This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Thyrotoxicosis from ectopic thyroid tissue
E4_THYTOXECT
Hyperthyroidism: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
31 |
4. Check minimum number of eventsNone |
31 |
5. Include endpointsNone |
31 |
6. Filter based on genotype QC (FinnGen only) |
31 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E05
- Name in latin
- Thyreotoxicosis ex textu thyreoideo ectopico
Similar endpoints
↥List of similar endpoints to
Thyrotoxicosis from ectopic thyroid tissue
based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 264 | 203 | 60 |
| Only index persons | 240 | 191 | 49 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 50.00 | 48.78 | 54.61 |
| Only index persons | 48.42 | 47.52 | 51.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 31 | 29 | - |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | - |
| Median age at first event (years) | 44.31 | 42.79 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3019225) pH of Specimen
7
14
6.11
2.91
1.9
3.3
—
—
—
0
0
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
5
6
9.61
2.85
1.0
1.2
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
7
18
4.70
2.41
1.3
1.3
—
—
—
0
0
(4010399)
6
14
5.03
2.27
1.8
1.3
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
17
92
2.88
2.11
1.4
1.6
pmol/l
96.2
95.8
—
8
51
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
8
28
3.48
2.03
2.6
7.3
—
—
—
0
0
(3013512) EKG study
15
78
2.79
1.98
4.9
3.4
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
8
31
3.12
1.81
1.3
1.3
—
—
—
0
0
(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma
13
73
2.34
1.37
2.0
2.1
u/l
51.1
49.3
0.09
13
67
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
14
86
2.15
1.17
3.9
4.2
ng/l
17.1
27.0
—
7
63
(3017143) Hepatitis C virus Ab [Presence] in Serum
6
28
2.41
0.98
1.8
1.4
—
—
—
0
0
(3012516) Albumin [Mass/volume] in Urine
10
58
2.07
0.93
3.5
2.6
mg/l
48.3
31.1
—
5
35
(3022145) Colonoscopy Study observation
6
32
2.08
0.87
1.2
1.4
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
9
56
1.85
0.82
2.1
1.7
mg/l
0.7
0.9
—
9
45
(4035726)
0
27
0.00
0.82
0.0
1.4
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
12
80
1.82
0.74
5.3
5.5
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
11
74
1.75
0.64
1.8
1.7
—
—
—
0
0
(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma
0
19
0.00
0.62
0.0
1.5
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
6
36
1.82
0.61
1.5
1.5
—
—
—
0
0
(3008898) HLA-B27 [Presence]
0
15
0.00
0.42
0.0
1.1
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
0
15
0.00
0.42
0.0
3.1
—
—
—
0
0
(3010813) Leukocytes [#/volume] in Blood
31
295
+∞
0.42
24.7
18.6
e9/l
6.5
6.5
0.00
31
289
(3035941) MCH [Entitic mass]
31
295
+∞
0.42
24.6
18.5
pg
30.1
30.1
0.01
31
290
(3026361) Erythrocytes [#/volume] in Blood
31
295
+∞
0.42
24.6
18.6
e12/l
4.6
4.4
1.40
31
288
(3000963) Hemoglobin [Mass/volume] in Blood
31
295
+∞
0.42
24.9
18.7
g/l
136.7
132.3
1.06
31
290
(3007461) Platelets [#/volume] in Blood
31
294
+∞
0.42
24.8
18.6
e9/l
256.2
260.7
0.18
31
288
(3024731) MCV [Entitic volume]
31
294
+∞
0.42
24.5
18.6
fl
90.5
90.9
0.16
31
289
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
14
110
1.50
0.42
4.9
4.1
—
—
—
0
0
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
5
35
1.51
0.41
2.0
2.1
e6/l
1.8
1.1
—
5
18
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
5
35
1.51
0.41
2.4
2.2
e6/l
3.8
3.1
—
5
18
(3037467) Urinalysis macro (dipstick) panel - Urine
21
180
1.52
0.40
8.3
5.0
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
6
44
1.45
0.37
2.2
1.4
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
11
84
1.48
0.36
2.5
11.9
inr
1.1
1.2
—
5
35
(36304419) Bacteria [Presence] in Urine
5
73
0.63
0.30
2.0
2.3
—
—
—
0
0
(3002256) Pathology report gross observation
5
42
1.23
0.22
1.4
1.2
—
—
—
0
0
(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum
0
11
0.00
0.22
0.0
1.1
—
—
—
0
0
(3003327) Ova and parasites identified in Stool by Light microscopy
0
11
0.00
0.22
0.0
1.7
—
—
—
0
0
(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma
0
10
0.00
0.22
0.0
2.3
—
199.3
—
0
10
(40768443) Skin Pathology biopsy report
0
10
0.00
0.22
0.0
1.1
—
—
—
0
0
(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight
0
10
0.00
0.22
0.0
1.1
—
—
—
0
0
(1001926) Buprenorphine [Presence] in Urine by Screen method
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
(3023511) Choriogonadotropin [Units/volume] in Urine
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
(3019473) Protein [Mass/volume] in Cerebral spinal fluid
0
12
0.00
0.21
0.0
1.2
—
400.2
—
0
12
(3000764) Benzodiazepines [Presence] in Urine
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
(1002224) Polysomnography panel
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
(3016879) Cocaine [Presence] in Urine
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
6
51
1.22
0.21
2.5
1.5
—
—
—
0
0
(3027944) Amphetamines [Presence] in Urine
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
(3028300) Cannabinoids [Presence] in Urine
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
(3027008) Opiates [Presence] in Urine
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
7
57
1.29
0.20
6.0
3.8
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
7
59
1.24
0.20
1.4
1.6
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
10
83
1.30
0.18
5.6
2.7
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
8
71
1.17
0.18
1.5
1.6
—
—
—
0
0
(3002582) Erythrocytes [#/volume] in Urine
7
87
0.75
0.17
2.4
2.8
e6/l
18.0
75.4
—
7
63
(3031040) Bacteria [#/volume] in Urine by Automated count
16
176
0.81
0.14
7.4
4.5
—
745.8
—
0
5
(40768804) Tissue Pathology biopsy report
10
114
0.82
0.12
2.9
1.9
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
18
193
0.84
0.10
4.5
3.4
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
6
55
1.11
0.09
2.8
1.8
—
—
—
0
0
(3026782) Osmolality of Urine
6
55
1.11
0.09
5.3
3.1
mosm/kgh2o
673.5
522.0
—
6
45
(1761868) Lipid panel - Serum or Plasma
11
98
1.19
0.09
4.1
2.8
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
5
59
0.82
0.09
3.4
3.3
—
—
—
0
0
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
25
239
1.24
0.08
8.0
5.2
mmol/mol
40.8
38.6
0.65
25
224
(3044889) 12 lead EKG panel
18
168
1.17
0.08
3.2
3.5
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
10
90
1.16
0.06
6.1
3.7
—
—
—
0
0
(3015736) pH of Urine
12
112
1.12
0.03
7.3
3.8
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
11
114
0.95
0.00
8.5
4.0
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
10
95
1.08
0.00
2.6
2.6
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
7
74
0.93
0.00
1.0
1.4
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
7
70
1.00
0.00
2.7
4.9
—
—
—
0
0
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis
0
6
0.00
0.00
0.0
1.0
—
0.0
—
0
6
(3023410) Appearance of Cerebral spinal fluid
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3024891) Influenza virus A+B Ag [Presence] in Specimen
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis
0
6
0.00
0.00
0.0
1.0
—
0.0
—
0
6
(3025130) Human papilloma virus identified in Specimen
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
(4034850)
0
7
0.00
0.00
0.0
5.9
—
—
—
0
0
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
2.6
—
1.6
—
0
5
(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3047181) Lactate [Moles/volume] in Blood
0
8
0.00
0.00
0.0
7.8
—
0.9
—
0
8
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method
0
7
0.00
0.00
0.0
2.1
—
89.9
—
0
7
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3039000) Anion gap in Blood
0
7
0.00
0.00
0.0
6.4
—
9.4
—
0
7
(44816559) Phosphatidylethanol [Mass/volume] in Blood
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis
0
6
0.00
0.00
0.0
1.0
—
38.8
—
0
6
(3030467) Casts [#/volume] in Urine by Automated count
8
78
1.03
0.00
1.7
2.5
e6/l
0.3
0.3
—
8
55
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
25
242
1.17
0.00
14.2
12.0
%
32.0
39.5
1.04
18
171
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011288) Drugs identified in Urine by Screen method
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3043109) Cytology report of Tissue fine needle aspirate Cyto stain
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3022806) Fractional oxyhemoglobin in Capillary blood
0
6
0.00
0.00
0.0
1.2
—
91.3
—
0
6
(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis
0
7
0.00
0.00
0.0
1.0
—
3.0
—
0
7
(3044290) Cell count panel - Cerebral spinal fluid
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3042631) Mycobacterium sp identified in Specimen
0
6
0.00
0.00
0.0
5.0
—
—
—
0
0
(3028707) Methadone [Presence] in Urine by Screen method
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3026179) Normetanephrine [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.2
—
0.5
—
0
6
(3034770) Mitochondria Ab [Titer] in Serum
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
(3052851) Hemolysis interference index of Serum or Plasma
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
(3018572) Chloride [Moles/volume] in Blood
0
7
0.00
0.00
0.0
6.4
—
104.6
—
0
7
(3037756) Immunofixation for Serum or Plasma
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
(40760888) Immunoglobulin light chains.free panel - Serum
0
7
0.00
0.00
0.0
10.4
—
—
—
0
0
(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis
0
6
0.00
0.00
0.0
1.0
—
0.0
—
0
6
(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
7
0.00
0.00
0.0
1.0
—
6.9
—
0
7
(3019897) Erythrocyte distribution width [Ratio] by Automated count
0
6
0.00
0.00
0.0
1.7
—
13.8
—
0
6
(3003740) Influenza virus B Ag [Presence] in Specimen
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(40768795) Lymph node Pathology biopsy report
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3023420) DNA double strand Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3009340) Metanephrine [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3002523) Influenza virus A Ag [Presence] in Specimen
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYTOXECT and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_THYTOXECT.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_THYTOXECT – Thyrotoxicosis from ectopic thyroid tissue
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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