Diffuse (eosinophilic) fasciitis

M13_DIFFASCITIS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M35.4 Cause of death: ICD-10 — M35.4 2 out of 7 registries used, show all original rules.	52
4. Check minimum number of events None	52
5. Include endpoints None	52
6. Filter based on genotype QC (FinnGen only)	52

Control definitions (FinnGen only)

Control exclude: M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M35
Name in latin: Fasci[i]tis [eosinophila] diffusa

NAME	M13_DIFFASCITIS
CONTROL_EXCLUDE	M13_SYSTCONNECT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M354
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M354
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Diffuse (eosinophilic) fasciitis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	308	198	108
Only index persons	287	185	102
Unadjusted period prevalence (%)
Whole population	0.00	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	58.90	60.24	56.13
Only index persons	56.83	58.34	54.10

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	52	36	16
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	58.31	56.87	61.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3037522) Nuclear Ab [Titer] in Serum

10.87

16.98

1.6

1.3

152.0

342.2

titre

—

(3015171) Extractable nuclear Ab [Units/volume] in Serum

21.05

9.11

1.2

1.0

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

7.96

8.69

2.2

2.3

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

138

5.70

8.56

5.0

1.8

83.7

146.1

u/l

1.51

133

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

11.02

8.36

2.0

5.1

—

(3006504) Eosinophils/100 leukocytes in Blood

185

6.04

7.85

20.6

5.9

2.7

2.5

0.46

172

(3007164) IgA [Mass/volume] in Serum or Plasma

5.05

7.71

2.3

1.4

2.3

2.2

g/l

0.17

(3022096) Basophils/100 leukocytes in Blood

179

5.72

7.66

20.8

5.7

0.7

0.6

0.91

164

(3019069) Monocytes/100 leukocytes in Blood

188

5.89

7.61

21.0

6.4

9.1

8.5

0.77

176

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

9.29

7.38

2.8

1.8

16.2

9.7

mg/l

—

(3002030) Lymphocytes/100 leukocytes in Blood

193

5.65

7.23

20.9

6.2

28.2

27.7

0.10

178

(3018010) Neutrophils/100 leukocytes in Blood

191

5.17

6.74

20.1

6.1

55.0

57.3

0.75

179

(42870588) Differential panel, method unspecified - Blood

128

4.52

6.72

18.7

5.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

6.48

6.35

1.9

4.5

—

(3018418) pH of Serum or Plasma

143

4.22

6.06

4.3

5.0

7.4

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

13.26

5.53

1.2

1.4

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

202

4.27

5.42

6.5

6.8

1.2

mmol/l

0.55

186

(3021440) Promyelocytes/100 leukocytes in Blood

5.08

5.26

7.3

4.3

0.0

0.3

—

(3025159) Blasts/100 leukocytes in Blood

5.08

5.26

7.2

4.3

0.0

1.3

—

(3017181) Myelocytes/100 leukocytes in Blood

4.67

5.04

6.9

4.1

0.8

1.0

—

(3035350) Ketones [Presence] in Urine by Test strip

218

4.16

5.02

5.1

3.5

0.0

estimate

—

(3021601) Nitrite [Presence] in Urine by Test strip

218

4.16

5.02

7.2

4.6

0.0

estimate

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

10.23

4.45

2.3

6.0

0.0

g/l

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

3.92

4.42

1.2

1.5

—

(3002179) Metamyelocytes/100 leukocytes in Blood

4.58

4.37

7.8

4.2

0.7

0.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

3.65

4.18

1.4

1.7

—

(3009261) Glucose [Presence] in Urine by Test strip

226

3.53

4.09

5.3

3.5

0.0

estimate

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

8.35

4.02

1.9

—

(3013707) Erythrocyte sedimentation rate by Westergren method

341

4.92

3.87

13.7

3.8

11.0

11.8

mm/h

0.21

309

(3021879) Hepatitis B virus core Ab [Presence] in Serum

4.23

3.71

1.2

1.5

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

11.07

3.59

1.0

1.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

101

3.04

3.59

4.5

3.3

—

(40768443) Skin Pathology biopsy report

5.80

3.55

1.0

1.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

3.28

3.44

1.3

1.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

2.87

3.13

9.9

6.6

—

(3015736) pH of Urine

167

2.67

2.97

4.1

3.3

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

365

3.98

2.95

17.4

7.9

67.4

78.5

u/l

1.64

334

(40760888) Immunoglobulin light chains.free panel - Serum

9.04

2.81

2.0

12.7

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

9.04

2.81

1.6

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.09

2.57

2.8

3.3

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

6.77

2.42

1.8

1.5

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

6.77

2.42

1.2

1.4

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

6.77

2.42

1.2

1.4

—

(3018095) Leukocytes [#/volume] in Urine

153

2.40

2.42

5.8

3.3

14.7

74.6

e6/l

1.56

112

(3037467) Urinalysis macro (dipstick) panel - Urine

309

2.87

2.38

10.8

4.1

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

5.06

2.34

1.3

1.1

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

6.00

2.26

3.6

2.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

2.56

2.26

1.1

1.2

10.2

21.3

iu/ml

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

4.09

2.24

1.4

1.1

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

5.40

2.12

1.0

—

(36660697) Celiac disease serology panel - Serum

3.44

2.11

1.1

1.2

—

(3045414) Leukocytes [Presence] in Urine

4.37

2.10

1.7

—

(40758558) Short blood count panel - Blood

120

2.26

2.02

21.1

9.1

—

(3029937) Albumin [Presence] in Urine by Test strip

125

1.98

1.46

5.8

3.7

0.0

estimate

—

(4035726)

2.44

1.46

1.4

1.2

—

(3027945) Reticulocytes/100 erythrocytes in Blood

2.38

1.42

9.8

5.5

2.1

1.9

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.30

1.25

1.1

1.5

—

(40768804) Tissue Pathology biopsy report

179

1.76

1.15

2.2

2.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.52

1.11

1.6

1.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

344

1.91

1.05

3.7

4.1

14.7

14.8

pmol/l

0.20

311

(3024561) Albumin [Mass/volume] in Serum or Plasma

193

1.69

1.03

3.5

5.1

34.8

35.9

g/l

0.53

185

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

176

1.68

0.98

5.9

3.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.38

0.97

1.2

1.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

159

1.66

0.94

4.0

2.7

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.20

0.93

1.5

2.0

—

(3000492) Spirometry study

2.13

0.90

1.5

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

2.13

0.90

1.5

2.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

125

1.67

0.88

5.4

3.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.88

0.82

2.0

1.8

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.29

0.78

7.4

8.0

27.6

24.9

mmol/l

—

(3002385) Erythrocyte distribution width [Ratio]

369

1.72

0.74

36.7

17.4

14.2

13.8

1.06

363

(3044640) Blood type and Crossmatch panel - Blood

149

1.56

0.73

4.4

2.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

2.02

0.73

2.2

1.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.72

0.72

2.2

1.8

—

(40768797) Stomach Pathology biopsy report

1.73

0.67

1.2

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

259

1.49

0.64

6.6

6.7

10.6

10.7

umol/l

0.02

240

(3042936) Bacteria identified in Isolate by Culture

1.70

0.64

1.7

2.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.63

0.63

2.1

1.9

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

182

1.47

0.62

4.8

3.6

16.0

32.4

ng/l

0.84

130

(1002224) Polysomnography panel

0.00

0.61

0.0

1.1

—

(40768793) Breast Pathology biopsy report

0.00

0.61

0.0

1.2

—

(3000494) Fungus identified in Specimen by Culture

1.57

0.58

1.1

1.3

—

(3019060) Gas panel - Arterial blood

1.70

0.58

2.2

4.0

—

(3026008) Bacteria identified in Urine by Culture

152

0.65

0.55

2.3

3.0

—

(3023368) Bacteria identified in Blood by Culture

111

1.49

0.54

6.7

3.9

—

(36304419) Bacteria [Presence] in Urine

121

1.47

0.52

3.6

2.7

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.53

0.46

2.0

1.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.68

0.44

1.4

1.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

173

1.36

0.42

2.2

1.9

92.4

100.4

pmol/l

—

(3044889) 12 lead EKG panel

312

1.37

0.42

3.9

—

(3022621) pH of Urine by Test strip

1.43

0.39

2.2

3.6

—

(40761535) Cells panel - Urine sediment

1.52

0.37

9.7

3.1

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.39

0.31

2.1

2.4

0.4

0.9

e6/l

—

(3009542) Hematocrit [Volume Fraction] of Blood

404

0.78

0.25

32.2

15.1

37.8

40.2

0.56

279

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

215

1.22

0.22

4.4

4.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

255

1.21

0.22

2.3

2.7

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

3.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.0

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.0

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.21

0.0

1.5

—

(3002256) Pathology report gross observation

1.25

0.21

1.0

1.2

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

142

0.80

0.21

5.8

2.4

69.8

56.2

u/l

0.56

133

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.20

0.0

3.6

—

63.6

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.21

0.18

2.9

2.4

19.4

13.8

umol/l

—

(3020682) Albumin/Creatinine [Ratio] in Urine

137

0.84

0.14

6.0

3.9

5.3

11.6

mg/mmol

—

(3019225) pH of Specimen

1.15

0.10

9.0

4.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

113

0.86

0.09

3.0

2.0

—

(3022145) Colonoscopy Study observation

1.15

0.09

1.7

1.2

—

(40761511) CBC panel - Blood by Automated count

466

0.89

0.09

21.6

12.9

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

0.79

0.09

4.0

2.4

2.5

g/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.83

0.08

1.3

1.4

—

(3013512) EKG study

139

0.91

0.04

6.5

3.9

—

(3012516) Albumin [Mass/volume] in Urine

127

0.93

0.02

4.3

3.0

23.7

65.8

mg/l

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

297

0.95

0.01

3.2

2.9

34.7

48.0

u/l

1.35

272

(1761868) Lipid panel - Serum or Plasma

141

0.99

0.00

2.4

3.1

—

(3003694) ABO and Rh group [Type] in Blood

127

1.03

0.00

1.8

1.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.3

—

(4281824)

0.00

0.0

1.0

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.2

—

189.5

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.0

1.1

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

1.0

—

388.0

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.6

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

3.4

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

2.5

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

3.2

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.5

—

(4146454)

0.00

0.0

3.1

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.0

2.0

—

1.4

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.4

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.2

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

3.2

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

2.0

—

(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

2.0

—

32.2

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

99.4

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.3

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.6

—

91.6

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.2

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.0

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.0

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

3.4

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.3

—

(44813793)

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_DIFFASCITIS and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_DIFFASCITIS	1.827 [1.31, 2.54]	< 0.001
Birth year	0.992 [0.98, 1.0]	0.086

During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 174 females with M13_DIFFASCITIS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_DIFFASCITIS.

N-year risk	Females	Males
1	0.141%	No data
5	0.953%	No data
10	2.411%	No data
15	4.638%	No data
20	8.067%	No data

Relationships between endpoints

↥

Index endpoint: M13_DIFFASCITIS – Diffuse (eosinophilic) fasciitis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Diffuse (eosinophilic) fasciitis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints