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Crohn's disease (strict) with PSC

DOID EFO Endpoint Browser PheWeb

K11_CD_STRICT_PSC

ileocolitis: Ileocolitis or ileal Crohn's is the most common type of Crohn's disease. It affects both the ileum (small intestine) and the colon.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • K11_CHOLANGI_STRICT
  • and K11_CD_STRICT
61

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

61

6. Filter based on genotype QC (FinnGen only)

61

Control definitions (FinnGen only)

Control exclude
K11_IBD, K11_CHOLANGI
Control conditions
not K11_CHOLANGI_STRICT
and not K11_CD_STRICT

Extra metadata

First used in FinnGen datafreeze
DF3

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 159 66 91
Only index persons 154 65 89
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population 30.30 29.94 30.31
Only index persons 30.01 29.61 30.31

-FinnGen-

Key figures

All Female Male
Number of individuals 61 32 29
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 31.23 30.94 31.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
57
Matched controls
572
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
81.7
57
*
K83.0
ICD-10 Finland
Cholangitis
+∞
81.7
57
*
A05AA02
ATC
ursodeoxycholic acid; oral
2801.8
69.7
54
*
A07EC02
ATC
mesalazine; oral, rectal
1458.1
63.6
51
*
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
2691.9
60.7
48
*
K50.8
ICD-10 Finland
Other Crohn disease
+∞
60.7
47
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
+∞
56.6
57
34
K50.1
ICD-10 Finland
Crohn disease of large intestine
+∞
47.8
39
*
K50.9
ICD-10 Finland
Crohn disease, unspecified
+∞
41.9
35
*
A07EA06
ATC
budesonide; oral, local oral
434.6
39.1
35
*
L04AX01
ATC
azathioprine; systemic
188.1
37.6
36
5
UJF30
NOMESCO Finland
Ileoscopy through colon
57.4
33.0
40
22
UJF32
NOMESCO Finland
Coloscopy
38.7
30.3
46
55
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
231.7
27.3
26
*
K50.0
ICD-10 Finland
Crohn disease of small intestine
+∞
27.3
24
*
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
+∞
26.0
23
*
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
+∞
24.8
22
*
K51.5
ICD-10 Finland
Left sided colitis
+∞
24.8
22
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
348.5
23.4
22
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
29.2
20.3
28
18
WX404
NOMESCO Finland
Intravenous generell anesthesy
15.6
19.2
39
69
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
12.5
16.7
38
78
UJK02
NOMESCO Finland
ERCP
+∞
16.4
15
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
11.7
15.5
35
68
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
+∞
15.3
14
*
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
+∞
15.3
14
*
J01MA12
ATC
levofloxacin; systemic
11.5
13.2
27
41
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
164.8
13.0
13
*
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
+∞
13.0
12
*
P01AB01
ATC
metronidazole; oral, rectal
8.6
12.6
42
140
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
11.9
11
*
K51.8
ICD-10 Finland
Other ulcerative colitis
+∞
11.9
11
*
K80.3
ICD-10 Finland
Calculus of bile duct with cholangitis
133.6
10.8
11
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
+∞
10.7
10
*
Z94.4
ICD-10 Finland
Liver transplant status
+∞
10.7
10
*
N02AX02
ATC
tramadol; systemic, rectal
6.8
10.5
37
122
UJF92
NOMESCO Finland
Capsular endoscopy
49.6
10.4
12
*
L04AB04
ATC
adalimumab; parenteral
32.9
10.3
13
5
UJK12
NOMESCO Finland
Peroral cholangioscopy
119.0
9.7
10
*
WX402
NOMESCO Finland
General anaesthesia
7.1
9.6
27
64
TPH04
NOMESCO Finland
Cathetrisation of vein
7.0
9.4
27
65
H02AB06
ATC
prednisolone; systemic
6.2
9.2
42
177
ZX120
NOMESCO Finland
Intravenous
11.6
9.1
17
20
J01MA02
ATC
ciprofloxacin; systemic
5.8
9.0
37
138
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
18.2
8.7
13
9
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
+∞
8.5
8
*
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
+∞
8.5
8
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.4
8.4
35
130
L01BB02
ATC
mercaptopurine; oral
52.5
8.0
9
*
A07EA02
ATC
hydrocortisone; rectal
91.5
7.6
8
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
19.0
7.6
11
7
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
+∞
7.4
7
*
L04AC05
ATC
ustekinumab; parenteral
+∞
7.4
7
*
K76.9
ICD-10 Finland
Liver disease, unspecified
+∞
7.4
7
*
K74.3
ICD-10 Finland
Primary biliary cirrhosis
+∞
7.4
7
*
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
+∞
7.4
7
*
UJF02
NOMESCO Finland
Peroral enteroscopy
+∞
7.4
7
*
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
+∞
7.4
7
*
R4110
NOMESCO Finland
Physiotherapy
5.0
6.8
25
77
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
78.3
6.6
7
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
20.9
6.5
9
5
127
Kela drug reimbursment
Transplant complication
30.4
6.4
8
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
7.4
6.4
15
26
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.5
6.4
20
51
K83.1
ICD-10 Finland
Obstruction of bile duct
+∞
6.4
6
*
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
+∞
6.4
6
*
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
+∞
6.4
6
*
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
+∞
6.4
6
*
WX002
NOMESCO Finland
Sedation and analgesia
5.5
6.2
19
47
L04AD01
ATC
ciclosporin; systemic
17.4
6.1
9
6

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
51
29
102.18
71.03
7.4
3.6
2.1
2.6
ug/l
0.49
40
20
48
42
49.93
53.41
3.3
1.1
—
—
—
0
0
34
9
82.36
31.48
3.4
1.0
—
—
—
0
0
33
9
77.11
30.24
3.6
1.0
60.0
—
titre
—
5
0
37
65
12.93
23.63
3.8
1.4
293.3
587.7
titre
1.00
15
13
53
144
21.32
22.08
18.5
6.6
—
—
—
0
0
35
63
11.69
21.65
2.8
2.2
—
—
—
0
0
51
148
15.92
20.80
17.5
6.5
1.0
1.1
inr
0.55
12
37
17
12
19.25
19.27
1.2
1.4
—
—
—
0
0
16
11
19.36
18.31
5.8
10.9
1.6
1.8
mg/l
0.11
16
11
53
184
15.28
17.51
13.5
9.1
1.2
1.2
mmol/l
0.89
53
167
50
167
12.06
16.90
10.7
6.6
1.2
1.2
mmol/l
0.50
50
156
56
225
19.09
16.89
23.4
5.8
3.0
2.8
%
0.41
56
209
56
226
18.96
16.80
23.7
6.1
8.9
8.1
%
1.37
56
211
56
231
18.31
16.36
22.9
5.6
56.1
56.6
%
0.14
56
216
28
52
9.10
16.28
4.4
2.7
19.3
23.0
%
0.74
23
44
56
233
18.06
16.18
23.6
5.8
29.3
29.4
%
0.02
56
217
55
222
15.96
16.04
23.6
5.6
0.8
0.7
%
1.61
55
204
40
120
7.78
14.43
16.4
7.1
—
—
—
0
0
43
139
8.09
14.34
2.3
1.9
92.8
95.5
pmol/l
0.15
29
80
16
20
10.49
12.50
1.4
1.5
—
—
—
0
0
42
150
6.78
12.04
5.5
2.1
—
—
—
0
0
49
205
8.07
11.70
24.1
8.4
0.0
0.0
e9/l
0.00
43
160
21
40
7.48
11.55
4.8
7.4
—
—
—
0
0
45
182
6.61
10.90
3.7
1.6
—
—
—
0
0
18
31
7.82
10.78
1.6
1.3
—
—
—
0
0
25
61
6.25
10.69
1.7
1.5
—
—
—
0
0
14
21
8.35
9.34
1.6
1.2
—
—
—
0
0
8
0
+∞
8.52
1.6
0.0
—
—
—
0
0
44
212
4.86
7.65
6.4
3.1
94.0
102.7
ug/l
0.13
44
203
29
103
4.46
7.60
11.7
4.6
—
—
—
0
0
10
5
23.45
7.40
1.1
1.0
—
—
—
0
0
10
5
23.45
7.40
1.1
1.0
—
—
—
0
0
15
31
6.09
7.38
9.9
7.4
—
—
—
0
0
19
56
4.48
6.19
1.4
1.3
—
—
—
0
0
9
6
17.24
6.11
1.2
1.0
1.7
1.2
g/l
—
9
6
27
105
3.82
6.01
2.0
1.7
—
—
—
0
0
51
310
4.94
5.72
4.2
2.9
—
—
—
0
0
5
0
+∞
5.27
2.0
0.0
25.2
—
umol/l
—
5
0
14
37
4.61
5.15
1.4
1.5
—
—
—
0
0
28
122
3.39
5.10
4.5
2.5
—
—
—
0
0
32
152
3.32
5.06
5.1
3.3
18.1
45.9
e6/l
0.52
27
103
11
24
5.37
5.01
10.3
10.7
22.9
24.9
mmol/l
0.66
11
24
7
5
15.54
4.69
1.0
1.0
—
—
—
0
0
17
58
3.68
4.43
1.8
1.3
—
—
—
0
0
7
6
12.94
4.39
1.3
1.3
—
—
—
0
0
7
7
11.08
4.12
2.6
2.4
—
—
—
0
0
30
152
2.92
4.04
1.9
1.9
—
—
—
0
0
8
12
7.48
3.81
2.4
2.3
—
—
—
0
0
9
20
5.08
3.26
16.7
6.4
—
—
—
0
0
13
46
3.32
3.15
1.5
1.8
265.2
424.8
nmol/l
2.20
13
41
6
8
8.16
3.13
1.2
1.1
—
—
—
0
0
46
320
2.78
3.01
6.5
4.1
—
—
—
0
0
7
14
5.49
2.81
1.3
1.2
—
—
—
0
0
14
59
2.78
2.51
1.1
1.1
—
—
—
0
0
6
13
4.99
2.33
1.5
1.2
—
—
—
0
0
5
9
5.93
2.25
9.2
1.7
22.3
23.5
mmol/l
—
5
9
23
131
2.21
2.18
2.3
1.8
1.3
1.5
mmol/l
0.57
23
118
26
157
2.14
2.12
1.7
1.5
—
—
—
0
0
21
117
2.21
2.09
12.5
4.1
—
—
—
0
0
7
23
3.30
1.86
7.0
4.4
—
—
—
0
0
6
18
3.58
1.79
16.2
8.5
95.8
94.5
%
—
6
18
6
19
3.38
1.70
16.2
8.2
1.2
1.4
%
—
6
19
6
19
3.38
1.70
16.2
8.2
0.8
0.8
%
—
6
19
5
14
3.79
1.65
11.2
4.6
23.2
24.5
mmol/l
—
5
14
18
105
2.01
1.55
3.7
1.9
0.6
0.6
mg/l
0.02
13
77
5
16
3.31
1.47
19.0
9.3
20.8
24.6
mmol/l
—
5
16
5
16
3.31
1.47
1.4
1.3
—
—
—
0
0
31
223
1.79
1.40
6.5
4.5
0.0
0.0
estimate
—
7
40
31
223
1.79
1.40
5.0
3.0
0.0
0.0
estimate
—
7
40
15
86
1.99
1.34
5.7
2.5
8.4
99.1
ng/l
—
9
54
31
227
1.74
1.29
5.5
3.1
0.0
0.0
estimate
—
7
36
7
37
2.00
0.97
6.7
6.9
—
—
—
0
0
6
27
2.35
0.96
1.0
2.1
—
—
—
0
0
18
122
1.67
0.94
2.5
1.9
82.6
152.1
u/l
1.42
18
117
20
141
1.62
0.90
1.3
1.5
0.5
1.5
u/ml
—
6
33
16
107
1.67
0.87
4.8
3.0
—
—
—
0
0
9
52
1.86
0.81
1.9
1.3
—
—
—
0
0
23
172
1.54
0.80
4.0
3.0
—
—
—
0
0
9
58
1.65
0.74
1.6
1.6
—
—
—
0
0
15
104
1.59
0.71
3.3
3.6
102.1
103.3
mg/l
—
9
69
16
113
1.56
0.70
7.0
2.9
0.0
0.0
estimate
—
5
37
14
194
0.64
0.70
2.6
2.2
—
—
—
0
0
15
105
1.57
0.68
3.0
2.5
—
—
—
0
0
15
106
1.55
0.65
4.0
4.2
18.5
15.2
mg/mmol
—
10
71
5
86
0.54
0.62
1.2
1.3
—
—
—
0
0
0
23
0.00
0.59
0.0
1.1
—
5.8
—
0
7
6
95
0.59
0.58
2.0
1.7
—
—
—
0
0
18
141
1.39
0.47
2.7
2.3
18.9
16.1
ng/l
0.18
12
68
16
123
1.41
0.47
4.9
2.6
—
—
—
0
0
5
31
1.67
0.44
4.4
2.7
—
—
—
0
0
5
32
1.61
0.43
6.6
2.6
—
—
—
0
0
0
15
0.00
0.42
0.0
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
4.0
—
0
9
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
5
35
1.47
0.40
1.0
1.1
—
—
—
0
0
16
131
1.30
0.31
3.6
3.1
8.3
8.8
mmol/l
0.17
16
121
0
10
0.00
0.21
0.0
26.5
—
1464.6
—
0
10
0
10
0.00
0.21
0.0
17.9
—
909.0
—
0
10
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
39
365
1.19
0.20
4.7
4.2
14.4
14.5
pmol/l
0.17
34
339
0
14
0.00
0.20
0.0
1.2
—
6.2
—
0
8
11
97
1.16
0.10
3.1
3.2
—
—
—
0
0
10
95
1.06
0.00
1.3
1.3
—
30.4
—
0
35
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
3.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
32.5
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
256.6
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
4.6
—
162.4
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
9
90
1.00
0.00
1.7
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
10.3
—
0.7
—
0
7

Mortality – FinRegistry

↥

Association

Association between endpoint K11_CD_STRICT_PSC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have K11_CD_STRICT_PSC.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: K11_CD_STRICT_PSC – Crohn's disease (strict) with PSC

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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