Febrile neutrophilic dermatosis [Sweet]

L12_FEBRILENEUTROPHIL

skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L98.2 Cause of death: ICD-10 — L98.2 2 out of 7 registries used, show all original rules.	46
4. Check minimum number of events None	46
5. Include endpoints None	46
6. Filter based on genotype QC (FinnGen only)	46

Control definitions (FinnGen only)

Control exclude: L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L98
Name in latin: Dermatosis neutrophila febrilis (Sweet)

NAME	L12_FEBRILENEUTROPHIL
CONTROL_EXCLUDE	L12_OTHERSKINSUBCUTIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L982
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L982
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Febrile neutrophilic dermatosis [Sweet] based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Sweet's syndrome

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	272	141	130
Only index persons	252	130	122
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	58.60	57.94	59.42
Only index persons	57.46	55.77	59.27

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	46	31	15
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	61.92	62.17	61.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768443) Skin Pathology biopsy report

15.82

15.54

1.7

1.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

9.92

12.11

6.2

1.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

6.47

9.24

2.3

1.3

3.2

2.5

g/l

0.36

(3037522) Nuclear Ab [Titer] in Serum

6.60

8.81

1.6

1.5

106.7

461.8

titre

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

6.45

8.78

2.7

2.6

23.4

22.6

0.05

(42870588) Differential panel, method unspecified - Blood

126

6.73

8.74

16.8

4.6

—

(3021440) Promyelocytes/100 leukocytes in Blood

7.47

8.37

7.4

4.5

0.1

0.0

—

(3017181) Myelocytes/100 leukocytes in Blood

7.19

8.08

7.5

4.4

0.6

0.5

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

7.03

6.69

5.9

1.0

—

(3025159) Blasts/100 leukocytes in Blood

6.58

6.68

7.8

4.7

0.0

—

(3002179) Metamyelocytes/100 leukocytes in Blood

6.58

6.68

7.5

4.3

0.3

0.0

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

6.32

6.42

1.5

1.3

—

(40760888) Immunoglobulin light chains.free panel - Serum

18.15

6.19

6.2

9.7

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

5.31

6.16

3.1

4.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

5.89

5.63

1.4

1.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

6.11

5.04

1.4

1.5

—

(3037756) Immunofixation for Serum or Plasma

13.46

4.99

5.5

1.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

4.94

4.93

1.5

—

(3023368) Bacteria identified in Blood by Culture

116

3.86

4.83

10.7

4.3

—

(3042936) Bacteria identified in Isolate by Culture

4.06

4.60

3.6

2.3

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

10.44

4.48

2.3

2.0

—

(3032080) INR in Blood by Coagulation assay

153

3.76

4.46

9.7

8.1

1.2

1.3

inr

0.11

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

13.42

4.43

6.4

1.5

61.1

57.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.91

4.37

2.2

1.8

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

9.39

4.25

1.4

—

(3026493) Urate [Moles/volume] in Serum or Plasma

102

3.51

4.19

5.9

3.1

313.3

6399.0

umol/l

0.79

(40760892) CBC W Ordered Manual Differential panel - Blood

3.44

3.92

9.9

4.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

145

3.38

3.91

3.6

3.5

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

13.49

3.87

1.2

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

13.49

3.87

1.2

1.8

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

13.49

3.87

1.7

1.4

—

(3020779) Urea [Moles/volume] in Serum or Plasma

4.35

3.74

5.5

6.4

6.0

9.1

mmol/l

1.19

(3030905) Polymorphonuclear cells [#/volume] in Blood

11.23

3.60

4.8

1.2

5.0

6.1

e9/l

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

8.01

3.50

1.1

1.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.72

3.46

1.7

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

128

3.09

3.44

3.5

2.1

134.5

156.1

u/l

0.14

121

(3007853) Bacteria identified in Skin by Aerobe culture

3.63

3.35

3.5

1.4

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

7.27

3.32

2.0

1.2

1.1

1.2

g/l

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

7.27

3.32

1.3

1.1

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

7.27

3.32

1.6

1.0

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

7.27

3.32

1.1

1.7

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

183

3.13

3.26

9.4

5.3

1.2

mmol/l

1.23

166

(3000494) Fungus identified in Specimen by Culture

3.46

3.12

1.4

1.6

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

3.13

3.05

1.6

1.3

39.9

5.9

u/ml

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

10.98

3.05

1.4

1.6

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

10.98

3.05

1.4

1.6

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

10.98

3.05

1.4

1.6

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

10.98

3.05

1.2

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

10.98

3.05

1.4

1.6

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

10.98

3.05

1.4

1.6

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

10.98

3.05

1.4

1.6

—

(36304419) Bacteria [Presence] in Urine

122

2.77

2.84

3.3

3.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

260

3.16

2.82

6.0

4.3

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

9.14

2.82

1.2

1.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

3.16

2.73

1.5

1.6

—

(3022145) Colonoscopy Study observation

3.16

2.73

1.6

1.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.25

2.70

1.6

1.7

—

(3026008) Bacteria identified in Urine by Culture

125

2.68

2.4

2.8

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

6.08

2.63

1.2

1.1

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

5.56

2.48

1.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.86

2.44

1.2

1.3

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

6.84

2.43

1.6

1.0

—

(3029937) Albumin [Presence] in Urine by Test strip

106

2.57

2.40

4.1

4.2

0.0

estimate

—

(3018418) pH of Serum or Plasma

132

2.48

2.32

7.3

3.9

7.4

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

6.07

2.27

1.2

1.0

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.50

2.13

1.6

1.5

—

(40761536) Microorganisms panel - Urine sediment

3.00

2.08

4.8

3.7

—

(3031040) Bacteria [#/volume] in Urine by Automated count

253

2.60

2.03

5.8

4.7

—

121.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.40

1.88

1.7

1.3

—

(3003327) Ova and parasites identified in Stool by Light microscopy

3.47

1.72

1.0

1.4

—

(3035350) Ketones [Presence] in Urine by Test strip

193

2.15

1.68

3.4

3.7

0.0

estimate

—

(4010399)

2.99

1.65

1.3

1.4

—

(40768804) Tissue Pathology biopsy report

158

2.09

1.60

2.4

1.9

—

(3021601) Nitrite [Presence] in Urine by Test strip

189

2.04

1.50

4.0

5.0

0.0

estimate

—

(40768797) Stomach Pathology biopsy report

2.31

1.49

1.6

1.2

—

(3009261) Glucose [Presence] in Urine by Test strip

193

1.97

1.37

3.6

3.8

0.0

estimate

—

(40758558) Short blood count panel - Blood

2.05

1.36

29.3

7.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

157

1.93

1.32

2.8

2.0

86.6

96.4

pmol/l

0.52

(3015736) pH of Urine

150

1.89

1.26

2.5

3.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

143

1.86

1.19

4.0

3.9

—

(4035726)

2.57

1.18

2.0

1.3

—

(3019060) Gas panel - Arterial blood

2.48

1.16

6.6

3.5

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

2.40

1.14

6.1

4.4

1.2

mmol/l

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

163

1.82

1.14

5.9

4.2

62.0

28.9

ng/l

0.57

120

(3016502) Oxygen saturation in Arterial blood

2.04

1.06

8.3

5.3

94.8

95.7

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.42

1.06

7.0

5.5

23.7

25.3

mmol/l

—

(3003396) Base excess in Arterial blood by calculation

1.99

1.04

8.3

5.5

1.8

1.2

mmol/l

—

(3022217) INR in Platelet poor plasma by Coagulation assay

1.99

1.04

8.8

20.1

—

1.1

—

(3044640) Blood type and Crossmatch panel - Blood

130

1.79

1.03

8.2

2.3

—

(3027801) Oxygen [Partial pressure] in Arterial blood

1.95

1.02

8.3

5.2

11.2

12.4

kpa

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.95

1.02

8.3

5.2

5.1

kpa

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

1.90

1.01

1.9

1.3

13.2

45.7

iu/ml

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.99

0.0

1.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.79

0.93

8.1

2.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

108

1.74

0.89

3.9

3.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

349

1.77

0.69

45.9

15.7

37.3

40.1

0.83

262

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

193

1.51

0.62

8.8

3.9

—

(3013512) EKG study

118

1.55

0.61

4.0

4.1

—

(3002256) Pathology report gross observation

1.58

0.61

1.3

1.1

—

(3019225) pH of Specimen

1.66

0.57

7.5

3.8

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

396

0.67

0.56

4.0

4.8

4.9

4.6

mmol/l

0.46

372

(3002385) Erythrocyte distribution width [Ratio]

333

1.57

0.53

51.4

18.3

14.4

13.7

2.23

328

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

104

0.61

0.46

3.6

4.7

0.8

1.6

ug/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.69

0.44

1.0

1.3

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

401

0.70

0.44

4.4

5.5

2.7

mmol/l

0.12

370

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

145

1.40

0.43

8.7

2.9

28.2

29.6

u/l

0.18

132

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.42

0.0

1.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.45

0.42

1.4

1.3

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.41

0.0

2.2

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

392

0.71

0.41

4.0

4.8

1.4

1.5

mmol/l

0.53

362

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.49

0.37

1.7

2.6

27.8

28.9

u/l

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

1.42

0.36

11.0

5.6

107.0

121.7

g/l

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

385

0.70

0.33

3.9

4.3

1.6

1.2

mmol/l

0.70

356

(3000991) Gas panel - Venous blood

1.39

0.24

7.0

6.6

—

(3012544) pH of Venous blood

1.35

0.24

2.8

4.2

—

(40761535) Cells panel - Urine sediment

1.35

0.24

3.2

3.5

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.1

—

18.6

—

(3027008) Opiates [Presence] in Urine

0.00

0.21

0.0

1.1

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

33.7

—

(1002224) Polysomnography panel

0.00

0.21

0.0

1.0

—

(4094501)

0.00

0.21

0.0

1.0

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.4

—

(3020682) Albumin/Creatinine [Ratio] in Urine

114

0.84

0.11

3.4

4.1

2.5

3.0

mg/mmol

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.12

0.10

6.0

8.3

—

(1761868) Lipid panel - Serum or Plasma

154

0.87

0.10

2.4

3.0

—

(3044889) 12 lead EKG panel

306

1.15

0.10

5.2

3.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.04

0.07

3.0

3.8

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

120

1.12

0.05

4.0

3.5

1827.9

1191.1

ng/l

0.33

104

(3003694) ABO and Rh group [Type] in Blood

108

0.91

0.03

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

229

1.01

0.00

2.1

2.9

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.6

—

(3035880) pH of Pleural fluid

0.00

0.0

1.2

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.2

—

59.6

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

2.9

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(4146454)

0.00

0.0

3.4

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.4

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

2.2

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.7

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.0

3.1

—

56.8

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

2.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_FEBRILENEUTROPHIL and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_FEBRILENEUTROPHIL.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: L12_FEBRILENEUTROPHIL – Febrile neutrophilic dermatosis [Sweet]

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Febrile neutrophilic dermatosis [Sweet]

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints