connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.
Systemic disorders of connective tissue in diseases classified elsewhere
DOID EFO Endpoint Browser PheWeb
M13_SYSTCONINOTH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
142 |
4. Check minimum number of eventsNone |
142 |
5. Include endpointsNone |
142 |
6. Filter based on genotype QC (FinnGen only) |
142 |
Control definitions (FinnGen only)
- Control exclude
- M13_SYSTCONNECT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Systemic disorders of connective tissue in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Other systemic involvement of connective tissue
- Systemic connective tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1422 | 617 | 803 |
| Only index persons | 1167 | 513 | 654 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 25.39 | 30.73 | 21.29 |
| Only index persons | 30.58 | 35.25 | 26.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 142 | 71 | 71 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 48.86 | 52.49 | 45.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 128
- Matched controls
- 1280
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M36.4*D69.0
ICD-10 Finland
Arthropathy in Henoch(-Schönlein) purpura
+∞
42.0
38
*
M36.8*D80.1
ICD-10 Finland
Systemic disorders of connective tissue in hypogammaglobulinaemia
+∞
30.4
28
*
D69.0
ICD-10 Finland
Allergic purpura
354.7
29.0
28
*
126
Kela drug reimbursment
Chronic coagulation defects
323.0
26.8
26
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
24.8
23
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
7.4
23.7
75
206
D66
ICD-10 Finland
Hereditary factor VIII deficiency
+∞
23.7
22
*
B02BD02
ATC
coagulation factor VIII; parenteral, topical, urethral
+∞
20.3
19
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
16.0
20.0
33
27
M362, D66
ICD-10 Finland
NA
+∞
19.2
18
*
ZX120
NOMESCO Finland
Intravenous
9.5
18.4
40
58
M36.1*C90.0
ICD-10 Finland
Arthropathy in multiple myeloma
+∞
18.1
17
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
17.0
16
*
C90.0
ICD-10 Finland
Multiple myeloma
64.7
15.2
17
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
14.9
14
*
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
168.4
14.8
15
*
M36.2
ICD-10 Finland
Haemophilic arthropathy
+∞
13.8
13
*
28600
ICD-8 Finland
Coagulation defects, Haemophilia
+∞
12.7
12
*
2860A
ICD-9 Finland
Coagulation defects, Congenital factor VIII disorder
+∞
12.7
12
*
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
143.5
12.7
13
*
B02AA02
ATC
tranexamic acid; systemic
5.9
12.4
37
82
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
14.6
12.1
20
16
6BA02
NOMESCO Finland
NA
71.7
11.8
13
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
12.3
11.8
21
20
N08.2*D69.0
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
+∞
11.6
11
*
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
8.3
11.6
26
38
J01MA12
ATC
levofloxacin; systemic
4.8
11.6
43
121
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
22.6
11.5
16
8
R50.9
ICD-10 Finland
Fever, unspecified
5.0
11.4
40
106
M36.4
ICD-10 Finland
Arthropathy in hypersensitivity reactions classified elsewhere
+∞
10.6
10
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.9
10.5
37
98
H02AB07
ATC
prednisone; oral
5.2
10.1
33
80
B18.2
ICD-10 Finland
Chronic viral hepatitis C
22.2
10.0
14
7
H02AB06
ATC
prednisolone; systemic
3.4
9.9
72
353
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.3
9.7
71
347
R4110
NOMESCO Finland
Physiotherapy
3.7
9.6
52
201
ZX121
NOMESCO Finland
Central venous catheter
107.7
9.5
10
*
M05BA02
ATC
clodronic acid; systemic
+∞
9.5
9
*
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
9.5
9
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.8
9.0
43
150
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
9.3
8.9
18
22
J01FF01
ATC
clindamycin; systemic
3.5
8.8
50
199
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
9.6
8.6
17
20
TPX10
NOMESCO Finland
Implantation of vascular injection port
14.1
8.6
14
11
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
96.1
8.5
9
*
L04AX04
ATC
lenalidomide; oral
96.1
8.5
9
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.4
8.5
26
58
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
7.2
8.4
20
32
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.1
8.1
26
61
A02BC02
ATC
pantoprazole; systemic
3.0
7.9
87
533
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
5.4
7.7
23
50
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
7.7
7.6
17
25
153
Kela drug reimbursment
Lenalidomid
84.8
7.5
8
*
N02AA05
ATC
oxycodone; systemic
4.2
7.4
29
84
J01MA14
ATC
moxifloxacin; systemic
5.3
7.3
22
48
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
9.7
7.3
14
16
C01CA24
ATC
epinephrine; parenteral
6.6
7.2
18
31
Z3226
NOMESCO Finland
Physiotherapist
3.5
7.1
37
134
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
6.8
7.1
17
28
L04AX01
ATC
azathioprine; systemic
9.1
7.0
14
17
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
14.9
7.0
11
8
UJF30
NOMESCO Finland
Ileoscopy through colon
5.3
7.0
21
46
TDM10
NOMESCO Finland
Puncture of maxillary antrum
7.9
6.9
15
21
M05BA04
ATC
alendronic acid; oral
6.2
6.9
18
33
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
6.2
6.9
18
33
J05AB11
ATC
valaciclovir; oral
3.9
6.9
29
89
ZXD10
NOMESCO Finland
Scheduled procedure
2.8
6.8
63
333
H02AB09
ATC
hydrocortisone; systemic
24.0
6.8
9
*
NE1AA
NOMESCO Finland
Pelvis X-ray examination
5.8
6.6
18
35
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
15.3
6.5
10
7
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
10.0
6.4
12
13
NF1AA
NOMESCO Finland
Hip X-ray examination
5.3
6.4
19
41
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.9
6.4
44
194
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
5.5
6.3
18
37
D67
ICD-10 Finland
Hereditary factor IX deficiency
+∞
6.3
6
*
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
6.3
6
*
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
6.3
6
*
5BA08
NOMESCO Finland
NA
+∞
6.3
6
*
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
+∞
6.3
6
*
N02AX02
ATC
tramadol; systemic, rectal
2.6
6.3
62
337
XW000
NOMESCO Finland
Bone marrow biopsy
7.3
6.2
14
21
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
4.3
6.1
22
59
Mortality – FinRegistry
↥Association
Association between endpoint M13_SYSTCONINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYSTCONINOTH | 5.224 [3.7, 7.37] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.051 |
During the follow-up period (1.1.1998 — 31.12.2019), 126 out of 560 females with M13_SYSTCONINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYSTCONINOTH | 3.748 [2.61, 5.38] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 135 out of 723 males with M13_SYSTCONINOTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_SYSTCONINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.508% | 0.623% |
| 5 | 2.696% | 4.136% |
| 10 | 6.368% | 10.073% |
| 15 | 12.205% | 18.83% |
| 20 | 21.608% | 30.435% |
Relationships between endpoints
↥Index endpoint: M13_SYSTCONINOTH – Systemic disorders of connective tissue in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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