This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Bacterial meningoencephalitis and meningomyelitis
G6_ENCEPHBACT
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
42 |
4. Check minimum number of eventsNone |
42 |
5. Include endpointsNone |
42 |
6. Filter based on genotype QC (FinnGen only) |
42 |
Control definitions (FinnGen only)
- Control exclude
- G6_NEUINFL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Bacterial meningoencephalitis and meningomyelitis
based on the number of shared cases.
Similar with more cases:
- Encephalitis
- Inflammatory diseases of the central nervous system
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 433 | 195 | 233 |
| Only index persons | 332 | 153 | 179 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 49.00 | 50.72 | 47.75 |
| Only index persons | 46.58 | 47.45 | 45.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 42 | 26 | 16 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 52.85 | 50.42 | 56.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(36304419) Bacteria [Presence] in Urine
20
76
4.11
4.76
2.8
2.6
—
—
—
0
0
(3044290) Cell count panel - Cerebral spinal fluid
7
6
13.62
4.45
1.9
1.0
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
21
95
3.42
3.69
4.8
2.5
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
22
105
3.30
3.51
3.2
3.0
e6/l
20.6
46.5
0.54
16
70
(42870588) Differential panel, method unspecified - Blood
21
99
3.24
3.40
8.3
4.8
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
18
84
3.00
2.88
7.6
3.8
estimate
0.0
0.0
—
6
24
(3023368) Bacteria identified in Blood by Culture
18
88
2.83
2.61
6.3
4.1
—
—
—
0
0
(40761535) Cells panel - Urine sediment
9
27
3.95
2.57
6.2
2.6
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
16
75
2.83
2.49
7.2
3.2
—
—
—
0
0
(3005719) IgG [Mass/volume] in Serum or Plasma
7
18
4.44
2.37
5.0
1.3
g/l
9.7
10.4
—
7
18
(3026782) Osmolality of Urine
12
51
2.89
2.19
2.8
2.4
mosm/kgh2o
450.8
619.7
2.18
12
42
(3032080) INR in Blood by Coagulation assay
20
112
2.50
2.14
4.5
8.4
inr
1.0
1.2
—
8
36
(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma
8
26
3.55
2.14
2.9
2.1
pmol/l
4.1
4.4
—
8
20
(3015736) pH of Urine
22
129
2.48
2.14
6.2
3.0
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
17
89
2.53
2.08
4.0
3.1
—
—
—
0
0
(3000991) Gas panel - Venous blood
7
21
3.78
2.07
3.3
12.4
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
7
22
3.60
1.98
4.9
3.9
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
7
23
3.44
1.89
1.6
1.5
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
5
15
3.63
1.57
5.4
5.4
mmol/l
26.9
26.0
—
5
15
(3021601) Nitrite [Presence] in Urine by Test strip
23
158
2.01
1.35
7.2
4.3
estimate
0.0
0.0
—
7
25
(3033658) Prothrombin time (PT) actual/Normal
13
73
2.13
1.29
2.2
3.1
%
89.8
96.1
0.36
13
73
(3035350) Ketones [Presence] in Urine by Test strip
23
160
1.97
1.28
6.6
3.3
estimate
0.0
0.0
—
7
24
(3009261) Glucose [Presence] in Urine by Test strip
23
160
1.97
1.28
6.6
3.3
estimate
0.0
0.0
—
7
23
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
19
124
1.97
1.27
7.4
3.4
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
8
38
2.36
1.27
2.3
1.6
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
6
26
2.52
1.23
5.3
2.5
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
7
30
2.59
1.19
12.0
12.1
—
—
—
0
0
(3012544) pH of Venous blood
7
30
2.59
1.19
1.1
3.1
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
8
41
2.17
1.16
2.3
1.6
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
8
41
2.17
1.16
1.6
1.5
—
—
—
0
0
(3019060) Gas panel - Arterial blood
5
21
2.56
1.12
1.8
27.0
—
—
—
0
0
(3000492) Spirometry study
0
28
0.00
1.02
0.0
1.5
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
8
43
2.06
0.94
2.0
2.8
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
11
65
1.94
0.93
1.6
2.2
—
—
—
0
0
(3017732) Neutrophils [#/volume] in Blood
0
24
0.00
0.82
0.0
2.8
—
4.0
—
0
19
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
16
111
1.71
0.82
6.1
3.6
ng/l
25.8
22.2
—
10
68
(3019225) pH of Specimen
5
23
2.33
0.79
3.8
6.3
—
—
—
0
0
(3012516) Albumin [Mass/volume] in Urine
12
80
1.70
0.69
2.2
3.4
mg/l
9289.2
745.7
—
5
58
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
18
227
0.64
0.66
3.9
3.2
—
—
—
0
0
(3013139) Helicobacter pylori Ag [Presence] in Stool
0
19
0.00
0.62
0.0
1.2
—
—
—
0
0
(3008898) HLA-B27 [Presence]
0
21
0.00
0.62
0.0
1.0
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
36
324
1.78
0.61
24.3
13.7
mg/l
23.6
22.0
0.13
31
244
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
9
59
1.67
0.60
2.8
1.6
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
18
139
1.52
0.57
4.9
4.5
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
26
299
0.66
0.55
22.3
16.1
%
39.2
39.9
0.33
17
228
(40768804) Tissue Pathology biopsy report
10
139
0.63
0.54
2.3
2.0
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
7
45
1.66
0.52
1.3
1.8
—
—
—
0
0
(3020682) Albumin/Creatinine [Ratio] in Urine
12
87
1.53
0.49
3.2
3.9
mg/mmol
1.2
6.5
—
5
56
(3037467) Urinalysis macro (dipstick) panel - Urine
27
235
1.42
0.42
7.6
3.9
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
10
72
1.51
0.41
7.0
4.2
—
—
—
0
0
(3002385) Erythrocyte distribution width [Ratio]
25
283
0.71
0.41
29.4
15.4
%
14.2
13.7
0.86
25
278
(3021960) Folate [Moles/volume] in Serum or Plasma
10
74
1.46
0.36
1.3
1.6
nmol/l
18.9
18.7
—
10
62
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
8
64
1.31
0.30
3.1
2.3
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
5
40
1.28
0.23
1.2
1.1
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
5
41
1.25
0.23
1.4
1.6
—
—
—
0
0
(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method
0
11
0.00
0.21
0.0
1.4
—
101.8
—
0
11
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma
0
10
0.00
0.21
0.0
3.4
—
16.8
—
0
10
(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay
0
10
0.00
0.21
0.0
1.6
—
3.6
—
0
10
(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
(1761482) Bacteria [#/volume] in Urine by Culture
0
10
0.00
0.21
0.0
4.0
—
—
—
0
0
(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay
0
10
0.00
0.21
0.0
1.5
—
202.3
—
0
10
(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method
0
13
0.00
0.21
0.0
1.5
—
3.1
—
0
6
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
6
51
1.21
0.20
1.7
1.4
—
—
—
0
0
(40768793) Breast Pathology biopsy report
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
11
91
1.28
0.20
2.8
2.2
—
—
—
0
0
(40758558) Short blood count panel - Blood
10
83
1.27
0.17
6.7
7.6
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
33
339
0.88
0.16
19.6
12.3
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
5
45
1.13
0.10
3.2
2.1
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
7
82
0.82
0.08
1.1
1.4
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
8
90
0.86
0.07
4.3
3.0
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
13
121
1.11
0.04
2.2
2.0
pmol/l
62.6
93.1
—
8
65
(1761868) Lipid panel - Serum or Plasma
10
107
0.91
0.02
2.2
2.6
—
—
—
0
0
(3044889) 12 lead EKG panel
23
227
1.03
0.00
5.4
3.3
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
6
64
0.93
0.00
2.2
1.7
—
—
—
0
0
(3013512) EKG study
7
75
0.92
0.00
2.0
3.6
—
—
—
0
0
(3007461) Platelets [#/volume] in Blood
36
359
1.02
0.00
31.6
20.0
e9/l
242.0
254.6
0.51
36
353
(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay
0
5
0.00
0.00
0.0
4.6
—
8.7
—
0
5
(3008037) Lactate [Moles/volume] in Venous blood
0
8
0.00
0.00
0.0
3.9
—
1.7
—
0
8
(3035941) MCH [Entitic mass]
36
360
1.00
0.00
31.6
19.8
pg
29.8
30.3
0.90
36
355
(3043238) Trisomy 21 risk [Likelihood] in Fetus
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
87.5
—
0
5
(3023419) Bacteria identified in Sputum by Culture
0
6
0.00
0.00
0.0
3.5
—
—
—
0
0
(3041354) Potassium [Moles/volume] in Venous blood
0
8
0.00
0.00
0.0
3.5
—
4.0
—
0
8
(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
1.2
—
59.8
—
0
9
(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.5
—
11.2
—
0
6
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3026389) Candida sp identified in Specimen by Organism specific culture
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3024928) Oxygen saturation in Venous blood
0
6
0.00
0.00
0.0
4.7
—
—
—
0
0
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3038515) Glucose [Moles/volume] in Venous blood
0
8
0.00
0.00
0.0
3.9
—
7.2
—
0
8
(3047007) Chlamydophila sp Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3033705) Calcium.ionized [Moles/volume] in Venous blood
0
8
0.00
0.00
0.0
3.5
—
—
—
0
0
(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3026361) Erythrocytes [#/volume] in Blood
36
360
1.00
0.00
31.6
19.9
e12/l
4.4
4.5
1.06
36
351
(3010813) Leukocytes [#/volume] in Blood
36
360
1.00
0.00
31.7
19.9
e9/l
6.8
6.6
0.14
36
350
(3010130) Cytomegalovirus IgG Ab [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3032773) Endomysium IgG Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3005033) Fetal Nuchal fold Thickness US
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3038177) Helicobacter pylori Ab [Presence] in Serum
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3009550) Parvovirus B19 IgG Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(4268621)
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
7
71
0.98
0.00
3.1
4.9
ug/l
2.2
1.9
—
7
58
(3035285) Chloride [Moles/volume] in Venous blood
0
8
0.00
0.00
0.0
3.5
—
107.9
—
0
8
(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay
0
9
0.00
0.00
0.0
3.9
—
91.6
—
0
9
(3047352) Trisomy 18 risk [Likelihood] in Fetus
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(4306422)
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3000963) Hemoglobin [Mass/volume] in Blood
36
360
1.00
0.00
31.9
20.0
g/l
129.6
135.8
2.31
36
355
(3023420) DNA double strand Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
5
53
0.94
0.00
2.0
1.7
—
—
—
0
0
(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
5
53
0.94
0.00
3.2
2.2
—
—
—
0
0
(3024731) MCV [Entitic volume]
36
360
1.00
0.00
31.6
19.9
fl
89.8
90.8
0.62
36
355
(3014702) Chromogranin A [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
3.0
—
4.2
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint G6_ENCEPHBACT and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ENCEPHBACT | 2.668 [1.69, 4.2] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 172 males with G6_ENCEPHBACT died.
Mortality risk
Mortality risk for people of age
years, who have G6_ENCEPHBACT.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.63% |
| 5 | No data | 3.27% |
| 10 | No data | 8.305% |
| 15 | No data | 15.33% |
| 20 | No data | 24.907% |
Relationships between endpoints
↥Index endpoint: G6_ENCEPHBACT – Bacterial meningoencephalitis and meningomyelitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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