

1.69

28.1

11.6

1.6

1.2

inr

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

170

1.95

1.65

2.1

1.9

98.7

106.5

pmol/l

0.52

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.04

1.47

1.4

1.3

—

(40768804) Tissue Pathology biopsy report

212

1.84

1.47

3.5

1.9

—

(3037467) Urinalysis macro (dipstick) panel - Urine

321

1.91

1.43

5.1

3.9

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.11

1.39

1.2

1.4

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.04

1.35

2.2

2.5

0.3

1.1

e6/l

—

(4010399)

2.56

1.35

1.1

1.4

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

2.78

1.24

50.4

4.8

24.6

25.1

mmol/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.99

1.15

1.2

1.8

—

(3008898) HLA-B27 [Presence]

2.50

1.11

1.6

1.1

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.96

1.10

9.3

7.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.13

1.10

1.1

1.8

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

1.00

0.0

1.6

—

(3025941) Bacteria identified in Stool by Culture

2.01

0.97

2.6

1.1

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.27

0.94

42.3

5.0

0.5

0.8

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.27

0.94

40.0

5.0

1.1

1.5

—

(3018095) Leukocytes [#/volume] in Urine

167

1.62

0.93

4.2

3.4

3.5

33.3

e6/l

0.98

124

(3022621) pH of Urine by Test strip

2.04

0.87

4.0

2.1

—

(3015736) pH of Urine

188

1.57

0.87

4.7

3.5

—

(3026008) Bacteria identified in Urine by Culture

143

1.60

0.85

2.6

2.7

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.81

0.85

1.1

1.9

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.82

0.80

1.7

1.5

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

145

1.57

0.80

2.7

2.2

111.9

108.8

u/l

0.06

137

(40758558) Short blood count panel - Blood

120

1.59

0.75

8.2

7.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.65

0.74

1.4

1.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

194

1.50

0.73

4.8

3.8

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.93

0.70

1.2

1.5

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.93

0.70

50.6

5.3

93.2

95.3

—

(3012544) pH of Venous blood

1.79

0.65

4.6

3.8

—

(40768793) Breast Pathology biopsy report

0.00

0.61

0.0

1.2

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

1.54

0.61

1.4

1.3

1.5

8.1

u/ml

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

183

1.42

0.57

5.0

3.8

16.4

31.8

ng/l

0.65

119

(3012516) Albumin [Mass/volume] in Urine

128

1.46

0.56

2.8

3.0

164.5

25.7

mg/l

—

(3042936) Bacteria identified in Isolate by Culture

1.50

0.55

3.2

1.7

—

(3019225) pH of Specimen

1.56

0.53

1.5

5.5

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

112

1.45

0.51

1.3

0.6

1.0

u/ml

—

(42870588) Differential panel, method unspecified - Blood

150

1.39

0.48

8.7

4.9

—

(3022145) Colonoscopy Study observation

1.45

0.47

1.3

1.2

—

(36304419) Bacteria [Presence] in Urine

124

1.40

0.45

3.0

2.6

—

(3000991) Gas panel - Venous blood

1.67

0.44

53.4

4.1

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.45

0.41

1.1

2.5

2.3

2.4

g/l

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

1.2

—

87.4

—

(1761868) Lipid panel - Serum or Plasma

187

0.73

0.40

4.9

2.9

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.40

0.33

1.1

2.5

13.2

12.9

umol/l

—

(3019309) Folate [Moles/volume] in Red Blood Cells

1.32

0.26

1.2

1.7

1075.1

1413.2

nmol/l

0.95

(3002582) Erythrocytes [#/volume] in Urine

144

1.25

0.26

3.8

2.8

12.9

44.7

e6/l

0.74

115

(3020682) Albumin/Creatinine [Ratio] in Urine

135

1.25

0.25

3.3

3.7

13.2

4.6

mg/mmol

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.34

0.24

1.4

—

(3022096) Basophils/100 leukocytes in Blood

214

1.20

0.22

10.4

5.1

0.6

0.7

0.24

198

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.0

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.28

0.21

1.7

1.6

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(4035726)

1.22

0.20

2.0

1.3

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.20

0.0

4.1

—

22.7

—

(3003694) ABO and Rh group [Type] in Blood

131

0.80

0.19

1.5

1.4

—

(3013512) EKG study

139

1.21

0.19

5.3

3.5

—

(3022217) INR in Platelet poor plasma by Coagulation assay

0.71

0.18

29.4

21.0

—

1.1

—

(3009542) Hematocrit [Volume Fraction] of Blood

460

0.83

0.18

26.8

13.0

35.8

40.2

0.88

345

(3018418) pH of Serum or Plasma

140

1.20

0.17

4.3

4.5

—

7.4

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

179

1.18

0.17

2.5

2.7

51.3

55.0

u/l

0.28

168

(40760892) CBC W Ordered Manual Differential panel - Blood

133

1.17

0.13

5.1

4.4

—

(40768797) Stomach Pathology biopsy report

1.11

0.08

1.0

1.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

508

1.20

0.07

20.9

13.4

28.2

21.0

mg/l

0.74

386

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

109

1.13

0.07

4.1

2.0

—

(3002030) Lymphocytes/100 leukocytes in Blood

228

1.09

0.06

10.8

5.1

29.4

29.9

0.10

211

(3018010) Neutrophils/100 leukocytes in Blood

228

1.09

0.06

10.8

4.9

57.0

55.5

0.34

215

(3044889) 12 lead EKG panel

359

0.94

0.03

6.1

3.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

232

1.06

0.02

5.7

4.2

—

(3002385) Erythrocyte distribution width [Ratio]

417

0.94

0.01

23.6

15.9

13.5

13.6

0.22

411

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

479

1.01

0.00

15.3

11.9

82.9

82.1

ml/min/173m2

0.10

397

(3041096) Erythrocytes [Presence] in Urine by Automated

149

1.01

0.00

3.8

3.2

—

(3044640) Blood type and Crossmatch panel - Blood

151

0.99

0.00

4.1

2.0

—

(44790047)

0.00

0.0

1.8

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

1.2

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.2

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.6

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.2

—

7.7

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(40761511) CBC panel - Blood by Automated count

524

1.11

0.00

17.7

12.4

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.0

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.3

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

1.8

—

4.6

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

1.6

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.3

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

1.8

—

59.6

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

5.7

—

27.0

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.2

—

(44806118)

0.00

0.0

1.8

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.2

—

(44790048)

0.00

0.0

1.8

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.4

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.4

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.0

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

2.1

—

8.9

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.0

—

(44790049)

0.00

0.0

1.8

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

1.3

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

12.1

—

(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid

0.00

0.0

1.2

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.6

—

91.8

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

2.3

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

2.1

—

4.9

—

(4281824)

0.00

0.0

1.0

—

(1616796) Gas panel - Central venous blood

0.00

0.0

1.4

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.5

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.2

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.5

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_POIKOLOCIVAT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_POIKOLOCIVAT.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_POIKOLOCIVAT – Poikiloderma of Civatte

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Poikiloderma of Civatte

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints