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Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs, including Hilmo

C3_RESPIRATORY_INTRATHORACIC3_NAS_WIDE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

None

519870

2. Check conditions

None

519870

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C39
  • Hospital discharge: ICD-9 165
  • Hospital discharge: ICD-8 1639
  • Cause of death: ICD-10 C39
  • Cause of death: ICD-9 165
  • Cause of death: ICD-8 1639
  • Cancer registry: Topography ICD-O-3 C39
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

112

4. Check minimum number of events

None

112

5. Include endpoints

None

112

6. Filter based on genotype QC (FinnGen only)

107

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs, including Hilmo based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 107 32 75
Unadjusted period prevalence (%) 0.03 0.01 0.03
Median age at first event (years) 69.74 64.42 72.01

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
112
Matched controls
1120
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C39.9
ICD-10 Finland
Malignant neoplasm: Ill-defined sites within the respiratory system
+∞
62.5
54
*
130
Kela drug reimbursment
Malignant tumour
+∞
44.8
40
*
C39.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of respiratory and intrathoracic organs
+∞
35.3
32
*
H02AB02
ATC
dexamethasone; systemic
465.0
35.0
33
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
12.1
30.6
37
44
C34.9
ICD-10 Finland
Malignant neoplasm: Bronchus or lung, unspecified
+∞
20.4
19
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
7.3
18.4
33
61
C39.0
ICD-10 Finland
Malignant neoplasm: Upper respiratory tract, part unspecified
+∞
18.2
17
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
18.2
17
*
A03FA01
ATC
metoclopramide; systemic, rectal
6.6
18.1
37
78
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
28.5
17.3
23
10
C34.1
ICD-10 Finland
Malignant neoplasm: Upper lobe, bronchus or lung
+∞
16.0
15
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
34.3
15.8
20
7
C34.99
ICD-10 Finland
Malignant tumor in unspecified localization in bronchial and pulmonary other or unspecified histology
+∞
14.9
14
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
14.9
14
*
8000/3-C34.9
ICD-O-3
Neoplasm, malignant of lung, NOS
+∞
14.9
14
*
8070/3-C34.9
ICD-O-3
Squamous cell carcinoma, NOS, of lung, NOS
+∞
13.8
13
*
8140/3-C34.9
ICD-O-3
Adenocarcinoma, NOS, of lung, NOS
+∞
13.8
13
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
12.7
12
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
12.7
12
*
C34.90
ICD-10 Finland
Malignant tumor in unspecified location in bronchus and lung without histology
+∞
12.7
12
*
N02AA05
ATC
oxycodone; systemic
4.8
12.6
36
100
A04AA01
ATC
ondansetron; systemic, rectal
26.3
12.0
16
7
116
Kela drug reimbursment
Prostate cancer
+∞
11.7
11
*
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
13.2
11.1
19
17
8000/3-C39.9
ICD-O-3
Neoplasm, malignant of ill-defined sites within respiratory system
+∞
10.6
10
*
C34.19
ICD-10 Finland
Malignant tumor of the upper lobe, bronchus or lung other or unspecified histology
+∞
10.6
10
*
L02AE02
ATC
leuprorelin; implant, parenteral
+∞
10.6
10
*
JN4BD
NOMESCO Finland
Extensive body CT
11.0
9.7
18
19
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
108.8
9.6
10
*
C34.11
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary epidermoid carcinoma
+∞
9.5
9
*
WF002
NOMESCO Finland
Radical radiotherapy
+∞
9.5
9
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
9.5
9
*
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
12.2
8.6
15
14
WF049
NOMESCO Finland
Radiotherapy of metastasis
97.1
8.5
9
*
C34.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bronchus and lung
+∞
8.4
8
*
C34.12
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary adenocarcinoma
+∞
8.4
8
*
XX3DW
NOMESCO Finland
Time consuming IT work
11.2
7.8
14
14
A04AA02
ATC
granisetron; systemic, transdermal
+∞
7.4
7
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
7.4
7
*
C34.10
ICD-10 Finland
Malignant tumor of the upper lobe, bronchus or lung without histology
+∞
7.4
7
*
Z51.5
ICD-10 Finland
Palliative care
6.1
6.8
18
34
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
6.3
6
*
GD1AT
NOMESCO Finland
Biopsy of the lung with ultrasound guidance
+∞
6.3
6
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
6.3
6
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
6.3
6
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
6.3
6
*
GDC00
NOMESCO Finland
Lobectomy of lung
+∞
6.3
6
*
C79.30
ICD-10 Finland
Secondary malignant tumor of the cerebrum
+∞
6.3
6
*
C34.00
ICD-10 Finland
Malignant tumor of the main bronchus without histology
+∞
6.3
6
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
17
20
9.80
8.68
1.8
1.2
0
0
10
6
18.10
6.88
1.5
1.7
90.11
13.41
ug/l
10
6
10
8
13.56
6.21
1.4
1.5
36.28
26.26
g/l
10
8
43
689
0.39
5.48
5.2
5.6
5.74
6.13
mmol/l
1.94
37
609
9
8
12.09
5.39
1.4
1.3
0
0
49
723
0.43
4.65
25.6
15.5
0
0
9
264
0.28
4.19
1.1
2.0
1.08
1.28
mmol/l
9
215
33
554
0.43
4.09
3.8
4.1
15.04
14.92
pmol/l
0.10
33
484
7
7
10.56
4.07
1.3
1.1
0
0
6
6
10.47
3.54
1.3
1.2
5.08
7.03
mmol/l
6
6
51
708
0.49
3.44
31.2
16.0
35.47
25.89
mg/l
1.25
46
591
11
278
0.33
3.26
3.0
3.5
6.61
7.30
mmol/l
0.37
11
237
21
395
0.42
3.20
1.9
2.3
91.30
91.38
pmol/l
10
209
8
16
5.29
3.11
2.5
1.2
75.88
74.53
u/ml
8
16
7
201
0.31
3.08
3.7
4.1
0
0
14
55
2.77
2.74
16.1
9.0
0
0
38
549
0.53
2.50
34.3
20.0
14.30
13.84
%
1.22
38
537
5
8
6.48
2.39
1.4
1.1
156.24
61.68
pmol/l
5
8
12
47
2.74
2.36
17.3
8.7
0.52
0.72
%
1.22
12
47
19
337
0.47
2.31
7.8
4.6
3.14
2.41
ug/l
0.45
19
292
12
48
2.68
2.27
1.4
1.1
0
0
5
9
5.75
2.23
1.4
4.8
0
0
12
49
2.62
2.19
17.1
8.5
0.93
1.30
%
1.52
12
49
22
119
2.06
2.16
3.8
1.9
0.79
0.83
mmol/l
0.96
22
111
0
58
0.00
2.11
0.0
1.2
0
0
25
394
0.53
2.07
5.8
3.8
0.00
0.00
estimate
5
81
20
106
2.08
2.07
2.4
1.6
0
0
25
388
0.54
1.94
5.8
3.8
0.00
0.00
estimate
5
78
19
102
2.04
1.90
16.1
6.0
103.63
103.89
mmol/l
0.07
19
102
26
395
0.55
1.86
5.7
3.8
0.00
0.05
estimate
5
73
18
300
0.52
1.74
3.1
4.0
0
0
9
175
0.47
1.44
5.3
2.8
0.98
0.85
ug/l
9
124
31
214
1.62
1.39
3.0
1.7
0
0
26
369
0.62
1.34
4.4
4.3
106.32
57.11
ng/l
0.35
19
284
17
262
0.59
1.20
1.8
1.8
19.09
18.55
nmol/l
0.07
17
216
14
226
0.57
1.17
7.0
3.9
0.00
0.00
estimate
5
68
22
316
0.62
1.17
5.4
3.6
6.50
6.20
ph
0.46
11
174
8
40
2.08
1.14
23.5
9.2
27.00
23.87
mmol/l
8
40
31
224
1.53
1.13
5.0
4.1
0
0
0
29
0.00
0.99
0.0
1.2
0.52
0
10
0
29
0.00
0.99
0.0
8.1
0
0
6
30
2.06
0.88
1.7
1.4
0
0
13
81
1.68
0.85
15.8
7.0
116.54
123.15
g/l
0.55
13
81
23
167
1.47
0.82
5.7
3.5
88.43
83.27
%
0.44
23
162
9
54
1.72
0.77
3.2
1.5
0
0
13
85
1.60
0.72
1.5
1.9
0
0
7
43
1.67
0.68
2.3
2.2
8.63
14.63
nmol/l
7
37
8
53
1.55
0.60
1.9
2.6
0.15
0.20
g/l
8
40
25
196
1.35
0.59
7.9
4.9
0
0
5
89
0.54
0.58
1.0
1.3
720.00
0
30
14
192
0.69
0.58
3.4
3.1
0.00
0
5
14
102
1.43
0.50
15.9
6.3
7.42
7.42
ph
8
69
7
45
1.59
0.50
4.0
3.5
24.64
23.72
mmol/l
7
45
12
85
1.46
0.49
7.4
2.6
3.65
4.37
e9/l
0.74
12
67
13
174
0.71
0.48
4.3
3.8
26.23
344.47
ng/l
1.31
13
143
0
15
0.00
0.41
0.0
5.3
104.67
0
15
0
15
0.00
0.41
0.0
2.4
1.19
0
15
0
15
0.00
0.41
0.0
2.4
4.15
0
15
0
15
0.00
0.41
0.0
2.4
105.47
0
15
0
15
0.00
0.41
0.0
5.3
10.47
0
15
0
16
0.00
0.41
0.0
3.1
0
0
7
100
0.68
0.32
2.4
1.6
77.50
61.31
e9/l
7
78
10
76
1.35
0.29
2.1
2.3
23.10
7.72
umol/l
10
66
8
67
1.21
0.27
2.4
2.5
7.39
7.42
ph
8
51
29
324
0.86
0.24
3.8
2.4
estimate
0
0
24
272
0.85
0.24
2.3
2.7
0
0
5
41
1.23
0.22
3.2
1.8
0
0
0
11
0.00
0.21
0.0
1.1
0
0
0
11
0.00
0.21
0.0
1.9
0
0
0
11
0.00
0.21
0.0
1.1
0
0
0
11
0.00
0.21
0.0
1.1
0
0
0
11
0.00
0.21
0.0
1.1
0
0
0
11
0.00
0.21
0.0
1.1
0
0
0
10
0.00
0.21
0.0
1.1
0
0
0
10
0.00
0.21
0.0
2.1
0
0
0
10
0.00
0.21
0.0
1.1
0
0
0
10
0.00
0.21
0.0
1.2
33.50
0
10
0
10
0.00
0.21
0.0
1.1
0
0
0
12
0.00
0.21
0.0
1.2
0.93
0
7
0
12
0.00
0.21
0.0
1.5
0
0
0
13
0.00
0.21
0.0
1.6
0
0
0
13
0.00
0.21
0.0
1.0
0
0
0
13
0.00
0.21
0.0
2.2
487.75
0
8
6
47
1.29
0.21
8.0
2.7
1.15
0.58
%
6
47
6
49
1.24
0.20
7.3
2.6
1.12
1.12
%
6
49
0
14
0.00
0.20
0.0
1.2
0
0
0
14
0.00
0.20
0.0
1.1
0
0
6
51
1.19
0.20
10.5
3.2
37.00
36.94
°c
6
51
5
65
0.76
0.17
9.8
2.8
0
0
7
88
0.78
0.15
2.9
1.8
0
0
25
228
1.12
0.15
3.8
2.0
0
0
11
127
0.85
0.13
5.1
2.5
21.64
21.88
%
0.03
11
118
37
353
1.07
0.08
16.6
5.3
1.20
1.20
mmol/l
0.08
37
314
23
245
0.92
0.08
3.4
2.1
65.22
76.26
u/l
0.24
23
225
7
81
0.86
0.07
1.3
1.7
0
0
9
84
1.08
0.07
6.8
3.5
1.24
1.23
mmol/l
9
71
14
128
1.11
0.07
2.3
1.7
28.22
29.78
s
0.97
14
121
9
102
0.87
0.06
1.3
1.3
0
0
19
178
1.08
0.06
1.6
1.4
0
0
40
394
1.02
0.00
15.0
17.4
1.31
1.39
inr
0.35
35
328
33
332
0.99
0.00
5.6
5.1
0.67
0.63
%
0.13
33
305
33
325
1.02
0.00
5.6
5.1
61.09
59.75
%
0.26
33
305
33
334
0.98
0.00
5.6
5.2
20.81
24.89
%
1.49
33
307
33
334
0.98
0.00
5.7
5.1
9.72
9.00
%
0.53
33
305
24
239
1.01
0.00
4.7
5.2
0
0
0
6
0.00
0.00
0.0
1.2
1240.00
0
6
0
6
0.00
0.00
0.0
1.0
0
0
0
6
0.00
0.00
0.0
1.2
0
0
0
6
0.00
0.00
0.0
1.0
0
0
0
6
0.00
0.00
0.0
1.0
0
0
0
6
0.00
0.00
0.0
1.0
0
0
0
6
0.00
0.00
0.0
1.5
0
0
0
6
0.00
0.00
0.0
1.0
0
0
0
8
0.00
-0.00
0.0
1.6
0.75
0
8
7
69
1.02
-0.00
1.0
1.3
0
0
0
5
0.00
-0.00
0.0
1.6
66.60
0
5
0
5
0.00
-0.00
0.0
2.4
27.80
0
5
0
7
0.00
-0.00
0.0
2.1
0
0
0
5
0.00
-0.00
0.0
1.8
89.36
0
5
7
74
0.94
-0.00
2.7
3.0
7.39
7.38
ph
7
47
33
330
1.00
-0.00
5.7
5.1
2.62
2.90
%
0.28
33
300
0
5
0.00
-0.00
0.0
1.4
9.60
0
5
0
7
0.00
-0.00
0.0
2.3
6.97
0
7
0
5
0.00
-0.00
0.0
2.0
1.70
0
5
0
5
0.00
-0.00
0.0
1.2
0
0
0
5
0.00
-0.00
0.0
2.6
0.70
0
5
13
130
1.00
-0.00
5.5
4.2
0
0
0
9
0.00
-0.00
0.0
2.3
5.29
0
9
0
9
0.00
-0.00
0.0
1.1
0
0
0
9
0.00
-0.00
0.0
1.1
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_RESPIRATORY_INTRATHORACIC3_NAS_WIDE – Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs, including Hilmo

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).