Postinflammatory hyperpigmentation

L12_POSTINFHYPERPIGM

obsolete_incontinentia pigmenti achromians: a dermal melanocytic condition affecting the shoulder area. Nevus of Ito often occurs in association with nevus of Ota in the same patient but is much less common, although the true incidence is unknown.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L81.0 Cause of death: ICD-10 — L81.0 2 out of 7 registries used, show all original rules.	54
4. Check minimum number of events None	54
5. Include endpoints None	54
6. Filter based on genotype QC (FinnGen only)	54

Control definitions (FinnGen only)

Control exclude: L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L81
Name in latin: Hyperpigmentatio postinflammatoria cutis

NAME	L12_POSTINFHYPERPIGM
CONTROL_EXCLUDE	L12_OTHERSKINSUBCUTIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L810
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L810
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Postinflammatory hyperpigmentation based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	536	307	226
Only index persons	490	288	202
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	49.03	53.76	42.84
Only index persons	50.25	52.89	46.48

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	54	33	21
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	52.84	47.11	61.85

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768443) Skin Pathology biopsy report

11.10

10.69

1.2

1.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

4.00

4.96

2.2

1.8

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

7.84

3.48

2.1

3.9

4.7

0.1

g/l

—

(42870588) Differential panel, method unspecified - Blood

143

2.78

3.31

14.6

5.0

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

5.17

3.28

1.6

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

6.51

3.13

2.1

3.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.48

3.09

1.9

1.7

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

3.33

3.07

12.2

4.0

1.2

1.0

mmol/l

0.97

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

7.33

2.95

2.3

4.2

0.0

g/l

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

7.33

2.95

2.3

4.2

0.0

g/l

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

7.33

2.95

2.3

4.2

0.0

g/l

—

(4035726)

3.73

2.94

1.8

1.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.65

2.77

5.5

2.3

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

5.19

2.69

2.1

2.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.03

2.35

2.1

1.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

4.30

2.34

2.3

4.8

—

(3000494) Fungus identified in Specimen by Culture

2.80

2.34

1.9

1.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.45

2.32

4.1

3.4

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

5.99

2.26

2.2

1.6

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

2.69

2.18

3.5

1.8

30.4

30.1

0.05

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.86

2.13

8.3

6.3

24.5

23.8

mmol/l

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

5.38

2.12

2.2

1.5

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

5.38

2.12

1.2

2.0

—

(3023939) Sjogrens syndrome-A extractable nuclear Ab [Units/volume] in Serum

5.38

2.12

1.4

1.1

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

4.36

2.10

2.2

1.9

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.68

2.05

1.6

1.4

—

(40768804) Tissue Pathology biopsy report

170

2.18

2.04

2.8

2.0

—

(3000991) Gas panel - Venous blood

3.29

2.03

25.6

6.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

4.08

1.99

2.3

1.2

—

(3032080) INR in Blood by Coagulation assay

157

2.10

1.86

13.6

7.5

1.2

inr

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.61

1.80

1.7

1.4

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

4.12

1.75

1.4

1.1

—

(40758558) Short blood count panel - Blood

118

2.10

1.73

14.8

7.4

—

(3042936) Bacteria identified in Isolate by Culture

2.42

1.70

4.3

2.2

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

236

2.02

1.68

12.5

5.4

11.3

10.7

umol/l

0.14

224

(3020682) Albumin/Creatinine [Ratio] in Urine

103

2.12

1.67

5.8

3.9

17.3

18.4

mg/mmol

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.56

1.64

1.9

1.6

—

(3045414) Leukocytes [Presence] in Urine

3.56

1.56

1.6

1.7

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

243

1.92

1.47

9.3

4.0

6.8

6.4

mmol/l

0.57

226

(3013650) Neutrophils [#/volume] in Blood by Automated count

265

1.91

1.41

19.8

9.1

4.0

4.4

e9/l

0.43

239

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.80

1.41

15.8

6.3

0.5

0.7

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.80

1.41

15.3

6.3

0.8

1.5

—

(36304419) Bacteria [Presence] in Urine

118

1.94

1.39

5.6

2.5

—

(3018095) Leukocytes [#/volume] in Urine

153

1.88

1.37

5.7

3.6

31.6

90.5

e6/l

0.84

105

(3021589) Normoblasts [#/volume] in Blood

199

1.85

1.36

17.4

8.8

0.0

e9/l

0.50

165

(4010399)

2.50

1.33

2.0

1.3

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

2.09

1.33

1.2

1.3

19.1

6.5

u/ml

—

(3002582) Erythrocytes [#/volume] in Urine

129

1.87

1.30

5.5

2.8

40.3

72.7

e6/l

0.36

101

(3012516) Albumin [Mass/volume] in Urine

1.95

1.28

4.8

3.2

58.3

105.8

mg/l

0.44

(3019550) Sodium [Moles/volume] in Serum or Plasma

435

2.36

1.17

32.5

13.7

139.1

139.5

mmol/l

0.58

416

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.44

1.15

2.9

4.2

—

(3044640) Blood type and Crossmatch panel - Blood

134

1.78

1.14

6.0

2.3

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.52

1.11

15.0

5.9

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

2.52

1.11

17.2

6.2

21.6

23.9

mmol/l

—

(1761868) Lipid panel - Serum or Plasma

153

0.51

1.11

4.7

2.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

201

1.69

1.04

7.1

4.0

—

(3044889) 12 lead EKG panel

290

1.72

1.03

4.3

3.4

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.96

1.03

7.6

3.0

12.4

11.1

umol/l

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

440

2.22

1.02

27.1

12.0

23.8

24.6

mg/l

0.05

344

(3023103) Potassium [Moles/volume] in Serum or Plasma

436

2.34

1.02

33.1

13.9

4.0

mmol/l

0.08

416

(3022621) pH of Urine by Test strip

2.37

0.97

2.5

3.0

—

(3012544) pH of Venous blood

2.28

0.95

20.2

2.9

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

160

1.63

0.90

2.9

1.6

96.3

101.4

pmol/l

0.20

(3041096) Erythrocytes [Presence] in Urine by Automated

131

0.54

0.88

5.9

3.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.05

0.87

1.2

1.0

—

(3023368) Bacteria identified in Blood by Culture

117

1.66

0.85

11.2

4.2

—

(36660697) Celiac disease serology panel - Serum

1.92

0.82

1.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.29

0.78

1.4

1.6

—

(3025941) Bacteria identified in Stool by Culture

2.19

0.77

1.2

1.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.91

0.76

1.7

2.2

—

(3007164) IgA [Mass/volume] in Serum or Plasma

1.64

0.73

2.2

1.3

3.0

2.4

g/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

327

1.55

0.69

3.1

3.2

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.61

0.0

1.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

154

1.47

0.61

9.5

2.9

—

(3037467) Urinalysis macro (dipstick) panel - Urine

306

1.41

0.51

7.2

4.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.54

0.50

1.2

1.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

135

1.38

0.42

2.2

1.9

—

(40768793) Breast Pathology biopsy report

0.00

0.41

0.0

1.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.43

0.39

1.8

—

(40761511) CBC panel - Blood by Automated count

465

1.58

0.39

22.3

11.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.41

0.33

2.7

1.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

171

0.76

0.32

7.1

3.6

—

(3002256) Pathology report gross observation

1.37

0.32

1.4

1.1

—

(40768797) Stomach Pathology biopsy report

1.37

0.32

1.1

1.4

—

(3026008) Bacteria identified in Urine by Culture

131

1.31

0.32

3.4

2.7

—

(3015736) pH of Urine

179

1.28

0.32

4.2

3.3

—

(3002385) Erythrocyte distribution width [Ratio]

372

1.29

0.28

33.5

15.4

14.0

13.6

0.62

367

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.21

0.0

1.1

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.21

0.0

2.9

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

70.0

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.21

0.0

1.9

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

1.4

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.21

0.0

4.4

—

15.7

—

(4034850)

0.00

0.21

0.0

20.0

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

0.00

0.21

0.0

2.2

—

24.8

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

0.00

0.20

0.0

1.3

—

2.2

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

0.00

0.20

0.0

1.7

—

128.1

—

(3022145) Colonoscopy Study observation

1.20

0.20

1.3

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

101

1.24

0.18

8.4

4.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.79

0.16

1.7

1.8

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

106

1.17

0.11

2.6

1.7

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

315

1.12

0.10

4.4

2.8

46.4

43.6

u/l

0.09

297

(3013512) EKG study

117

1.15

0.09

2.4

3.7

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.05

0.08

2.4

2.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.06

0.07

2.0

2.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

411

1.10

0.04

35.2

13.1

37.8

40.0

0.86

307

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

154

1.06

0.01

7.7

3.0

47.6

28.6

u/l

0.79

145

(3003694) ABO and Rh group [Type] in Blood

141

0.99

0.00

1.3

1.6

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

1.4

—

5.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

2.9

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.3

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

1.4

—

59.5

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

2.1

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.7

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.2

—

(4146454)

0.00

0.0

1.7

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

2.3

—

90.7

—

(1616796) Gas panel - Central venous blood

0.00

0.0

2.0

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.4

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.8

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.3

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

6.4

—

806.8

—

(3016701) Glucose [Moles/volume] in Serum or Plasma --2 hours post dose glucose

0.00

0.0

1.0

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

11.8

—

1196.4

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

2.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

1.6

—

41.0

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

2.6

—

6.1

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.0

—

13.2

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

100

1.00

0.00

2.1

1.6

—

(4281824)

0.00

0.0

1.0

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

1.3

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

2.6

—

1.3

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_POSTINFHYPERPIGM and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_POSTINFHYPERPIGM.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_POSTINFHYPERPIGM – Postinflammatory hyperpigmentation

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Postinflammatory hyperpigmentation

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints