sclerosing cholangitis: A chronic, autoimmune inflammatory liver disorder characterized by narrowing and scarring of the lumen of the bile ducts. It is often seen in patients with ulcerative colitis. Signs and symptoms include jaundice, fatigue, and malabsorption. It may lead to cirrhosis and liver failure.
Cholangitis (primary sclerosing, PSC), with reimbursement 202
DOID EFO Endpoint Browser PheWeb
K11_CHOLANGI_STRICT
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
30353 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
666 |
4. Check minimum number of eventsNone |
666 |
5. Include endpointsNone |
666 |
6. Filter based on genotype QC (FinnGen only) |
666 |
Control definitions (FinnGen only)
- Control exclude
- K11_IBD_STRICT_PSC
- Control conditions
- not K11_REIMB_202
Extra metadata
- First used in FinnGen datafreeze
- DF3
- Parent code in ICD-10
- K83
- Name in latin
- Cholangitis
Similar endpoints
↥List of similar endpoints to
Cholangitis (primary sclerosing, PSC), with reimbursement 202
based on the number of shared cases.
Similar with more cases:
- Cholangitis (primary sclerosing, PSC)
- Reimbursement for rheumatic diseases
- Disorders of gallbladder, biliary tract and pancreas
- Gastrointestinal diseases
- Any reimbursement code in KELA
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2699 | 1491 | 1192 |
| Only index persons | 2473 | 1364 | 1109 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 52.12 | 57.80 | 44.91 |
| Only index persons | 50.38 | 56.59 | 42.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 666 | 369 | 297 |
| Unadjusted period prevalence (%) | 0.13 | 0.13 | 0.13 |
| Median age at first event (years) | 45.25 | 49.06 | 40.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 602
- Matched controls
- 6021
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
291.9
323.0
353
29
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
+∞
323.0
602
*
A05AA02
ATC
ursodeoxycholic acid; oral
1326.8
323.0
496
21
K83.0
ICD-10 Finland
Cholangitis
4503599627370496.0
323.0
597
15
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
57.0
276.9
330
125
A07EC02
ATC
mesalazine; oral, rectal
41.3
250.1
324
165
K51.5
ICD-10 Finland
Left sided colitis
72.5
234.9
264
64
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
130.2
220.7
228
28
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
161.5
208.5
211
20
UJF30
NOMESCO Finland
Ileoscopy through colon
24.1
207.3
323
276
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
51.4
190.4
229
71
UJK02
NOMESCO Finland
ERCP
63.8
182.6
210
50
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
72.2
177.8
200
41
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
20.5
174.3
283
249
L04AX01
ATC
azathioprine; systemic
36.0
160.5
210
88
UJF32
NOMESCO Finland
Coloscopy
11.0
151.6
382
818
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
190.9
132.5
134
9
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
56.7
125.0
147
34
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
8.4
122.4
368
946
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
45.2
120.2
148
43
WX404
NOMESCO Finland
Intravenous generell anesthesy
8.5
117.5
334
773
K51.8
ICD-10 Finland
Other ulcerative colitis
60.4
107.5
125
26
A07EC01
ATC
sulfasalazine; oral, rectal
31.9
105.3
141
57
A07EA06
ATC
budesonide; oral, local oral
28.0
104.9
146
68
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
66.2
95.2
109
20
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
6.4
91.8
321
906
UJK12
NOMESCO Finland
Peroral cholangioscopy
178.1
88.8
91
6
K83.1
ICD-10 Finland
Obstruction of bile duct
62.1
85.5
99
19
WX402
NOMESCO Finland
General anaesthesia
6.6
85.0
272
667
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
7.9
82.2
215
393
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
280.5
74.2
74
*
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
276.2
73.1
73
*
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
38.5
72.4
92
28
J01MA12
ATC
levofloxacin; systemic
6.0
69.3
228
551
TPH04
NOMESCO Finland
Cathetrisation of vein
5.5
65.9
242
660
Z94.4
ICD-10 Finland
Liver transplant status
188.0
65.4
67
*
K74.3
ICD-10 Finland
Primary biliary cirrhosis
150.4
64.3
67
5
K50.8
ICD-10 Finland
Other Crohn disease
27.3
62.8
87
37
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
19.1
61.7
96
59
K76.9
ICD-10 Finland
Liver disease, unspecified
34.0
61.2
80
27
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
10.6
60.0
123
142
K50.1
ICD-10 Finland
Crohn disease of large intestine
45.9
59.8
73
18
JJC00
NOMESCO Finland
Allogenic transplantation of liver
217.5
58.1
59
*
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
613.5
57.6
56
*
P01AB01
ATC
metronidazole; oral, rectal
4.1
57.3
352
1544
K50.9
ICD-10 Finland
Crohn disease, unspecified
32.7
57.0
75
26
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
66.0
56.7
65
11
H02AB06
ATC
prednisolone; systemic
4.0
56.6
370
1709
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
47.0
55.1
67
16
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
193.2
51.8
53
*
WX002
NOMESCO Finland
Sedation and analgesia
4.6
51.1
213
634
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
100.7
50.8
55
6
J01MA02
ATC
ciprofloxacin; systemic
3.8
50.1
313
1341
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
68.4
49.2
56
9
K80.3
ICD-10 Finland
Calculus of bile duct with cholangitis
55.9
47.7
56
11
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.6
47.5
328
1500
ZX120
NOMESCO Finland
Intravenous
6.1
45.6
136
273
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
49.3
45.0
54
12
JN3BD
NOMESCO Finland
Extensive abdominal CT
6.1
44.9
135
273
L04AD01
ATC
ciclosporin; systemic
25.0
44.6
63
28
127
Kela drug reimbursment
Transplant complication
21.0
44.2
66
35
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
51.6
43.7
52
11
H02AB07
ATC
prednisone; oral
5.1
43.5
155
382
P01BA02
ATC
hydroxychloroquine; oral
11.4
43.0
83
83
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
17.4
42.0
67
43
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
34.7
41.8
54
17
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
154.0
41.3
43
*
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
19.5
39.3
60
34
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
37.9
38.8
49
14
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
13.6
38.0
67
55
JKD20
NOMESCO Finland
Anastomosis of bile duct to jejunum
+∞
36.8
35
*
JKE18
NOMESCO Finland
Endoscopic internal drainage of bile duct
32.5
36.7
48
16
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
378.8
36.4
36
*
A07EA02
ATC
hydrocortisone; rectal
14.6
36.3
62
47
L04AA06
ATC
mycophenolic acid; systemic
18.2
35.3
55
33
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
191.0
35.1
36
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.0
34.4
291
1431
JKE32
NOMESCO Finland
Endoscopic dilatation of bile duct
69.3
34.4
39
6
H02AB04
ATC
methylprednisolone; systemic
4.3
34.1
143
407
K50.0
ICD-10 Finland
Crohn disease of small intestine
20.1
33.3
50
27
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
95.6
33.1
36
*
N02AX02
ATC
tramadol; systemic, rectal
2.9
32.5
301
1551
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
4.4
32.5
132
363
WX408
NOMESCO Finland
General anesthesy, balanced
3.1
32.4
231
1002
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
76.2
32.2
36
5
R50.9
ICD-10 Finland
Fever, unspecified
3.9
32.1
152
480
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.5
31.8
87
152
L04AB04
ATC
adalimumab; parenteral
37.8
31.0
39
11
5761C
ICD-9 Finland
Other disorders of biliary tract, Cholangitis[CHOLANGITIS SCLEROSIVA]
+∞
30.5
29
*
JJ5AT
NOMESCO Finland
NA
317.5
30.1
30
*
L01BB02
ATC
mercaptopurine; oral
21.5
30.0
44
22
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
112.4
30.0
32
*
JN3AD
NOMESCO Finland
Abdominal CT examination
5.7
29.1
89
179
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
18.2
28.4
44
26
JKE22
NOMESCO Finland
Endoscopic extraction of foreign body from bile duct
44.9
28.0
34
8
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
294.4
28.0
28
*
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
7.6
26.2
63
91
L88
ICPC
Rheumatoid/seropositive arthritis
32.6
26.2
34
11
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
8.4
25.9
58
75
K80.5
ICD-10 Finland
Calculus of bile duct without cholangitis or cholecystitis
9.5
25.8
54
62
JFH30
NOMESCO Finland
Total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
141.0
25.8
27
*
R10.1
ICD-10 Finland
Pain localized to upper abdomen
3.4
25.7
143
505
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
17.0
25.3
40
25
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
40.7
25.1
31
8
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
23.9
24.2
34
15
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
+∞
24.1
23
*
K51
ICD-10 Finland
Ulcerative colitis
19.0
23.8
36
20
L04AA01
ATC
[U] ciclosporin; systemic
21.1
23.3
34
17
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
23.2
23.2
33
15
K85.8
ICD-10 Finland
Other acute pancreatitis
56.4
23.2
27
5
JJ1CE
NOMESCO Finland
Liver, bile duct and pancreas endoscopic ultrasound examination
67.7
23.0
26
*
A02BC02
ATC
pantoprazole; systemic
2.4
22.3
391
2641
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
26.2
21.9
30
12
L04AA13
ATC
leflunomide; oral
119.3
21.7
23
*
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
8.3
21.5
48
62
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
21.7
21.5
31
15
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
10.9
21.4
41
40
TK800
NOMESCO Finland
Hemodialysis
11.8
21.2
39
35
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
5.3
21.2
67
139
JJA20
NOMESCO Finland
Open biopsy of liver
43.3
20.6
25
6
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
15.8
20.4
33
22
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
8.4
20.4
45
57
C10AC01
ATC
colestyramine; oral
9.0
20.2
43
51
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
4.1
20.2
83
225
JN4CD
NOMESCO Finland
Very extensive body CT
7.2
20.0
49
73
K75.4
ICD-10 Finland
Autoimmune hepatitis
108.6
19.7
21
*
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
20.2
19.7
29
15
R94.5
ICD-10 Finland
Abnormal results of liver function studies
15.3
19.6
32
22
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
32.5
19.4
25
8
3AC01
NOMESCO Finland
NA
19.0
19.3
29
16
K85.0
ICD-10 Finland
Idiopathic acute pancreatitis
35.6
19.0
24
7
JX1XE
NOMESCO Finland
Other ultrasound examinaton of alimentary organs
195.8
18.6
19
*
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
3.5
18.5
94
305
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
5.6
18.4
55
107
5561A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) ileocolitis
54.3
18.1
21
*
R4110
NOMESCO Finland
Physiotherapy
2.4
17.9
191
982
JFG00
NOMESCO Finland
Closure of loop enterostomy without resection
98.0
17.7
19
*
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
6.5
17.5
46
76
WX302
NOMESCO Finland
Thoracal epidural anesthesy
4.7
17.5
61
141
JKE12
NOMESCO Finland
Endoscopic extraction of calculus from bile duct
14.4
17.4
29
21
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
12.0
17.2
31
27
JAH00
NOMESCO Finland
Laparotomy
7.4
16.9
40
57
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.6
16.9
81
251
UJF92
NOMESCO Finland
Capsular endoscopy
8.6
16.7
36
44
M13.9
ICD-10 Finland
Arthritis, unspecified
5.4
16.7
51
102
M45
ICD-10 Finland
Ankylosing spondylitis
18.6
16.6
25
14
K83.3
ICD-10 Finland
Fistula of bile duct
174.6
16.6
17
*
WX419
NOMESCO Finland
Other general anesthesy
14.8
16.5
27
19
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
11.6
16.4
30
27
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
16.0
138
629
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
87.4
15.6
17
*
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
9.8
15.6
31
33
H02AB09
ATC
hydrocortisone; systemic
6.8
15.5
39
61
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
15.4
146
699
JN1CM
NOMESCO Finland
Upper part of abdomen extensive MRI examination with 3 Tesla magnet
46.2
15.1
18
*
K85
ICD-10 Finland
Acute pancreatitis
11.2
15.1
28
26
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
14.8
104
420
ZJX00
NOMESCO Finland
Double balloon technique in gastroenterological endoscopy
+∞
14.6
14
*
JCA32
NOMESCO Finland
Endoscopic injection in oesophagus
153.5
14.5
15
*
JKD50
NOMESCO Finland
Hepatoportoenterostomy
153.5
14.5
15
*
TPH07
NOMESCO Finland
Cathetrisation of artery
3.1
14.4
83
294
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
3.1
14.2
84
302
WVA20
NOMESCO Finland
Medicine administration
6.8
14.1
35
54
5568X
ICD-9 Finland
Idiopathic proctocolitis, Other ulcerative colitis
30.8
13.9
18
6
C03DA01
ATC
spironolactone; oral
3.4
13.9
69
219
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
6.7
13.9
35
55
UJF02
NOMESCO Finland
Peroral enteroscopy
20.6
13.9
20
10
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
4.4
13.7
50
121
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.6
13.7
48
112
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
76.9
13.6
15
*
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
+∞
13.6
13
*
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
143.1
13.5
14
*
Q44.29
ICD-10 Finland
Atresia of bile ducts
143.1
13.5
14
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.0
13.4
55
149
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
8.8
13.4
28
33
D64.9
ICD-10 Finland
Anaemia, unspecified
3.5
13.1
63
195
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
17.2
13.1
20
12
TBW99
NOMESCO Finland
Other minor procedure in endocrine surgery
29.1
13.0
17
6
JK3NB
NOMESCO Finland
Percutaneous transhepatic cholangiography
51.1
12.9
15
*
M07.5*K51.9
ICD-10 Finland
Arthropathy in ulcerative colitis
51.1
12.9
15
*
K92.1
ICD-10 Finland
Melaena
4.5
12.8
45
105
A02BC01
ATC
omeprazole; systemic
2.1
12.7
165
904
JK3SB
NOMESCO Finland
Endoscopic retrorade cholangiography
32.8
12.6
16
5
C22.1
ICD-10 Finland
Malignant neoplasm: Intrahepatic bile duct carcinoma
32.8
12.6
16
5
JK3BT
NOMESCO Finland
Catherisation of bile duct with X-ray guidance
32.8
12.6
16
5
K81.0
ICD-10 Finland
Acute cholecystitis
11.3
12.6
23
21
D94
ICPC
Chronic enteritis/ulcerative colitis
17.8
12.6
19
11
Q44.21
ICD-10 Finland
Atresia of extrahepatic bile ducts
+∞
12.5
12
*
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
13.5
12.5
21
16
JKA20
NOMESCO Finland
Cholecystectomy
6.7
12.5
31
48
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
4.2
12.5
48
123
A07EA01
ATC
prednisolone; rectal
14.7
12.3
20
14
JN1BD
NOMESCO Finland
Extensive CT examination of upper part of abdomen
27.3
12.1
16
6
JN1DM
NOMESCO Finland
Upper part of abdomen very extensive MRI examination with 3 Tesla magnet
66.2
11.6
13
*
1370
FHL
Colonoscopy, whole colon
19.4
11.6
17
9
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
11.4
11.6
21
19
M05BA04
ATC
alendronic acid; oral
3.5
11.6
54
164
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
4.7
11.5
39
88
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.5
11.5
55
170
K83.2
ICD-10 Finland
Perforation of bile duct
+∞
11.5
11
*
M01CB01
ATC
sodium aurothiomalate; parenteral
+∞
11.5
11
*
1280
FHL
Endoscopic retrograde cholangiography and pancreaticography
122.2
11.5
12
*
K83
ICD-10 Finland
Other diseases of biliary tract
122.2
11.5
12
*
L04AC05
ATC
ustekinumab; parenteral
17.4
11.2
17
10
WX004
NOMESCO Finland
Patient-controlled sedation
14.2
11.0
18
13
JN4AD
NOMESCO Finland
Body CT examination
3.3
10.9
55
177
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
12.2
10.9
19
16
A09AA02
ATC
multienzymes (lipase, protease etc.)
8.5
10.9
23
28
JN1CD
NOMESCO Finland
Very extensive CT examination of upper part of abdomen
15.9
10.9
17
11
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
6.3
10.9
28
46
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
3.3
10.6
54
176
L04AB01
ATC
etanercept; parenteral
111.9
10.4
11
*
JK3FT
NOMESCO Finland
Exchange of bile duct catheter with radiological guidance
+∞
10.4
10
*
L04AB06
ATC
golimumab; parenteral
+∞
10.4
10
*
A06AC01
ATC
ispaghula (psylla seeds); oral
2.1
10.4
142
786
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.8
10.4
213
1376
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
9.0
10.3
21
24
WX872
NOMESCO Finland
Intensive care
4.4
10.3
37
89
A41.9
ICD-10 Finland
Sepsis, unspecified
5.1
10.2
31
63
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
6.3
10.1
26
43
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
10.0
106
527
JFH33
NOMESCO Finland
Total colectomy, mucosal proctectomy, ileoanal anastomosis and ileostomy
40.8
10.0
12
*
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
40.8
10.0
12
*
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
26.5
9.8
13
5
Z93.2
ICD-10 Finland
Ileostomy status
26.5
9.8
13
5
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.8
9.8
65
252
B99
ICD-10 Finland
Other and unspecified infectious diseases
7.6
9.8
22
30
N02AA05
ATC
oxycodone; systemic
2.4
9.7
82
364
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
9.6
103
514
D97
ICPC
Liver disease NOS
30.5
9.4
12
*
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
30.5
9.4
12
*
B01AB05
ATC
enoxaparin; parenteral
1.9
9.4
166
1008
K83.4
ICD-10 Finland
Spasm of sphincter of Oddi
+∞
9.4
9
*
JL5AM
NOMESCO Finland
Bile and pancreas ducts simple MRI examination with 3 Tesla magnet
+∞
9.4
9
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.6
9.4
41
119
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.0
9.3
36
94
A41.8
ICD-10 Finland
Other specified sepsis
8.5
9.1
19
23
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.9
9.1
56
206
M81.9
ICD-10 Finland
Osteoporosis, unspecified
4.8
9.0
29
63
E0000UV
ATC
NA
1.7
8.8
233
1612
6611
FHL
Needle biopsy in the operating room
50.7
8.7
10
*
A07AA11
ATC
rifaximin; oral
50.7
8.7
10
*
C23
ICD-10 Finland
Malignant neoplasm of gallbladder
50.7
8.7
10
*
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
11.8
8.6
15
13
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
4.5
8.5
29
67
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
3.7
8.5
36
102
4AA12
NOMESCO Finland
NA
20.4
8.5
12
6
JN4BD
NOMESCO Finland
Extensive body CT
2.5
8.5
66
279
Z94.9
ICD-10 Finland
Transplanted organ and tissue status, unspecified
91.3
8.4
9
*
JLW98
NOMESCO Finland
Other transluminal endoscopic operation on pancreas
91.3
8.4
9
*
M05
ICD-10 Finland
Seropositive rheumatoid arthritis
91.3
8.4
9
*
C24.9
ICD-10 Finland
Malignant neoplasm: Biliary tract, unspecified
91.3
8.4
9
*
K86.1
ICD-10 Finland
Other chronic pancreatitis
13.0
8.4
14
11
PC2DE
NOMESCO Finland
Ultrasound examination of liver vasculature with Doppler method
+∞
8.3
8
*
M06.8
ICD-10 Finland
Other specified rheumatoid arthritis
+∞
8.3
8
*
JK3NT
NOMESCO Finland
Percutaneous transhepatic dilatation of bileducts
+∞
8.3
8
*
8170/3-C22.0
ICD-O-3
Hepatocellular carcinoma, NOS, of liver
+∞
8.3
8
*
Q44.20
ICD-10 Finland
Atresia of intrahepatic bile ducts
+∞
8.3
8
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
9.6
8.3
16
17
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
6.2
8.2
21
35
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.9
8.2
32
85
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
10.2
8.1
15
15
JLC30
NOMESCO Finland
Pancreatoduodenectomy
22.4
8.0
11
5
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
6.7
7.9
19
29
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.3
7.8
73
340
K86.8
ICD-10 Finland
Other specified diseases of pancreas
45.6
7.7
9
*
K74.5
ICD-10 Finland
Biliary cirrhosis, unspecified
45.6
7.7
9
*
UJF30
SPAT
NA
18.6
7.6
11
6
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
3.7
7.6
32
91
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
25.4
7.6
10
*
NH3EA
NOMESCO Finland
Feet X-ray examination with load
10.2
7.6
14
14
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.1
7.5
86
439
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.5
7.5
60
258
WX892
NOMESCO Finland
Monitored bed care
2.6
7.5
52
209
5714X
ICD-9 Finland
Chronic liver disease and cirrhosis, Chronic hepatitis[HEPATITIS CHRONICA ALIA SEU NUD]
81.0
7.4
8
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
7.8
7.4
16
21
K85.1
ICD-10 Finland
Biliary acute pancreatitis
13.6
7.4
12
9
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
8.5
7.4
15
18
5714B
ICD-9 Finland
Chronic liver disease and cirrhosis, Chronic hepatitis[HEPATITIS CHRONICA ACTIVA (HBSAG-)]
+∞
7.3
7
*
57505
ICD-8 Finland
Cholecystitis and cholangitis, without mention of calculus, Cholangitis alia sive NUD
+∞
7.3
7
*
K73.89
ICD-10 Finland
Other long-term hepatitis, not classified differently
+∞
7.3
7
*
JL5CM
NOMESCO Finland
Bile and pancreas ducts extensive MRI examination with 3 Tesla magnet
+∞
7.3
7
*
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
+∞
7.3
7
*
Q44.3
ICD-10 Finland
Congenital stenosis and stricture of bile ducts
+∞
7.3
7
*
K80.8
ICD-10 Finland
Other cholelithiasis
6.4
7.3
18
29
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.7
7.3
47
181
C03CA01
ATC
furosemide; systemic
1.9
7.2
117
685
JL5BM
NOMESCO Finland
Bile and pancreas ducts MRI examination with 3 Tesla magnet
30.4
7.2
9
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.7
7.1
46
177
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
6.1
7.1
18
30
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
8.9
7.1
14
16
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.2
7.1
25
61
K81.9
ICD-10 Finland
Cholecystitis, unspecified
10.2
7.1
13
13
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
10.2
7.1
13
13
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
7.1
7.0
16
23
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.4
7.0
60
268
XX3DW
NOMESCO Finland
Time consuming IT work
2.3
6.9
60
271
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.1
6.9
84
440
XW000
NOMESCO Finland
Bone marrow biopsy
3.5
6.9
30
88
WX882
NOMESCO Finland
High dependency care
3.6
6.9
29
83
XPX08
NOMESCO Finland
Intraoperative flow measurement
9.5
6.8
13
14
UJG02
NOMESCO Finland
Proctoscopy
5.8
6.8
18
32
RD210
NOMESCO Finland
NA
4.4
6.8
23
54
K74.0
ICD-10 Finland
Hepatic fibrosis
40.5
6.8
8
*
A11CC03
ATC
alfacalcidol; systemic
4.5
6.7
22
50
R93.2
ICD-10 Finland
Abnormal findings on diagnostic imaging of liver and biliary tract
22.8
6.7
9
*
H26.3
ICD-10 Finland
Drug-induced cataract
22.8
6.7
9
*
R74.9
ICD-10 Finland
Abnormal level of unspecified serum enzyme
22.8
6.7
9
*
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
6.0
6.6
17
29
J01DB01
ATC
cefalexin; oral
1.7
6.6
468
4075
M81.8
ICD-10 Finland
Other osteoporosis
12.4
6.6
11
9
ZX108
NOMESCO Finland
Inhalation
10.2
6.6
12
12
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
10.2
6.6
12
12
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.2
6.5
64
305
A07DA03
ATC
loperamide; oral
3.6
6.5
27
77
UJD02
NOMESCO Finland
Gastroscopy
3.1
6.5
33
110
RS220
NOMESCO Finland
NA
4.8
6.5
20
43
JJC60
NOMESCO Finland
Total excision of transplanted liver
70.5
6.4
7
*
L04AA11
ATC
[U] etanercept; parenteral
70.5
6.4
7
*
M06
ICD-10 Finland
Other rheumatoid arthritis
70.5
6.4
7
*
JFF10
NOMESCO Finland
Loop enterostomy
14.5
6.4
10
7
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.5
6.4
46
190
C25.0
ICD-10 Finland
Malignant neoplasm: Head of pancreas
8.3
6.4
13
16
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
5.6
6.3
17
31
Z98.0
ICD-10 Finland
Intestinal bypass and anastomosis status
18.2
6.3
9
5
XW4AT
NOMESCO Finland
Biopsy of other inner organ with ultrasound guidance
18.2
6.3
9
5
D12.3
ICD-10 Finland
Benign neoplasm: Transverse colon
4.9
6.3
19
40
JGB50
NOMESCO Finland
Mucosal proctectomy and ileoanal anastomosis
+∞
6.3
6
*
K73.8
ICD-10 Finland
Other chronic hepatitis, not elsewhere classified
+∞
6.3
6
*
M01CB03
ATC
auranofin; oral
+∞
6.3
6
*
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
+∞
6.3
6
*
8140/3-C23.9
ICD-O-3
Adenocarcinoma, NOS, of gallbladder
+∞
6.3
6
*
JFF13
NOMESCO Finland
Terminal enterostomy
27.0
6.2
8
*
S01AD03
ATC
aciclovir; ophthalmic
3.6
6.2
26
75
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.7
6.2
25
70
R11
ICD-10 Finland
Nausea and vomiting
2.5
6.1
47
201
4AB02
NOMESCO Finland
NA
12.7
6.1
10
8
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
12.7
6.1
10
8
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
8.7
6.1
12
14
Z94.0
ICD-10 Finland
Kidney transplant status
5.6
6.0
16
29
Mortality – FinRegistry
↥Association
Association between endpoint K11_CHOLANGI_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_CHOLANGI_STRICT | 2.908 [2.29, 3.7] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.435 |
During the follow-up period (1.1.1998 — 31.12.2019), 280 out of 1127 females with K11_CHOLANGI_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_CHOLANGI_STRICT | 2.237 [1.71, 2.93] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 180 out of 971 males with K11_CHOLANGI_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have K11_CHOLANGI_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.293% | 0.479% |
| 5 | 1.856% | 2.601% |
| 10 | 4.805% | 6.542% |
| 15 | 8.555% | 12.088% |
| 20 | 14.957% | 19.247% |
Relationships between endpoints
↥Index endpoint: K11_CHOLANGI_STRICT – Cholangitis (primary sclerosing, PSC), with reimbursement 202
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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