Postinflammatory hyperpigmentation

L12_POSTINFHYPERPIGM

obsolete_incontinentia pigmenti achromians: a dermal melanocytic condition affecting the shoulder area. Nevus of Ito often occurs in association with nevus of Ota in the same patient but is much less common, although the true incidence is unknown.

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L81.0 Cause of death: ICD-10 — L81.0 2 out of 7 registries used, show all original rules.	57
4. Check minimum number of events None	57
5. Include endpoints None	57
6. Filter based on genotype QC (FinnGen only)	52

Control definitions (FinnGen only)

Control exclude: L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L81
Name in latin: Hyperpigmentatio postinflammatoria cutis

NAME	L12_POSTINFHYPERPIGM
CONTROL_EXCLUDE	L12_OTHERSKINSUBCUTIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L810
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L810
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Postinflammatory hyperpigmentation based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	536	307	226
Only index persons	490	288	202
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	49.03	53.76	42.84
Only index persons	50.25	52.89	46.48

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	52	32	20
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	54.68	52.72	57.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
57: Matched controls
570

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L81.0

ICD-10 Finland

Postinflammatory hyperpigmentation

+∞

81.7

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

17.5

14.2

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768443) Skin Pathology biopsy report

11.94

7.83

1.3

1.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

4.10

5.40

2.1

1.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.71

3.64

1.8

1.6

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

7.79

3.47

2.1

3.9

4.71

0.10

g/l

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

3.31

3.27

11.4

3.8

1.21

1.04

mmol/l

1.06

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

4.88

3.15

1.6

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

6.47

3.12

2.1

3.4

—

(4035726) Immunohistochemistry procedure

3.88

3.01

1.9

1.3

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

7.29

2.94

2.3

1.6

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

7.29

2.94

2.3

4.2

0.00

g/l

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

7.29

2.94

2.3

4.2

0.00

g/l

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

7.29

2.94

2.3

4.2

0.00

g/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.27

2.85

2.0

1.7

—

(3004588) Protein electrophoresis panel - Serum or Plasma

4.71

2.79

2.1

4.6

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

6.55

2.77

2.0

1.5

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

5.16

2.69

2.1

2.0

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

2.82

2.66

3.5

3.3

24.80

311.33

ng/l

—

(3000494) Fungus identified in Specimen by Culture

2.87

2.61

1.9

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

103

2.45

2.44

5.5

2.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

215

2.27

2.33

15.8

5.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.77

2.32

1.6

1.4

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

5.96

2.26

1.0

1.3

—

(3015171) Extractable nuclear Ab [Units/volume] in Serum

5.96

2.26

1.4

1.3

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

5.36

2.11

1.4

1.2

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

5.36

2.11

1.2

2.0

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

4.34

2.10

1.3

1.1

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

4.34

2.10

2.2

1.9

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

2.61

2.09

3.5

1.8

30.35

30.07

0.05

(3011397) Hemoglobin [Presence] in Urine by Test strip

102

2.29

2.08

4.1

3.3

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

253

2.15

1.99

8.6

3.9

7.11

6.35

mmol/l

0.91

234

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

4.06

1.99

2.3

1.2

—

(3000991) Gas panel - Venous blood

3.15

1.95

25.6

6.0

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

245

2.11

1.94

11.9

5.6

11.06

10.62

umol/l

0.11

233

(4200892) Spirometry reversibility

2.86

1.90

1.9

1.4

—

(3020682) Albumin/Creatinine [Ratio] in Urine

106

2.19

1.88

5.2

3.5

15.86

17.86

mg/mmol

0.07

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.32

1.86

8.3

5.7

24.51

23.97

mmol/l

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

4.45

1.86

1.0

1.1

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

4.10

1.75

2.0

1.7

247.20

170.35

ug/l

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.40

1.71

1.7

1.4

—

(3022217) INR in Platelet poor plasma by Coagulation assay

187

1.98

1.70

27.2

13.0

1.11

1.21

inr

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.54

1.66

1.9

1.6

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

276

1.97

1.60

19.2

9.2

3.92

4.31

e9/l

0.45

249

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

2.18

1.56

1.1

1.3

19.13

11.94

u/ml

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.07

1.55

12.7

6.1

—

(40758558) Short blood count panel - Blood

123

1.96

1.50

14.7

7.8

—

(3012516) Albumin [Mass/volume] in Urine

2.02

1.48

4.6

3.1

54.07

102.56

mg/l

0.48

(40768804) Tissue Pathology biopsy report

186

1.86

1.44

2.8

2.0

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.79

1.40

15.8

6.3

0.53

0.69

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.79

1.40

15.3

6.3

0.83

1.51

—

(3042936) Bacteria identified in Isolate by Culture

2.18

1.40

4.3

2.1

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.24

1.34

22.0

7.3

105.89

104.36

mmol/l

—

(3045414) Leukocytes [Presence] in Urine

2.94

1.31

1.6

1.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

212

1.75

1.22

5.1

2.5

—

(3021589) Normoblasts [#/volume] in Blood

213

1.74

1.20

17.4

8.7

0.00

e9/l

0.50

174

(3023103) Potassium [Moles/volume] in Serum or Plasma

462

2.43

1.16

31.5

13.7

3.95

3.96

mmol/l

0.10

442

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

465

2.35

1.16

26.0

11.9

23.14

24.61

mg/l

0.10

360

(3019550) Sodium [Moles/volume] in Serum or Plasma

461

2.46

1.16

30.9

13.5

139.25

139.60

mmol/l

0.48

442

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.43

1.15

20.4

5.4

1.29

1.01

mmol/l

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

2.51

1.11

17.2

6.2

21.60

23.90

mmol/l

—

(3018095) Leukocytes [#/volume] in Urine

161

1.72

1.11

5.7

3.5

31.63

87.21

e6/l

0.81

110

(36304419) Bacteria [Presence] in Urine

126

1.76

1.10

5.6

2.4

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

2.03

1.04

6.9

3.0

11.50

10.45

umol/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.14

1.04

2.7

4.0

—

(3002582) Erythrocytes [#/volume] in Urine

137

1.71

1.03

5.5

2.7

40.31

71.30

e6/l

0.35

106

(3044889) 12 lead EKG panel

309

1.69

1.02

4.4

3.3

—

(3023368) Bacteria identified in Blood by Culture

121

1.71

0.98

10.2

4.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

343

1.70

0.96

3.0

3.2

—

(3044640) Blood type and Crossmatch panel - Blood

140

1.66

0.94

6.0

2.3

—

(3022621) pH of Urine by Test strip

2.19

0.92

2.5

2.9

—

(3012544) pH of Venous blood

2.11

0.90

20.2

2.9

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.98

0.84

1.2

1.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

135

1.61

0.83

2.1

1.9

—

(1761868) Lipid panel - Serum or Plasma

166

0.58

0.81

4.4

2.5

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.28

0.78

1.4

1.6

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.90

0.76

1.6

2.1

—

(3007164) IgA [Mass/volume] in Serum or Plasma

103

1.62

0.74

2.2

1.3

2.87

2.42

g/l

—

(3025941) Bacteria identified in Stool by Culture

2.09

0.74

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

136

0.60

0.72

5.3

3.3

—

(3002385) Erythrocyte distribution width [Ratio]

409

1.65

0.70

30.0

14.9

16.31

14.91

0.59

401

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

168

1.50

0.70

2.9

1.6

96.27

100.93

pmol/l

0.18

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.66

0.69

2.5

1.5

—

(3035350) Ketones [Presence] in Urine by Test strip

228

1.45

0.63

4.5

3.6

0.00

estimate

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.61

0.0

1.6

—

(36660697) Celiac disease serology panel - Serum

1.80

0.60

1.2

1.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

232

1.41

0.56

5.3

5.0

0.00

estimate

—

(3009261) Glucose [Presence] in Urine by Test strip

234

1.39

0.52

4.6

3.7

0.20

0.00

estimate

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.52

0.52

1.4

1.3

—

(3002256) Pathology report gross observation

1.50

0.45

1.6

1.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

320

1.34

0.42

7.0

4.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

163

1.35

0.42

9.5

2.9

—

(40768793) Breast Pathology biopsy report

0.00

0.40

0.0

1.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.47

0.40

1.8

—

(40761511) CBC panel - Blood by Automated count

494

1.60

0.39

21.5

11.1

—

(3026008) Bacteria identified in Urine by Culture

137

1.34

0.38

3.4

2.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

110

1.36

0.36

2.4

1.7

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

1.28

0.31

4.7

4.1

35.00

34.37

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

177

0.79

0.26

6.7

3.7

—

(3000492) Spirometry study

1.38

0.24

1.4

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.21

0.0

1.1

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

71.00

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.5

—

88.90

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.21

0.0

2.9

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.21

0.0

1.9

—

(1616796) Gas panel - Central venous blood

0.00

0.21

0.0

1.9

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

1.42

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.21

0.0

4.4

—

15.70

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(3022145) Colonoscopy Study observation

1.22

0.20

1.3

1.4

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

0.00

0.20

0.0

1.7

—

128.14

—

(40768797) Stomach Pathology biopsy report

1.26

0.19

1.1

1.4

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.79

0.16

1.7

1.8

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

332

1.14

0.13

4.3

2.8

48.43

43.39

u/l

0.18

314

(40761536) Microorganisms panel - Urine sediment

1.05

0.09

7.2

2.7

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.04

0.07

2.0

2.3

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

161

1.08

0.04

7.4

3.0

46.35

29.45

u/l

0.73

152

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

159

1.01

0.00

3.1

3.2

25.09

47.28

ng/l

0.48

103

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

105

0.94

0.00

2.1

1.6

—

(3013512) EKG study

125

1.05

0.00

2.4

3.6

—

(3029937) Albumin [Presence] in Urine by Test strip

122

0.98

0.00

7.8

3.6

0.00

estimate

—

(3003694) ABO and Rh group [Type] in Blood

148

1.02

0.00

1.3

1.6

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

1.3

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

1.4

—

59.50

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.2

—

13.17

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

1.4

—

5.02

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.2

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.2

—

(3000012) Reticulocyte production index

0.00

0.0

2.0

—

(4146454) Self-monitoring of blood glucose

0.00

0.0

1.7

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

2.9

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

2.3

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

-0.00

0.0

2.1

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

2.44

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

-0.00

0.0

1.3

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

-0.00

0.0

2.6

—

6.08

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.03

-0.00

2.4

2.2

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

11.8

—

1196.40

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.6

—

41.00

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

-0.00

0.0

2.6

—

1.28

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

6.4

—

806.80

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

-0.00

0.0

1.4

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_POSTINFHYPERPIGM and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_POSTINFHYPERPIGM.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_POSTINFHYPERPIGM – Postinflammatory hyperpigmentation

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Postinflammatory hyperpigmentation

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints