ulcerative colitis: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
294 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
294 |
6. Filter based on genotype QC (FinnGen only) |
294 |
Control definitions (FinnGen only)
- Control exclude
- K11_IBD, K11_CHOLANGI
- Control conditions
- not K11_CHOLANGI_STRICT
and not K11_UC_STRICT
Extra metadata
- First used in FinnGen datafreeze
- DF4
Similar endpoints
↥List of similar endpoints to
Ulcerative colitis (strict) with PSC
based on the number of shared cases.
Similar with more cases:
- IBD (strict) with PSC
- Colitis, primary sclerosing
- Cholangitis (primary sclerosing, PSC), with reimbursement 202
- Cholangitis (primary sclerosing, PSC)
- Ulcerative colitis (strict definition, require KELA)
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 896 | 350 | 542 |
| Only index persons | 876 | 342 | 534 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 26.31 | 27.84 | 25.12 |
| Only index persons | 26.07 | 27.64 | 25.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 294 | 136 | 158 |
| Unadjusted period prevalence (%) | 0.06 | 0.05 | 0.07 |
| Median age at first event (years) | 27.13 | 27.63 | 26.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 267
- Matched controls
- 2668
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K83.0
ICD-10 Finland
Cholangitis
+∞
323.0
267
*
A05AA02
ATC
ursodeoxycholic acid; oral
9041.3
323.0
260
7
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
323.0
267
*
A07EC02
ATC
mesalazine; oral, rectal
9009.5
323.0
258
5
K51.5
ICD-10 Finland
Left sided colitis
13589.1
291.7
225
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
+∞
277.8
267
133
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
+∞
251.5
200
*
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
837.6
233.2
198
9
UJF30
NOMESCO Finland
Ileoscopy through colon
82.8
163.5
183
68
UJF32
NOMESCO Finland
Coloscopy
54.6
158.3
223
226
K51.8
ICD-10 Finland
Other ulcerative colitis
+∞
122.6
108
*
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
463.9
118.3
110
*
UJK02
NOMESCO Finland
ERCP
241.8
107.2
104
7
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
32.3
101.7
141
89
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
127.7
100.0
103
13
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
99.3
89
*
L04AX01
ATC
azathioprine; systemic
64.7
95.5
109
28
WX404
NOMESCO Finland
Intravenous generell anesthesy
15.1
85.0
182
330
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
78.5
84.2
93
18
A07EA06
ATC
budesonide; oral, local oral
149.3
81.4
83
8
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
159.2
77.9
79
7
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
314.2
72.1
70
*
WX402
NOMESCO Finland
General anaesthesia
13.3
71.9
150
234
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
11.5
68.0
160
307
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
+∞
66.5
61
*
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
+∞
65.3
60
*
UJK12
NOMESCO Finland
Peroral cholangioscopy
765.2
63.6
60
*
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
56.4
58.2
68
16
A07EA02
ATC
hydrocortisone; rectal
229.5
55.2
55
*
P01AB01
ATC
metronidazole; oral, rectal
7.6
50.9
190
655
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
577.8
50.1
48
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
6.8
41.5
131
329
K50.8
ICD-10 Finland
Other Crohn disease
+∞
40.7
38
*
K50.9
ICD-10 Finland
Crohn disease, unspecified
+∞
39.6
37
*
K83.1
ICD-10 Finland
Obstruction of bile duct
156.0
38.9
40
*
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
+∞
37.4
35
*
H02AB06
ATC
prednisolone; systemic
5.5
36.9
181
742
WX002
NOMESCO Finland
Sedation and analgesia
7.2
36.9
104
217
K50.1
ICD-10 Finland
Crohn disease of large intestine
+∞
36.3
34
*
J01MA12
ATC
levofloxacin; systemic
7.3
36.2
100
202
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
396.3
35.8
35
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
8.2
35.6
89
154
TPH04
NOMESCO Finland
Cathetrisation of vein
6.5
34.6
106
244
H02AB07
ATC
prednisone; oral
8.1
33.8
84
143
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
365.1
32.6
32
*
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
365.1
32.6
32
*
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
100.3
32.6
35
*
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
+∞
31.9
30
*
ZX120
NOMESCO Finland
Intravenous
9.3
31.9
71
100
A07EC01
ATC
sulfasalazine; oral, rectal
9.4
31.7
70
97
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
13.9
31.7
56
50
K51
ICD-10 Finland
Ulcerative colitis
351.7
31.5
31
*
J01MA02
ATC
ciprofloxacin; systemic
4.8
30.7
143
515
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
312.3
28.3
28
*
K74.3
ICD-10 Finland
Primary biliary cirrhosis
161.8
28.2
29
*
K76.9
ICD-10 Finland
Liver disease, unspecified
34.4
28.0
36
12
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
60.2
27.9
32
6
JJC00
NOMESCO Finland
Allogenic transplantation of liver
+∞
27.6
26
*
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
+∞
26.5
25
*
L01BB02
ATC
mercaptopurine; oral
149.4
26.1
27
*
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
149.4
26.1
27
*
JFH30
NOMESCO Finland
Total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
+∞
25.4
24
*
5761C
ICD-9 Finland
Other disorders of biliary tract, Cholangitis[CHOLANGITIS SCLEROSIVA]
+∞
25.4
24
*
K50.0
ICD-10 Finland
Crohn disease of small intestine
274.4
25.1
25
*
Z94.4
ICD-10 Finland
Liver transplant status
143.3
25.1
26
*
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
+∞
24.3
23
*
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
74.6
24.3
27
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
9.2
22.2
48
62
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
+∞
21.1
20
*
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
35.8
20.6
26
8
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
62.6
20.2
23
*
5561A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) ileocolitis
+∞
20.0
19
*
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
+∞
20.0
19
*
JKD20
NOMESCO Finland
Anastomosis of bile duct to jejunum
215.1
19.8
20
*
K80.3
ICD-10 Finland
Calculus of bile duct with cholangitis
215.1
19.8
20
*
JKE32
NOMESCO Finland
Endoscopic dilatation of bile duct
+∞
19.0
18
*
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
203.6
18.8
19
*
5568X
ICD-9 Finland
Idiopathic proctocolitis, Other ulcerative colitis
+∞
17.9
17
*
A07EA01
ATC
prednisolone; rectal
192.1
17.7
18
*
JJ5AT
NOMESCO Finland
NA
+∞
16.8
16
*
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
14.1
16.6
28
22
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
10.8
16.2
31
32
WX302
NOMESCO Finland
Thoracal epidural anesthesy
10.2
15.7
31
34
WX419
NOMESCO Finland
Other general anesthesy
169.4
15.6
16
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
5.1
15.1
50
115
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
33.9
15.0
19
6
JFG00
NOMESCO Finland
Closure of loop enterostomy without resection
84.8
14.7
16
*
K85.8
ICD-10 Finland
Other acute pancreatitis
158.2
14.6
15
*
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
10.6
14.6
28
29
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.9
14.1
117
567
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
21.5
14.0
20
10
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
25.4
14.0
19
8
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
4.4
13.9
54
146
JN4CD
NOMESCO Finland
Very extensive body CT
13.1
13.9
24
20
L04AD01
ATC
ciclosporin; systemic
11.9
13.8
25
23
127
Kela drug reimbursment
Transplant complication
11.9
13.8
25
23
C10AC01
ATC
colestyramine; oral
17.4
13.7
21
13
M07.5*K51.9
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
13.7
13
*
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
147.1
13.6
14
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
6.8
13.4
34
56
JKE18
NOMESCO Finland
Endoscopic internal drainage of bile duct
42.4
13.3
16
*
3AC01
NOMESCO Finland
NA
24.0
13.1
18
8
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
9.5
12.8
26
30
WX408
NOMESCO Finland
General anesthesy, balanced
3.0
12.8
91
395
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
12.7
119
613
D94
ICPC
Chronic enteritis/ulcerative colitis
136.0
12.5
13
*
K85.0
ICD-10 Finland
Idiopathic acute pancreatitis
136.0
12.5
13
*
H02AB04
ATC
methylprednisolone; systemic
3.7
12.4
59
191
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
19.2
12.2
18
10
R10.1
ICD-10 Finland
Pain localized to upper abdomen
3.5
11.8
60
204
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
68.0
11.7
13
*
JX1XE
NOMESCO Finland
Other ultrasound examinaton of alimentary organs
+∞
11.5
11
*
K92.1
ICD-10 Finland
Melaena
9.6
11.5
23
26
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
36.7
11.4
14
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.8
11.3
38
89
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
29.4
10.8
14
5
1370
FHL
Colonoscopy, whole colon
114.2
10.5
11
*
JN1CM
NOMESCO Finland
Upper part of abdomen extensive MRI examination with 3 Tesla magnet
114.2
10.5
11
*
JKE22
NOMESCO Finland
Endoscopic extraction of foreign body from bile duct
114.2
10.5
11
*
L04AA06
ATC
mycophenolic acid; systemic
9.4
10.5
21
24
JFH33
NOMESCO Finland
Total colectomy, mucosal proctectomy, ileoanal anastomosis and ileostomy
+∞
10.5
10
*
C22.1
ICD-10 Finland
Malignant neoplasm: Intrahepatic bile duct carcinoma
+∞
10.5
10
*
N02AX02
ATC
tramadol; systemic, rectal
2.5
10.4
114
621
WVA20
NOMESCO Finland
Medicine administration
9.3
10.0
20
23
UJF92
NOMESCO Finland
Capsular endoscopy
21.0
9.9
14
7
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
14.1
9.8
16
12
L04AB04
ATC
adalimumab; parenteral
9.6
9.7
19
21
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
6.5
9.5
24
40
R50.9
ICD-10 Finland
Fever, unspecified
3.2
9.4
53
193
A07DA03
ATC
loperamide; oral
11.3
9.4
17
16
K83.3
ICD-10 Finland
Fistula of bile duct
+∞
9.4
9
*
4AA12
NOMESCO Finland
NA
+∞
9.4
9
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.8
9.4
31
71
K80.5
ICD-10 Finland
Calculus of bile duct without cholangitis or cholecystitis
12.1
9.2
16
14
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
9.6
9.2
18
20
L04AC05
ATC
ustekinumab; parenteral
38.1
9.1
11
*
JN3AD
NOMESCO Finland
Abdominal CT examination
4.7
9.0
30
70
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
5.1
8.7
27
58
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
6.8
8.7
21
33
WX004
NOMESCO Finland
Patient-controlled sedation
92.8
8.5
9
*
ZJX00
NOMESCO Finland
Double balloon technique in gastroenterological endoscopy
+∞
8.4
8
*
JN1DM
NOMESCO Finland
Upper part of abdomen very extensive MRI examination with 3 Tesla magnet
+∞
8.4
8
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
10.5
8.1
15
15
JKE12
NOMESCO Finland
Endoscopic extraction of calculus from bile duct
34.5
8.1
10
*
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
5.0
8.1
25
54
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.7
8.0
34
100
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
46.3
7.8
9
*
UJF02
NOMESCO Finland
Peroral enteroscopy
46.3
7.8
9
*
JJ1CE
NOMESCO Finland
Liver, bile duct and pancreas endoscopic ultrasound examination
46.3
7.8
9
*
L04AA01
ATC
[U] ciclosporin; systemic
10.5
7.6
14
14
JL5BM
NOMESCO Finland
Bile and pancreas ducts MRI examination with 3 Tesla magnet
82.2
7.5
8
*
Z93.2
ICD-10 Finland
Ileostomy status
82.2
7.5
8
*
A02BC01
ATC
omeprazole; systemic
2.4
7.4
69
336
1280
FHL
Endoscopic retrograde cholangiography and pancreaticography
+∞
7.3
7
*
K83
ICD-10 Finland
Other diseases of biliary tract
+∞
7.3
7
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
7.3
62
289
JN1BD
NOMESCO Finland
Extensive CT examination of upper part of abdomen
20.7
7.2
10
5
H02AB09
ATC
hydrocortisone; systemic
7.3
7.1
16
23
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
14.3
6.9
11
8
D64.9
ICD-10 Finland
Anaemia, unspecified
4.2
6.9
25
64
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.9
6.9
18
32
JFF10
NOMESCO Finland
Loop enterostomy
41.1
6.8
8
*
4AB02
NOMESCO Finland
NA
71.4
6.5
7
*
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
18.5
6.3
9
5
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
7.3
6.3
14
20
K83.2
ICD-10 Finland
Perforation of bile duct
+∞
6.3
6
*
JK3NB
NOMESCO Finland
Percutaneous transhepatic cholangiography
+∞
6.3
6
*
ZXD08
NOMESCO Finland
NA
+∞
6.3
6
*
JJC60
NOMESCO Finland
Total excision of transplanted liver
+∞
6.3
6
*
JFG20
NOMESCO Finland
Closure of enterostomy with resection of exteriorised loop
27.4
6.3
8
*
M81.8
ICD-10 Finland
Other osteoporosis
27.4
6.3
8
*
R94.5
ICD-10 Finland
Abnormal results of liver function studies
10.4
6.1
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
198
11
549.19
307.65
2.7
1.0
—
—
—
0
0
236
57
205.80
307.65
8.5
2.8
30.7
2493.5
u/ml
0.50
221
48
189
41
127.27
307.65
3.2
1.3
0.9
0.6
g/l
1.43
178
31
187
22
231.80
307.65
2.9
1.0
—
—
—
0
0
259
147
140.60
307.65
9.2
4.5
2.5
9.6
ug/l
1.37
204
117
179
60
74.71
293.42
2.8
1.1
4.3
—
iu/ml
—
11
0
135
13
191.17
274.24
1.9
1.4
11.3
10.2
umol/l
0.42
135
13
142
22
123.91
272.11
1.9
1.1
196.7
—
titre
—
9
0
262
277
78.71
265.79
6.8
1.3
178.4
72.6
ug/g
7.39
251
212
222
172
49.62
263.46
4.6
2.4
13.0
9.7
g/l
19.19
217
161
188
252
18.92
151.90
11.7
2.1
8.0
9.1
umol/l
0.23
182
222
215
519
12.70
102.55
3.7
1.4
2.6
2.2
g/l
3.18
208
335
138
218
11.05
93.09
2.9
2.4
21.8
25.0
%
1.35
128
195
95
98
13.84
87.14
2.2
1.4
—
—
—
0
0
68
43
20.27
82.17
7.2
5.7
962.0
821.2
iu/ml
—
16
6
44
13
39.63
70.25
1.1
1.1
—
—
—
0
0
152
387
7.06
62.78
4.7
1.9
3.2
3.0
mg/l
0.28
141
332
232
885
8.69
62.01
10.2
6.8
1.2
1.2
mmol/l
0.58
205
770
217
798
7.56
59.54
9.3
6.3
1.2
1.2
mmol/l
0.01
211
732
40
17
27.08
56.57
4.7
2.4
89.4
93.9
%
0.20
40
17
187
640
6.28
54.19
5.7
2.2
70.1
55.5
u/l
1.11
181
599
41
21
22.53
53.81
1.4
1.3
—
—
—
0
0
266
1293
12.10
51.13
21.7
10.1
3.5
4.0
e9/l
6.39
261
1137
52
51
12.17
48.05
1.3
1.4
422.5
163.9
u/ml
2.09
26
29
53
56
11.33
46.51
1.3
1.4
—
—
—
0
0
33
14
26.43
46.46
1.2
1.2
42.7
72.1
u/l
—
24
9
68
116
7.32
40.26
1.4
1.4
—
—
—
0
0
52
66
9.36
39.64
1.8
1.4
0.0
0.1
iu/ml
—
18
9
31
17
20.27
39.18
3.7
1.4
0.8
1.1
g/l
1.12
31
17
44
50
10.17
36.38
1.3
1.6
120.0
103.2
u/ml
—
5
6
140
489
4.56
36.35
3.7
2.4
—
—
—
0
0
202
978
4.40
32.31
6.1
3.9
—
—
—
0
0
29
21
15.21
31.80
1.1
1.6
—
—
—
0
0
74
174
5.35
30.96
3.2
2.9
—
—
—
0
0
91
268
4.47
28.72
3.6
3.1
30.5
29.4
s
0.93
91
263
58
122
5.68
27.30
4.9
3.3
1.2
1.2
mmol/l
0.96
53
111
49
97
5.86
24.51
5.4
5.3
23.7
24.2
mmol/l
0.55
49
90
124
539
3.25
21.01
3.7
2.7
0.3
0.3
e6/l
0.04
100
396
88
312
3.60
20.68
2.6
2.5
2.1
2.4
e6/l
0.22
54
166
30
44
7.48
19.92
1.4
1.2
—
—
—
0
0
57
156
4.29
19.28
2.6
2.4
66.8
73.5
ml/min/173m2
0.29
19
56
35
68
5.71
17.69
1.8
2.1
1.3
1.4
g/l
0.38
30
62
36
72
5.56
17.65
3.1
4.4
213.8
166.1
%
2.77
36
72
22
7
33.80
17.29
1.1
1.0
—
—
—
0
0
16
0
+∞
16.83
4.7
0.0
—
—
—
0
0
56
169
3.86
16.44
5.4
4.7
1.0
1.7
mmol/l
0.80
48
135
137
703
2.78
16.31
3.7
2.8
—
—
—
0
0
276
2085
6.29
16.30
47.2
13.4
13.7
13.4
%
3.43
276
2051
83
329
3.12
15.85
2.8
2.4
0.6
0.9
e6/l
0.81
51
183
17
18
9.96
14.46
1.4
1.1
—
—
—
0
0
22
33
7.13
14.23
6.7
3.6
52.9
57.7
%
0.70
22
33
282
2233
7.44
14.13
35.1
9.4
94.9
91.6
ml/min/173m2
1.56
260
1804
94
428
2.76
13.72
2.3
1.8
1.4
1.4
%
0.24
87
402
131
703
2.56
13.68
2.4
1.7
93.4
97.0
pmol/l
0.48
81
360
13
0
+∞
13.64
4.3
0.0
3.3
—
mg/l
—
13
0
84
383
2.67
12.04
2.0
1.4
19.2
20.4
nmol/l
0.38
84
331
20
33
6.43
11.82
7.2
3.2
3.6
4.1
e9/l
0.45
20
33
33
93
3.87
10.54
1.8
1.6
—
—
—
0
0
12
12
10.38
10.51
1.2
1.0
1287.2
1327.6
miu/ml
0.04
12
12
67
296
2.64
10.07
2.3
1.8
—
—
—
0
0
73
342
2.51
9.69
1.9
1.5
473.2
13115182.1
pmol/l
0.50
65
305
21
44
5.06
9.69
1.0
1.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
20
42
5.04
9.20
2.3
6.8
0.2
0.3
u/ml
—
10
25
14
22
6.63
8.60
1.0
1.1
—
—
—
0
0
278
2381
4.08
7.98
39.1
11.4
39.7
41.6
%
4.99
255
1984
45
185
2.69
7.70
16.0
8.9
-0.2
1.1
mmol/l
2.10
38
147
57
266
2.42
7.51
2.1
1.5
1370.5
1180.4
nmol/l
0.59
47
209
40
158
2.77
7.38
17.6
8.3
118.4
125.7
g/l
1.11
40
148
100
591
2.05
7.36
1.5
1.3
1.2
1.2
u/ml
0.02
23
157
11
16
7.10
7.20
2.3
1.4
31.2
33.8
pg
0.99
11
16
10
5
20.62
7.18
1.3
1.2
—
—
—
0
0
44
193
2.51
6.59
2.3
1.6
—
—
—
0
0
44
197
2.45
6.31
2.3
1.7
—
—
—
0
0
42
188
2.44
6.02
11.0
14.4
1.2
1.2
inr
—
5
33
151
1080
1.82
5.93
3.5
3.1
0.0
0.0
estimate
0.00
45
193
151
1094
1.78
5.57
3.5
3.2
0.0
0.0
estimate
0.50
47
188
149
1080
1.77
5.45
5.1
4.5
0.0
0.0
estimate
0.00
46
198
24
86
2.95
5.28
1.8
1.5
—
—
—
0
0
5
0
+∞
5.22
1.4
0.0
1.8
—
mg/l
—
5
0
13
33
4.08
4.76
3.8
2.7
14.3
16.9
%
—
6
19
78
484
1.83
4.70
2.3
2.2
1.8
1.0
mg/l
1.10
66
358
16
50
3.33
4.40
2.4
1.3
—
—
—
0
0
13
36
3.73
4.25
1.6
1.7
—
—
—
0
0
24
101
2.50
3.93
1.3
1.4
—
—
—
0
0
7
10
7.14
3.38
1.7
2.2
206.9
132.3
%
—
7
10
226
1958
1.67
3.37
3.5
3.4
—
—
—
0
0
8
14
5.84
3.36
1.3
1.2
—
—
—
0
0
15
55
2.82
3.20
2.4
2.5
—
—
—
0
0
11
34
3.32
3.09
1.7
1.6
—
—
—
0
0
6
8
7.63
3.07
1.7
1.6
25.2
32.1
umol/l
—
6
8
9
234
0.37
2.81
3.9
5.5
—
—
—
0
0
54
349
1.67
2.75
3.1
3.7
24.0
336.2
ng/l
2.01
40
231
6
10
6.10
2.71
1.7
1.8
—
—
—
0
0
96
716
1.51
2.65
3.4
3.1
24.9
26.9
ng/l
0.07
52
394
6
11
5.54
2.55
1.7
1.3
13.4
8.4
ug/l
—
6
11
6
11
5.54
2.55
2.0
3.7
—
—
—
0
0
11
39
2.89
2.50
1.5
1.3
—
—
—
0
0
11
39
2.89
2.50
1.5
1.3
—
—
—
0
0
9
26
3.54
2.50
1.6
1.7
—
—
—
0
0
13
52
2.57
2.39
2.6
2.6
3.3
3.1
g/l
0.34
13
44
109
849
1.45
2.38
3.6
3.1
—
—
—
0
0
76
554
1.50
2.31
3.9
3.4
0.0
0.0
estimate
0.50
47
196
8
23
3.55
2.28
1.5
1.5
—
—
—
0
0
16
77
2.14
2.00
1.1
1.1
—
—
—
0
0
16
77
2.14
2.00
1.1
1.1
—
—
—
0
0
8
27
3.02
1.95
1.9
1.6
—
—
—
0
0
20
107
1.93
1.91
1.3
1.4
266.3
254.5
miu/ml
—
10
52
18
95
1.95
1.79
2.2
2.7
—
—
—
0
0
7
24
2.96
1.73
1.7
1.5
—
—
—
0
0
7
24
2.96
1.73
2.0
1.6
—
—
—
0
0
11
48
2.34
1.72
1.5
1.4
—
—
—
0
0
0
47
0.00
1.72
0.0
1.5
—
17.0
—
0
40
57
418
1.45
1.67
2.4
3.3
985.4
603.7
ng/l
0.36
48
339
257
2408
1.53
1.65
5.6
4.1
2.7
2.9
mmol/l
3.75
252
2261
5
15
3.37
1.53
1.0
1.4
—
8.7
—
0
6
35
497
0.66
1.47
2.7
3.6
21.8
22.4
%
—
10
173
11
53
2.12
1.40
2.3
2.2
—
—
—
0
0
5
17
2.97
1.36
2.2
3.4
631.4
710.6
u/ml
—
5
17
0
37
0.00
1.35
0.0
1.1
—
—
—
0
0
0
39
0.00
1.34
0.0
1.1
—
—
—
0
0
10
48
2.12
1.29
1.8
1.6
—
—
—
0
0
9
45
2.03
1.24
1.2
1.6
0.7
0.9
nmol/l
—
9
39
5
19
2.66
1.22
1.0
1.1
—
—
—
0
0
5
19
2.66
1.22
1.0
1.1
—
—
—
0
0
26
375
0.66
1.19
2.2
2.4
1.0
0.7
ug/l
0.33
12
187
5
20
2.52
1.15
1.2
1.9
—
—
—
0
0
0
36
0.00
1.14
0.0
1.1
—
—
—
0
0
41
539
0.72
1.13
1.9
2.1
—
—
—
0
0
37
491
0.72
1.08
1.8
2.0
—
—
—
0
0
10
52
1.96
1.07
1.8
1.6
—
—
—
0
0
9
47
1.94
1.03
1.2
1.1
—
—
—
0
0
5
23
2.19
0.98
1.2
2.1
—
—
—
0
0
7
36
1.97
0.97
1.0
1.1
—
—
—
0
0
13
205
0.62
0.91
2.3
2.0
—
—
—
0
0
6
29
2.09
0.90
1.3
1.5
—
—
—
0
0
6
29
2.09
0.90
1.3
1.5
—
—
—
0
0
6
29
2.09
0.90
1.3
1.5
—
—
—
0
0
6
29
2.09
0.90
1.3
1.5
—
—
—
0
0
6
29
2.09
0.90
1.3
1.5
—
—
—
0
0
6
29
2.09
0.90
1.3
1.5
—
—
—
0
0
8
138
0.57
0.85
1.0
1.0
—
—
—
0
0
10
57
1.78
0.84
1.1
1.3
—
—
—
0
0
9
55
1.66
0.74
1.1
1.2
—
1.0
—
0
5
7
38
1.86
0.74
1.6
1.7
—
—
—
0
0
5
25
2.02
0.73
1.2
1.2
—
—
—
0
0
5
25
2.02
0.73
1.2
1.2
—
—
—
0
0
5
26
1.94
0.71
1.2
1.2
—
—
—
0
0
5
26
1.94
0.71
1.2
1.2
—
—
—
0
0
5
26
1.94
0.71
1.2
1.2
—
—
—
0
0
186
1743
1.18
0.69
4.4
3.7
14.5
14.6
pmol/l
0.21
172
1617
12
78
1.56
0.66
2.3
2.2
—
—
—
0
0
22
166
1.35
0.60
1.2
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
2.7
—
—
—
0
0
6
36
1.68
0.57
1.3
1.4
—
—
—
0
0
11
73
1.53
0.57
2.2
1.9
—
—
—
0
0
13
91
1.45
0.54
1.8
1.8
—
—
—
0
0
17
126
1.37
0.53
3.9
4.1
0.8
1.4
mmol/l
—
8
94
20
252
0.78
0.45
2.1
2.1
—
—
—
0
0
220
2121
1.15
0.44
4.7
4.3
2.0
2.4
mu/l
0.32
208
1970
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
1.2
—
0
8
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
5
36
1.40
0.38
1.2
1.5
—
—
—
0
0
6
41
1.47
0.36
1.0
1.5
—
—
—
0
0
55
606
0.89
0.31
1.7
1.5
—
—
—
0
0
11
142
0.77
0.31
1.4
2.2
1.8
8.3
ug/l
2.55
11
133
7
100
0.69
0.31
1.6
1.5
—
—
—
0
0
13
163
0.79
0.30
1.5
1.5
—
—
—
0
0
6
83
0.72
0.24
1.3
1.1
—
—
—
0
0
22
190
1.17
0.24
1.0
1.3
76.6
170.6
iu/ml
—
5
76
5
38
1.32
0.23
1.4
1.2
—
—
—
0
0
7
91
0.76
0.23
1.4
1.5
—
—
—
0
0
7
92
0.76
0.23
1.4
1.5
—
—
—
0
0
7
92
0.76
0.23
1.4
1.5
—
—
—
0
0
12
98
1.23
0.21
3.8
3.1
117.4
128.8
ng/l
0.08
12
85
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
24.4
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
5.8
—
0
13
205
2090
0.94
0.17
6.4
4.6
37.3
38.5
mmol/mol
0.83
198
1980
43
399
1.09
0.17
1.2
1.3
20.9
25.4
iu/ml
0.20
14
120
8
71
1.13
0.16
1.4
1.5
—
—
—
0
0
6
77
0.77
0.16
1.5
1.4
—
—
—
0
0
5
48
1.04
0.09
1.0
1.1
—
—
—
0
0
32
339
0.94
0.09
1.2
1.6
—
—
—
0
0
5
65
0.77
0.08
2.8
1.8
—
—
—
0
0
222
2233
0.98
0.04
3.7
3.7
5.8
5.8
mmol/l
0.26
216
2075
40
392
1.02
0.01
1.3
1.3
1.3
7.2
u/ml
2.19
13
156
36
354
1.02
0.00
1.6
1.4
—
—
—
0
0
14
141
0.99
0.00
1.9
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
6
65
0.92
0.00
1.2
1.5
—
—
—
0
0
5
54
0.92
0.00
1.4
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
3.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
106.8
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint K11_UC_STRICT_PSC and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have K11_UC_STRICT_PSC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: K11_UC_STRICT_PSC – Ulcerative colitis (strict) with PSC
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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