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Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs

C3_RESPIRATORY_INTRATHORACIC3_NAS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C39
  • Cause of death: ICD-9 165
  • Cause of death: ICD-8 1639
  • Cancer registry: Topography ICD-O-3 C39
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

18

4. Check minimum number of events

None

18

5. Include endpoints

None

18

6. Filter based on genotype QC (FinnGen only)

18

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9

Similar endpoints

List of similar endpoints to Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

None

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 18 - 15
Unadjusted period prevalence (%) 0.01 - 0.01
Median age at first event (years) 80.24 - 80.43

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(4035726)
5
5
13.07
3.17
1.2
1.0
—
—
—
0
0
(3021960) Folate [Moles/volume] in Serum or Plasma
0
34
0.00
1.33
0.0
1.5
—
21.0
—
0
26
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
0
32
0.00
1.31
0.0
1.9
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
0
25
0.00
0.87
0.0
4.8
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
0
23
0.00
0.86
0.0
3.9
—
0.0
—
0
6
(3006504) Eosinophils/100 leukocytes in Blood
7
42
2.08
0.80
3.4
4.6
%
2.0
2.7
—
7
37
(3002030) Lymphocytes/100 leukocytes in Blood
7
42
2.08
0.80
3.4
4.7
%
22.1
21.5
—
7
37
(3018010) Neutrophils/100 leukocytes in Blood
7
42
2.08
0.80
3.4
4.5
%
60.6
62.5
—
7
36
(3019069) Monocytes/100 leukocytes in Blood
7
42
2.08
0.80
3.4
4.7
%
10.4
9.2
—
7
37
(3022096) Basophils/100 leukocytes in Blood
7
42
2.08
0.80
3.4
4.6
%
0.7
0.5
—
7
37
(40768804) Tissue Pathology biopsy report
6
36
1.99
0.65
2.7
2.6
—
—
—
0
0
(3019198) Lymphocytes [#/volume] in Blood
7
45
1.90
0.59
3.4
4.4
e9/l
1.4
1.7
—
7
40
(3001604) Monocytes [#/volume] in Blood
7
45
1.90
0.59
3.4
4.4
e9/l
0.7
0.7
—
7
38
(3006315) Basophils [#/volume] in Blood
7
46
1.85
0.58
3.4
4.3
e9/l
0.0
0.0
—
7
39
(3013115) Eosinophils [#/volume] in Blood
7
47
1.79
0.57
3.7
4.5
e9/l
0.1
0.2
—
7
40
(42870588) Differential panel, method unspecified - Blood
5
31
1.84
0.48
2.8
3.3
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
0
16
0.00
0.43
0.0
4.2
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
0
16
0.00
0.43
0.0
12.7
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
0
18
0.00
0.42
0.0
1.8
—
—
—
0
0
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
6
45
1.50
0.39
3.7
5.5
mmol/l
1.2
1.2
—
6
39
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
6
79
0.64
0.34
3.8
6.9
mmol/mol
42.2
44.4
—
6
72
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
6
78
0.66
0.33
4.3
4.2
mu/l
2.5
2.5
—
6
63
(40761511) CBC panel - Blood by Automated count
7
87
0.68
0.33
20.4
18.5
—
—
—
0
0
(3013650) Neutrophils [#/volume] in Blood by Automated count
7
58
1.34
0.22
10.0
7.5
e9/l
4.3
5.2
—
7
49
(3007164) IgA [Mass/volume] in Serum or Plasma
0
11
0.00
0.22
0.0
1.0
—
3.8
—
0
6
(3014218) Bicarbonate [Moles/volume] standard in Arterial blood
0
11
0.00
0.22
0.0
3.6
—
22.7
—
0
11
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
0
11
0.00
0.22
0.0
1.6
—
—
—
0
0
(3012544) pH of Venous blood
0
10
0.00
0.22
0.0
2.9
—
—
—
0
0
(3022145) Colonoscopy Study observation
0
10
0.00
0.22
0.0
1.3
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
0
10
0.00
0.22
0.0
2.0
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
0
10
0.00
0.22
0.0
1.5
—
—
—
0
0
(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood
0
10
0.00
0.22
0.0
4.5
—
1.0
—
0
10
(3006217) Methemoglobin/Hemoglobin.total in Arterial blood
0
10
0.00
0.22
0.0
4.5
—
0.5
—
0
10
(3000991) Gas panel - Venous blood
0
10
0.00
0.22
0.0
4.4
—
—
—
0
0
(3014007) Fractional oxyhemoglobin in Arterial blood
0
10
0.00
0.22
0.0
4.5
—
95.0
—
0
10
(40761535) Cells panel - Urine sediment
0
12
0.00
0.22
0.0
2.6
—
—
—
0
0
(3044889) 12 lead EKG panel
5
67
0.65
0.22
5.0
4.3
—
—
—
0
0
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
5
64
0.70
0.21
4.4
5.2
ug/l
3.6
2.8
—
5
54
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
0
14
0.00
0.21
0.0
1.5
—
—
—
0
0
(3026361) Erythrocytes [#/volume] in Blood
8
95
0.72
0.21
29.3
27.9
e12/l
4.3
4.2
—
8
89
(3010813) Leukocytes [#/volume] in Blood
8
95
0.72
0.21
29.3
27.9
e9/l
6.8
7.2
—
8
89
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
7
82
0.76
0.20
24.9
18.7
ml/min/173m2
64.9
66.4
—
7
62
(3020564) Creatinine [Moles/volume] in Serum or Plasma
8
92
0.77
0.20
27.6
22.7
umol/l
90.8
92.1
—
8
92
(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma
5
44
1.19
0.11
2.6
4.3
mmol/l
1.3
1.2
—
5
37
(3023368) Bacteria identified in Blood by Culture
5
45
1.15
0.11
2.0
3.7
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
8
88
0.84
0.09
17.0
20.4
mg/l
38.1
38.6
—
8
74
(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
8
75
1.12
0.09
13.4
6.5
u/l
103.0
76.2
—
8
70
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3022621) pH of Urine by Test strip
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
6
60
1.00
0.00
2.8
3.3
pmol/l
13.5
14.9
—
6
47
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
2.2
—
20.6
—
0
5
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
0
9
0.00
0.00
0.0
3.8
—
—
—
0
0
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
(3018405) Lactate [Moles/volume] in Arterial blood
0
5
0.00
0.00
0.0
3.2
—
1.8
—
0
5
(3025941) Bacteria identified in Stool by Culture
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
(3019060) Gas panel - Arterial blood
0
9
0.00
0.00
0.0
2.3
—
—
—
0
0
(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3012336) Haptoglobin [Mass/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.5
—
1.3
—
0
8
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
5
50
1.00
0.00
1.8
2.3
u/l
103.2
58.0
—
5
41

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_RESPIRATORY_INTRATHORACIC3_NAS – Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).