connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.
Systemic disorders of connective tissue in diseases classified elsewhere
DOID EFO Endpoint Browser PheWeb
M13_SYSTCONINOTH
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
144 |
4. Check minimum number of eventsNone |
144 |
5. Include endpointsNone |
144 |
6. Filter based on genotype QC (FinnGen only) |
142 |
Control definitions (FinnGen only)
- Control exclude
- M13_SYSTCONNECT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Systemic disorders of connective tissue in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Other systemic involvement of connective tissue
- Systemic connective tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1422 | 617 | 803 |
| Only index persons | 1167 | 513 | 654 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 25.39 | 30.73 | 21.29 |
| Only index persons | 30.58 | 35.25 | 26.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 142 | 71 | 71 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 48.94 | 52.64 | 45.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 144
- Matched controls
- 1440
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M36.4*D69.0
ICD-10 Finland
Arthropathy in Henoch(-Schönlein) purpura
+∞
51.1
46
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
13.3
36.2
39
39
M36.8*D80.1
ICD-10 Finland
Systemic disorders of connective tissue in hypogammaglobulinaemia
+∞
34.8
32
*
126
Kela drug reimbursment
Chronic coagulation defects
410.6
33.3
32
*
ZX120
NOMESCO Finland
Intravenous
9.1
30.6
46
71
D66
ICD-10 Finland
Hereditary factor VIII deficiency
+∞
30.3
28
*
D69.0
ICD-10 Finland
Allergic purpura
130.6
30.0
31
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
28.0
26
*
M362, D66,
ICD-10 Finland
+∞
25.8
24
*
B02BD02
ATC
coagulation factor VIII; parenteral
+∞
25.8
24
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.5
23.3
81
274
B02AA02
ATC
tranexamic acid; systemic
6.4
21.6
44
92
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
7.9
20.6
32
50
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
7.6
20.4
33
54
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.1
19.4
41
88
M36.1*C90.0
ICD-10 Finland
Arthropathy in multiple myeloma
+∞
19.2
18
*
J01MA12
ATC
levofloxacin; systemic
5.3
19.0
50
131
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
18.1
17
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
18.1
17
*
2860A
ICD-9 Finland
Coagulation defects, Congenital factor VIII disorder
+∞
17.0
16
*
28600
ICD-8 Finland
Coagulation defects, Haemophilia
+∞
17.0
16
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
16.7
15.2
24
17
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
14.8
14
*
N08.2*D69.0
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
+∞
14.8
14
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
6.3
14.3
27
51
R50.9
ICD-10 Finland
Fever, unspecified
4.4
13.9
45
136
TPH04
NOMESCO Finland
Cathetrisation of vein
4.1
13.9
52
175
6BA02, ,
NOMESCO Finland
82.9
13.9
15
*
C90.0
ICD-10 Finland
Multiple myeloma
38.2
13.8
17
5
H02AB07
ATC
prednisone; oral
4.8
13.7
37
97
H02AB06
ATC
prednisolone; systemic
3.6
12.8
86
421
M36.2
ICD-10 Finland
Haemophilic arthropathy
+∞
12.7
12
*
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
12.7
12
*
B18.2
ICD-10 Finland
Chronic viral hepatitis C
21.2
11.9
17
9
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
33.2
11.9
15
5
R4110
NOMESCO Finland
Physiotherapy
3.5
11.7
61
252
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
10.5
11.0
21
23
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
5.5
10.9
23
48
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
5.5
10.9
23
48
N02AX02
ATC
tramadol; systemic, rectal
3.2
10.8
72
342
M05BA04
ATC
alendronic acid; oral
5.8
10.7
21
41
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
118.3
10.6
11
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.4
10.6
51
199
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.4
10.3
30
82
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.1
10.3
79
404
Z3226
NOMESCO Finland
Physiotherapist
3.5
10.0
45
167
J01FF01
ATC
clindamycin; systemic
3.2
9.9
54
226
ZXD10
NOMESCO Finland
Scheduled procedure
3.0
9.7
71
350
M19.2
ICD-10 Finland
Other secondary arthrosis
32.5
9.6
12
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
23.6
9.5
13
6
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
4.2
9.5
29
82
B02BX06
ATC
emicizumab; parenteral
+∞
9.5
9
*
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
5.0
9.5
22
50
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
15.0
9.4
15
11
ZXA05
NOMESCO Finland
Left side
3.2
9.4
49
199
M13.9
ICD-10 Finland
Arthritis, unspecified
5.1
9.2
21
47
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
8.6
9.0
19
25
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
7.3
8.9
21
33
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
5.2
8.6
19
41
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
5.4
8.6
18
37
NF1AA
NOMESCO Finland
Hip X-ray examination
4.7
8.5
21
50
M36.4
ICD-10 Finland
Arthropathy in hypersensitivity reactions classified elsewhere
+∞
8.4
8
*
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
+∞
8.4
8
*
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
8.4
8
*
C01CA24
ATC
epinephrine; parenteral
4.6
8.3
21
51
Z2221
NOMESCO Finland
Medical doctor
2.9
8.3
53
239
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
35.5
8.2
10
*
ZX121
NOMESCO Finland
Central venous catheter
35.5
8.2
10
*
UJF30
NOMESCO Finland
Ileoscopy through colon
4.2
8.1
24
66
Z3231
NOMESCO Finland
Registered nurse
2.8
7.9
55
259
J01MA14
ATC
moxifloxacin; systemic
4.2
7.8
23
63
TPX10
NOMESCO Finland
Implantation of vascular injection port
9.7
7.8
15
17
XF400
NOMESCO Finland
ECG with 12 standard connections
3.4
7.7
33
117
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
7.9
7.7
17
24
J47
ICD-10 Finland
Bronchiectasis
19.7
7.7
11
6
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.9
7.7
18
41
A02BC02
ATC
pantoprazole; systemic
2.8
7.6
102
663
N02AA05
ATC
oxycodone; systemic
3.2
7.5
35
131
ZXA00
NOMESCO Finland
Right side
2.8
7.4
49
223
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
7.3
7
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
9.6
7.2
14
16
XW000
NOMESCO Finland
Bone marrow biopsy
8.2
7.1
15
20
L04AX01
ATC
azathioprine; systemic
8.2
7.1
15
20
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
4.5
7.0
18
44
R01BA52
ATC
pseudoephedrine, combinations; oral
2.7
7.0
48
223
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.8
6.9
42
183
EBA10
NOMESCO Finland
Operative extraction of tooth
3.1
6.8
33
126
M05BA02
ATC
clodronic acid; systemic
23.8
6.8
9
*
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.8
6.7
22
65
J01DA06
ATC
[U] cefuroxime
3.2
6.7
30
109
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
13.1
6.7
11
9
TDM10
NOMESCO Finland
Puncture of maxillary antrum
6.8
6.7
16
26
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.1
6.6
19
51
C03CA01
ATC
furosemide; systemic
2.7
6.5
46
215
L04AX04
ATC
lenalidomide; oral
72.9
6.5
7
*
Z2446
NOMESCO Finland
Social worker
4.1
6.3
18
48
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
+∞
6.3
6
*
3047, ,
Kela drug reimbursment
+∞
6.3
6
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
+∞
6.3
6
*
M15.3
ICD-10 Finland
Secondary multiple arthrosis
+∞
6.3
6
*
1520, ,
Kela drug reimbursment
+∞
6.3
6
*
D67
ICD-10 Finland
Hereditary factor IX deficiency
+∞
6.3
6
*
2BD02, ,
NOMESCO Finland
+∞
6.3
6
*
R06.0
ICD-10 Finland
Dyspnoea
2.7
6.3
44
205
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
9.2
6.2
12
14
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.7
6.2
39
172
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.4
6.1
60
327
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
33
33
12.68
30.34
1.5
1.2
0.23
0.23
g/l
0.15
33
33
33
35
11.93
29.12
1.5
1.2
1.21
1.17
g/l
0.25
33
35
33
63
6.50
17.51
3.7
1.5
—
—
—
0
0
38
85
5.71
17.08
5.3
2.0
0.23
0.21
g/l
0.58
38
78
62
229
4.00
14.59
3.9
1.9
2.90
3.11
mg/l
0.34
54
191
32
81
4.79
12.25
4.9
3.4
88.77
63.54
ml/min/173m2
3.38
22
41
112
663
4.10
12.15
22.2
9.3
4.11
4.03
e9/l
0.14
106
579
10
0
+∞
10.54
2.7
0.0
—
—
—
0
0
72
351
3.10
10.18
5.5
3.0
2.33
2.35
mmol/l
0.58
67
309
23
53
4.97
9.74
10.1
4.4
0.94
1.38
mmol/l
0.19
18
38
90
507
3.07
9.68
20.2
6.1
1.21
1.22
mmol/l
0.19
72
437
18
19
10.65
9.59
1.3
1.2
1.50
15.20
u/ml
—
6
5
17
21
9.02
8.36
1.4
1.2
2.27
6.90
u/ml
—
11
10
17
22
8.60
8.15
1.2
1.0
—
—
—
0
0
16
19
9.32
8.06
3.4
1.7
—
—
—
0
0
16
19
9.32
8.06
3.4
1.7
—
—
—
0
0
16
19
9.32
8.06
3.6
1.6
—
—
—
0
0
17
23
8.22
7.94
2.2
1.5
—
—
—
0
0
17
25
7.56
7.56
3.3
1.7
—
—
—
0
0
17
25
7.56
7.56
3.6
1.6
—
—
—
0
0
10
5
21.33
7.24
1.8
1.4
100.10
107.20
%
—
10
5
10
5
21.33
7.24
1.7
7.2
—
—
—
0
0
11
8
14.75
7.01
2.5
2.4
11.36
9.50
%
—
11
8
13
14
10.08
6.95
2.5
2.2
—
—
—
0
0
13
14
10.08
6.95
6.5
1.6
—
—
—
0
0
69
387
2.50
6.75
9.9
3.0
—
—
—
0
0
13
15
9.40
6.71
6.5
1.5
—
—
—
0
0
18
35
5.72
6.59
3.5
1.6
—
—
—
0
0
11
10
11.79
6.41
4.5
1.9
—
—
—
0
0
11
10
11.79
6.41
4.5
1.9
—
—
—
0
0
11
10
11.79
6.41
4.5
1.9
—
—
—
0
0
17
32
5.88
6.39
4.4
1.4
—
—
—
0
0
15
24
6.84
6.36
1.3
1.2
—
—
—
0
0
15
26
6.31
6.03
3.5
1.8
12.85
11.03
mg/l
0.39
15
26
9
6
15.87
5.98
4.4
1.0
—
—
—
0
0
14
23
6.62
5.86
1.3
1.5
—
—
—
0
0
14
23
6.62
5.86
1.3
1.5
—
—
—
0
0
13
20
7.03
5.70
1.3
1.2
—
—
—
0
0
37
165
2.67
5.70
3.8
1.6
—
—
—
0
0
9
7
13.60
5.66
4.4
1.1
—
—
—
0
0
48
248
2.40
5.41
5.0
1.9
1.23
1.00
mg/l
0.32
39
187
10
11
9.67
5.38
6.7
1.7
—
—
—
0
0
10
11
9.67
5.38
6.7
1.7
—
—
—
0
0
10
11
9.67
5.38
6.7
1.7
—
—
—
0
0
10
11
9.67
5.38
6.7
1.7
—
—
—
0
0
9
8
11.89
5.37
1.6
1.0
—
—
—
0
0
9
8
11.89
5.37
1.6
1.0
—
—
—
0
0
9
8
11.89
5.37
1.6
1.0
—
—
—
0
0
9
8
11.89
5.37
1.6
1.0
—
—
—
0
0
9
8
11.89
5.37
1.6
1.0
—
—
—
0
0
10
12
8.86
5.15
6.7
1.7
—
—
—
0
0
10
12
8.86
5.15
6.7
1.7
—
—
—
0
0
8
6
14.01
5.14
7.0
1.2
21.75
29.67
umol/l
—
8
6
9
9
10.57
5.10
2.0
2.3
—
—
—
0
0
8
7
12.00
4.84
1.4
1.1
14.85
14.29
umol/l
—
8
7
38
187
2.40
4.70
7.4
2.7
0.63
0.72
e6/l
0.14
24
103
9
11
8.64
4.63
1.1
1.0
—
—
—
0
0
8
8
10.50
4.58
2.0
2.4
35.38
27.25
%
—
8
8
11
21
5.58
4.23
6.5
1.7
—
—
—
0
0
44
244
2.16
4.06
4.9
2.1
—
—
—
0
0
35
178
2.28
3.98
8.3
2.7
1.82
2.85
e6/l
0.47
22
95
13
33
4.22
3.91
6.8
1.8
—
—
—
0
0
13
33
4.22
3.91
5.5
1.7
—
—
—
0
0
14
45
3.34
3.76
1.6
1.2
—
—
—
0
0
51
310
2.00
3.64
11.1
3.1
0.12
0.37
e6/l
1.70
42
228
9
17
5.57
3.57
1.1
1.2
—
—
—
0
0
8
13
6.44
3.55
1.3
1.5
—
—
—
0
0
25
116
2.40
3.47
1.9
1.5
—
—
—
0
0
9
20
4.73
3.17
1.3
1.6
—
—
—
0
0
6
8
7.76
3.08
1.3
1.1
—
—
—
0
0
6
8
7.76
3.08
1.2
1.1
—
—
—
0
0
9
21
4.50
3.05
1.7
2.0
—
—
—
0
0
14
53
2.82
2.89
2.1
1.5
—
—
—
0
0
11
34
3.42
2.79
1.2
1.3
—
—
—
0
0
8
19
4.39
2.72
1.0
1.1
—
—
—
0
0
11
35
3.32
2.71
1.0
1.1
—
—
—
0
0
65
463
1.74
2.65
18.2
11.0
1.42
1.29
inr
0.34
17
130
8
20
4.17
2.61
6.0
4.5
58.62
62.80
%
—
8
20
19
90
2.28
2.52
3.0
4.0
—
—
—
0
0
30
174
1.91
2.37
1.2
1.2
1.54
8.66
u/ml
—
8
67
43
284
1.73
2.24
1.3
1.3
3.30
1.48
u/ml
0.34
13
68
7
19
3.82
2.18
1.6
1.3
—
—
—
0
0
7
19
3.82
2.18
1.4
1.6
—
—
—
0
0
6
14
4.42
2.17
1.5
1.1
—
—
—
0
0
6
14
4.42
2.17
1.0
1.1
—
—
—
0
0
72
551
1.61
2.11
5.3
3.5
0.00
0.00
estimate
-0.00
12
97
6
15
4.12
2.06
1.0
1.1
—
—
—
0
0
6
15
4.12
2.06
3.8
3.2
—
—
—
0
0
13
57
2.41
2.04
1.4
1.4
—
—
—
0
0
22
122
1.95
1.98
1.9
1.5
—
—
—
0
0
6
16
3.86
1.95
1.2
1.6
—
—
—
0
0
6
16
3.86
1.95
1.2
1.6
—
—
—
0
0
5
12
4.27
1.84
1.2
1.5
—
—
—
0
0
28
175
1.74
1.74
1.4
1.3
16.44
32.81
iu/ml
—
5
57
21
121
1.86
1.69
19.1
6.0
104.10
103.99
mmol/l
0.03
21
121
69
544
1.52
1.66
5.4
3.4
0.00
0.00
estimate
-0.00
12
104
30
196
1.67
1.60
2.2
2.9
24.50
229.97
ng/l
1.64
20
143
69
548
1.50
1.58
8.4
4.7
0.00
0.00
estimate
-0.00
12
100
8
33
2.51
1.56
3.5
2.2
—
—
—
0
0
43
311
1.55
1.52
5.0
3.8
19.73
10.40
mg/mmol
0.44
33
199
5
16
3.20
1.45
1.4
1.6
—
—
—
0
0
126
1154
1.73
1.37
38.4
13.3
139.52
139.74
mmol/l
0.53
120
1122
126
1157
1.71
1.32
39.1
13.3
3.93
3.97
mmol/l
0.67
120
1123
126
1157
1.71
1.32
38.2
12.0
16.86
22.84
mg/l
2.00
109
883
11
57
2.01
1.20
4.1
7.5
94.62
94.13
%
0.16
11
57
50
391
1.43
1.18
2.6
1.8
81.42
94.25
pmol/l
1.41
33
186
116
1063
1.47
1.02
27.3
11.4
89.49
86.11
ml/min/173m2
0.77
103
837
7
37
1.94
0.95
1.3
1.7
349.43
481.89
mg/l
—
7
37
6
27
2.27
0.94
10.3
5.9
10.38
8.78
kpa
—
6
27
6
28
2.19
0.92
1.0
1.3
—
—
—
0
0
6
32
1.91
0.82
1.0
1.2
—
—
—
0
0
6
33
1.85
0.80
1.0
1.2
—
—
—
0
0
0
24
0.00
0.80
0.0
1.5
—
—
—
0
0
99
1073
0.75
0.79
5.1
4.1
6.06
5.90
mmol/l
0.34
91
982
9
53
1.74
0.77
3.3
3.9
63.71
50.93
%
—
9
53
33
260
1.35
0.73
1.7
1.7
—
—
—
0
0
11
70
1.62
0.67
1.1
1.0
—
—
—
0
0
22
172
1.33
0.52
1.9
1.7
1273.53
1142.85
nmol/l
0.28
17
125
25
201
1.29
0.49
2.4
2.7
0.67
0.75
ug/l
0.30
17
127
7
47
1.51
0.48
5.1
3.5
9.00
3131.13
u/ml
—
7
40
34
288
1.24
0.45
4.4
3.6
0.00
0.01
estimate
0.50
12
98
56
501
1.19
0.43
4.9
2.4
—
—
—
0
0
99
1037
0.85
0.33
5.5
4.4
1.99
1.83
mu/l
0.76
94
944
97
1010
0.88
0.26
5.8
5.3
39.34
39.52
mmol/mol
0.05
90
945
88
842
1.12
0.22
4.7
3.8
14.46
14.76
pmol/l
0.47
82
756
0
11
0.00
0.21
0.0
4.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
4.00
—
0
5
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
6
52
1.16
0.19
2.0
3.1
24.50
24.75
mmol/l
—
6
52
8
70
1.15
0.16
1.0
1.3
—
—
—
0
0
109
1114
0.91
0.14
4.9
4.5
2.87
2.76
mmol/l
0.50
104
1029
10
117
0.84
0.13
1.5
1.8
—
—
—
0
0
130
1316
0.87
0.12
51.8
17.6
40.41
40.80
%
0.43
124
1243
108
1100
0.93
0.10
4.6
4.1
4.66
4.63
mmol/l
0.10
103
1017
17
154
1.12
0.10
1.4
1.4
—
—
—
0
0
41
392
1.06
0.08
5.3
3.4
159.77
35.69
ng/l
0.69
32
255
5
60
0.83
0.08
3.8
5.4
23.02
24.13
mmol/l
—
5
55
108
1094
0.95
0.06
4.5
4.0
1.36
1.43
mmol/l
1.18
102
1009
104
1052
0.96
0.04
4.4
3.7
1.46
1.30
mmol/l
1.07
97
968
84
830
1.03
0.03
3.8
3.4
—
—
—
0
0
17
162
1.06
0.02
1.4
2.4
—
—
—
0
0
18
174
1.04
0.00
1.5
2.6
—
—
—
0
0
123
1224
1.03
0.00
40.6
13.8
81.19
76.51
umol/l
0.35
123
1224
15
147
1.02
0.00
1.7
1.7
1.56
1.38
%
—
10
139
42
425
0.98
0.00
4.4
3.5
—
—
—
0
0
27
268
1.01
0.00
3.3
4.0
22.24
22.58
%
0.05
17
112
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
9
97
0.92
-0.00
1.6
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
7.32
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
110.86
—
0
7
8
82
0.97
-0.00
1.6
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.0
—
222.40
—
0
5
12
120
1.00
-0.00
12.4
6.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
0.28
—
0
7
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_SYSTCONINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYSTCONINOTH | 5.224 [3.7, 7.37] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.051 |
During the follow-up period (1.1.1998 — 31.12.2019), 126 out of 560 females with M13_SYSTCONINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYSTCONINOTH | 3.748 [2.61, 5.38] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 135 out of 723 males with M13_SYSTCONINOTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_SYSTCONINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.508% | 0.623% |
| 5 | 2.696% | 4.136% |
| 10 | 6.368% | 10.073% |
| 15 | 12.205% | 18.83% |
| 20 | 21.608% | 30.435% |
Relationships between endpoints
↥Index endpoint: M13_SYSTCONINOTH – Systemic disorders of connective tissue in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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