This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Thyrotoxicosis from ectopic thyroid tissue
E4_THYTOXECT
Hyperthyroidism: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
31 |
4. Check minimum number of eventsNone |
31 |
5. Include endpointsNone |
31 |
6. Filter based on genotype QC (FinnGen only) |
31 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E05
- Name in latin
- Thyreotoxicosis ex textu thyreoideo ectopico
Similar endpoints
↥List of similar endpoints to
Thyrotoxicosis from ectopic thyroid tissue
based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 264 | 203 | 60 |
| Only index persons | 240 | 191 | 49 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 50.00 | 48.78 | 54.61 |
| Only index persons | 48.42 | 47.52 | 51.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 31 | 29 | - |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | - |
| Median age at first event (years) | 44.31 | 42.79 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
5
6
9.61
2.85
1.0
1.2
—
—
—
0
0
17
92
2.88
2.11
1.4
1.6
96.15
95.85
pmol/l
—
8
51
8
28
3.48
2.03
2.6
7.3
—
—
—
0
0
13
73
2.34
1.37
2.0
2.1
51.08
49.33
u/l
0.09
13
67
14
86
2.15
1.17
3.9
4.2
17.14
27.04
ng/l
—
7
63
9
56
1.85
0.82
2.1
1.7
0.75
0.89
mg/l
—
9
45
0
19
0.00
0.62
0.0
1.5
—
—
—
0
0
6
36
1.82
0.61
1.5
1.5
—
—
—
0
0
14
110
1.50
0.42
4.9
4.1
—
—
—
0
0
5
35
1.51
0.41
2.0
2.1
1.82
1.13
e6/l
—
5
18
5
35
1.51
0.41
2.4
2.2
3.82
3.10
e6/l
—
5
18
0
11
0.00
0.22
0.0
1.7
—
—
—
0
0
0
10
0.00
0.22
0.0
2.3
—
199.30
—
0
10
0
10
0.00
0.22
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
7
59
1.24
0.20
1.4
1.6
—
—
—
0
0
18
193
0.84
0.10
4.5
3.4
—
—
—
0
0
25
239
1.24
0.08
8.0
5.2
40.78
38.58
mmol/mol
0.65
25
224
11
114
0.95
0.00
8.5
4.0
—
—
—
0
0
10
95
1.08
0.00
2.6
2.6
—
—
—
0
0
7
74
0.93
0.00
1.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
0.00
—
0
6
0
6
0.00
0.00
0.0
1.0
—
0.00
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
89.86
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
38.82
—
0
6
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
25
242
1.17
0.00
14.2
12.0
32.04
39.45
%
1.04
18
171
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
3.00
—
0
7
0
6
0.00
0.00
0.0
1.0
—
0.00
—
0
6
0
7
0.00
0.00
0.0
1.0
—
6.94
—
0
7
0
6
0.00
0.00
0.0
1.7
—
13.75
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYTOXECT and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_THYTOXECT.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_THYTOXECT – Thyrotoxicosis from ectopic thyroid tissue
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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