No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
388 |
4. Check minimum number of eventsNone |
388 |
5. Include endpointsNone |
388 |
6. Filter based on genotype QC (FinnGen only) |
388 |
Control definitions (FinnGen only)
- Control exclude
- G6_NEUINFL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Intracranial and intraspinal abscess and granuloma
based on the number of shared cases.
Similar with more cases:
- Inflammatory diseases of the central nervous system
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3266 | 1188 | 2050 |
| Only index persons | 2599 | 978 | 1621 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.03 | 0.06 |
| Only index persons | 0.05 | 0.04 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 56.24 | 57.43 | 55.51 |
| Only index persons | 55.94 | 56.94 | 55.33 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 388 | 155 | 233 |
| Unadjusted period prevalence (%) | 0.08 | 0.05 | 0.10 |
| Median age at first event (years) | 59.25 | 56.49 | 61.09 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 352
- Matched controls
- 3520
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G06.1
ICD-10 Finland
Intraspinal abscess and granuloma
+∞
191.7
166
*
G06.0
ICD-10 Finland
Intracranial abscess and granuloma
+∞
143.9
128
*
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
42.2
75.5
94
30
G06.2
ICD-10 Finland
Extradural and subdural abscess, unspecified
+∞
48.0
45
*
J04AB02
ATC
rifampicin; systemic
43.5
40.0
49
13
M46.3
ICD-10 Finland
Infection of intervertebral disc (pyogenic)
118.8
39.7
42
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
7.0
36.7
101
192
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
9.2
36.0
80
109
M46.4
ICD-10 Finland
Discitis, unspecified
62.4
34.0
39
7
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
12.9
31.4
57
52
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.9
30.7
118
328
AAM00
NOMESCO Finland
Puncture and evacuation of intracerebral abscess
+∞
28.5
27
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.6
28.5
116
339
NA3DG
NOMESCO Finland
Lumbar spine very extensive MRI examination with high intensity magnet
51.8
28.0
33
7
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.6
27.8
113
328
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
24.9
25.8
36
16
AA1AD
NOMESCO Finland
CT of head and brain
3.7
24.9
137
516
WX408
NOMESCO Finland
General anesthesy, balanced
3.5
24.5
148
599
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
6.1
24.1
70
137
JN4BD
NOMESCO Finland
Extensive body CT
4.8
23.2
86
223
J01FF01
ATC
clindamycin; systemic
3.4
23.1
150
636
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
11.5
21.8
41
40
N03AX14
ATC
levetiracetam; systemic
12.8
21.3
38
33
AAM30
NOMESCO Finland
Evacuation of epidural or subdural empyema
+∞
21.0
20
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
7.7
21.0
50
74
B18.2
ICD-10 Finland
Chronic viral hepatitis C
44.7
20.7
25
6
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
17.1
19.2
30
19
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
5.3
19.1
62
137
AA1BD
NOMESCO Finland
Extensive CT of head and brain
11.0
18.9
36
36
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.8
18.9
196
1093
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
15.5
18.5
30
21
N02AA05
ATC
oxycodone; systemic
3.7
17.7
88
293
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
18.2
17.7
27
16
TPH04
NOMESCO Finland
Cathetrisation of vein
3.2
17.3
109
434
R4110
NOMESCO Finland
Physiotherapy
3.0
17.1
128
570
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
9.8
16.9
34
38
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
13.7
16.5
28
22
J01CF05
ATC
flucloxacillin; systemic
8.1
16.4
37
50
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
12.6
15.9
28
24
AAM10
NOMESCO Finland
Excision of intracerebral abscess
+∞
15.7
15
*
R50.9
ICD-10 Finland
Fever, unspecified
3.4
15.1
81
283
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
11.1
14.5
27
26
A41.9
ICD-10 Finland
Sepsis, unspecified
6.8
14.2
36
58
TKC20
NOMESCO Finland
Catheterisation of bladder
4.7
14.1
49
116
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
5.3
14.1
44
93
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
11.6
13.7
25
23
NAS20
NOMESCO Finland
Incision and debridement of infection of vertebra, unspecified
+∞
13.6
13
*
J01MA12
ATC
levofloxacin; systemic
2.9
13.6
95
396
N03AX16
ATC
pregabalin; oral
2.7
13.1
110
513
G40.9
ICD-10 Finland
Epilepsy, unspecified
7.5
12.9
30
43
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.9
12.8
86
349
N02AX02
ATC
tramadol; systemic, rectal
2.3
12.6
173
1039
L28
ICPC
Limited function/disability (L)
3.0
12.1
75
288
NA1DG
NOMESCO Finland
Cervical spine very extensive MRI examination with high intensity magnet
31.2
11.7
15
5
G09
ICD-10 Finland
Sequelae of inflammatory diseases of central nervous system
+∞
11.5
11
*
T36
ICD-10 Finland
Poisoning by systemic antibiotics
6.5
11.3
29
48
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
13.3
11.3
19
15
WX892
NOMESCO Finland
Monitored bed care
4.1
11.2
44
118
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.4
10.8
55
183
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
18.6
10.8
16
9
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.0
10.7
67
257
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
10.6
150
893
WX110
NOMESCO Finland
Local anesthesy
2.2
10.6
248
1835
AAK00
NOMESCO Finland
Cranioplasty
113.3
10.5
11
*
AWC00
NOMESCO Finland
Reoperation of nervous system because of deep wound infection in the nervous system
113.3
10.5
11
*
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
+∞
10.5
10
*
32200
ICD-8 Finland
Intracranial and intraspinal abscess, Intracerebralis
+∞
10.5
10
*
N03AX18
ATC
lacosamide; systemic
19.5
10.3
15
8
ZXC95
NOMESCO Finland
Use of surgical navigator
13.7
10.3
17
13
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.8
10.1
44
129
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
10.1
96
470
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.2
10.1
56
197
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.3
10.1
52
175
A46
ICD-10 Finland
Erysipelas
2.9
10.0
67
267
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
15.6
9.6
15
10
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
15.6
9.6
15
10
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.5
9.5
45
142
M46.2
ICD-10 Finland
Osteomyelitis of vertebra
+∞
9.4
9
*
3240A
ICD-9 Finland
Intracranial and intraspinal abscess, Intracranial abscess
+∞
9.4
9
*
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
4.0
9.4
37
100
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.9
9.2
59
227
F11.22
ICD-10 Finland
Addiction-induced dependence is currently independent but uses substitute intermittent medication
37.7
9.1
11
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.1
9.0
50
176
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
7.1
9.0
21
31
X59
ICD-10 Finland
Exposure to unspecified factor
2.4
8.9
80
379
XF400
NOMESCO Finland
ECG with 12 standard connections
2.6
8.8
72
322
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
8.8
86
425
R4120
NOMESCO Finland
Occupational therapy
3.8
8.7
36
102
A40.8
ICD-10 Finland
Other streptococcal sepsis
10.4
8.6
16
16
N03AB02
ATC
phenytoin; systemic
16.8
8.6
13
8
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
16.8
8.6
13
8
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.1
8.6
49
177
EBA15
NOMESCO Finland
Extraction of large number of teeth
4.6
8.5
29
68
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
7.0
8.5
20
30
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.1
8.5
47
165
F11.29
ICD-10 Finland
Addiction caused by opiates UNS
+∞
8.4
8
*
AAG00
NOMESCO Finland
Stereotactic intracranial biopsy
+∞
8.4
8
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.7
8.3
36
106
ABC60
NOMESCO Finland
Decompression of cervical spinal cord
14.9
8.3
13
9
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
5.5
8.2
23
44
XA800
NOMESCO Finland
Neuropsychological investigation
4.7
7.9
26
59
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
13.4
7.9
13
10
ZXA00
NOMESCO Finland
Right side
2.1
7.9
107
609
WX882
NOMESCO Finland
High dependency care
6.2
7.8
20
34
N02BE01
ATC
paracetamol; systemic, rectal
2.3
7.8
300
2529
P19
ICPC
Drug abuse
15.5
7.8
12
8
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
46.0
7.7
9
*
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
46.0
7.7
9
*
F15.1
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, harmful use
46.0
7.7
9
*
A41.8
ICD-10 Finland
Other specified sepsis
7.0
7.7
18
27
EBA10
NOMESCO Finland
Surgical removal of tooth
2.9
7.7
48
184
A28
ICPC
Limited function/disability NOS
2.5
7.7
65
296
AAA10
NOMESCO Finland
Biopsy through craniotomy
25.6
7.6
10
*
M00.0
ICD-10 Finland
Staphylococcal arthritis and polyarthritis
25.6
7.6
10
*
N05BA01
ATC
diazepam; systemic, rectal
2.5
7.5
60
267
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
4.4
7.5
26
63
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
9.7
7.3
14
15
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.7
7.3
52
214
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.6
7.3
24
55
WX872
NOMESCO Finland
Intensive care
3.5
7.2
32
97
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
30.7
7.2
9
*
F11.25
ICD-10 Finland
Relationship caused by opiates continuously used
30.7
7.2
9
*
Z72.2
ICD-10 Finland
Drug use
20.5
7.2
10
5
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
4.9
7.2
22
47
SPAT1255
SPAT
Intravenous administration of medicine
3.1
7.1
38
132
B01AB05
ATC
enoxaparin; parenteral
2.0
7.1
111
663
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
6.6
7.0
17
27
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
6.1
7.0
18
31
N03AF01
ATC
carbamazepine; oral, rectal
4.3
6.8
24
59
M54.5
ICD-10 Finland
Low back pain
1.9
6.8
117
724
T91.3
ICD-10 Finland
Sequelae of injury of spinal cord
40.9
6.8
8
*
J01XX08
ATC
linezolid; systemic
17.1
6.8
10
6
M79.6
ICD-10 Finland
Pain in limb
1.9
6.8
115
708
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
4.8
6.7
21
46
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
23.0
6.7
9
*
N03AX12
ATC
gabapentin; oral
2.3
6.7
62
296
WX002
NOMESCO Finland
Sedation and analgesia
2.1
6.7
78
413
R60.0
ICD-10 Finland
Localized oedema
2.8
6.7
42
162
TPH07
NOMESCO Finland
Cathetrisation of artery
2.6
6.6
49
208
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.9
6.6
26
71
F10.24
ICD-10 Finland
Alcohol depence active use
9.0
6.6
13
15
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
3.4
6.6
30
93
C03CA01
ATC
furosemide; systemic
1.9
6.5
110
674
G40.10
ICD-10 Finland
Simple partial seizures
14.7
6.4
10
7
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.7
6.4
44
178
F10.25
ICD-10 Finland
Alcohol dependence continuous use
6.8
6.4
15
23
Z46.3
ICD-10 Finland
Fitting and adjustment of dental prosthetic device
8.4
6.4
13
16
K90
ICPC
Stroke/cerebrovascular accident
6.2
6.4
16
27
A06AD11
ATC
lactulose; oral
2.4
6.3
55
254
F19.29
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances UNS
18.4
6.3
9
5
J01DB01
ATC
cefalexin; oral
1.9
6.3
282
2375
F11.24
ICD-10 Finland
Addiction-induced dependence caused by opiates active addiction
+∞
6.3
6
*
D43.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, unspecified
+∞
6.3
6
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
6.2
163
1152
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.8
6.2
19
41
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
4.8
6.2
19
41
H02AB07
ATC
prednisone; oral
2.3
6.2
58
277
P15
ICPC
Chronic alcohol abuse
5.4
6.1
17
33
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.0
6.1
34
120
N18
ICPC
Paralysis/weakness
6.2
6.1
15
25
R33
ICD-10 Finland
Retention of urine
2.8
6.0
38
146
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
90
63
18.30
103.21
1.8
1.6
—
—
—
0
0
70
78
10.73
59.08
1.5
1.5
—
—
—
0
0
71
110
7.68
45.53
2.2
2.8
—
—
—
0
0
91
236
4.73
33.32
2.1
1.5
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
50
86
6.53
28.67
3.6
2.2
0.3
0.3
u/ml
0.72
30
47
29
25
12.46
28.58
3.3
1.2
—
—
—
0
0
118
412
3.68
28.35
7.4
5.8
1.1
1.0
mmol/l
0.43
109
384
87
271
3.85
24.44
10.2
7.4
9.3
10.1
mmol/l
0.54
81
254
42
72
6.42
24.07
1.5
1.4
—
—
—
0
0
126
522
3.09
22.30
5.6
3.3
0.8
0.8
mmol/l
2.17
120
489
228
1326
2.74
20.85
9.0
5.0
31.9
35.5
g/l
10.67
219
1239
248
1511
2.78
20.57
16.2
6.5
24.4
27.4
%
4.79
238
1415
245
1486
2.76
20.47
15.9
6.3
60.0
57.4
%
3.07
235
1402
260
1638
2.78
19.92
11.8
6.9
10.9
11.7
umol/l
0.49
251
1564
23
25
9.72
19.27
1.7
1.5
—
—
—
0
0
119
517
2.88
18.94
2.3
1.9
—
—
—
0
0
17
12
14.77
18.59
3.8
1.2
—
—
—
0
0
97
387
3.01
17.93
12.1
8.7
5.0
5.1
kpa
0.48
91
368
97
387
3.01
17.93
12.1
8.7
13.2
12.2
kpa
1.07
91
370
82
297
3.23
17.89
2.9
2.5
0.2
0.2
g/l
1.48
77
276
273
1816
2.70
17.85
18.4
9.8
4.4
4.1
e9/l
1.32
240
1604
148
739
2.62
17.76
4.2
2.3
—
—
—
0
0
96
389
2.95
17.19
12.1
8.8
0.8
1.1
mmol/l
0.29
76
315
32
59
5.82
16.95
3.0
1.3
270.4
15.4
e6/l
0.65
24
47
32
59
5.82
16.95
3.1
1.4
318.4
1933.1
e6/l
0.43
25
49
53
149
3.96
16.95
1.8
2.1
2.0
1.5
g/l
2.68
47
128
194
1126
2.45
16.60
4.5
3.1
—
—
—
0
0
19
20
9.94
16.23
2.5
1.5
—
—
—
0
0
222
1395
2.38
15.54
11.6
6.3
1.2
1.2
mmol/l
2.14
207
1267
144
755
2.44
15.14
3.0
2.0
3.3
3.2
mg/l
0.22
125
653
156
869
2.33
14.10
4.4
3.0
0.4
0.5
e6/l
0.62
123
666
233
1535
2.30
14.06
13.0
7.2
1.2
1.2
mmol/l
1.48
206
1306
267
1874
2.36
13.71
10.0
5.1
6.7
6.8
mmol/l
0.28
254
1766
72
280
2.93
13.68
3.5
2.5
218.9
33.0
u/l
0.50
62
240
14
12
12.07
13.60
1.3
1.1
—
—
—
0
0
74
314
2.68
11.84
5.1
3.3
—
—
—
0
0
101
499
2.38
11.71
3.7
2.8
2.1
2.0
e6/l
0.08
61
286
91
430
2.46
11.64
11.7
6.5
105.0
104.0
mmol/l
1.01
91
417
213
1426
2.09
11.44
5.9
4.1
—
—
—
0
0
91
436
2.42
11.26
3.1
2.3
21.1
23.0
%
0.45
84
377
82
375
2.50
11.22
5.3
3.1
8.9
9.4
umol/l
0.07
68
332
28
66
4.49
11.21
4.5
8.0
454.7
263.0
iu/ml
—
6
14
80
369
2.47
10.72
2.2
1.8
—
—
—
0
0
93
463
2.33
10.49
3.2
2.2
2.2
2.3
g/l
1.71
88
427
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
13
15
8.93
10.29
1.3
1.1
—
—
—
0
0
109
591
2.17
9.95
4.1
3.9
715.3
226.3
ng/l
0.73
88
475
101
535
2.20
9.76
3.7
2.6
1.4
1.0
e6/l
0.58
61
316
78
371
2.38
9.71
2.2
1.8
—
—
—
0
0
32
93
3.66
9.69
1.4
1.2
—
—
—
0
0
304
2403
2.22
9.66
20.0
8.0
90.8
77.7
u/l
4.58
296
2255
32
95
3.58
9.40
1.7
1.1
—
—
—
0
0
186
1249
1.94
9.26
2.3
2.0
99.8
94.9
pmol/l
0.59
97
662
15
24
6.46
9.06
1.5
1.5
23864.2
37139.3
e6/l
—
10
15
47
183
2.78
8.80
2.0
1.6
—
—
—
0
0
157
1015
1.92
8.60
4.0
2.6
57.8
57.1
u/l
0.07
145
946
24
62
4.06
8.55
1.3
1.5
—
—
—
0
0
24
62
4.06
8.55
1.3
1.5
—
—
—
0
0
35
117
3.19
8.55
2.3
2.0
—
—
—
0
0
65
302
2.38
8.48
8.5
3.7
0.6
2.1
mmol/l
2.06
59
246
289
2296
2.01
8.25
7.5
4.0
22.0
12.0
mm/h
11.78
275
2100
176
1193
1.87
8.24
2.6
2.3
73.2
76.3
nmol/l
0.67
157
1056
161
1063
1.88
8.17
6.3
3.7
36.9
32.4
u/l
1.00
154
1016
104
599
2.01
7.88
1.8
1.7
1014.8
1186.7
nmol/l
1.24
80
456
44
181
2.61
7.40
1.4
1.2
—
33.4
—
0
11
25
76
3.45
7.09
1.5
1.3
—
—
—
0
0
181
1289
1.76
6.82
3.5
2.6
191.0
146.2
ug/l
0.90
166
1181
11
17
6.63
6.81
1.2
1.2
497.4
187.0
iu/ml
0.61
11
17
14
28
5.15
6.75
1.3
1.0
—
—
—
0
0
26
84
3.25
6.72
1.4
1.7
—
—
—
0
0
16
37
4.47
6.55
3.0
3.6
—
—
—
0
0
15
33
4.69
6.51
2.1
2.1
—
—
—
0
0
75
411
2.02
6.43
22.9
22.8
1.2
1.3
inr
0.35
11
52
21
61
3.58
6.38
1.3
1.2
—
—
—
0
0
30
110
2.87
6.27
2.2
1.8
—
—
—
0
0
23
73
3.29
6.12
2.1
1.6
15656.9
17074.3
e6/l
0.06
13
57
45
205
2.35
6.10
3.9
3.4
2.3
1.6
mmol/l
0.67
38
152
28
102
2.88
5.93
4.0
3.0
3.1
3.2
g/l
0.09
22
84
52
256
2.19
5.88
6.9
2.9
5.3
4.4
kpa
1.49
52
247
46
217
2.27
5.76
5.7
3.9
99.4
81.3
ng/l
0.46
41
198
29
110
2.77
5.71
3.9
2.9
7.7
7.4
g/l
0.28
22
87
29
110
2.77
5.71
3.9
2.9
—
—
—
0
0
11
21
5.36
5.55
1.0
1.0
—
—
—
0
0
8
5
16.28
5.43
2.3
1.4
—
—
—
0
0
19
59
3.33
5.24
1.3
1.2
216.3
309.3
u/ml
0.72
12
32
28
110
2.67
5.17
4.0
2.9
4.3
3.8
g/l
0.49
21
83
40
187
2.27
5.12
1.6
1.4
—
—
—
0
0
12
27
4.55
5.07
1.8
3.2
—
—
—
0
0
9
9
10.20
5.05
1.6
1.1
—
—
—
0
0
24
89
2.81
4.94
1.4
1.6
0.0
0.1
iu/ml
—
7
20
102
679
1.68
4.57
2.0
1.7
1.9
1.3
mg/l
0.80
86
523
18
61
3.05
4.34
1.4
1.4
—
—
—
0
0
138
1007
1.57
4.23
4.3
3.3
2.3
2.3
mmol/l
0.36
124
876
50
275
1.94
4.21
2.8
2.5
7.2
7.4
ug/l
0.04
45
242
47
253
1.98
4.21
2.4
2.8
255.1
231.1
ng/l
0.15
41
222
9
13
7.06
4.18
1.2
1.2
—
—
—
0
0
250
2102
1.53
3.87
7.4
3.3
75.8
51.6
u/l
2.05
235
1973
8
12
6.78
3.69
1.9
2.0
1913.5
657.4
u/ml
—
8
12
9
16
5.73
3.68
2.0
2.9
—
—
—
0
0
13
40
3.33
3.66
1.9
1.7
—
—
—
0
0
105
745
1.56
3.55
2.0
1.5
19.1
20.7
nmol/l
0.46
96
628
12
36
3.41
3.50
1.4
1.3
4.4
1.7
u/ml
—
5
10
16
58
2.83
3.46
1.7
1.7
—
—
—
0
0
81
544
1.62
3.44
4.0
2.9
2.4
2.4
mmol/l
0.06
64
475
28
134
2.17
3.43
4.4
4.0
25.4
25.1
mmol/l
0.28
28
127
8
14
5.81
3.35
1.3
1.1
—
—
—
0
0
125
939
1.49
3.20
3.4
3.2
2518.0
1302.3
ng/l
0.50
111
803
8
17
4.78
2.93
1.3
1.9
—
—
—
0
0
8
17
4.78
2.93
1.3
1.9
—
—
—
0
0
8
17
4.78
2.93
1.3
1.9
—
—
—
0
0
8
17
4.78
2.93
1.3
1.9
—
—
—
0
0
12
41
2.99
2.88
1.4
1.2
12.4
4.1
u/ml
—
7
18
15
59
2.60
2.82
3.1
2.5
17.5
15.6
%
—
8
32
7
14
5.07
2.74
1.3
2.1
—
—
—
0
0
7
14
5.07
2.74
1.3
2.1
—
—
—
0
0
7
15
4.73
2.61
1.3
2.0
—
—
—
0
0
11
38
2.95
2.60
1.6
1.7
—
—
—
0
0
18
81
2.28
2.58
1.6
1.7
—
—
—
0
0
18
81
2.28
2.58
1.9
1.6
—
—
—
0
0
59
394
1.59
2.56
2.5
1.9
1.8
1.6
%
0.71
53
344
6
11
5.52
2.55
1.7
1.1
—
—
—
0
0
180
1496
1.38
2.51
5.1
3.6
0.0
0.0
estimate
0.00
35
269
7
16
4.43
2.48
1.1
1.1
—
—
—
0
0
15
64
2.40
2.42
1.4
1.3
—
—
—
0
0
335
3109
1.57
2.41
44.6
14.6
31.5
23.6
mg/l
4.79
309
2464
7
17
4.17
2.37
1.9
1.9
—
—
—
0
0
21
105
2.06
2.35
7.5
3.4
3.8
4.0
mmol/l
0.98
21
94
10
36
2.82
2.21
1.2
1.4
—
—
—
0
0
11
42
2.67
2.20
1.1
1.1
—
—
—
0
0
50
335
1.57
2.15
2.7
4.6
5.3
39.3
ug/l
0.84
43
285
15
68
2.25
2.14
1.1
1.1
—
—
—
0
0
9
31
2.95
2.08
2.1
1.5
—
—
—
0
0
342
3216
1.54
2.01
45.0
17.0
139.1
139.7
mmol/l
4.72
337
3130
17
84
2.07
1.98
1.4
1.5
192.2
280.9
ug/g
1.22
12
50
7
21
3.37
1.97
1.1
1.3
—
—
—
0
0
177
1509
1.32
1.94
7.0
4.9
0.0
0.0
estimate
0.00
35
271
6
16
3.79
1.94
1.0
1.0
—
—
—
0
0
318
2954
1.42
1.93
33.7
13.5
81.8
80.5
ml/min/173m2
0.42
284
2426
106
839
1.36
1.92
3.8
2.8
349.4
7222.6
umol/l
3.54
90
719
342
3225
1.51
1.88
45.0
17.2
4.0
4.0
mmol/l
0.07
336
3137
178
1527
1.31
1.84
5.1
3.6
0.0
0.0
estimate
0.00
38
254
45
306
1.53
1.83
2.1
2.3
13.4
13.6
nmol/l
0.02
40
279
9
35
2.61
1.81
1.3
1.8
—
—
—
0
0
9
35
2.61
1.81
1.3
1.8
—
—
—
0
0
9
35
2.61
1.81
1.3
1.8
—
—
—
0
0
6
18
3.37
1.75
1.5
1.7
—
—
—
0
0
6
18
3.37
1.75
1.5
1.7
—
—
—
0
0
150
1266
1.30
1.73
5.0
3.7
37.3
68.3
ng/l
0.56
116
901
12
55
2.22
1.69
1.5
1.4
—
99.8
—
0
12
123
1018
1.30
1.62
4.3
3.9
27.2
9.4
mg/mmol
0.88
87
664
5
14
3.60
1.62
1.8
3.5
94.6
97.1
%
—
5
14
5
14
3.60
1.62
1.0
1.1
—
—
—
0
0
281
2586
1.31
1.61
44.9
18.0
14.4
13.7
%
8.98
271
2533
8
33
2.45
1.54
1.4
1.4
—
—
—
0
0
209
1862
1.27
1.51
3.2
2.8
—
—
—
0
0
10
45
2.25
1.47
1.4
1.3
—
—
—
0
0
15
80
1.91
1.46
1.3
1.4
—
—
—
0
0
6
22
2.75
1.44
1.5
1.2
—
—
—
0
0
5
17
2.97
1.36
2.2
1.2
—
—
—
0
0
9
43
2.12
1.31
1.1
1.1
—
—
—
0
0
8
34
2.38
1.30
1.9
1.6
—
—
—
0
0
10
48
2.11
1.28
1.5
1.4
—
—
—
0
0
10
48
2.11
1.28
1.5
1.4
—
—
—
0
0
16
92
1.77
1.27
1.4
2.3
—
—
—
0
0
16
92
1.77
1.27
1.6
1.5
—
—
—
0
0
13
70
1.89
1.25
1.4
1.3
2.9
3.3
u/ml
—
5
11
10
49
2.07
1.23
1.5
1.4
—
—
—
0
0
8
38
2.13
1.19
1.8
1.5
—
—
—
0
0
5
20
2.52
1.15
1.8
1.4
—
—
—
0
0
5
20
2.52
1.15
1.8
1.4
—
—
—
0
0
5
21
2.40
1.09
1.2
1.2
—
—
—
0
0
7
33
2.14
1.06
1.4
1.2
—
—
—
0
0
9
47
1.94
1.03
1.4
1.4
—
—
—
0
0
9
48
1.90
1.01
1.6
1.4
—
—
—
0
0
9
48
1.90
1.01
1.9
1.5
—
—
—
0
0
9
48
1.90
1.01
1.6
1.4
—
—
—
0
0
7
35
2.02
1.00
1.3
1.0
—
—
—
0
0
5
23
2.19
0.98
1.2
1.2
—
72.2
—
0
5
293
2774
1.23
0.98
4.7
4.4
1.8
1.9
mu/l
1.25
261
2518
9
50
1.82
0.97
1.7
1.5
—
—
—
0
0
8
145
0.54
0.95
1.1
1.0
—
—
—
0
0
25
177
1.44
0.91
2.2
2.6
0.4
0.1
e6/l
1.38
25
170
19
276
0.67
0.90
1.5
1.8
—
—
—
0
0
8
42
1.92
0.89
1.4
2.0
15.8
16.4
ug/l
—
8
42
23
161
1.46
0.89
1.3
1.3
1256.7
341.4
u/ml
0.89
23
146
6
30
2.02
0.87
1.0
1.1
—
—
u/ml
—
0
0
6
30
2.02
0.87
1.3
1.2
—
—
—
0
0
8
45
1.79
0.84
1.4
1.1
1.4
1.5
g/l
—
8
40
6
32
1.89
0.82
1.5
1.2
57.5
49.8
u/l
—
6
20
299
3113
0.83
0.81
4.4
4.6
4.4
4.6
mmol/l
3.74
275
2886
297
3094
0.83
0.81
4.3
4.5
1.4
1.4
mmol/l
1.78
266
2851
6
33
1.83
0.79
1.0
1.2
—
—
—
0
0
8
48
1.68
0.79
1.1
1.6
—
—
—
0
0
5
24
2.10
0.75
1.4
1.6
—
—
—
0
0
5
24
2.10
0.75
1.0
1.2
—
—
—
0
0
5
24
2.10
0.75
1.0
1.2
—
—
—
0
0
303
2906
1.19
0.73
6.5
6.0
40.3
40.3
mmol/mol
0.01
278
2703
5
25
2.01
0.73
1.0
1.2
—
—
—
0
0
5
25
2.01
0.73
5.0
1.1
—
—
—
0
0
5
25
2.01
0.73
1.0
1.2
—
—
—
0
0
5
25
2.01
0.73
1.0
1.2
—
—
—
0
0
57
476
1.23
0.71
1.2
1.4
—
—
—
0
0
7
41
1.72
0.70
1.0
1.1
—
—
—
0
0
10
61
1.66
0.69
1.3
1.2
—
—
—
0
0
7
42
1.68
0.68
1.3
1.0
—
—
—
0
0
149
1361
1.15
0.68
4.7
4.8
1.7
2.4
ug/l
1.71
127
1226
26
333
0.77
0.62
1.2
1.5
—
—
—
0
0
8
52
1.55
0.60
1.1
1.1
—
—
—
0
0
10
65
1.55
0.56
1.7
1.6
—
—
—
0
0
89
796
1.15
0.54
2.9
2.9
0.6
0.7
ug/l
1.98
56
512
55
474
1.19
0.52
1.4
1.3
20.2
37.1
iu/ml
1.15
15
161
236
2251
1.12
0.51
4.0
3.6
15.0
14.8
pmol/l
0.76
214
2025
308
3166
0.87
0.50
4.9
5.0
2.5
2.7
mmol/l
5.10
280
2915
75
669
1.15
0.47
1.8
1.8
535.5
433.2
pmol/l
0.85
67
559
118
1092
1.12
0.43
3.7
4.2
19.6
20.9
%
0.29
48
496
8
57
1.41
0.42
1.1
1.6
—
—
—
0
0
0
17
0.00
0.40
0.0
3.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
78.4
—
0
12
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
3.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
26.8
—
0
12
0
18
0.00
0.40
0.0
1.7
—
7.5
—
0
11
0
19
0.00
0.39
0.0
1.0
—
39.6
—
0
10
0
19
0.00
0.39
0.0
1.0
—
580.6
—
0
11
292
2842
1.11
0.37
42.6
15.7
38.1
40.4
%
4.30
204
2051
13
99
1.32
0.36
1.5
1.2
—
—
—
0
0
58
643
0.88
0.34
1.4
1.2
0.7
1.4
u/ml
—
7
190
13
100
1.31
0.34
1.5
1.2
—
—
—
0
0
294
3005
0.91
0.31
4.0
4.1
1.4
1.3
mmol/l
0.99
269
2766
338
3328
1.12
0.29
25.3
10.8
30.3
27.4
u/l
1.22
331
3219
28
244
1.16
0.26
2.0
2.7
59.4
63.3
ml/min/173m2
0.20
16
106
12
95
1.27
0.26
1.8
1.7
—
—
—
0
0
6
85
0.70
0.24
1.3
1.1
—
11.1
—
0
9
29
256
1.14
0.24
2.0
2.0
—
—
—
0
0
114
1193
0.94
0.21
6.1
3.7
—
—
—
0
0
48
448
1.08
0.16
1.3
1.3
5.1
11.6
u/ml
0.73
16
174
8
70
1.15
0.16
1.6
1.3
—
—
—
0
0
15
172
0.87
0.16
1.0
1.2
63.8
152.4
iu/ml
—
5
64
7
89
0.78
0.14
1.3
2.2
—
—
—
0
0
85
815
1.05
0.14
6.4
3.8
0.0
0.0
estimate
0.50
35
256
5
46
1.09
0.09
1.4
1.6
—
—
—
0
0
83
852
0.97
0.07
1.8
1.7
1.3
1.4
mmol/l
0.77
69
708
10
110
0.91
0.05
1.4
2.2
—
—
—
0
0
348
3467
1.04
0.04
54.1
21.5
4.3
4.5
e12/l
10.51
338
3370
39
401
0.97
0.03
4.6
4.5
30.7
31.2
%
0.11
30
267
348
3469
1.03
0.03
54.5
21.6
127.3
137.2
g/l
19.02
342
3414
38
371
1.03
0.02
10.9
8.3
—
—
—
0
0
24
232
1.04
0.02
2.0
1.8
—
—
—
0
0
305
3043
1.01
0.01
4.8
4.6
6.1
6.0
mmol/l
0.30
275
2778
15
156
0.96
0.00
1.4
1.3
—
—
—
0
0
6
62
0.97
0.00
2.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
9.5
—
0
9
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
9
0.00
0.00
0.0
1.0
—
133.6
—
0
9
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
59.4
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
194.0
—
0
5
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
6
65
0.92
0.00
1.2
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
24.4
—
0
5
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_CNSABSC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CNSABSC | 2.858 [2.2, 3.71] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.345 |
During the follow-up period (1.1.1998 — 31.12.2019), 249 out of 827 females with G6_CNSABSC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CNSABSC | 3.057 [2.48, 3.77] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 456 out of 1360 males with G6_CNSABSC died.
Mortality risk
Mortality risk for people of age
years, who have G6_CNSABSC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.342% | 0.607% |
| 5 | 2.032% | 3.043% |
| 10 | 4.479% | 7.957% |
| 15 | 7.857% | 15.197% |
| 20 | 13.336% | 24.356% |
Relationships between endpoints
↥Index endpoint: G6_CNSABSC – Intracranial and intraspinal abscess and granuloma
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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