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This is a non-core endpoint: only basic statistics are computed.

Secondary lactase deficiency

E4_LACTOSEC

lactose intolerance: Inability to fully digest and absorb lactose due to limited or no lactase activity in the small intestine. Congenital intolerance is inherited following an autosomal recessive pattern but is rare. It is more often due to a gradual decline of lactase production in adulthood following the ingestion of fewer lactose-containing foods or secondary to an intestinal mucosal brush-border injury. Prevalence is highest among Asians, Native Americans and Africans. Clinical signs include abdominal cramping, bloating, flatulence and diarrhea following the dietary intake of lactose.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E73.1
  • Cause of death: ICD-10 E73.1

2 out of 7 registries used, show all original rules.

46

4. Check minimum number of events

None

46

5. Include endpoints

None

46

6. Filter based on genotype QC (FinnGen only)

46

Control definitions (FinnGen only)

Control exclude
E4_METABOLIA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E73
Name in latin
Deficientia lactasae secundaria

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 449 259 189
Only index persons 412 248 164
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 21.74 28.44 12.62
Only index persons 23.45 29.66 14.06

-FinnGen-

Key figures

All Female Male
Number of individuals 46 30 16
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 44.47 37.73 57.12

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(40761536) Microorganisms panel - Urine sediment
21
34
10.52
13.87
7.9
2.9
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
16
26
8.90
10.23
2.6
3.4
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
27
104
4.86
6.59
6.8
3.1
estimate
0.0
0.0
0.00
17
35
(3022145) Colonoscopy Study observation
14
34
5.48
5.85
1.5
1.3
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
25
104
4.08
5.23
7.3
2.5
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
28
144
3.41
3.97
6.8
2.9
—
—
—
0
0
(3018418) pH of Serum or Plasma
19
78
3.45
3.85
5.5
3.9
ph
7.4
7.4
—
9
22
(3048689) Calprotectin [Mass/mass] in Stool
14
47
3.84
3.80
1.7
2.4
ug/g
45.4
55.7
—
9
34
(3021601) Nitrite [Presence] in Urine by Test strip
31
173
3.43
3.78
7.3
3.7
estimate
0.0
0.0
0.00
18
38
(3035350) Ketones [Presence] in Urine by Test strip
31
173
3.43
3.78
6.6
2.8
estimate
0.0
0.0
0.00
18
36
(1616796) Gas panel - Central venous blood
6
6
11.23
3.60
4.2
1.8
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
20
89
3.21
3.51
7.3
6.7
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
7
10
8.01
3.50
4.7
5.1
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
30
176
3.03
3.16
6.8
2.9
estimate
0.0
0.0
0.00
17
36
(3017766) Complement C4 [Mass/volume] in Serum or Plasma
6
8
8.40
3.15
1.0
1.3
g/l
0.3
0.2
—
6
8
(3004789) Transferrin [Mass/volume] in Serum or Plasma
12
41
3.61
3.13
5.6
1.5
g/l
2.3
2.4
0.11
12
34
(40763571) Iron/Transferrin [Ratio] in Serum or Plasma
12
41
3.61
3.13
5.7
1.5
%
31.4
27.5
0.25
12
35
(3028271) Lactate [Moles/volume] in Capillary blood
5
5
10.98
3.05
1.4
1.8
mmol/l
1.6
1.5
—
5
5
(3037467) Urinalysis macro (dipstick) panel - Urine
36
238
3.36
2.99
7.6
3.2
—
—
—
0
0
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
21
106
2.81
2.85
3.3
2.2
ng/l
16.9
23.3
0.56
14
58
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
24
130
2.77
2.85
12.9
6.8
mmol/l
1.2
1.2
0.01
14
108
(3015171) Extractable nuclear Ab [Units/volume] in Serum
6
10
6.70
2.79
1.3
1.2
—
—
—
0
0
(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma
15
66
2.89
2.58
1.6
1.2
iu/ml
24.4
12.5
—
5
19
(3022948) Iron [Moles/volume] in Serum or Plasma
12
47
3.10
2.51
6.2
1.7
umol/l
17.7
16.2
0.21
12
41
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
15
67
2.84
2.51
1.4
1.3
u/ml
1.0
2.3
—
8
25
(3030467) Casts [#/volume] in Urine by Automated count
18
90
2.64
2.43
4.8
2.0
e6/l
0.3
0.3
0.01
13
64
(3044889) 12 lead EKG panel
34
238
2.64
2.19
4.7
3.4
—
—
—
0
0
(3026493) Urate [Moles/volume] in Serum or Plasma
15
72
2.61
2.16
2.1
1.9
umol/l
17726.7
6834.1
0.25
15
63
(40760892) CBC W Ordered Manual Differential panel - Blood
17
87
2.51
2.15
7.2
5.1
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
18
95
2.47
2.14
3.8
1.8
—
—
—
0
0
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
6
15
4.43
2.11
1.2
1.5
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
17
89
2.44
2.04
5.1
2.0
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
6
16
4.14
2.00
1.7
1.8
—
—
—
0
0
(3003327) Ova and parasites identified in Stool by Light microscopy
5
11
4.95
1.99
1.0
1.6
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
5
11
4.95
1.99
1.0
1.4
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
19
106
2.35
1.98
7.4
2.3
—
—
—
0
0
(3036481) Cortisol [Moles/volume] in Serum or Plasma
8
29
3.12
1.89
2.1
2.9
nmol/l
333.8
398.6
—
8
24
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
16
84
2.39
1.89
1.8
1.6
mmol/l
1.1
1.2
0.16
11
67
(21494755) Public health laboratory ask at order entry panel
0
48
0.00
1.83
0.0
1.3
—
—
—
0
0
(3013512) EKG study
15
78
2.37
1.80
3.4
3.0
—
—
—
0
0
(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
36
272
2.49
1.76
12.4
6.4
u/l
75.4
80.0
0.44
31
241
(3023368) Bacteria identified in Blood by Culture
13
64
2.44
1.75
6.5
4.4
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
20
120
2.18
1.72
6.8
5.5
inr
1.1
1.1
0.24
14
40
(3018095) Leukocytes [#/volume] in Urine
19
112
2.19
1.70
5.3
2.6
e6/l
10.6
31.1
0.91
13
77
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
13
65
2.39
1.69
1.8
2.3
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
6
20
3.29
1.64
1.0
1.3
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
14
74
2.28
1.60
2.4
1.4
mg/l
10.2
0.7
—
9
56
(3002582) Erythrocytes [#/volume] in Urine
17
98
2.17
1.59
5.1
2.1
e6/l
38.2
43.6
0.07
12
72
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
5
16
3.37
1.48
6.6
15.9
mmol/l
24.1
26.3
—
5
16
(40758558) Short blood count panel - Blood
14
77
2.18
1.45
3.4
8.3
—
—
—
0
0
(3006504) Eosinophils/100 leukocytes in Blood
23
154
1.99
1.42
8.1
5.4
%
3.0
2.7
0.24
23
142
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
13
70
2.19
1.41
1.8
2.5
—
—
—
0
0
(3019069) Monocytes/100 leukocytes in Blood
23
155
1.97
1.39
8.3
5.6
%
8.3
8.4
0.08
23
144
(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
14
79
2.11
1.36
3.0
2.5
mg/l
2.9
2.7
0.12
14
68
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
8
35
2.55
1.35
2.1
1.7
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
10
49
2.33
1.33
1.5
1.5
—
—
—
0
0
(3022096) Basophils/100 leukocytes in Blood
22
148
1.93
1.32
8.3
5.6
%
0.5
0.6
0.37
22
136
(3018010) Neutrophils/100 leukocytes in Blood
23
158
1.91
1.29
7.8
5.3
%
56.4
56.7
0.04
23
148
(3013742) Prealbumin [Mass/volume] in Serum or Plasma
6
25
2.60
1.29
2.5
2.4
g/l
0.2
0.2
—
6
25
(3002030) Lymphocytes/100 leukocytes in Blood
23
162
1.84
1.17
8.3
5.5
%
27.4
29.0
0.29
23
149
(3021879) Hepatitis B virus core Ab [Presence] in Serum
7
31
2.48
1.16
1.4
1.4
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
9
48
2.08
1.08
2.2
1.6
—
—
—
0
0
(3033658) Prothrombin time (PT) actual/Normal
12
70
1.97
1.05
3.9
3.4
%
92.0
95.2
0.18
12
70
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
33
272
1.75
0.88
4.1
3.7
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
8
46
1.89
0.88
2.4
2.2
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
9
54
1.83
0.81
2.7
1.4
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
22
166
1.62
0.80
6.4
4.0
—
—
—
0
0
(3012544) pH of Venous blood
5
23
2.31
0.79
5.4
9.0
—
—
—
0
0
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
17
122
1.62
0.74
3.3
2.1
nmol/l
79.3
80.6
0.05
17
103
(3015736) pH of Urine
17
123
1.61
0.72
5.8
2.5
—
—
—
0
0
(3000492) Spirometry study
5
27
1.95
0.71
1.0
1.4
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
12
82
1.63
0.62
2.3
1.5
—
—
—
0
0
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
0
22
0.00
0.61
0.0
1.2
—
—
—
0
0
(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma
9
60
1.62
0.59
2.2
3.1
mmol/l
2.4
2.4
—
9
50
(46235355) HIV 1 and 2 tests - Meaningful Use set
14
101
1.56
0.58
2.9
1.8
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
18
138
1.50
0.57
4.1
2.4
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
13
93
1.55
0.56
1.7
1.7
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
6
40
1.57
0.54
1.5
1.2
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
7
45
1.65
0.52
1.4
1.3
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
19
150
1.45
0.52
2.1
1.8
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
41
377
1.80
0.51
22.7
10.4
mg/l
13.8
21.0
1.05
35
270
(3018677) aPTT in Platelet poor plasma by Coagulation assay
7
48
1.54
0.49
4.1
1.9
s
28.7
28.5
—
7
48
(3002256) Pathology report gross observation
7
48
1.54
0.49
1.1
1.1
—
—
—
0
0
(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction
5
31
1.69
0.44
3.4
4.3
u/l
374.8
236.7
—
5
31
(3019832) Treponema pallidum Ab [Presence] in Serum
8
60
1.40
0.43
2.6
1.8
—
—
—
0
0
(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age
0
16
0.00
0.42
0.0
1.4
—
—
—
0
0
(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma
0
16
0.00
0.42
0.0
1.4
—
—
—
0
0
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
0
16
0.00
0.42
0.0
2.1
—
—
—
0
0
(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight
0
16
0.00
0.42
0.0
1.4
—
—
—
0
0
(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma
0
16
0.00
0.42
0.0
1.4
—
—
—
0
0
(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma
0
17
0.00
0.41
0.0
1.6
—
—
—
0
0
(3021960) Folate [Moles/volume] in Serum or Plasma
10
75
1.43
0.33
2.3
1.3
nmol/l
18.1
22.5
—
10
62
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
15
122
1.34
0.32
2.5
1.6
pmol/l
89.9
91.4
—
9
54
(3003694) ABO and Rh group [Type] in Blood
14
114
1.33
0.29
1.6
1.6
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
8
64
1.30
0.29
5.0
2.6
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
0
11
0.00
0.21
0.0
1.8
—
—
—
0
0
(3020044) Glucose [Moles/volume] in Cerebral spinal fluid
0
11
0.00
0.21
0.0
1.2
—
3.5
—
0
11
(3000330) Specific gravity of Urine by Test strip
0
11
0.00
0.21
0.0
2.2
—
—
—
0
0
(3019473) Protein [Mass/volume] in Cerebral spinal fluid
0
12
0.00
0.21
0.0
1.3
—
480.8
—
0
12
(3047352) Trisomy 18 risk [Likelihood] in Fetus
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
(3005033) Fetal Nuchal fold Thickness US
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
(3043238) Trisomy 21 risk [Likelihood] in Fetus
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
(42529406) Shigella sp [Presence] in Stool by Culture
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
8
96
0.80
0.15
2.8
4.6
ug/l
1.8
2.0
—
8
83
(3044640) Blood type and Crossmatch panel - Blood
10
84
1.24
0.15
4.8
2.6
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
6
73
0.80
0.08
3.7
2.9
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
36
355
1.06
0.00
14.4
11.6
%
39.0
40.1
0.67
25
275
(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma
5
57
0.86
0.00
2.4
3.4
ug/l
0.4
0.8
—
5
41
(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
1.2
—
46.9
—
0
9
(3047007) Chlamydophila sp Ab [Presence] in Serum
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3024891) Influenza virus A+B Ag [Presence] in Specimen
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(44816844) Macroprolactin [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting
0
5
0.00
0.00
0.0
1.2
—
1.0
—
0
5
(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(44790049)
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3044290) Cell count panel - Cerebral spinal fluid
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
(3023410) Appearance of Cerebral spinal fluid
0
6
0.00
0.00
0.0
2.5
—
—
—
0
0
(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3014051) Protein [Presence] in Urine by Test strip
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay
0
5
0.00
0.00
0.0
1.4
—
11.4
—
0
5
(3013327) Hepatitis A virus IgM Ab [Presence] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
9
92
0.97
0.00
1.6
1.5
—
—
—
0
0
(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation
0
6
0.00
0.00
0.0
1.3
—
231.0
—
0
6
(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain
0
8
0.00
0.00
0.0
1.7
—
—
—
0
0
(44790047)
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3043109) Cytology report of Tissue fine needle aspirate Cyto stain
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(44790048)
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(40768800) Prostate Pathology biopsy report
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay
0
7
0.00
0.00
0.0
5.1
—
161.4
—
0
7
(3012110) Lysozyme [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.2
—
14.5
—
0
6
(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(44806118)
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3053028) Streptococcus sp identified in Specimen by Organism specific culture
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint E4_LACTOSEC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_LACTOSEC.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: E4_LACTOSEC – Secondary lactase deficiency

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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