Bacterial meningoencephalitis and meningomyelitis

G6_ENCEPHBACT

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G04.2, G05.0, G05.0A17.8, G05.0A32.1, G05.0A39.8, G05.0A50.4, G05.0A52.1 Hospital discharge: ICD-9 — 3238A Cause of death: ICD-10 — G04.2, G05.0, G05.0A17.8, G05.0A32.1, G05.0A39.8, G05.0A50.4, G05.0A52.1 Cause of death: ICD-9 — 3238A 2 out of 7 registries used, show all original rules.	42
4. Check minimum number of events None	42
5. Include endpoints None	42
6. Filter based on genotype QC (FinnGen only)	42

Control definitions (FinnGen only)

Control exclude: G6_NEUINFL

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	G6_ENCEPHBACT
CONTROL_EXCLUDE	G6_NEUINFL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G042\|G050
HD_ICD_9	3238A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G042\|G050
COD_ICD_9	3238A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Bacterial meningoencephalitis and meningomyelitis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	433	195	233
Only index persons	332	153	179
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	49.00	50.72	47.75
Only index persons	46.58	47.45	45.85

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	42	26	16
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	52.85	50.42	56.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(36304419) Bacteria [Presence] in Urine

4.11

4.76

2.8

2.6

—

(3044290) Cell count panel - Cerebral spinal fluid

13.62

4.45

1.9

1.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

3.42

3.69

4.8

2.5

—

(3018095) Leukocytes [#/volume] in Urine

105

3.30

3.51

3.2

3.0

20.6

46.5

e6/l

0.54

(42870588) Differential panel, method unspecified - Blood

3.24

3.40

8.3

4.8

—

(3029937) Albumin [Presence] in Urine by Test strip

3.00

2.88

7.6

3.8

0.0

estimate

—

(3023368) Bacteria identified in Blood by Culture

2.83

2.61

6.3

4.1

—

(40761535) Cells panel - Urine sediment

3.95

2.57

6.2

2.6

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.83

2.49

7.2

3.2

—

(3005719) IgG [Mass/volume] in Serum or Plasma

4.44

2.37

5.0

1.3

9.7

10.4

g/l

—

(3026782) Osmolality of Urine

2.89

2.19

2.8

2.4

450.8

619.7

mosm/kgh2o

2.18

(3032080) INR in Blood by Coagulation assay

112

2.50

2.14

4.5

8.4

1.0

1.2

inr

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

3.55

2.14

2.9

2.1

4.1

4.4

pmol/l

—

(3015736) pH of Urine

129

2.48

2.14

6.2

3.0

—

(3026008) Bacteria identified in Urine by Culture

2.53

2.08

4.0

3.1

—

(3000991) Gas panel - Venous blood

3.78

2.07

3.3

12.4

—

(40761536) Microorganisms panel - Urine sediment

3.60

1.98

4.9

3.9

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.44

1.89

1.6

1.5

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.63

1.57

5.4

26.9

26.0

mmol/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

158

2.01

1.35

7.2

4.3

0.0

estimate

—

(3033658) Prothrombin time (PT) actual/Normal

2.13

1.29

2.2

3.1

89.8

96.1

0.36

(3035350) Ketones [Presence] in Urine by Test strip

160

1.97

1.28

6.6

3.3

0.0

estimate

—

(3009261) Glucose [Presence] in Urine by Test strip

160

1.97

1.28

6.6

3.3

0.0

estimate

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

124

1.97

1.27

7.4

3.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.36

1.27

2.3

1.6

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.52

1.23

5.3

2.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.59

1.19

12.0

12.1

—

(3012544) pH of Venous blood

2.59

1.19

1.1

3.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.17

1.16

2.3

1.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.17

1.16

1.6

1.5

—

(3019060) Gas panel - Arterial blood

2.56

1.12

1.8

27.0

—

(3000492) Spirometry study

0.00

1.02

0.0

1.5

—

(3042936) Bacteria identified in Isolate by Culture

2.06

0.94

2.0

2.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.94

0.93

1.6

2.2

—

(3017732) Neutrophils [#/volume] in Blood

0.00

0.82

0.0

2.8

—

4.0

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

111

1.71

0.82

6.1

3.6

25.8

22.2

ng/l

—

(3019225) pH of Specimen

2.33

0.79

3.8

6.3

—

(3012516) Albumin [Mass/volume] in Urine

1.70

0.69

2.2

3.4

9289.2

745.7

mg/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

227

0.64

0.66

3.9

3.2

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.62

0.0

1.2

—

(3008898) HLA-B27 [Presence]

0.00

0.62

0.0

1.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

324

1.78

0.61

24.3

13.7

23.6

22.0

mg/l

0.13

244

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.67

0.60

2.8

1.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

139

1.52

0.57

4.9

4.5

—

(3009542) Hematocrit [Volume Fraction] of Blood

299

0.66

0.55

22.3

16.1

39.2

39.9

0.33

228

(40768804) Tissue Pathology biopsy report

139

0.63

0.54

2.3

2.0

—

(3000494) Fungus identified in Specimen by Culture

1.66

0.52

1.3

1.8

—

(3020682) Albumin/Creatinine [Ratio] in Urine

1.53

0.49

3.2

3.9

1.2

6.5

mg/mmol

—

(3037467) Urinalysis macro (dipstick) panel - Urine

235

1.42

0.42

7.6

3.9

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.51

0.41

7.0

4.2

—

(3002385) Erythrocyte distribution width [Ratio]

283

0.71

0.41

29.4

15.4

14.2

13.7

0.86

278

(3021960) Folate [Moles/volume] in Serum or Plasma

1.46

0.36

1.3

1.6

18.9

18.7

nmol/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.31

0.30

3.1

2.3

—

(36660697) Celiac disease serology panel - Serum

1.28

0.23

1.2

1.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.25

0.23

1.4

1.6

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

0.21

0.0

1.4

—

101.8

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.4

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.4

—

16.8

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

0.00

0.21

0.0

1.6

—

3.6

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.2

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

1.4

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.21

0.0

4.0

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.21

0.0

1.5

—

202.3

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.21

0.0

1.5

—

3.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.21

0.0

1.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.21

0.20

1.7

1.4

—

(40768793) Breast Pathology biopsy report

0.00

0.20

0.0

1.4

—

(3044640) Blood type and Crossmatch panel - Blood

1.28

0.20

2.8

2.2

—

(40758558) Short blood count panel - Blood

1.27

0.17

6.7

7.6

—

(40761511) CBC panel - Blood by Automated count

339

0.88

0.16

19.6

12.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.13

0.10

3.2

2.1

—

(3003694) ABO and Rh group [Type] in Blood

0.82

0.08

1.1

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.86

0.07

4.3

3.0

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

121

1.11

0.04

2.2

2.0

62.6

93.1

pmol/l

—

(1761868) Lipid panel - Serum or Plasma

107

0.91

0.02

2.2

2.6

—

(3044889) 12 lead EKG panel

227

1.03

0.00

5.4

3.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.93

0.00

2.2

1.7

—

(3013512) EKG study

0.92

0.00

2.0

3.6

—

(3007461) Platelets [#/volume] in Blood

359

1.02

0.00

31.6

20.0

242.0

254.6

e9/l

0.51

353

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.6

—

8.7

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

3.9

—

1.7

—

(3035941) MCH [Entitic mass]

360

1.00

0.00

31.6

19.8

29.8

30.3

0.90

355

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.6

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

87.5

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

3.5

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

3.5

—

4.0

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

59.8

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.0

1.5

—

11.2

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

(3024928) Oxygen saturation in Venous blood

0.00

0.0

4.7

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.0

1.2

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

3.9

—

7.2

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.2

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

3.5

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3026361) Erythrocytes [#/volume] in Blood

360

1.00

0.00

31.6

19.9

4.4

4.5

e12/l

1.06

351

(3010813) Leukocytes [#/volume] in Blood

360

1.00

0.00

31.7

19.9

6.8

6.6

e9/l

0.14

350

(3010130) Cytomegalovirus IgG Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.6

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.1

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.5

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.2

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.5

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(4268621)

0.00

0.0

1.7

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

0.98

0.00

3.1

4.9

2.2

1.9

ug/l

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

3.5

—

107.9

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.9

—

91.6

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.1

—

(4306422)

0.00

0.0

1.2

—

(3000963) Hemoglobin [Mass/volume] in Blood

360

1.00

0.00

31.9

20.0

129.6

135.8

g/l

2.31

355

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

0.94

0.00

2.0

1.7

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.5

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.6

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.0

1.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.94

0.00

3.2

2.2

—

(3024731) MCV [Entitic volume]

360

1.00

0.00

31.6

19.9

89.8

90.8

0.62

355

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

3.0

—

4.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_ENCEPHBACT and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
G6_ENCEPHBACT	2.668 [1.69, 4.2]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.035

During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 172 males with G6_ENCEPHBACT died.

Mortality risk

Mortality risk for people of age

years, who have G6_ENCEPHBACT.

N-year risk	Females	Males
1	No data	0.63%
5	No data	3.27%
10	No data	8.305%
15	No data	15.33%
20	No data	24.907%

Relationships between endpoints

↥

Index endpoint: G6_ENCEPHBACT – Bacterial meningoencephalitis and meningomyelitis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Bacterial meningoencephalitis and meningomyelitis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints