ileocolitis: Ileocolitis or ileal Crohn's is the most common type of Crohn's disease. It affects both the ileum (small intestine) and the colon.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditions
|
67 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
67 |
6. Filter based on genotype QC (FinnGen only) |
66 |
Control definitions (FinnGen only)
- Control exclude
- K11_IBD, K11_CHOLANGI
- Control conditions
- not K11_CHOLANGI_STRICT
and not K11_CD_STRICT
Extra metadata
- First used in FinnGen datafreeze
- DF3
Similar endpoints
↥List of similar endpoints to
Crohn's disease (strict) with PSC
based on the number of shared cases.
Similar with more cases:
- IBD (strict) with PSC
- Cholangitis (primary sclerosing, PSC), with reimbursement 202
- Cholangitis (primary sclerosing, PSC)
- Crohn disease (strict definition, require KELA)
- Crohn's disease patients in KELA-register (KELA code 209, or 208 with ICD K50)
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 159 | 66 | 91 |
| Only index persons | 154 | 65 | 89 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 30.30 | 29.94 | 30.31 |
| Only index persons | 30.01 | 29.61 | 30.31 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 66 | 35 | 31 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 31.15 | 31.18 | 31.11 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 67
- Matched controls
- 670
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K83.0
ICD-10 Finland
Cholangitis
+∞
96.2
67
*
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
96.2
67
*
A05AA02
ATC
ursodeoxycholic acid; oral
3904.4
83.8
64
*
A07EC02
ATC
mesalazine; oral, rectal
1567.6
76.3
61
*
UJF30
NOMESCO Finland
Ileoscopy through colon
89.5
74.9
46
16
K50.8
ICD-10 Finland
Other Crohn disease
+∞
72.7
56
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
+∞
69.3
67
34
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
2399.0
65.8
53
*
K50.1
ICD-10 Finland
Crohn disease of large intestine
+∞
59.5
48
*
UJF32
NOMESCO Finland
Coloscopy
40.7
50.9
54
62
L04AX01
ATC
azathioprine; systemic
339.7
45.0
41
*
K50.9
ICD-10 Finland
Crohn disease, unspecified
849.1
43.4
38
*
A07EA06
ATC
budesonide; oral, local oral
160.4
40.8
40
6
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
20.1
35.5
47
70
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
23.2
34.8
31
24
K50.0
ICD-10 Finland
Crohn disease of small intestine
+∞
33.1
29
*
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
+∞
31.8
28
*
K51.5
ICD-10 Finland
Left sided colitis
+∞
26.9
24
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
110.3
26.2
27
*
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
365.5
25.5
24
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
365.5
25.5
24
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
11.3
23.1
41
82
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
+∞
20.9
19
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
9.7
18.3
29
49
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
8.6
17.9
42
109
UJK02
NOMESCO Finland
ERCP
120.6
17.5
18
*
TPH04
NOMESCO Finland
Cathetrisation of vein
8.5
17.1
32
65
L04AB04
ATC
adalimumab; parenteral
80.4
16.7
18
*
J01MA12
ATC
levofloxacin; systemic
8.4
16.4
30
59
WX402
NOMESCO Finland
General anaesthesia
7.7
16.0
36
88
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
+∞
15.2
14
*
UJF92
NOMESCO Finland
Capsular endoscopy
94.8
14.2
15
*
Z2221
NOMESCO Finland
Medical doctor
6.9
14.2
42
131
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
63.2
13.5
15
*
ZXD10
NOMESCO Finland
Scheduled procedure
6.7
13.4
44
149
L01BB02
ATC
mercaptopurine; oral
86.9
13.1
14
*
P01AB01
ATC
metronidazole; oral, rectal
6.9
12.9
48
180
K51.8
ICD-10 Finland
Other ulcerative colitis
158.5
12.9
13
*
UJK12
NOMESCO Finland
Peroral cholangioscopy
+∞
12.9
12
*
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
12.9
12
*
K80.3
ICD-10 Finland
Calculus of bile duct with cholangitis
+∞
12.9
12
*
H02AB06
ATC
prednisolone; systemic
6.8
12.2
50
202
JJC00
NOMESCO Finland
Allogenic transplantation of liver
+∞
11.8
11
*
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
+∞
11.8
11
*
Z94.4
ICD-10 Finland
Liver transplant status
+∞
11.8
11
*
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
43.4
11.8
14
*
ZX120
NOMESCO Finland
Intravenous
13.5
10.9
19
19
ZXE00
NOMESCO Finland
One hour or less
5.6
10.8
45
179
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
+∞
10.7
10
*
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
+∞
10.7
10
*
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
+∞
10.7
10
*
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
+∞
10.7
10
*
J01MA02
ATC
ciprofloxacin; systemic
5.3
10.4
41
154
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.4
10.4
44
175
A07EA02
ATC
hydrocortisone; rectal
115.7
9.7
10
*
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
+∞
9.6
9
*
WX002
NOMESCO Finland
Sedation and analgesia
5.7
9.3
22
53
K83.1
ICD-10 Finland
Obstruction of bile duct
57.8
8.9
10
*
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
23.9
8.8
12
6
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
102.4
8.6
9
*
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
102.4
8.6
9
*
L04AC05
ATC
ustekinumab; parenteral
102.4
8.6
9
*
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
14.4
8.5
14
12
256, ,
Kela drug reimbursment
+∞
8.5
8
*
UJF02
NOMESCO Finland
Peroral enteroscopy
+∞
8.5
8
*
K74.3
ICD-10 Finland
Primary biliary cirrhosis
+∞
8.5
8
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
25.8
8.3
11
5
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
13.2
8.3
14
13
N02AX02
ATC
tramadol; systemic, rectal
4.4
8.3
40
169
A07EC01
ATC
sulfasalazine; oral, rectal
9.2
7.8
16
22
H02AB07
ATC
prednisone; oral
7.1
7.7
19
35
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
89.6
7.6
8
*
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
89.6
7.6
8
*
K76.9
ICD-10 Finland
Liver disease, unspecified
+∞
7.4
7
*
L04AD01
ATC
ciclosporin; systemic
23.1
7.4
10
5
127
Kela drug reimbursment
Transplant complication
23.1
7.4
10
5
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
44.7
6.9
8
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
7.0
6.9
17
31
JN4AD
NOMESCO Finland
Body CT examination
9.8
6.7
13
16
Z3226
NOMESCO Finland
Physiotherapist
4.1
6.6
24
80
H02AB04
ATC
methylprednisolone; systemic
6.5
6.6
17
33
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
12.9
6.6
11
10
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.1
6.5
16
39
L04AA06
ATC
mycophenolic acid; systemic
29.8
6.4
8
*
TK800
NOMESCO Finland
Hemodialysis
29.8
6.4
8
*
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
+∞
6.3
6
*
M07.4*K50.9
ICD-10 Finland
Arthropathy in Crohn's disease [regional enteritis]
+∞
6.3
6
*
R4110
NOMESCO Finland
Physiotherapy
3.7
6.2
28
108
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
54
32
82.82
73.54
7.1
4.1
2.08
2.55
ug/l
0.48
40
23
39
6
150.88
39.50
5.2
2.7
3.75
13.92
u/ml
—
39
6
35
29
24.18
38.20
4.0
1.8
—
—
—
0
0
38
7
121.14
37.40
3.1
1.0
—
—
—
0
0
59
178
20.30
22.69
18.6
9.1
1.03
1.11
inr
0.85
14
50
32
54
10.43
20.48
4.3
2.6
19.66
23.35
%
0.77
27
46
54
184
10.97
17.60
10.0
6.3
1.21
1.22
mmol/l
0.47
54
173
31
67
7.75
15.43
4.6
2.5
10.85
14.39
umol/l
1.94
31
62
47
157
7.68
14.93
2.3
1.8
99.03
94.35
pmol/l
0.28
33
90
19
12
21.48
13.11
1.4
1.6
—
—
—
0
0
15
8
23.61
10.85
1.1
1.1
—
—
—
0
0
16
11
18.61
10.65
5.8
10.9
1.64
1.76
mg/l
0.11
16
11
12
6
23.89
8.83
1.2
1.0
1.64
1.15
g/l
—
12
6
20
49
5.39
8.23
11.3
9.3
106.40
104.65
mmol/l
1.01
20
49
49
242
4.81
8.12
6.0
3.0
89.10
98.54
ug/l
0.16
49
229
32
120
4.19
7.67
4.3
2.1
—
—
—
0
0
10
5
23.08
7.38
4.0
1.0
98.70
113.60
%
—
10
5
14
18
9.51
7.04
1.3
1.4
—
—
—
0
0
17
45
4.72
6.28
2.6
1.4
—
—
—
0
0
24
83
3.95
6.26
3.0
2.5
5.00
2.82
e6/l
0.25
18
44
12
15
9.47
6.15
3.0
4.0
99.33
104.93
%
0.20
12
15
46
253
3.61
5.76
5.3
2.4
—
—
—
0
0
17
49
4.31
5.61
2.6
1.4
—
—
—
0
0
21
73
3.73
5.36
2.4
1.8
—
—
—
0
0
5
0
+∞
5.27
2.0
0.0
25.20
—
umol/l
—
5
0
5
0
+∞
5.27
2.8
0.0
1.80
—
mg/l
—
5
0
10
13
8.81
5.05
3.0
1.9
—
—
—
0
0
10
14
8.17
4.85
1.6
1.3
—
—
—
0
0
22
89
3.19
4.36
3.2
2.4
1.23
0.88
e6/l
0.16
16
50
7
7
10.97
4.11
1.4
1.0
—
—
—
0
0
7
7
10.97
4.11
1.1
1.1
—
—
—
0
0
14
38
4.38
4.10
2.9
2.4
—
—
—
0
0
7
8
9.59
3.87
1.0
1.0
—
—
—
0
0
11
26
4.85
3.70
10.3
10.0
22.95
24.80
mmol/l
0.60
11
26
31
166
2.61
3.57
5.0
2.9
—
—
—
0
0
13
39
3.88
3.47
3.2
1.6
64.33
85.85
ml/min/173m2
—
6
13
14
49
3.35
3.43
2.5
1.7
266.86
420.50
nmol/l
2.32
14
44
8
17
5.19
3.02
4.0
4.4
215.75
135.29
%
—
8
17
9
25
3.99
2.69
1.1
1.6
—
—
—
0
0
5
8
6.64
2.41
2.6
2.5
—
—
—
0
0
5
8
6.64
2.41
2.6
2.5
—
—
—
0
0
5
8
6.64
2.41
2.2
2.5
—
—
—
0
0
5
8
6.64
2.41
2.4
2.5
—
—
—
0
0
5
9
5.90
2.25
2.2
2.3
—
—
—
0
0
5
9
5.90
2.25
2.2
2.3
—
—
—
0
0
5
10
5.30
2.11
9.2
1.9
22.26
23.57
mmol/l
—
5
10
24
142
2.08
2.00
2.3
1.8
1.32
1.47
mmol/l
0.63
24
126
6
16
4.01
1.98
9.5
4.4
24.18
24.66
mmol/l
—
6
16
20
111
2.14
1.96
3.4
1.9
0.61
0.70
mg/l
0.17
14
78
25
154
1.99
1.86
1.4
1.5
0.49
1.54
u/ml
—
7
37
6
18
3.55
1.79
2.5
1.4
—
—
—
0
0
6
20
3.19
1.62
16.2
7.8
1.23
1.44
%
—
6
20
6
20
3.19
1.62
16.2
7.8
0.80
0.75
%
—
6
20
5
15
3.51
1.55
2.4
2.5
48.16
52.74
%
—
5
15
5
17
3.09
1.38
19.0
8.8
20.80
24.36
mmol/l
—
5
17
5
17
3.09
1.38
1.0
1.3
—
—
—
0
0
5
18
2.91
1.31
10.2
12.0
131.20
141.06
g/l
—
5
18
16
95
1.90
1.28
5.4
2.4
11.30
94.11
ng/l
—
10
57
6
26
2.43
1.21
1.5
1.9
—
—
—
0
0
33
247
1.66
1.20
4.8
3.0
0.00
0.00
estimate
—
8
49
33
247
1.66
1.20
6.3
4.4
0.00
0.00
estimate
—
8
46
33
251
1.62
1.10
5.3
3.1
0.00
0.00
estimate
—
8
41
20
135
1.69
1.05
2.4
2.1
82.70
145.05
u/l
1.40
20
130
7
37
1.99
0.97
1.0
1.1
—
—
—
0
0
0
24
0.00
0.81
0.0
1.5
—
—
—
0
0
20
152
1.45
0.62
2.6
2.3
18.94
15.49
ng/l
0.23
12
74
17
125
1.48
0.61
6.7
3.0
0.00
0.00
estimate
—
6
43
0
23
0.00
0.59
0.0
1.5
—
—
—
0
0
12
85
1.50
0.51
1.6
2.4
216.77
512.94
ng/l
1.37
12
65
21
167
1.38
0.50
1.9
1.9
—
—
—
0
0
5
84
0.56
0.49
1.4
1.7
—
—
—
0
0
53
488
1.41
0.47
3.9
3.6
—
—
—
0
0
44
400
1.29
0.39
4.4
4.1
14.53
14.51
pmol/l
0.03
39
370
53
500
1.29
0.29
3.3
3.6
5.79
5.78
mmol/l
0.01
48
470
9
74
1.25
0.26
1.2
3.0
2.44
2.44
mmol/l
—
9
66
21
182
1.22
0.25
6.3
3.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
11
131
0.81
0.19
2.0
2.1
—
—
—
0
0
5
48
1.04
0.09
1.0
1.0
—
—
—
0
0
13
143
0.89
0.08
1.9
2.3
—
—
—
0
0
6
72
0.82
0.08
2.0
1.6
—
—
—
0
0
11
102
1.09
0.03
1.3
1.3
—
29.56
—
0
37
11
104
1.07
0.01
1.5
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
8.15
—
0
8
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
13.33
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
-0.00
0.0
1.0
—
152.40
—
0
5
0
5
0.00
-0.00
0.0
2.2
—
17.94
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
7
0.00
-0.00
0.0
2.6
—
88.86
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint K11_CD_STRICT_PSC and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have K11_CD_STRICT_PSC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: K11_CD_STRICT_PSC – Crohn's disease (strict) with PSC
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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