inflammatory bowel disease: A spectrum of small and large bowel inflammatory diseases of unknown etiology. It includes Crohn's disease, ulcerative colitis, and colitis of indeterminate type.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
361 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
361 |
6. Filter based on genotype QC (FinnGen only) |
361 |
Control definitions (FinnGen only)
- Control exclude
- K11_IBD, K11_CHOLANGI
- Control conditions
- not K11_CHOLANGI_STRICT
and not K11_IBD_STRICT
Extra metadata
- First used in FinnGen datafreeze
- DF3
Similar endpoints
↥List of similar endpoints to
IBD (strict) with PSC
based on the number of shared cases.
Similar with more cases:
- Cholangitis (primary sclerosing, PSC), with reimbursement 202
- Cholangitis (primary sclerosing, PSC)
- IBD patients in KELA-register
- Inflammatory bowel disease, strict (require KELA)
- Inflammatory bowel disease
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1111 | 437 | 667 |
| Only index persons | 1084 | 428 | 656 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 25.72 | 27.13 | 24.52 |
| Only index persons | 25.50 | 27.02 | 24.51 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 361 | 169 | 192 |
| Unadjusted period prevalence (%) | 0.07 | 0.06 | 0.08 |
| Median age at first event (years) | 25.83 | 26.63 | 25.12 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 330
- Matched controls
- 3299
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A05AA02
ATC
ursodeoxycholic acid; oral
4927.8
323.0
320
17
K83.0
ICD-10 Finland
Cholangitis
+∞
323.0
330
*
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
323.0
330
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
+∞
323.0
330
156
A07EC02
ATC
mesalazine; oral, rectal
5259.0
323.0
315
10
K51.5
ICD-10 Finland
Left sided colitis
11435.2
314.8
251
*
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
1698.8
305.7
251
6
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
3302.5
267.6
222
*
UJF30
NOMESCO Finland
Ileoscopy through colon
64.0
189.5
226
108
UJF32
NOMESCO Finland
Coloscopy
46.4
183.9
273
308
L04AX01
ATC
azathioprine; systemic
125.0
142.7
147
21
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
178.7
138.0
137
13
K51.8
ICD-10 Finland
Other ulcerative colitis
+∞
134.9
120
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
304.3
123.0
118
6
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
28.0
119.3
174
126
A07EA06
ATC
budesonide; oral, local oral
165.8
117.3
118
11
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
116.8
105
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
73.0
116.2
130
29
UJK02
NOMESCO Finland
ERCP
101.0
114.6
122
19
WX404
NOMESCO Finland
Intravenous generell anesthesy
16.3
109.5
225
383
K50.8
ICD-10 Finland
Other Crohn disease
+∞
92.1
84
*
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
1136.3
91.3
85
*
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
143.0
90.5
93
9
WX402
NOMESCO Finland
General anaesthesia
12.4
83.5
181
295
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
10.3
78.3
201
434
K50.1
ICD-10 Finland
Crohn disease of large intestine
+∞
77.2
71
*
UJK12
NOMESCO Finland
Peroral cholangioscopy
897.4
75.3
71
*
K50.9
ICD-10 Finland
Crohn disease, unspecified
464.9
74.9
72
*
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
69.9
74.5
84
16
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
+∞
71.5
66
*
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
+∞
70.4
65
*
P01AB01
ATC
metronidazole; oral, rectal
7.8
64.0
234
789
A07EA02
ATC
hydrocortisone; rectal
253.4
62.5
62
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
7.4
55.9
168
404
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
625.5
55.2
53
*
K50.0
ICD-10 Finland
Crohn disease of small intestine
+∞
51.4
48
*
H02AB06
ATC
prednisolone; systemic
5.8
48.2
229
927
J01MA12
ATC
levofloxacin; systemic
7.3
46.6
131
272
K83.1
ICD-10 Finland
Obstruction of bile duct
114.7
46.2
49
5
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
8.1
43.8
111
195
ZX120
NOMESCO Finland
Intravenous
10.0
41.9
90
119
WX002
NOMESCO Finland
Sedation and analgesia
6.6
41.7
127
287
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
+∞
41.5
39
*
H02AB07
ATC
prednisone; oral
8.0
40.3
101
172
TPH04
NOMESCO Finland
Cathetrisation of vein
6.0
40.1
134
338
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
155.5
39.7
41
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
+∞
39.4
37
*
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
96.0
38.8
42
5
J01MA02
ATC
ciprofloxacin; systemic
4.8
38.3
180
658
A07EC01
ATC
sulfasalazine; oral, rectal
9.3
37.3
83
115
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
+∞
37.2
35
*
K51
ICD-10 Finland
Ulcerative colitis
398.7
36.7
36
*
Z94.4
ICD-10 Finland
Liver transplant status
142.6
36.5
38
*
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
12.7
36.2
67
65
K76.9
ICD-10 Finland
Liver disease, unspecified
42.0
35.7
44
12
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
+∞
35.0
33
*
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
+∞
35.0
33
*
L01BB02
ATC
mercaptopurine; oral
195.0
34.4
35
*
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
62.9
34.1
39
7
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
188.8
33.4
34
*
K74.3
ICD-10 Finland
Primary biliary cirrhosis
77.9
31.6
35
5
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
176.5
31.3
32
*
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
91.5
30.3
33
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
10.4
30.1
61
70
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
41.4
30.0
37
10
K80.3
ICD-10 Finland
Calculus of bile duct with cholangitis
113.7
29.2
31
*
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
+∞
28.6
27
*
JKD20
NOMESCO Finland
Anastomosis of bile duct to jejunum
+∞
27.5
26
*
5761C
ICD-9 Finland
Other disorders of biliary tract, Cholangitis[CHOLANGITIS SCLEROSIVA]
+∞
27.5
26
*
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
293.7
27.1
27
*
JFH30
NOMESCO Finland
Total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
281.5
26.1
26
*
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
146.5
26.0
27
*
L04AD01
ATC
ciclosporin; systemic
22.3
24.9
36
18
JKE32
NOMESCO Finland
Endoscopic dilatation of bile duct
+∞
24.3
23
*
127
Kela drug reimbursment
Transplant complication
19.8
22.7
34
19
C10AC01
ATC
colestyramine; oral
27.3
22.2
30
12
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.2
21.9
159
734
L04AB04
ATC
adalimumab; parenteral
20.7
21.7
32
17
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
25.2
21.7
30
13
JJ5AT
NOMESCO Finland
NA
+∞
21.1
20
*
5561A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) ileocolitis
+∞
21.1
20
*
A07EA01
ATC
prednisolone; rectal
+∞
21.1
20
*
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
61.6
20.2
23
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.9
20.0
47
68
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
16.0
19.8
32
22
H02AB04
ATC
methylprednisolone; systemic
4.5
19.7
76
204
JN3BD
NOMESCO Finland
Extensive abdominal CT
5.0
19.3
66
156
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
13.4
19.1
33
27
5568X
ICD-9 Finland
Idiopathic proctocolitis, Other ulcerative colitis
+∞
18.9
18
*
JFG00
NOMESCO Finland
Closure of loop enterostomy without resection
200.9
18.7
19
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
9.3
18.6
39
47
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
15.6
18.5
30
21
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
4.5
18.4
71
190
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
9.8
18.2
37
42
L04AC05
ATC
ustekinumab; parenteral
+∞
17.9
17
*
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
30.8
17.7
23
8
JN4CD
NOMESCO Finland
Very extensive body CT
11.7
17.4
32
30
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
53.0
17.2
20
*
L04AA06
ATC
mycophenolic acid; systemic
13.7
17.0
29
23
3AC01
NOMESCO Finland
NA
29.3
16.7
22
8
D94
ICPC
Chronic enteritis/ulcerative colitis
178.7
16.7
17
*
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
10.1
16.6
33
36
UJF92
NOMESCO Finland
Capsular endoscopy
15.6
16.1
26
18
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.7
16.1
148
753
N02AX02
ATC
tramadol; systemic, rectal
2.7
16.0
155
814
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
63.2
15.9
18
*
M07.5*K51.9
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
15.7
15
*
K85.8
ICD-10 Finland
Other acute pancreatitis
40.2
15.6
19
5
JN3AD
NOMESCO Finland
Abdominal CT examination
6.0
15.3
43
80
UJF02
NOMESCO Finland
Peroral enteroscopy
59.5
14.9
17
*
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
19.5
14.9
22
12
JJ1CE
NOMESCO Finland
Liver, bile duct and pancreas endoscopic ultrasound examination
+∞
14.7
14
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
14.6
115
526
JKE18
NOMESCO Finland
Endoscopic internal drainage of bile duct
37.9
14.6
18
5
WX419
NOMESCO Finland
Other general anesthesy
28.7
14.4
19
7
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
6.4
14.3
38
66
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
55.8
13.9
16
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
7.1
13.5
33
51
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.8
13.0
44
102
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
52.2
12.9
15
*
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
21.1
12.6
18
9
JFH33
NOMESCO Finland
Total colectomy, mucosal proctectomy, ileoanal anastomosis and ileostomy
+∞
12.6
12
*
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
12.3
12.5
22
19
R50.9
ICD-10 Finland
Fever, unspecified
3.2
12.3
71
258
TK800
NOMESCO Finland
Hemodialysis
11.7
12.2
22
20
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
11.7
12.2
22
20
JKE22
NOMESCO Finland
Endoscopic extraction of foreign body from bile duct
48.5
12.0
14
*
R4110
NOMESCO Finland
Physiotherapy
2.6
11.9
101
473
R10.1
ICD-10 Finland
Pain localized to upper abdomen
3.0
11.7
74
290
JX1XE
NOMESCO Finland
Other ultrasound examinaton of alimentary organs
+∞
11.5
11
*
JN1CM
NOMESCO Finland
Upper part of abdomen extensive MRI examination with 3 Tesla magnet
124.2
11.5
12
*
WVA20
NOMESCO Finland
Medicine administration
9.7
11.2
22
24
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
44.9
11.0
13
*
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
12.5
11.0
19
16
K80.5
ICD-10 Finland
Calculus of bile duct without cholangitis or cholecystitis
11.8
10.7
19
17
4AA12
NOMESCO Finland
NA
62.1
10.7
12
*
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
10.6
10.7
20
20
A07DA03
ATC
loperamide; oral
8.6
10.5
22
27
K83.3
ICD-10 Finland
Fistula of bile duct
+∞
10.5
10
*
JFF10
NOMESCO Finland
Loop enterostomy
+∞
10.5
10
*
Z93.2
ICD-10 Finland
Ileostomy status
+∞
10.5
10
*
K85.0
ICD-10 Finland
Idiopathic acute pancreatitis
16.7
10.5
16
10
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
6.8
10.2
25
39
A02BC02
ATC
pantoprazole; systemic
2.1
10.2
198
1359
JN1BD
NOMESCO Finland
Extensive CT examination of upper part of abdomen
41.4
10.0
12
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.7
9.9
33
76
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.6
9.6
77
345
K92.1
ICD-10 Finland
Melaena
5.7
9.6
27
51
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
22.5
9.4
13
6
K83
ICD-10 Finland
Other diseases of biliary tract
+∞
9.4
9
*
JN1DM
NOMESCO Finland
Upper part of abdomen very extensive MRI examination with 3 Tesla magnet
+∞
9.4
9
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.8
9.2
30
67
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
5.2
9.2
28
58
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
6.9
9.1
22
34
JAH00
NOMESCO Finland
Laparotomy
9.9
8.9
17
18
JK3SB
NOMESCO Finland
Endoscopic retrorade cholangiography
92.3
8.5
9
*
JFG20
NOMESCO Finland
Closure of enterostomy with resection of exteriorised loop
92.3
8.5
9
*
K85
ICD-10 Finland
Acute pancreatitis
9.8
8.4
16
17
JL5BM
NOMESCO Finland
Bile and pancreas ducts MRI examination with 3 Tesla magnet
+∞
8.4
8
*
K83.4
ICD-10 Finland
Spasm of sphincter of Oddi
+∞
8.4
8
*
JJA20
NOMESCO Finland
Open biopsy of liver
+∞
8.4
8
*
TPH07
NOMESCO Finland
Cathetrisation of artery
3.8
8.3
35
101
H02AB09
ATC
hydrocortisone; systemic
7.1
8.2
19
28
A02BC01
ATC
omeprazole; systemic
2.3
8.1
85
433
L04AA01
ATC
[U] ciclosporin; systemic
9.3
8.1
16
18
JKE12
NOMESCO Finland
Endoscopic extraction of calculus from bile duct
17.7
8.1
12
7
4AB02
NOMESCO Finland
NA
34.3
8.1
10
*
A07AA09
ATC
vancomycin; oral
22.7
8.1
11
5
C22.1
ICD-10 Finland
Malignant neoplasm: Intrahepatic bile duct carcinoma
22.7
8.1
11
5
1370
FHL
Colonoscopy, whole colon
22.7
8.1
11
5
ZJX00
NOMESCO Finland
Double balloon technique in gastroenterological endoscopy
46.1
7.7
9
*
WX004
NOMESCO Finland
Patient-controlled sedation
18.9
7.6
11
6
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
5.1
7.6
23
48
XPX08
NOMESCO Finland
Intraoperative flow measurement
81.9
7.4
8
*
K75.4
ICD-10 Finland
Autoimmune hepatitis
81.9
7.4
8
*
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
81.9
7.4
8
*
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
81.9
7.4
8
*
R94.5
ICD-10 Finland
Abnormal results of liver function studies
9.7
7.4
14
15
B01AB05
ATC
enoxaparin; parenteral
2.2
7.4
82
429
1280
FHL
Endoscopic retrograde cholangiography and pancreaticography
+∞
7.3
7
*
K83.2
ICD-10 Finland
Perforation of bile duct
+∞
7.3
7
*
JJC60
NOMESCO Finland
Total excision of transplanted liver
+∞
7.3
7
*
M07.4*K50.9
ICD-10 Finland
Arthropathy in Crohn's disease [regional enteritis]
+∞
7.3
7
*
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
3.8
7.3
30
85
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
8.2
7.2
15
19
J04AB02
ATC
rifampicin; systemic
30.7
7.2
9
*
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
6.3
7.2
18
30
M81.9
ICD-10 Finland
Osteoporosis, unspecified
9.1
7.1
14
16
D64.9
ICD-10 Finland
Anaemia, unspecified
3.6
6.9
30
89
M81.8
ICD-10 Finland
Other osteoporosis
40.9
6.8
8
*
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
40.9
6.8
8
*
JKA20
NOMESCO Finland
Cholecystectomy
8.1
6.7
14
18
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.1
6.7
37
130
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.9
6.7
26
71
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
12.6
6.6
11
9
8170/3-C22.0
ICD-O-3
Hepatocellular carcinoma, NOS, of liver
71.2
6.4
7
*
D12.3
ICD-10 Finland
Benign neoplasm: Transverse colon
8.4
6.4
13
16
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.9
6.3
38
144
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.1
6.3
33
114
JK3NB
NOMESCO Finland
Percutaneous transhepatic cholangiography
+∞
6.3
6
*
4AA33
NOMESCO Finland
NA
+∞
6.3
6
*
JF1DG
NOMESCO Finland
Small bowel very extensive MRI with with high intensity magnet
+∞
6.3
6
*
5552A
ICD-9 Finland
Regional enteritis, Small intestine with large intestine
+∞
6.3
6
*
JGB50
NOMESCO Finland
Mucosal proctectomy and ileoanal anastomosis
+∞
6.3
6
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
6.3
52
236
JFF13
NOMESCO Finland
Terminal enterostomy
27.2
6.3
8
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
6.3
73
388
A06AC01
ATC
ispaghula (psylla seeds); oral
2.2
6.2
65
329
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
10.3
6.1
11
11
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
6.2
6.1
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
226
28
214.16
307.65
3.0
1.0
—
—
—
0
0
216
71
74.25
307.65
2.8
1.1
4.4
—
iu/ml
—
12
0
317
183
134.92
307.65
9.0
4.5
2.4
33.0
ug/l
0.68
252
145
291
66
223.23
307.65
8.4
2.9
29.5
2136.2
u/ml
0.51
272
57
226
50
119.19
307.65
3.3
1.3
0.8
0.5
g/l
2.16
213
40
235
19
352.50
307.65
2.8
1.1
—
—
—
0
0
168
23
135.75
307.65
2.0
1.1
179.0
—
titre
—
10
0
166
14
218.66
307.65
1.9
1.4
11.2
10.0
umol/l
0.53
166
14
325
354
83.04
307.65
7.0
1.3
188.7
70.7
ug/g
9.38
309
271
265
216
43.37
304.61
4.6
2.3
12.9
10.0
g/l
16.06
259
200
238
303
21.12
200.98
12.1
2.2
8.2
8.8
umol/l
0.13
228
262
339
993
40.61
141.80
17.7
3.1
36.4
31.6
u/l
2.64
334
948
128
123
15.57
123.93
2.7
1.4
—
—
—
0
0
261
647
11.95
120.27
3.8
1.4
2.6
2.3
g/l
2.65
251
413
88
48
23.92
114.39
7.6
5.9
762.2
721.0
iu/ml
—
21
7
169
281
10.43
108.65
3.2
2.4
21.4
24.7
%
1.81
155
248
125
194
9.33
83.07
16.1
7.6
7.1
7.8
mmol/l
0.58
120
188
53
18
34.34
81.27
1.2
1.1
—
—
—
0
0
193
499
7.16
78.60
4.8
1.9
3.0
3.0
mg/l
0.02
181
432
290
1111
9.19
77.55
11.0
7.0
1.2
1.2
mmol/l
0.53
262
962
52
20
30.21
76.48
4.6
2.2
90.8
96.1
%
0.29
52
20
271
1008
7.77
73.44
9.6
6.3
1.2
1.2
mmol/l
0.05
265
927
235
780
6.77
71.70
6.5
2.3
69.3
55.3
u/l
1.45
228
731
57
33
20.32
71.09
1.3
1.4
—
—
—
0
0
70
64
13.33
68.01
1.4
1.4
482.0
163.9
u/ml
3.52
38
35
71
69
12.56
66.27
1.4
1.3
—
—
—
0
0
330
1599
13.39
64.26
22.8
9.6
3.5
4.0
e9/l
7.71
323
1408
61
53
13.65
60.97
6.7
3.2
32.9
36.7
umol/l
0.53
56
45
45
22
23.22
60.16
1.2
1.3
44.5
60.1
u/l
1.18
36
15
68
73
11.24
59.08
1.9
1.4
0.0
0.4
iu/ml
0.61
25
11
63
66
11.35
55.57
1.4
1.5
119.3
102.0
u/ml
—
10
8
40
22
20.32
50.65
3.6
1.3
0.8
1.1
g/l
1.66
40
22
82
134
7.62
50.51
1.4
1.4
—
—
—
0
0
175
600
4.72
46.86
3.7
2.3
—
—
—
0
0
46
44
11.84
42.84
2.4
4.8
1393.7
4958.0
u/ml
—
6
5
254
1208
4.72
42.60
4.9
2.7
88.2
101.9
ug/l
0.89
249
1133
32
16
21.85
42.04
2.0
1.4
1.1
0.6
u/l
—
21
5
251
1218
4.48
40.06
6.5
3.8
—
—
—
0
0
36
27
14.70
38.78
1.1
1.5
—
—
—
0
0
90
214
5.27
37.03
3.1
2.8
—
—
—
0
0
114
381
3.91
29.61
2.8
2.6
2.7
2.4
e6/l
0.11
74
197
154
659
3.33
26.88
3.9
2.7
0.3
0.3
e6/l
0.24
127
477
39
56
7.69
26.41
1.5
1.1
—
—
—
0
0
65
154
4.93
26.38
5.7
3.2
1.2
1.2
mmol/l
1.19
60
138
40
60
7.37
26.06
3.4
2.5
36.6
5.0
umol/l
2.65
35
44
76
211
4.30
25.22
5.6
5.5
0.9
1.5
mmol/l
0.76
67
168
70
190
4.33
23.86
2.7
2.2
65.7
77.0
ml/min/173m2
0.70
26
73
177
869
3.03
23.71
2.4
1.7
93.3
97.0
pmol/l
0.58
113
457
45
87
5.77
22.85
3.2
4.3
214.4
164.1
%
3.67
45
87
49
104
5.29
22.47
15.6
12.2
—
—
—
0
0
107
405
3.33
22.27
2.9
2.5
0.7
0.9
e6/l
0.18
69
221
171
859
2.88
21.44
4.0
2.9
—
—
—
0
0
20
0
+∞
21.04
4.2
0.0
—
—
—
0
0
29
39
8.00
20.66
6.6
3.4
52.6
57.7
%
0.83
29
39
26
8
34.87
20.48
1.1
1.0
—
—
—
0
0
42
85
5.46
20.25
1.7
2.5
1.2
1.4
g/l
0.64
35
77
338
2560
6.03
19.46
51.3
13.3
13.7
13.4
%
4.44
338
2521
118
531
2.82
17.61
2.4
1.9
1.4
1.4
%
0.13
109
488
345
2716
7.10
17.47
37.3
9.4
94.3
91.6
ml/min/173m2
1.33
320
2188
26
39
7.11
16.81
7.2
2.9
3.6
4.2
e9/l
0.53
26
39
16
0
+∞
16.80
4.1
0.0
3.0
—
mg/l
—
16
0
88
351
2.99
16.27
2.4
1.8
—
—
—
0
0
16
13
12.83
16.13
1.2
1.2
24.8
5.8
u/l
—
11
6
28
49
6.11
15.64
1.0
1.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
28
50
5.99
15.33
2.3
6.6
0.2
0.3
u/ml
1.49
13
30
80
327
2.86
13.99
2.0
1.5
1247.6
1161.0
nmol/l
0.29
66
255
93
412
2.69
13.93
1.8
1.5
470.1
10899616.1
pmol/l
0.50
82
367
41
111
4.04
13.79
1.6
1.6
—
—
—
0
0
61
236
2.91
11.68
2.4
1.6
—
—
—
0
0
61
241
2.84
11.23
2.4
1.7
—
—
—
0
0
58
225
2.88
11.03
11.0
15.2
1.1
1.2
inr
—
7
40
13
14
9.60
10.82
1.2
1.0
1363.3
1367.1
miu/ml
0.00
13
14
58
228
2.84
10.76
15.4
9.2
-0.7
1.0
mmol/l
2.58
47
176
17
26
6.81
10.73
1.0
1.1
—
—
—
0
0
342
2935
4.14
9.63
43.4
11.4
39.5
41.5
%
6.50
313
2435
124
729
2.07
9.18
1.4
1.3
1.1
1.2
u/ml
0.10
29
187
112
634
2.11
9.17
4.4
2.6
344.1
6926.2
umol/l
2.86
107
570
338
2923
3.45
8.47
6.7
3.8
4.6
4.8
mmol/l
2.27
332
2760
11
5
22.62
8.06
1.3
1.2
—
—
—
0
0
125
774
1.94
7.77
4.6
3.1
2.3
2.4
mmol/l
1.11
119
684
12
18
6.86
7.65
2.3
1.7
31.5
33.7
pg
0.89
12
18
188
1334
1.85
7.62
3.8
3.0
0.0
0.0
estimate
0.00
53
236
188
1352
1.81
7.13
3.9
3.1
0.0
0.0
estimate
0.50
55
229
186
1334
1.81
7.11
5.5
4.3
0.0
0.0
estimate
0.00
54
241
11
9
12.56
6.62
1.8
1.7
25.2
30.4
umol/l
—
11
9
10
15
6.83
6.34
1.2
1.2
—
—
—
0
0
31
116
2.83
6.26
1.7
1.7
—
—
—
0
0
21
62
3.53
6.24
2.2
1.3
—
—
—
0
0
16
39
4.25
6.15
5.7
2.6
14.0
16.5
%
—
8
23
98
603
1.86
6.00
2.5
2.2
1.7
0.9
mg/l
1.31
80
446
5
0
+∞
5.22
1.4
0.0
1.8
—
mg/l
—
5
0
20
65
3.20
5.15
2.4
1.5
—
—
—
0
0
20
67
3.10
4.91
1.6
1.3
222.9
323.7
ug/g
1.13
15
39
28
118
2.49
4.52
1.5
1.4
—
—
—
0
0
16
51
3.24
4.26
2.3
3.9
30.7
29.6
mg/l
—
9
45
16
51
3.24
4.26
2.3
3.9
38.5
47.9
mg/l
—
9
46
11
27
4.17
4.19
1.5
1.4
—
—
—
0
0
277
2397
1.67
4.08
3.7
3.4
—
—
—
0
0
70
436
1.75
4.00
3.6
3.5
23.5
320.3
ng/l
2.39
48
289
15
48
3.22
3.97
1.5
1.4
—
—
—
0
0
15
48
3.22
3.97
1.5
1.4
—
—
—
0
0
14
45
3.20
3.69
1.6
2.1
—
—
—
0
0
13
41
3.25
3.53
1.6
1.6
—
—
—
0
0
11
31
3.63
3.51
1.5
1.6
—
—
—
0
0
96
675
1.58
3.41
4.4
3.3
0.0
0.0
estimate
0.50
53
234
118
872
1.52
3.35
3.3
3.0
22.7
42.7
ng/l
0.54
69
481
7
12
5.92
3.03
1.7
2.0
206.9
132.6
%
—
7
12
134
1042
1.45
2.88
4.1
3.0
—
—
—
0
0
22
106
2.15
2.69
2.3
2.5
—
—
—
0
0
14
55
2.61
2.65
1.7
1.6
—
—
—
0
0
9
25
3.66
2.59
1.8
1.4
—
—
—
0
0
6
11
5.52
2.55
1.7
1.7
—
—
—
0
0
16
69
2.38
2.52
2.3
2.2
—
—
—
0
0
9
26
3.52
2.50
1.1
1.0
—
—
—
0
0
9
26
3.52
2.50
1.1
1.0
—
—
—
0
0
7
16
4.44
2.48
2.0
3.1
—
—
—
0
0
25
131
1.98
2.47
1.2
1.4
256.7
260.9
miu/ml
0.02
11
65
72
509
1.52
2.45
2.2
3.2
828.8
586.9
ng/l
0.28
62
412
6
12
5.06
2.41
1.7
1.2
13.4
9.0
ug/l
—
6
12
14
59
2.43
2.32
1.7
1.6
—
—
—
0
0
15
66
2.33
2.27
1.9
2.2
—
—
—
0
0
317
2955
1.60
2.24
5.7
4.1
2.7
2.9
mmol/l
5.21
309
2779
313
2915
1.55
2.15
5.6
3.8
1.5
1.4
mmol/l
4.37
308
2748
14
283
0.47
2.06
4.1
5.7
—
—
—
0
0
14
64
2.24
1.97
2.5
2.3
3.4
3.1
g/l
0.55
14
54
9
33
2.77
1.94
1.8
1.5
—
—
—
0
0
19
99
1.97
1.94
1.1
1.1
—
—
—
0
0
10
39
2.61
1.93
1.8
1.4
—
—
—
0
0
10
39
2.61
1.93
1.9
1.4
—
—
—
0
0
10
39
2.61
1.93
1.9
1.4
—
—
—
0
0
10
39
2.61
1.93
1.7
1.4
—
—
—
0
0
42
610
0.65
1.91
2.8
3.5
21.2
21.7
%
0.07
11
214
19
100
1.95
1.89
1.1
1.1
—
—
—
0
0
0
54
0.00
1.87
0.0
1.5
—
18.3
—
0
45
10
40
2.54
1.85
1.7
1.4
—
—
—
0
0
10
40
2.54
1.85
1.7
1.4
—
—
—
0
0
7
23
3.08
1.80
1.7
1.1
—
—
—
0
0
302
2820
1.43
1.76
5.0
3.4
1.2
1.3
mmol/l
3.35
295
2657
8
30
2.70
1.73
1.9
1.5
—
—
—
0
0
7
24
2.95
1.73
1.3
2.1
—
—
—
0
0
5
13
3.88
1.72
1.2
1.0
—
—
—
0
0
30
456
0.63
1.67
2.4
2.5
0.9
0.7
ug/l
0.27
15
231
6
19
3.19
1.67
3.2
3.2
564.2
660.7
u/ml
—
6
19
10
44
2.31
1.54
1.6
1.6
—
—
—
0
0
10
46
2.21
1.41
1.1
1.2
—
—
—
0
0
6
23
2.63
1.37
1.2
1.7
—
—
—
0
0
15
256
0.57
1.34
2.1
1.9
—
—
—
0
0
5
19
2.65
1.22
1.0
1.4
—
8.6
—
0
7
45
592
0.73
1.21
1.8
2.0
—
—
—
0
0
6
26
2.33
1.19
1.0
1.2
—
—
—
0
0
20
126
1.62
1.17
3.0
2.7
84.8
109.0
ng/l
0.30
20
111
25
167
1.53
1.16
5.2
3.8
-0.1
1.3
mmol/l
0.60
15
128
12
65
1.88
1.14
1.3
1.2
—
—
—
0
0
15
88
1.74
1.13
2.1
2.1
—
—
—
0
0
5
21
2.40
1.09
2.8
2.2
—
—
—
0
0
51
646
0.75
1.07
1.8
2.2
—
—
—
0
0
14
82
1.74
1.06
1.9
1.9
—
—
—
0
0
10
53
1.91
1.02
3.0
2.2
70.7
136.6
ug/min
—
5
34
6
28
2.16
0.92
1.2
1.1
—
—
—
0
0
6
28
2.16
0.92
1.2
1.1
—
—
—
0
0
11
63
1.77
0.91
1.4
1.2
—
1.0
—
0
5
6
29
2.09
0.89
1.0
1.6
—
—
—
0
0
6
29
2.09
0.89
1.2
1.1
—
—
—
0
0
6
29
2.09
0.89
1.2
1.1
—
—
—
0
0
6
29
2.09
0.89
1.2
1.1
—
—
—
0
0
23
317
0.71
0.84
2.0
2.0
—
—
—
0
0
17
114
1.52
0.81
1.7
1.7
—
—
—
0
0
5
24
2.10
0.75
1.0
1.1
—
—
—
0
0
9
58
1.57
0.70
1.2
1.1
—
—
—
0
0
12
179
0.66
0.68
1.0
1.0
—
—
—
0
0
27
209
1.32
0.62
1.2
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
1.1
—
0
11
273
2624
1.17
0.59
4.7
4.3
2.0
2.3
mu/l
0.28
257
2448
229
2174
1.15
0.59
4.3
3.6
14.5
14.5
pmol/l
0.16
210
2010
8
125
0.63
0.55
1.6
1.5
—
—
—
0
0
17
125
1.38
0.54
1.6
1.5
5.4
8.3
u/l
0.98
11
104
7
46
1.53
0.48
1.1
1.5
—
—
—
0
0
16
210
0.75
0.47
1.5
1.5
—
—
—
0
0
8
118
0.67
0.46
1.5
1.4
—
—
—
0
0
8
118
0.67
0.46
1.5
1.4
—
—
—
0
0
8
119
0.66
0.46
1.5
1.4
—
—
—
0
0
8
119
0.66
0.46
1.5
1.4
—
—
—
0
0
7
49
1.44
0.46
1.3
1.4
—
—
—
0
0
5
33
1.52
0.41
1.2
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
8
60
1.34
0.40
1.3
1.1
—
—
—
0
0
49
435
1.15
0.35
1.6
1.5
—
—
—
0
0
36
411
0.86
0.33
1.2
1.6
—
—
—
0
0
7
54
1.30
0.30
1.1
1.5
—
—
—
0
0
54
490
1.12
0.29
1.2
1.3
20.1
23.6
iu/ml
0.17
15
150
11
140
0.78
0.28
1.4
1.4
—
—
—
0
0
12
94
1.29
0.28
1.3
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
24.4
—
0
11
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
5
44
1.14
0.10
5.6
1.8
13.5
12.9
%
—
5
44
6
56
1.07
0.08
1.2
1.1
—
—
—
0
0
278
2756
1.04
0.08
3.7
3.7
5.8
5.8
mmol/l
0.14
267
2570
8
92
0.87
0.07
1.4
1.5
—
—
—
0
0
259
2571
1.03
0.06
6.3
4.6
37.1
38.5
mmol/mol
1.40
251
2438
18
170
1.06
0.04
2.2
1.8
—
—
—
0
0
11
101
1.09
0.04
1.3
1.1
—
—
—
0
0
78
766
1.02
0.04
1.7
1.6
—
—
—
0
0
24
232
1.04
0.02
1.0
1.3
61.6
174.0
iu/ml
—
7
97
48
484
0.99
0.00
1.3
1.3
1.3
6.5
u/ml
2.34
16
190
6
69
0.87
0.00
1.5
1.5
—
—
—
0
0
9
89
1.01
0.00
1.3
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
7
75
0.93
0.00
2.9
1.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
5
50
1.00
0.00
1.4
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
3.8
—
—
—
0
0
0
5
0.00
0.00
0.0
3.6
—
57.3
—
0
5
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
105.5
—
0
6
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint K11_IBD_STRICT_PSC and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have K11_IBD_STRICT_PSC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: K11_IBD_STRICT_PSC – IBD (strict) with PSC
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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