Other hypertrophic osteoarthropathy

M13_HYPERTRPHOSTEOARTHR

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M89.4 Hospital discharge: ICD-9 — 7312 Hospital discharge: ICD-8 — 72310 Cause of death: ICD-10 — M89.4 Cause of death: ICD-9 — 7312 Cause of death: ICD-8 — 72310 2 out of 7 registries used, show all original rules.	32
4. Check minimum number of events None	32
5. Include endpoints None	32
6. Filter based on genotype QC (FinnGen only)	32

Control definitions (FinnGen only)

Control exclude: M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M89
Name in latin: Alia osteoarthropathia hypertrophica

NAME	M13_HYPERTRPHOSTEOARTHR
CONTROL_EXCLUDE	M13_OSTEOCHONDRO
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M894
HD_ICD_9	7312
HD_ICD_8	72310
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M894
COD_ICD_9	7312
COD_ICD_8	72310
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other hypertrophic osteoarthropathy based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	261	127	127
Only index persons	198	101	97
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	47.39	50.39	43.54
Only index persons	41.42	45.82	36.84

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	32	19	13
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	39.93	37.23	43.87

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3052851) Hemolysis interference index of Serum or Plasma

7.14

2.46

5.8

4.5

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

2.45

1.41

1.7

2.0

1.8

2.9

mg/l

—

(3048689) Calprotectin [Mass/mass] in Stool

2.71

1.31

1.2

2.2

87.8

94.6

ug/g

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.92

1.26

2.2

5.1

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

2.60

1.25

2.3

2.7

18.3

28.2

—

(3021960) Folate [Moles/volume] in Serum or Plasma

2.20

0.98

1.6

1.9

22.4

18.0

nmol/l

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.20

0.98

1.4

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.40

0.97

2.2

2.5

2.1

2.4

g/l

—

(3022096) Basophils/100 leukocytes in Blood

118

1.94

0.97

7.6

5.5

0.7

0.12

111

(3022948) Iron [Moles/volume] in Serum or Plasma

2.22

0.92

2.3

2.4

11.2

15.7

umol/l

—

(3018010) Neutrophils/100 leukocytes in Blood

122

1.84

0.85

7.5

5.6

52.0

57.2

1.01

116

(3006504) Eosinophils/100 leukocytes in Blood

122

1.84

0.85

7.8

5.5

3.9

2.7

0.82

114

(36660697) Celiac disease serology panel - Serum

0.00

0.83

0.0

1.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.84

0.82

3.8

6.9

—

(3019069) Monocytes/100 leukocytes in Blood

123

1.82

0.82

8.5

5.7

9.2

8.4

0.67

116

(3002030) Lymphocytes/100 leukocytes in Blood

124

1.79

0.79

7.8

5.7

33.3

28.3

0.95

117

(3044889) 12 lead EKG panel

177

1.78

0.69

2.9

3.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

173

0.58

0.69

8.7

3.8

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

225

1.83

0.65

12.4

12.2

85.0

80.6

ml/min/173m2

0.53

181

(3019225) pH of Specimen

0.00

0.62

0.0

3.8

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.61

0.0

1.4

—

(3000494) Fungus identified in Specimen by Culture

1.79

0.46

1.4

—

(3003694) ABO and Rh group [Type] in Blood

1.50

0.44

1.0

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

119

1.49

0.42

4.5

3.6

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.42

0.0

1.4

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.42

0.0

1.2

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.42

0.0

1.5

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

0.61

0.42

3.2

4.8

0.9

2.3

ug/l

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.42

0.0

1.1

—

(40761536) Microorganisms panel - Urine sediment

0.00

0.41

0.0

3.9

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

192

1.47

0.36

7.6

7.1

70.1

83.1

u/l

1.12

178

(3013512) EKG study

1.41

0.32

2.1

4.1

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

250

0.72

0.30

4.2

4.3

3.2

2.8

mmol/l

1.78

236

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

189

1.32

0.23

3.0

4.4

14.4

14.9

pmol/l

0.37

176

(1002224) Polysomnography panel

0.00

0.22

0.0

1.1

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.22

0.0

1.2

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.22

0.0

2.2

—

1.2

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.22

0.0

1.1

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.22

0.0

2.3

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.22

0.0

1.2

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.22

0.0

1.2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.25

0.21

1.3

1.8

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

3.3

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.20

0.0

1.4

—

(3022313) Gas panel - Capillary blood

0.00

0.20

0.0

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.21

0.19

2.9

3.2

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

254

1.40

0.19

15.8

15.7

74.9

75.9

umol/l

0.07

254

(36304419) Bacteria [Presence] in Urine

0.69

0.19

6.4

2.9

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

243

1.37

0.18

12.6

15.0

139.5

140.0

mmol/l

0.50

237

(3023103) Potassium [Moles/volume] in Serum or Plasma

243

1.37

0.18

12.8

14.9

4.0

mmol/l

0.12

238

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

242

0.82

0.17

4.2

4.0

5.1

4.6

mmol/l

1.65

232

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

168

0.80

0.17

4.1

3.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

0.79

0.17

4.9

2.8

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

239

0.87

0.17

4.1

1.4

1.5

mmol/l

0.32

228

(3015736) pH of Urine

0.78

0.16

3.5

3.6

—

(3044640) Blood type and Crossmatch panel - Blood

1.28

0.16

2.3

2.0

—

(40768804) Tissue Pathology biopsy report

103

0.82

0.16

1.9

2.0

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

226

0.79

0.16

6.6

5.1

39.1

mmol/mol

0.00

216

(3026782) Osmolality of Urine

1.08

0.10

5.2

2.8

493.4

588.2

mosm/kgh2o

—

(3007164) IgA [Mass/volume] in Serum or Plasma

1.09

0.09

1.2

1.4

2.7

2.8

g/l

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

1.19

0.09

3.5

2.7

58.6

118.0

ug/l

1.28

(3023368) Bacteria identified in Blood by Culture

1.08

0.09

2.9

3.5

—

(40761511) CBC panel - Blood by Automated count

254

0.93

0.09

9.8

12.3

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

234

0.94

0.08

3.7

3.5

1.4

1.2

mmol/l

0.94

224

(3015377) Calcium [Moles/volume] in Serum or Plasma

1.05

0.00

2.0

3.5

2.3

2.4

mmol/l

—

(40758558) Short blood count panel - Blood

0.85

0.00

6.2

5.4

—

(42870588) Differential panel, method unspecified - Blood

1.05

0.00

6.9

4.6

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.0

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

2.0

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.0

1.7

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

0.00

0.0

1.8

—

3.9

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.6

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

1.00

0.00

1.0

4.3

565.7

2799.6

ng/l

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.1

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(3026008) Bacteria identified in Urine by Culture

0.86

0.00

1.3

2.8

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.5

—

(3019309) Folate [Moles/volume] in Red Blood Cells

0.93

0.00

1.4

1.5

1450.2

1187.2

nmol/l

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.0

1.4

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

0.94

0.00

1.7

1.6

1.2

mmol/l

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.4

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

2.0

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.4

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.2

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.0

2.3

—

0.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

252

0.96

0.00

14.6

12.9

18.1

22.9

mg/l

0.33

196

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.4

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.0

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.4

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

0.87

0.00

2.3

1.9

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3028626) Oxygen [Partial pressure] in Capillary blood

0.00

0.0

1.2

—

7.6

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(1761868) Lipid panel - Serum or Plasma

0.89

0.00

2.3

2.8

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.0

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

14.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3009508) Creatinine [Moles/volume] in Urine

0.94

0.00

9.0

2.6

6.1

7.6

mmol/l

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.0

—

106.6

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

0.91

0.00

2.8

3.9

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.0

2.2

—

(4268621)

0.00

0.0

1.8

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

2.2

—

15.3

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.0

1.5

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.4

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.0

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_HYPERTRPHOSTEOARTHR and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_HYPERTRPHOSTEOARTHR.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: M13_HYPERTRPHOSTEOARTHR – Other hypertrophic osteoarthropathy

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other hypertrophic osteoarthropathy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints