Sweet's syndrome

L12_SWEET_SDR

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L98.2 Cause of death: ICD-10 — L98.2 2 out of 7 registries used, show all original rules.	46
4. Check minimum number of events None	46
5. Include endpoints None	46
6. Filter based on genotype QC (FinnGen only)	46

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze: DF7

NAME	L12_SWEET_SDR
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L982
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L982
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Sweet's syndrome based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Febrile neutrophilic dermatosis [Sweet]

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	272	141	130
Only index persons	252	130	122
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	58.60	57.94	59.42
Only index persons	57.46	55.77	59.27

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	46	31	15
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	61.92	62.17	61.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768443) Skin Pathology biopsy report

10.13

11.38

1.7

1.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

8.60

10.72

6.2

1.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

5.99

8.49

2.3

1.4

3.2

2.7

g/l

0.25

(42870588) Differential panel, method unspecified - Blood

129

6.51

8.42

16.8

4.7

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

6.06

8.21

2.7

2.6

23.4

21.8

0.11

(3021440) Promyelocytes/100 leukocytes in Blood

6.94

7.81

7.4

5.5

0.1

—

(3037522) Nuclear Ab [Titer] in Serum

5.55

7.30

1.6

1.4

106.7

502.5

titre

—

(3017181) Myelocytes/100 leukocytes in Blood

6.47

7.29

7.5

5.3

0.6

0.9

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

7.03

6.69

5.9

1.0

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

6.58

6.68

1.5

1.3

—

(3025159) Blasts/100 leukocytes in Blood

6.08

6.18

7.8

5.8

0.0

—

(40760888) Immunoglobulin light chains.free panel - Serum

15.54

5.86

6.2

8.7

—

(3002179) Metamyelocytes/100 leukocytes in Blood

5.65

5.72

7.5

5.1

0.3

0.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

4.92

5.64

3.1

4.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

6.45

5.30

1.4

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

4.47

5.03

7.7

4.9

1.2

1.0

mmol/l

0.81

(3023368) Bacteria identified in Blood by Culture

114

3.95

5.00

10.7

4.5

—

(3037756) Immunofixation for Serum or Plasma

13.46

4.99

5.5

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

5.06

4.78

1.4

1.6

—

(3042936) Bacteria identified in Isolate by Culture

4.06

4.60

3.6

2.3

—

(3032080) INR in Blood by Coagulation assay

153

3.76

4.46

9.7

7.9

1.2

1.3

inr

0.17

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

4.50

4.43

1.5

1.4

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

9.39

4.25

1.4

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

8.52

4.05

2.3

1.9

—

(3026493) Urate [Moles/volume] in Serum or Plasma

104

3.42

4.03

5.9

3.2

313.3

6395.6

umol/l

0.79

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.63

3.93

2.2

2.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

145

3.38

3.91

3.6

3.5

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

13.49

3.87

1.7

1.4

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

8.91

3.70

1.1

1.3

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

11.23

3.60

1.2

1.7

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

8.01

3.50

6.4

1.6

61.1

62.0

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

8.01

3.50

1.6

14.5

10.5

mg/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

3.16

3.43

9.8

5.2

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

129

3.05

3.38

3.5

2.2

134.5

157.0

u/l

0.15

121

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.63

3.35

1.7

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

6.65

3.15

1.3

1.1

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

6.65

3.15

1.1

1.7

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

6.65

3.15

2.0

1.3

1.1

1.2

g/l

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

6.65

3.15

1.6

1.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.46

3.12

3.5

1.5

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

186

3.04

3.12

9.4

5.3

1.2

mmol/l

1.38

169

(21494890) Protein electrophoresis panel - 24 hour Urine

10.98

3.05

5.6

1.0

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

10.98

3.05

1.4

1.6

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

10.98

3.05

1.0

1.2

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

10.98

3.05

1.2

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

10.98

3.05

1.0

1.4

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

10.98

3.05

1.4

1.6

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

10.98

3.05

1.4

1.6

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

10.98

3.05

1.4

1.6

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

10.98

3.05

1.4

1.6

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

10.98

3.05

1.4

1.6

—

(3000494) Fungus identified in Specimen by Culture

3.38

3.02

1.4

1.5

—

(3022145) Colonoscopy Study observation

3.30

2.92

1.6

1.4

—

(36304419) Bacteria [Presence] in Urine

122

2.77

2.84

3.3

3.1

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

9.14

2.82

1.2

1.3

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

6.70

2.79

4.8

1.4

4.9

6.2

e9/l

—

(3026008) Bacteria identified in Urine by Culture

126

2.65

2.62

2.4

2.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.18

2.60

1.6

1.7

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

3.03

2.55

1.5

1.6

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

2.78

2.51

1.6

1.3

39.9

5.4

u/ml

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

5.56

2.48

1.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.86

2.44

1.2

1.3

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

6.84

2.43

1.6

1.4

—

(3037467) Urinalysis macro (dipstick) panel - Urine

269

2.91

2.40

6.0

4.3

—

(3018418) pH of Serum or Plasma

133

2.46

2.27

7.3

4.1

7.4

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

4.75

2.23

1.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.65

2.21

1.6

1.4

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

4.95

1.99

1.2

1.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.56

1.97

1.7

1.3

—

(3029937) Albumin [Presence] in Urine by Test strip

115

2.31

1.94

4.2

4.1

0.0

estimate

—

(40761536) Microorganisms panel - Urine sediment

2.84

1.90

4.8

4.0

—

(3031040) Bacteria [#/volume] in Urine by Automated count

260

2.45

1.80

5.8

4.5

—

101.2

—

(4010399)

2.99

1.65

1.3

1.4

—

(40768804) Tissue Pathology biopsy report

159

2.07

1.57

2.4

1.9

—

(3003327) Ova and parasites identified in Stool by Light microscopy

3.13

1.56

1.0

1.6

—

(4035726)

2.66

1.46

2.0

1.2

—

(40768797) Stomach Pathology biopsy report

2.27

1.43

1.6

1.2

—

(3035350) Ketones [Presence] in Urine by Test strip

201

2.00

1.42

3.4

3.8

0.0

estimate

—

(40758558) Short blood count panel - Blood

2.05

1.36

29.2

7.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

159

1.89

1.26

2.8

2.0

86.6

97.6

pmol/l

0.61

(3021601) Nitrite [Presence] in Urine by Test strip

197

1.90

1.25

4.0

5.0

0.0

estimate

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

2.82

1.25

7.6

7.5

24.8

24.3

mmol/l

—

(3019060) Gas panel - Arterial blood

2.57

1.18

6.6

3.6

—

(3009261) Glucose [Presence] in Urine by Test strip

201

1.83

1.14

3.6

3.8

0.0

estimate

—

(3016502) Oxygen saturation in Arterial blood

2.18

1.12

8.3

5.5

94.8

95.9

—

(3003396) Base excess in Arterial blood by calculation

2.13

1.10

8.3

5.7

1.8

1.2

mmol/l

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

2.08

1.08

8.3

5.4

5.2

5.1

kpa

—

(3027801) Oxygen [Partial pressure] in Arterial blood

2.08

1.08

8.3

5.4

11.2

12.6

kpa

—

(3015736) pH of Urine

156

1.79

1.07

2.5

3.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

167

1.75

1.02

5.9

4.5

62.0

29.5

ng/l

0.55

119

(21494755) Public health laboratory ask at order entry panel

0.00

1.01

0.0

1.2

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

2.05

0.99

6.1

5.1

1.2

mmol/l

—

(3044640) Blood type and Crossmatch panel - Blood

132

1.75

0.97

8.2

2.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.81

0.97

8.1

2.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

151

1.72

0.95

4.0

3.9

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

1.82

0.90

1.9

1.3

13.2

43.6

iu/ml

—

(3022217) INR in Platelet poor plasma by Coagulation assay

1.91

0.83

8.8

20.2

—

1.3

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.21

0.77

7.0

6.0

23.7

24.9

mmol/l

—

(3041096) Erythrocytes [Presence] in Urine by Automated

113

1.64

0.74

3.9

3.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

349

1.77

0.69

45.9

15.5

37.3

40.3

0.90

257

(3002256) Pathology report gross observation

1.69

0.65

1.3

1.1

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

105

0.61

0.57

3.6

4.8

0.8

1.7

ug/l

—

(3013512) EKG study

120

1.51

0.56

4.0

4.1

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

396

0.67

0.56

4.0

4.9

4.6

mmol/l

0.48

371

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

197

1.46

0.54

8.8

3.9

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

402

0.69

0.44

4.4

5.5

2.7

mmol/l

0.10

369

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.58

0.43

1.0

1.3

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.48

0.42

1.4

1.3

—

(3002385) Erythrocyte distribution width [Ratio]

336

1.52

0.42

51.4

18.3

14.4

13.7

2.24

331

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.42

0.0

1.5

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.42

0.0

1.6

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.41

0.0

2.2

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

392

0.71

0.41

4.0

4.9

1.4

1.5

mmol/l

0.50

360

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

146

1.38

0.41

8.7

3.0

28.2

32.1

u/l

0.47

133

(3019225) pH of Specimen

1.53

0.38

7.5

3.6

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.53

0.38

1.7

2.5

27.8

29.0

u/l

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

1.49

0.37

11.0

5.8

107.0

122.5

g/l

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

385

0.70

0.33

3.9

4.4

1.6

1.2

mmol/l

0.70

354

(3000991) Gas panel - Venous blood

1.39

0.24

7.0

6.6

—

(40761535) Cells panel - Urine sediment

1.32

0.24

3.2

3.6

—

(3012544) pH of Venous blood

1.32

0.24

2.8

4.1

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

33.7

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.2

—

19.0

—

(3027008) Opiates [Presence] in Urine

0.00

0.21

0.0

1.1

—

(1002224) Polysomnography panel

0.00

0.21

0.0

1.0

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.20

0.0

1.4

—

(4094501)

0.00

0.20

0.0

1.0

—

(3020682) Albumin/Creatinine [Ratio] in Urine

118

0.81

0.16

3.4

4.0

2.5

3.2

mg/mmol

—

(1761868) Lipid panel - Serum or Plasma

155

0.86

0.11

2.4

3.1

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.05

0.09

6.0

8.1

—

(3044889) 12 lead EKG panel

308

1.13

0.07

5.2

3.9

—

(3003694) ABO and Rh group [Type] in Blood

109

0.89

0.04

1.4

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

122

1.09

0.03

4.0

3.6

1827.9

1774.8

ng/l

0.02

104

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.7

—

53.5

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

2.1

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

3.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

230

1.00

0.00

2.1

3.0

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.7

—

(4146454)

0.00

0.0

3.4

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.0

3.5

—

62.8

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

2.3

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.00

0.00

3.0

3.9

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_SWEET_SDR and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_SWEET_SDR.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: L12_SWEET_SDR – Sweet's syndrome

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Sweet's syndrome

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints