No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditions
|
- |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
- Control exclude
- C3_CANCER, C3_CANCER_WIDE
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF9
- Parent code in ICD-10
- D02
- Name in latin
- Carcinoma in situ bronchi
Similar endpoints
↥List of similar endpoints to
Carcinoma in situ of larynx
based on the number of shared cases.
Similar with more cases:
- Carcinoma in situ of larynx
- Carcinoma in situ of middle ear and respiratory system
- Carcinoma in situ of middle ear and respiratory system
- In situ neoplasms
- In situ neoplasms
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | - | - | - |
| Only index persons | - | - | - |
| Unadjusted period prevalence (%) | |||
| Whole population | - | - | - |
| Only index persons | - | - | - |
| Median age at first event (years) | |||
| Whole population | - | - | - |
| Only index persons | - | - | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 58 | 11 | 47 |
| Unadjusted period prevalence (%) | 0.02 | 0.00 | 0.02 |
| Median age at first event (years) | 64.56 | 38.69 | 70.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 56
- Matched controls
- 559
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
DQB10
NOMESCO Finland
Endoscopic excision of lesion of larynx
145.3
29.3
29
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
56.5
25.8
30
11
C32.0
ICD-10 Finland
Malignant neoplasm: Glottis
+∞
24.8
22
*
D14.1
ICD-10 Finland
Benign neoplasm: Larynx
126.3
22.7
23
*
DQA10
NOMESCO Finland
Biopsy of larynx
+∞
22.4
20
*
D02.0
ICD-10 Finland
Carcinoma in situ: Larynx
+∞
20.0
18
*
8070/2-C32.0
ICD-O-3
Squamous cell carcinoma in situ, NOS, of glottis
+∞
18.8
17
*
D38.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Larynx
+∞
17.6
16
*
C320, 8077, 2
ICD-O-3
NA
+∞
15.3
14
*
130
Kela drug reimbursment
Malignant tumour
+∞
14.1
13
*
J37.0
ICD-10 Finland
Chronic laryngitis
39.6
13.9
17
6
J38.3
ICD-10 Finland
Other diseases of vocal cords
91.2
13.3
14
*
ZXC10
NOMESCO Finland
Use of laser
36.4
12.9
16
6
WF002
NOMESCO Finland
Radical radiotherapy
+∞
11.9
11
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
9.6
9
*
A03FA01
ATC
metoclopramide; systemic, rectal
13.0
9.6
17
18
UDQ22
NOMESCO Finland
Microlaryngoscopy
29.8
9.4
12
5
EP1AE
NOMESCO Finland
Neck ultrasound examination
20.6
9.1
13
8
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
8.5
8
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
5.5
7.7
27
81
2310A
ICD-9 Finland
Carcinoma in situ of respiratory system, Larynx
+∞
7.4
7
*
C32.9
ICD-10 Finland
Malignant neoplasm: Larynx, unspecified
+∞
7.4
7
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
16.7
7.2
11
8
WX404
NOMESCO Finland
Intravenous generell anesthesy
5.9
7.2
22
55
XX3DW
NOMESCO Finland
Time consuming IT work
13.3
6.6
11
10
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
6.4
6
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
+∞
6.4
6
*
8070/2-C32.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of larynx, NOS
+∞
6.4
6
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
13.2
6.1
10
9
Mortality – FinRegistry
↥Association
Association between endpoint CD2_INSITU_LARYNX_EXALLC and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have CD2_INSITU_LARYNX_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: CD2_INSITU_LARYNX_EXALLC – Carcinoma in situ of larynx
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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