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Bacterial meningoencephalitis and meningomyelitis

G6_ENCEPHBACT

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

42

4. Check minimum number of events

None

42

5. Include endpoints

None

42

6. Filter based on genotype QC (FinnGen only)

42

Control definitions (FinnGen only)

Control exclude
G6_NEUINFL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 433 195 233
Only index persons 332 153 179
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 49.00 50.72 47.75
Only index persons 46.58 47.45 45.85

-FinnGen-

Key figures

All Female Male
Number of individuals 42 26 16
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 52.85 50.42 56.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
20
76
4.11
4.76
2.8
2.6
—
—
—
0
0
7
6
13.62
4.45
1.9
1.0
—
—
—
0
0
22
105
3.30
3.51
3.2
3.0
20.6
46.5
e6/l
0.54
16
70
21
99
3.24
3.40
8.3
4.8
—
—
—
0
0
18
84
3.00
2.88
7.6
3.8
0.0
0.0
estimate
—
6
24
18
88
2.83
2.61
6.3
4.1
—
—
—
0
0
9
27
3.95
2.57
6.2
2.6
—
—
—
0
0
16
75
2.83
2.49
7.2
3.2
—
—
—
0
0
7
18
4.44
2.37
5.0
1.3
9.7
10.4
g/l
—
7
18
12
51
2.89
2.19
2.8
2.4
450.8
619.7
mosm/kgh2o
2.18
12
42
20
112
2.50
2.14
4.5
8.4
1.0
1.2
inr
—
8
36
8
26
3.55
2.14
2.9
2.1
4.1
4.4
pmol/l
—
8
20
22
129
2.48
2.14
6.2
3.0
—
—
—
0
0
17
89
2.53
2.08
4.0
3.1
—
—
—
0
0
7
21
3.78
2.07
3.3
12.4
—
—
—
0
0
7
22
3.60
1.98
4.9
3.9
—
—
—
0
0
5
15
3.63
1.57
5.4
5.4
26.9
26.0
mmol/l
—
5
15
23
158
2.01
1.35
7.2
4.3
0.0
0.0
estimate
—
7
25
13
73
2.13
1.29
2.2
3.1
89.8
96.1
%
0.36
13
73
23
160
1.97
1.28
6.6
3.3
0.0
0.0
estimate
—
7
24
23
160
1.97
1.28
6.6
3.3
0.0
0.0
estimate
—
7
23
7
30
2.59
1.19
1.1
3.1
—
—
—
0
0
8
41
2.17
1.16
1.6
1.5
—
—
—
0
0
5
21
2.56
1.12
1.8
27.0
—
—
—
0
0
0
28
0.00
1.02
0.0
1.5
—
—
—
0
0
8
43
2.06
0.94
2.0
2.8
—
—
—
0
0
11
65
1.94
0.93
1.6
2.2
—
—
—
0
0
0
24
0.00
0.82
0.0
2.8
—
4.0
—
0
19
16
111
1.71
0.82
6.1
3.6
25.8
22.2
ng/l
—
10
68
5
23
2.33
0.79
3.8
6.3
—
—
—
0
0
12
80
1.70
0.69
2.2
3.4
9289.2
745.7
mg/l
—
5
58
0
19
0.00
0.62
0.0
1.2
—
—
—
0
0
0
21
0.00
0.62
0.0
1.0
—
—
—
0
0
36
324
1.78
0.61
24.3
13.7
23.6
22.0
mg/l
0.13
31
244
26
299
0.66
0.55
22.3
16.1
39.2
39.9
%
0.33
17
228
10
139
0.63
0.54
2.3
2.0
—
—
—
0
0
7
45
1.66
0.52
1.3
1.8
—
—
—
0
0
12
87
1.53
0.49
3.2
3.9
1.2
6.5
mg/mmol
—
5
56
27
235
1.42
0.42
7.6
3.9
—
—
—
0
0
10
72
1.51
0.41
7.0
4.2
—
—
—
0
0
25
283
0.71
0.41
29.4
15.4
14.2
13.7
%
0.86
25
278
10
74
1.46
0.36
1.3
1.6
18.9
18.7
nmol/l
—
10
62
5
40
1.28
0.23
1.2
1.1
—
—
—
0
0
5
41
1.25
0.23
1.4
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
3.4
—
16.8
—
0
10
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
4.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
11
91
1.28
0.20
2.8
2.2
—
—
—
0
0
10
83
1.27
0.17
6.7
7.6
—
—
—
0
0
33
339
0.88
0.16
19.6
12.3
—
—
—
0
0
7
82
0.82
0.08
1.1
1.4
—
—
—
0
0
8
90
0.86
0.07
4.3
3.0
—
—
—
0
0
13
121
1.11
0.04
2.2
2.0
62.6
93.1
pmol/l
—
8
65
10
107
0.91
0.02
2.2
2.6
—
—
—
0
0
23
227
1.03
0.00
5.4
3.3
—
—
—
0
0
7
75
0.92
0.00
2.0
3.6
—
—
—
0
0
36
359
1.02
0.00
31.6
20.0
242.0
254.6
e9/l
0.51
36
353
0
8
0.00
0.00
0.0
3.9
—
1.7
—
0
8
36
360
1.00
0.00
31.6
19.8
29.8
30.3
pg
0.90
36
355
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
3.5
—
—
—
0
0
0
8
0.00
0.00
0.0
3.5
—
4.0
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
4.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
3.9
—
7.2
—
0
8
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
3.5
—
—
—
0
0
36
360
1.00
0.00
31.6
19.9
4.4
4.5
e12/l
1.06
36
351
36
360
1.00
0.00
31.7
19.9
6.8
6.6
e9/l
0.14
36
350
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
7
71
0.98
0.00
3.1
4.9
2.2
1.9
ug/l
—
7
58
0
8
0.00
0.00
0.0
3.5
—
107.9
—
0
8
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
36
360
1.00
0.00
31.9
20.0
129.6
135.8
g/l
2.31
36
355
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
0.00
2.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
36
360
1.00
0.00
31.6
19.9
89.8
90.8
fl
0.62
36
355
0
6
0.00
0.00
0.0
3.0
—
4.2
—
0
6

Mortality – FinRegistry

Association

Association between endpoint G6_ENCEPHBACT and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
G6_ENCEPHBACT 2.668 [1.69, 4.2] < 0.001
Birth year 0.989 [0.98, 1.0] 0.035

During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 172 males with G6_ENCEPHBACT died.

Mortality risk

Mortality risk for people of age

years, who have G6_ENCEPHBACT.

N-year risk Females Males
1 No data 0.63%
5 No data 3.27%
10 No data 8.305%
15 No data 15.33%
20 No data 24.907%

Relationships between endpoints

Index endpoint: G6_ENCEPHBACT – Bacterial meningoencephalitis and meningomyelitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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