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Arthropathy in hypersensitivity reactions classified elsewhere

ARTHROPATHY_HYPERSENS

arthritis: An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

48

4. Check minimum number of events

None

48

5. Include endpoints

None

48

6. Filter based on genotype QC (FinnGen only)

48

Control definitions (FinnGen only)

Control exclude
SYSTINOTH_FG

Extra metadata

First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 839 349 489
Only index persons 660 280 380
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 8.38 8.71 8.09
Only index persons 11.65 12.89 10.73

-FinnGen-

Key figures

All Female Male
Number of individuals 48 28 20
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 30.49 26.82 35.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
28
30
21.00
26.28
1.8
1.3
613.3
272.0
titre
—
6
5
17
12
21.39
19.49
1.5
1.1
0.2
0.2
g/l
0.25
17
12
17
13
19.70
18.67
1.5
1.1
1.2
1.3
g/l
0.20
17
13
15
12
17.73
15.90
1.5
4.1
—
—
—
0
0
31
112
5.99
8.60
12.0
4.5
—
—
—
0
0
14
24
7.82
8.40
8.9
7.2
8.2
6.9
mmol/l
0.26
14
24
10
12
10.26
7.88
1.4
1.4
—
—
—
0
0
17
40
6.03
7.47
3.8
2.2
28.6
29.1
s
0.23
17
40
7
0
+∞
7.47
1.1
0.0
—
—
—
0
0
36
163
5.83
7.27
12.6
4.9
0.6
0.6
%
0.03
36
156
36
169
5.52
6.79
12.6
4.8
2.4
2.7
%
0.42
36
161
26
95
4.79
6.75
8.7
6.4
—
—
—
0
0
36
170
5.47
6.71
12.7
4.9
7.5
8.3
%
1.48
36
163
28
111
4.65
6.49
10.1
2.7
34.2
51.9
e6/l
0.28
23
88
6
0
+∞
6.38
1.2
0.0
—
—
—
0
0
36
175
5.23
6.34
12.6
4.6
59.7
54.7
%
1.93
36
168
36
178
5.09
6.12
13.0
4.7
27.4
31.2
%
1.77
36
170
26
103
4.33
5.91
1.8
1.3
3.1
2.2
g/l
1.82
19
53
25
102
4.03
5.35
10.3
2.6
—
—
—
0
0
28
124
4.02
5.32
11.3
3.3
34.6
36.1
g/l
0.65
28
118
29
135
3.90
5.06
13.0
3.1
9.1
26.9
e6/l
1.50
23
93
24
101
3.75
4.81
10.5
2.6
0.1
0.4
e6/l
1.13
18
77
10
21
5.75
4.77
9.8
7.2
—
—
—
0
0
10
21
5.75
4.77
9.8
7.2
4.9
5.0
kpa
—
10
21
7
5
16.02
4.73
1.3
1.0
—
—
—
0
0
41
262
4.86
4.64
9.5
3.5
14.9
9.3
mm/h
1.17
41
245
20
77
3.74
4.53
8.9
2.3
3.0
7.2
e6/l
1.84
20
71
13
39
4.20
4.11
1.2
1.5
—
—
—
0
0
9
15
7.10
4.03
1.1
1.3
—
—
—
0
0
11
30
4.46
3.89
8.5
5.2
—
—
—
0
0
18
72
3.40
3.75
10.3
2.3
591.3
559.3
mosm/kgh2o
0.22
18
62
8
13
7.13
3.67
13.9
6.6
1.0
1.1
mg/l
—
8
13
18
73
3.35
3.66
1.4
1.5
—
—
—
0
0
26
132
3.12
3.63
12.1
4.9
1.2
1.2
mmol/l
0.51
26
122
9
19
5.57
3.43
12.2
6.2
—
—
—
0
0
12
40
3.67
3.24
2.1
1.8
—
—
—
0
0
5
5
10.94
3.04
1.2
1.0
—
—
—
0
0
5
5
10.94
3.04
1.0
1.0
—
—
—
0
0
16
69
2.98
2.86
4.8
3.8
—
—
—
0
0
15
69
2.71
2.35
1.7
1.7
—
—
—
0
0
15
69
2.71
2.35
2.7
2.8
383.7
341.8
umol/l
0.84
15
56
38
273
2.88
2.34
12.9
3.5
—
—
—
0
0
18
92
2.53
2.29
7.5
3.0
—
—
—
0
0
10
37
3.15
2.26
8.0
3.1
—
—
—
0
0
8
25
3.63
2.21
5.6
4.3
23.0
24.9
mmol/l
—
8
25
10
38
3.06
2.17
8.0
3.0
5.5
5.7
kpa
—
10
38
24
147
2.27
2.00
5.7
2.7
—
—
—
0
0
7
22
3.54
1.96
1.1
1.8
—
—
—
0
0
6
17
3.88
1.90
1.7
1.6
—
—
—
0
0
6
18
3.65
1.81
4.7
1.7
0.1
0.1
e6/l
—
6
18
6
23
2.83
1.41
1.2
1.1
—
—
—
0
0
17
102
2.03
1.40
3.4
2.2
2.3
2.4
mmol/l
0.73
17
87
8
34
2.62
1.37
3.1
2.5
—
—
—
0
0
16
97
1.97
1.27
5.6
2.2
—
—
—
0
0
5
19
2.81
1.25
1.2
1.1
—
—
—
0
0
6
26
2.49
1.23
5.3
2.7
—
—
—
0
0
18
116
1.88
1.19
1.4
1.3
1.1
1.5
u/ml
—
6
25
8
41
2.14
1.15
1.4
1.2
—
—
—
0
0
9
47
2.12
1.10
3.7
2.6
3.9
7.8
umol/l
—
9
40
16
103
1.83
1.05
1.6
1.7
—
—
—
0
0
6
29
2.22
0.93
11.5
3.3
—
—
—
0
0
6
31
2.07
0.88
6.0
1.4
—
—
—
0
0
7
39
1.93
0.76
1.6
1.2
—
—
—
0
0
13
87
1.68
0.73
1.8
1.8
2.1
1.4
mmol/l
0.60
13
78
0
20
0.00
0.62
0.0
1.4
—
—
—
0
0
0
20
0.00
0.62
0.0
1.4
—
—
—
0
0
0
20
0.00
0.62
0.0
1.5
—
—
—
0
0
6
35
1.81
0.60
11.8
3.2
7.2
5.1
kpa
—
6
35
15
111
1.51
0.55
2.5
1.6
77.8
94.3
pmol/l
—
8
51
39
353
1.56
0.52
30.2
10.9
13.7
13.3
%
1.17
39
345
32
358
0.68
0.51
4.8
3.9
1.9
1.9
mu/l
0.18
32
327
17
133
1.43
0.47
2.3
2.2
—
—
—
0
0
11
79
1.51
0.46
3.5
4.2
—
—
—
0
0
5
31
1.68
0.44
1.4
1.3
—
—
—
0
0
5
31
1.68
0.44
1.2
1.3
—
—
—
0
0
0
16
0.00
0.42
0.0
2.3
—
—
—
0
0
27
233
1.36
0.41
2.5
3.0
—
—
—
0
0
13
103
1.36
0.32
5.5
1.9
—
—
—
0
0
13
104
1.34
0.30
3.4
2.6
—
—
—
0
0
5
41
1.24
0.23
1.2
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
461.4
—
0
5
14
126
1.16
0.10
2.1
2.7
—
—
—
0
0
5
45
1.12
0.10
1.2
1.1
—
—
—
0
0
7
81
0.84
0.08
3.6
3.7
—
—
—
0
0
8
92
0.84
0.07
1.6
1.8
—
—
—
0
0
12
119
1.01
0.00
1.5
1.4
—
—
—
0
0
12
115
1.06
0.00
2.1
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
329.7
—
0
6
0
5
0.00
0.00
0.0
2.4
—
6.4
—
0
5
0
5
0.00
0.00
0.0
3.4
—
3.8
—
0
5
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
2.5
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint ARTHROPATHY_HYPERSENS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have ARTHROPATHY_HYPERSENS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: ARTHROPATHY_HYPERSENS – Arthropathy in hypersensitivity reactions classified elsewhere

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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