Ependymoma, excluding all cancers (controls excluding all cancers)

C3_EPENDYDOMA_EXALLC

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 ANY
  • Cancer registry: Morphology ICD-O-3 939[1-3]
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

60

4. Check minimum number of events

None

60

5. Include endpoints

None

60

6. Filter based on genotype QC (FinnGen only)

60

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 60 36 24
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 46.43 43.60 50.68

-FinnGen-

Age distribution of first events

01030405060700123456789101112AgeIndividuals

-FinnGen-

Year distribution of first events

197019751980198520002005201020152020202302468101214161820YearIndividuals

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
54
Matched controls
541
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
9391/3-C72.0
ICD-O-3
Ependymoma, NOS, of spinal cord
+∞
32.6
28
*
H02AB02
ATC
dexamethasone; systemic
154.3
20.1
20
*
ABB10
NOMESCO Finland
Resection of lesion of spinal canal
+∞
16.5
15
*
ABB00
NOMESCO Finland
Excision of lesion of spinal canal
+∞
16.5
15
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
73.9
14.7
16
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
15.8
13.5
23
24
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
167.3
13.0
13
*
130
Kela drug reimbursment
Malignant tumour
+∞
13.0
12
*
C71.74
ICD-10 Finland
Malignant tumor of the brainstem ependyoma
+∞
11.9
11
*
C72.09
ICD-10 Finland
Malignant tumor of the spinal cord other histology
+∞
11.9
11
*
C72.01
ICD-10 Finland
Malignant tumor of the spinal cord grade II glioma
+∞
10.8
10
*
C72.00
ICD-10 Finland
Malignant tumor of the spinal cord without histology
+∞
10.8
10
*
C71.51
ICD-10 Finland
Malignant tumor of cerebral ventricle ependymoma
+∞
9.7
9
*
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
105.9
8.7
9
*
9391/3-C71.7
ICD-O-3
Ependymoma, NOS, of brain stem
+∞
8.5
8
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
8.5
8
*
D43.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Spinal cord
+∞
8.5
8
*
XX3DW
NOMESCO Finland
Time consuming IT work
18.8
8.2
12
8
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
52.9
8.0
9
*
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
30.0
7.9
10
*
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
92.2
7.6
8
*
WF002
NOMESCO Finland
Radical radiotherapy
92.2
7.6
8
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
7.5
7
*
D33.43
ICD-10 Finland
Spinal cord
+∞
7.5
7
*
L28
ICPC
Limited function/disability (L)
7.9
7.0
16
27
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
5.8
6.8
21
53
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
17.1
6.7
10
7
A04AA02
ATC
granisetron; systemic, transdermal
78.8
6.6
7
*
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
21.1
6.5
9
5
D33.40
ICD-10 Finland
Benign glioma of the spinal cord (grade I)
+∞
6.4
6
*
D33.41
ICD-10 Finland
Myxopapillary epndymoma of the spinal cord (grade I)
+∞
6.4
6
*
D33.4
ICD-10 Finland
Benign neoplasm: Spinal cord
+∞
6.4
6
*
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
+∞
6.4
6
*
ZX050
NOMESCO Finland
Stereotactic radiotherapy
+∞
6.4
6
*
9391/3-C71.5
ICD-O-3
Ependymoma, NOS, of ventricle, NOS
+∞
6.4
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
22
10
34.16
30.99
1.5
2.0
—
—
—
0
0
24
37
10.14
16.33
6.3
6.4
0.51
0.87
mmol/l
0.22
15
30
11
13
10.14
8.75
3.1
1.3
—
—
—
0
0
34
146
4.07
6.72
3.2
1.6
—
—
—
0
0
32
138
3.83
6.17
3.2
2.2
—
—
—
0
0
12
24
6.00
6.03
5.3
7.7
0.76
0.86
%
0.38
12
24
12
25
5.75
5.78
5.3
7.5
1.14
1.89
%
0.82
12
25
16
45
4.48
5.49
8.2
12.2
23.88
24.76
mmol/l
0.62
16
45
22
92
3.20
4.18
2.6
2.7
550.09
560.22
mosm/kgh2o
0.08
22
74
29
145
2.94
4.01
3.3
3.8
9.51
24.98
e6/l
0.74
24
108
28
140
2.88
3.84
3.9
8.4
1.04
1.23
inr
—
7
43
6
6
10.91
3.58
2.0
1.2
—
—
—
0
0
15
54
3.37
3.57
8.2
10.1
—
—
—
0
0
22
100
2.89
3.55
2.5
3.2
1.94
4.67
e6/l
1.97
22
87
36
213
2.73
3.49
10.0
4.6
8.83
10.30
umol/l
0.96
36
197
20
88
2.91
3.40
4.6
3.3
—
—
—
0
0
26
132
2.71
3.39
3.5
3.3
—
—
—
0
0
5
5
10.73
3.03
1.8
1.2
—
—
—
0
0
5
5
10.73
3.03
1.8
2.8
27.40
24.20
%
—
5
5
8
18
4.95
2.91
6.4
4.4
—
—
—
0
0
5
6
8.94
2.80
1.8
2.7
70.80
60.33
%
—
5
6
15
63
2.84
2.72
5.8
2.6
29.87
30.32
s
0.13
15
63
5
7
7.65
2.60
1.8
3.4
19.80
12.29
%
—
5
7
27
160
2.25
2.37
12.2
6.3
—
—
—
0
0
6
13
5.00
2.33
4.7
5.6
16.33
21.28
nmol/l
—
6
13
29
179
2.20
2.29
4.0
4.2
36.13
35.33
e6/l
0.01
24
112
22
127
2.16
2.00
4.1
2.7
—
—
—
0
0
8
31
2.82
1.73
1.1
1.1
—
—
—
0
0
22
136
1.98
1.63
4.0
2.7
2.37
2.36
mmol/l
0.09
22
120
32
228
1.86
1.53
22.1
7.1
0.00
0.00
e9/l
0.00
27
171
20
122
1.96
1.52
1.2
1.6
—
—
—
0
0
12
61
2.21
1.45
7.8
7.1
—
—
—
0
0
0
38
0.00
1.40
0.0
1.4
—
—
—
0
0
5
17
3.11
1.38
4.2
2.4
—
—
—
0
0
5
19
2.77
1.24
3.8
4.2
—
—
—
0
0
5
20
2.63
1.17
1.8
1.8
—
—
—
0
0
8
40
2.15
1.17
8.4
14.7
5.05
5.03
kpa
—
8
35
55
495
2.33
1.15
18.9
10.9
26.52
17.78
mg/l
0.95
50
359
12
191
0.54
1.09
3.6
2.6
—
—
—
0
0
32
253
1.57
0.90
16.5
5.3
0.03
0.04
e9/l
1.38
27
214
6
31
2.04
0.87
9.2
16.9
—
—
—
0
0
39
325
1.57
0.85
6.1
4.2
—
—
—
0
0
10
59
1.83
0.81
1.7
4.0
24.49
25.56
%
—
10
54
0
24
0.00
0.81
0.0
1.7
—
—
—
0
0
0
25
0.00
0.81
0.0
1.7
—
—
—
0
0
0
26
0.00
0.80
0.0
1.7
—
—
—
0
0
0
26
0.00
0.80
0.0
1.7
—
—
—
0
0
0
27
0.00
0.79
0.0
1.2
—
—
—
0
0
0
27
0.00
0.79
0.0
1.6
—
—
—
0
0
9
55
1.75
0.78
2.3
4.9
1.36
1.59
%
—
9
48
9
58
1.65
0.74
2.0
1.9
—
—
—
0
0
10
61
1.77
0.74
1.9
1.9
—
—
—
0
0
20
148
1.53
0.72
2.8
3.3
15.30
49.37
ng/l
—
10
90
8
49
1.73
0.65
1.6
1.9
—
—
—
0
0
0
19
0.00
0.61
0.0
1.7
—
—
—
0
0
0
19
0.00
0.61
0.0
1.1
—
—
—
0
0
0
21
0.00
0.61
0.0
1.2
—
218.25
—
0
8
6
35
1.79
0.60
2.2
2.7
—
—
—
0
0
6
36
1.74
0.59
1.3
1.4
—
—
—
0
0
18
136
1.46
0.58
19.3
4.7
—
—
—
0
0
10
68
1.56
0.51
5.1
1.7
2.47
2.44
mmol/l
—
10
55
17
131
1.42
0.49
1.8
4.5
7.98
7.25
mmol/l
0.18
17
113
15
114
1.42
0.46
6.5
4.2
0.00
0.00
estimate
—
8
38
5
32
1.61
0.43
5.2
5.8
—
—
—
0
0
20
162
1.35
0.43
2.1
1.9
92.40
100.19
pmol/l
—
10
71
5
33
1.56
0.42
1.6
1.2
—
—
—
0
0
0
15
0.00
0.42
0.0
1.5
—
—
—
0
0
0
15
0.00
0.42
0.0
1.5
—
—
—
0
0
0
15
0.00
0.42
0.0
5.3
—
25.72
—
0
9
0
15
0.00
0.42
0.0
1.7
—
—
—
0
0
0
15
0.00
0.42
0.0
1.0
—
—
—
0
0
0
17
0.00
0.41
0.0
2.9
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
0.55
—
0
18
35
312
1.29
0.37
3.8
3.1
—
—
—
0
0
21
247
0.77
0.37
6.3
3.7
0.00
0.00
estimate
—
7
36
16
195
0.76
0.36
4.3
3.7
—
—
—
0
0
10
74
1.42
0.35
1.0
1.1
—
—
—
0
0
21
244
0.79
0.32
7.0
5.2
0.00
0.00
estimate
—
8
38
8
65
1.27
0.28
1.4
1.6
—
—
—
0
0
42
390
1.26
0.28
4.9
4.1
14.54
14.65
pmol/l
0.11
42
357
13
105
1.30
0.27
3.7
3.9
0.75
2.46
ug/l
3.89
13
95
10
125
0.76
0.26
3.6
3.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
6
48
1.28
0.21
1.2
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
2.1
—
—
—
0
0
5
67
0.72
0.18
1.4
1.1
—
—
—
0
0
5
69
0.70
0.18
1.2
1.6
—
—
—
0
0
22
241
0.86
0.16
6.1
3.7
0.00
0.00
estimate
—
8
38
11
127
0.84
0.14
8.3
3.9
—
—
—
0
0
7
83
0.82
0.07
2.0
2.0
451.86
464.48
pmol/l
—
7
69
13
142
0.89
0.07
3.5
1.4
1.83
2.28
g/l
—
8
78
10
111
0.88
0.06
1.5
2.0
—
—
—
0
0
10
101
0.99
0.00
9.3
4.5
—
—
—
0
0
11
107
1.03
0.00
4.1
3.3
—
—
—
0
0
47
474
0.96
0.00
27.3
11.8
40.12
39.92
%
0.09
35
374
8
87
0.91
0.00
1.4
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
11.78
—
0
6
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
24.8
—
201.20
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
3.7
—
4.91
—
0
8
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
2.03
—
0
7
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
6.0
—
1.76
—
0
8
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
293.43
—
0
7
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
0.00
3.5
2.2
0.67
1.04
ug/l
—
6
33
0
5
0.00
0.00
0.0
1.0
—
13.28
—
0
5
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
3.7
—
8.38
—
0
8
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
2.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
98.83
—
0
6
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
5
58
0.85
0.00
1.8
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
10.6
—
0.80
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
0.30
—
0
9
0
9
0.00
-0.00
0.0
1.2
—
2.25
—
0
9
0
9
0.00
-0.00
0.0
1.2
—
6.89
—
0
9
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_EPENDYDOMA_EXALLC – Ependymoma, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).