Ependymoma

C3_EPENDYDOMA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 ANY
  • Cancer registry: Morphology ICD-O-3 939[1-3]
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

63

4. Check minimum number of events

None

63

5. Include endpoints

None

63

6. Filter based on genotype QC (FinnGen only)

59

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF9

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 59 33 26
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 49.75 49.26 50.38

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
63
Matched controls
630
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
9391/3-C72.0
ICD-O-3
Ependymoma, NOS, of spinal cord
+∞
38.5
33
*
H02AB02
ATC
dexamethasone; systemic
126.0
23.6
24
*
ABB10
NOMESCO Finland
Resection of lesion of spinal canal
+∞
21.0
19
*
ABB00
NOMESCO Finland
Excision of lesion of spinal canal
+∞
19.8
18
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
246.6
18.6
18
*
130
Kela drug reimbursment
Malignant tumour
+∞
16.3
15
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
+∞
16.3
15
*
C72.01
ICD-10 Finland
Malignant tumor of the spinal cord grade II glioma
+∞
16.3
15
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
16.6
16.1
27
27
C72.00
ICD-10 Finland
Malignant tumor of the spinal cord without histology
+∞
14.1
13
*
C72.09
ICD-10 Finland
Malignant tumor of the spinal cord other histology
+∞
12.9
12
*
C71.74
ICD-10 Finland
Malignant tumor of the brainstem ependyoma
+∞
12.9
12
*
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
72.7
11.0
12
*
WF002
NOMESCO Finland
Radical radiotherapy
130.9
10.8
11
*
D33.41
ICD-10 Finland
Myxopapillary epndymoma of the spinal cord (grade I)
+∞
10.7
10
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
10.7
10
*
D43.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Spinal cord
+∞
10.7
10
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
6.4
10.6
23
52
9391/3-C71.7
ICD-O-3
Ependymoma, NOS, of brain stem
+∞
9.6
9
*
D33.43
ICD-10 Finland
Spinal cord
+∞
9.6
9
*
C71.51
ICD-10 Finland
Malignant tumor of cerebral ventricle ependymoma
+∞
9.6
9
*
ZXE20
NOMESCO Finland
More than three and less than five hours
6.4
9.0
18
37
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
38.9
8.4
10
*
A04AA01
ATC
ondansetron; systemic, rectal
38.9
8.4
10
*
XX3DW
NOMESCO Finland
Time consuming IT work
16.0
8.3
13
10
M03BX01
ATC
baclofen; systemic
51.6
7.9
9
*
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
51.6
7.9
9
*
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
51.6
7.9
9
*
A04AA02
ATC
granisetron; systemic, transdermal
90.3
7.6
8
*
R4110
NOMESCO Finland
Physiotherapy
4.3
7.4
29
104
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
+∞
7.4
7
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
7.4
7
*
D33.40
ICD-10 Finland
Benign glioma of the spinal cord (grade I)
+∞
7.4
7
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.3
7.4
28
98
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
23.3
7.4
10
5
L28
ICPC
Limited function/disability (L)
5.0
7.3
20
54
WX404
NOMESCO Finland
Intravenous generell anesthesy
4.4
6.9
23
73
AA1AD
NOMESCO Finland
CT of head and brain
4.2
6.7
25
86
ZXE30
NOMESCO Finland
More than five and less than seven hours
16.6
6.6
10
7
Z51.5
ICD-10 Finland
Palliative care
77.4
6.6
7
*
XKD06
NOMESCO Finland
Physiologic investigation of micturition
20.6
6.5
9
5
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
20.6
6.5
9
5
D33.4
ICD-10 Finland
Benign neoplasm: Spinal cord
+∞
6.3
6
*
9391/3-C71.5
ICD-O-3
Ependymoma, NOS, of ventricle, NOS
+∞
6.3
6
*
D43.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, infratentorial
+∞
6.3
6
*
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
+∞
6.3
6
*
ZX050
NOMESCO Finland
Stereotactic radiotherapy
+∞
6.3
6
*
D33.45
ICD-10 Finland
Benign Schwannom in the nerve root of the spinal cord
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
26
35
11.95
19.88
5.9
6.2
0.69
0.97
mmol/l
0.17
17
30
24
10
37.59
19.15
1.5
1.9
—
—
—
0
0
16
15
13.84
9.46
6.1
8.7
23.94
24.48
mmol/l
0.30
16
15
36
154
4.12
7.17
3.1
1.6
—
—
—
0
0
34
140
4.10
7.15
3.0
2.1
—
—
—
0
0
17
42
5.17
6.87
7.8
12.6
24.12
24.65
mmol/l
0.30
17
42
11
13
9.97
5.84
3.1
1.3
—
—
—
0
0
13
22
7.15
5.58
5.2
7.7
0.76
0.86
%
0.37
13
22
13
23
6.83
5.42
5.2
7.7
1.09
1.97
%
0.95
13
23
31
140
3.39
5.34
3.2
3.8
9.29
24.85
e6/l
0.73
25
106
28
125
3.23
4.83
3.4
3.4
0.04
0.36
e6/l
2.68
23
92
23
92
3.36
4.73
2.5
2.7
542.91
564.05
mosm/kgh2o
0.19
23
74
28
127
3.17
4.67
3.4
3.3
—
—
—
0
0
23
97
3.16
4.29
2.4
3.1
1.92
4.75
e6/l
2.06
23
85
15
50
3.63
4.01
4.6
4.6
106.93
103.50
mmol/l
1.80
15
50
15
51
3.55
3.89
8.2
9.3
—
—
—
0
0
6
6
10.87
3.57
2.0
1.2
—
—
—
0
0
9
18
5.64
3.52
6.0
4.1
—
—
—
0
0
20
89
2.83
3.30
4.5
3.1
—
—
—
0
0
31
175
2.52
3.18
3.8
4.1
34.88
30.40
e6/l
0.08
25
110
36
219
2.50
3.13
10.0
4.5
8.83
10.41
umol/l
1.06
36
204
29
164
2.42
2.91
13.9
12.3
1.04
1.28
inr
—
7
51
5
6
8.91
2.80
1.8
2.5
70.80
69.50
%
—
5
6
5
6
8.91
2.80
1.8
2.5
27.40
24.33
%
—
5
6
6
10
6.49
2.76
3.5
4.4
3.83
3.80
mmol/l
—
6
10
15
64
2.76
2.63
5.8
2.6
29.87
30.01
s
0.04
15
64
23
125
2.32
2.45
1.2
1.6
—
—
—
0
0
5
8
6.67
2.41
1.8
3.1
19.80
12.25
%
—
5
8
23
129
2.23
2.25
4.0
2.6
—
—
—
0
0
6
14
4.61
2.20
4.7
5.3
16.33
22.63
nmol/l
—
6
14
23
141
1.99
1.74
3.9
2.7
2.37
2.36
mmol/l
0.11
23
126
10
41
2.71
1.74
8.4
7.6
24.80
23.47
mmol/l
—
10
41
6
19
3.38
1.70
3.7
4.3
—
—
—
0
0
39
288
1.93
1.69
19.0
6.3
3.60
3.81
e9/l
0.24
34
253
8
32
2.71
1.66
1.1
1.1
—
—
—
0
0
33
236
1.84
1.54
21.4
6.8
0.00
0.00
e9/l
-0.00
27
179
12
60
2.24
1.50
7.7
6.3
—
—
—
0
0
5
16
3.30
1.46
4.2
2.2
—
—
—
0
0
0
39
0.00
1.39
0.0
1.4
—
—
—
0
0
32
234
1.75
1.33
13.3
6.3
—
—
—
0
0
5
18
2.92
1.31
1.8
1.8
—
—
—
0
0
58
520
2.45
1.29
18.2
10.3
27.32
17.74
mg/l
1.13
52
371
11
60
2.01
1.11
1.8
1.9
—
—
—
0
0
41
334
1.65
1.05
6.0
4.1
—
—
—
0
0
0
29
0.00
1.00
0.0
1.6
—
—
—
0
0
0
29
0.00
1.00
0.0
1.2
—
—
—
0
0
0
28
0.00
1.00
0.0
1.6
—
—
—
0
0
0
30
0.00
1.00
0.0
1.6
—
—
—
0
0
0
30
0.00
1.00
0.0
1.6
—
—
—
0
0
0
31
0.00
0.99
0.0
1.5
—
—
—
0
0
14
205
0.59
0.91
3.8
2.6
—
—
—
0
0
10
57
1.90
0.89
1.7
3.7
24.49
25.84
%
—
10
52
33
264
1.52
0.85
16.0
5.2
0.50
0.53
e9/l
0.42
28
225
33
265
1.52
0.83
16.0
5.1
0.03
0.04
e9/l
1.36
27
225
8
48
1.76
0.82
1.4
1.9
—
—
—
0
0
11
67
1.78
0.81
4.7
1.7
2.47
2.44
mmol/l
0.44
11
53
6
33
1.90
0.81
9.2
16.0
—
—
—
0
0
9
54
1.78
0.79
2.3
4.9
1.36
1.60
%
—
9
47
33
269
1.48
0.75
16.1
5.3
1.71
2.09
e9/l
1.69
28
237
21
157
1.51
0.72
2.7
3.3
15.30
51.16
ng/l
—
10
98
33
272
1.45
0.69
16.9
5.2
0.14
0.21
e9/l
2.31
28
239
16
116
1.51
0.62
6.3
4.2
0.00
0.00
estimate
—
9
40
0
20
0.00
0.61
0.0
1.2
—
218.25
—
0
8
0
20
0.00
0.61
0.0
2.5
—
—
—
0
0
0
19
0.00
0.61
0.0
1.1
—
—
—
0
0
0
19
0.00
0.61
0.0
1.3
—
0.54
—
0
19
6
34
1.84
0.60
1.3
1.4
—
—
—
0
0
0
23
0.00
0.59
0.0
1.6
—
—
—
0
0
6
36
1.74
0.58
1.5
1.1
—
—
—
0
0
9
59
1.61
0.58
2.0
1.8
—
—
—
0
0
6
37
1.69
0.57
2.2
2.6
—
—
—
0
0
21
164
1.42
0.57
2.1
1.9
93.36
102.59
pmol/l
0.47
11
72
37
319
1.39
0.56
3.6
3.0
—
—
—
0
0
18
140
1.40
0.49
19.3
4.5
—
—
—
0
0
5
32
1.61
0.43
5.2
5.6
—
—
—
0
0
0
15
0.00
0.42
0.0
1.7
—
—
—
0
0
0
15
0.00
0.42
0.0
1.5
—
—
—
0
0
0
15
0.00
0.42
0.0
1.5
—
—
—
0
0
17
135
1.36
0.41
1.8
4.5
7.98
7.30
mmol/l
0.17
17
117
5
35
1.46
0.40
1.4
1.4
—
—
—
0
0
17
208
0.75
0.39
4.3
3.7
—
5.78
—
0
27
5
36
1.42
0.39
14.4
3.5
—
—
—
0
0
5
78
0.61
0.38
1.2
1.6
—
—
—
0
0
10
75
1.40
0.32
1.0
1.1
—
—
—
0
0
13
104
1.31
0.29
3.7
3.8
0.75
2.30
ug/l
3.31
13
93
8
63
1.31
0.29
1.4
1.6
—
—
—
0
0
10
123
0.78
0.23
3.6
2.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
6.92
—
0
10
0
10
0.00
0.21
0.0
1.2
—
2.46
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
0.30
—
0
10
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
6
49
1.25
0.21
1.2
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
4.9
—
27.44
—
0
8
0
14
0.00
0.20
0.0
2.0
—
—
—
0
0
43
406
1.19
0.19
4.8
4.1
14.45
14.66
pmol/l
0.20
43
371
5
69
0.70
0.18
1.4
1.2
—
—
—
0
0
13
150
0.83
0.17
3.5
1.4
1.83
2.24
g/l
—
8
85
23
250
0.87
0.14
6.1
3.7
0.00
0.00
estimate
—
8
38
23
247
0.89
0.11
7.0
5.2
0.00
0.00
estimate
—
9
40
6
55
1.10
0.09
3.5
2.1
0.67
0.99
ug/l
—
6
29
6
58
1.04
0.08
1.7
1.7
—
—
—
0
0
10
112
0.87
0.08
1.5
1.9
—
—
—
0
0
11
113
0.97
0.00
4.1
3.3
—
—
—
0
0
13
133
0.97
0.00
7.6
3.9
—
—
—
0
0
24
244
0.97
0.00
5.9
3.7
0.00
0.00
estimate
—
9
41
0
6
0.00
0.00
0.0
1.2
—
98.83
—
0
6
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
24.8
—
201.20
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
13.28
—
0
5
0
8
0.00
-0.00
0.0
3.8
—
4.91
—
0
8
0
5
0.00
-0.00
0.0
3.4
—
13.42
—
0
5
0
9
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
20.28
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
81
0.99
-0.00
1.9
2.0
448.75
462.63
pmol/l
—
8
67
0
7
0.00
-0.00
0.0
1.1
—
0.52
—
0
7
8
85
0.93
-0.00
1.4
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
2.03
—
0
7
0
5
0.00
-0.00
0.0
10.6
—
0.80
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.8
—
8.38
—
0
8
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
293.43
—
0
7
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
6.0
—
1.76
—
0
8

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_EPENDYDOMA – Ependymoma

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).