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Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs, including Hilmo

C3_RESPIRATORY_INTRATHORACIC3_NAS_WIDE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C39
  • Hospital discharge: ICD-9 165
  • Hospital discharge: ICD-8 1639
  • Cause of death: ICD-10 C39
  • Cause of death: ICD-9 165
  • Cause of death: ICD-8 1639
  • Cancer registry: Topography ICD-O-3 C39
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

109

4. Check minimum number of events

None

109

5. Include endpoints

None

109

6. Filter based on genotype QC (FinnGen only)

105

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 105 31 74
Unadjusted period prevalence (%) 0.03 0.01 0.03
Median age at first event (years) 69.71 64.39 71.94

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
109
Matched controls
1090
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C39.9
ICD-10 Finland
Malignant neoplasm: Ill-defined sites within the respiratory system
+∞
61.4
53
*
130
Kela drug reimbursment
Malignant tumour
+∞
42.5
38
*
C39.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of respiratory and intrathoracic organs
+∞
33.0
30
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
12.5
31.2
37
43
H02AB02
ATC
dexamethasone; systemic
204.3
30.4
30
*
C34.9
ICD-10 Finland
Malignant neoplasm: Bronchus or lung, unspecified
+∞
20.4
19
*
A03FA01
ATC
metoclopramide; systemic, rectal
7.5
20.4
37
70
C39.0
ICD-10 Finland
Malignant neoplasm: Upper respiratory tract, part unspecified
+∞
18.2
17
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
17.1
16
*
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
30.1
16.8
22
9
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
6.9
16.8
31
59
C34.1
ICD-10 Finland
Malignant neoplasm: Upper lobe, bronchus or lung
+∞
16.0
15
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
34.5
15.8
20
7
8000/3-C34.9
ICD-O-3
Neoplasm, malignant of lung, NOS
+∞
14.9
14
*
N02AA05
ATC
oxycodone; systemic
5.5
14.7
36
89
8070/3-C34.9
ICD-O-3
Squamous cell carcinoma, NOS, of lung, NOS
+∞
13.8
13
*
C34.99
ICD-10 Finland
Malignant tumor in unspecified localization in bronchial and pulmonary other or unspecified histology
+∞
13.8
13
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
13.8
13
*
8140/3-C34.9
ICD-O-3
Adenocarcinoma, NOS, of lung, NOS
+∞
13.8
13
*
C34.90
ICD-10 Finland
Malignant tumor in unspecified location in bronchus and lung without histology
+∞
12.7
12
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
11.7
11
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
11.7
11
*
116
Kela drug reimbursment
Prostate cancer
+∞
11.7
11
*
A04AA01
ATC
ondansetron; systemic, rectal
28.6
11.5
15
6
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
14.1
11.4
19
16
C34.19
ICD-10 Finland
Malignant tumor of the upper lobe, bronchus or lung other or unspecified histology
+∞
10.6
10
*
L02AE02
ATC
leuprorelin; implant, parenteral
+∞
10.6
10
*
8000/3-C39.9
ICD-O-3
Neoplasm, malignant of ill-defined sites within respiratory system
+∞
9.5
9
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
9.5
9
*
JN4BD
NOMESCO Finland
Extensive body CT
9.1
8.8
18
23
C34.12
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary adenocarcinoma
+∞
8.4
8
*
C34.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bronchus and lung
+∞
8.4
8
*
C34.11
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary epidermoid carcinoma
+∞
8.4
8
*
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
11.4
8.3
15
15
Z51.5
ICD-10 Finland
Palliative care
8.7
7.7
16
21
XX3DW
NOMESCO Finland
Time consuming IT work
10.5
7.5
14
15
WF002
NOMESCO Finland
Radical radiotherapy
85.7
7.5
8
*
C34.10
ICD-10 Finland
Malignant tumor of the upper lobe, bronchus or lung without histology
+∞
7.4
7
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
7.4
7
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
7.4
7
*
ZX120
NOMESCO Finland
Intravenous
4.9
7.0
17
40
WF049
NOMESCO Finland
Radiotherapy of metastasis
74.0
6.5
7
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
19.4
6.4
9
5
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
6.3
6
*
C34.00
ICD-10 Finland
Malignant tumor of the main bronchus without histology
+∞
6.3
6
*
GDC00
NOMESCO Finland
Lobectomy of lung
+∞
6.3
6
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
6.3
6
*
C79.30
ICD-10 Finland
Secondary malignant tumor of the cerebrum
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
16
20
9.17
7.93
1.8
1.2
—
—
—
0
0
37
657
0.34
6.72
3.7
5.2
2.47
2.53
mmol/l
0.15
32
588
10
7
15.54
6.53
1.4
1.3
36.28
25.87
g/l
—
10
7
9
5
19.41
6.38
1.6
1.6
35.68
10.43
ug/l
—
9
5
9
7
13.85
5.69
1.3
1.1
—
—
—
0
0
40
650
0.39
5.20
4.7
5.0
5.74
6.13
mmol/l
1.94
34
564
47
692
0.44
4.32
22.3
14.3
—
—
—
0
0
7
7
10.57
4.07
1.3
1.0
—
—
—
0
0
6
5
12.58
3.81
1.3
1.0
5.08
7.32
mmol/l
—
6
5
8
12
7.09
3.74
2.5
1.2
75.88
93.96
u/ml
—
8
12
33
539
0.44
3.70
30.5
17.0
14.34
15.46
%
2.29
33
523
30
502
0.44
3.52
3.3
3.8
15.36
14.92
pmol/l
0.47
30
432
16
335
0.39
3.17
1.9
2.1
87.29
90.56
pmol/l
—
7
181
6
184
0.29
3.05
3.5
3.7
—
—
—
0
0
6
181
0.29
2.89
2.5
3.7
—
—
—
0
0
9
221
0.35
2.87
2.6
3.2
6.71
7.20
mmol/l
—
9
183
5
7
7.41
2.57
1.4
1.1
156.24
60.77
pmol/l
—
5
7
32
486
0.52
2.51
4.2
4.2
—
—
—
0
0
17
316
0.45
2.38
7.6
4.3
2.78
2.46
ug/l
0.17
17
270
11
42
2.80
2.22
13.9
8.4
—
—
—
0
0
5
10
5.18
2.09
1.4
4.0
—
—
—
0
0
10
39
2.72
2.00
14.3
7.6
0.49
0.80
%
—
10
39
10
39
2.72
2.00
14.1
7.7
0.87
1.47
%
—
10
39
18
94
2.10
1.94
2.6
1.6
—
—
—
0
0
12
232
0.46
1.80
3.4
4.3
—
—
—
0
0
0
46
0.00
1.75
0.0
1.2
—
—
—
0
0
10
40
2.65
1.72
1.5
1.1
—
—
—
0
0
18
99
1.98
1.70
2.9
1.9
0.81
0.83
mmol/l
0.36
18
91
15
79
2.04
1.58
13.8
5.7
102.27
103.62
mmol/l
0.29
15
79
35
476
0.61
1.58
4.2
4.0
—
—
—
0
0
8
160
0.46
1.38
5.0
2.5
0.94
0.85
ug/l
—
8
111
23
337
0.60
1.37
4.2
4.1
49.47
55.93
ng/l
0.15
15
255
28
195
1.59
1.21
3.0
1.7
—
—
—
0
0
12
200
0.55
1.13
1.6
1.6
21.81
18.80
nmol/l
0.48
12
167
7
32
2.27
1.10
2.3
1.9
8.63
14.43
nmol/l
—
7
27
19
272
0.63
0.99
4.7
3.7
—
5.85
—
0
13
27
197
1.49
0.94
5.4
3.9
—
—
—
0
0
0
26
0.00
0.79
0.0
8.3
—
—
—
0
0
5
27
1.89
0.69
21.8
7.8
—
—
—
0
0
19
140
1.43
0.64
8.3
5.3
—
—
—
0
0
8
49
1.68
0.64
1.9
2.5
0.15
0.19
g/l
—
8
35
10
67
1.54
0.51
14.1
6.8
115.50
123.88
g/l
—
10
67
19
147
1.35
0.49
5.8
3.2
86.11
82.66
%
0.22
19
140
20
247
0.77
0.44
2.6
2.7
—
—
—
0
0
5
33
1.54
0.42
23.8
7.5
27.40
24.02
mmol/l
—
5
33
0
15
0.00
0.41
0.0
2.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
2.4
—
105.47
—
0
15
0
15
0.00
0.41
0.0
2.4
—
4.15
—
0
15
0
16
0.00
0.41
0.0
5.8
—
10.19
—
0
16
0
16
0.00
0.41
0.0
5.8
—
105.13
—
0
16
0
17
0.00
0.41
0.0
1.5
—
—
—
0
0
9
68
1.35
0.39
1.9
2.3
25.22
7.95
umol/l
—
9
57
5
76
0.64
0.37
2.6
1.7
—
—
—
0
0
11
82
1.38
0.35
1.5
1.9
—
—
—
0
0
6
44
1.38
0.35
3.3
1.5
—
—
—
0
0
12
154
0.75
0.35
4.1
3.4
193.33
189.30
ng/l
0.01
12
124
5
37
1.37
0.24
2.8
1.7
—
—
—
0
0
5
41
1.23
0.22
1.8
2.4
6.98
11.92
g/l
—
5
36
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
2.5
—
5.68
—
0
12
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.0
—
16.64
—
0
7
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
487.75
—
0
8
28
309
0.87
0.20
5.1
5.4
9.94
9.02
%
0.61
28
276
5
66
0.75
0.17
9.6
2.9
—
—
—
0
0
28
306
0.89
0.17
5.1
5.1
2.75
2.94
%
0.15
28
273
6
77
0.77
0.16
1.8
2.1
78.08
61.99
e9/l
—
6
64
34
316
1.11
0.15
11.6
4.8
1.20
1.21
mmol/l
0.23
34
274
8
97
0.81
0.14
5.4
2.3
24.00
23.23
%
—
8
87
20
221
0.88
0.14
2.5
2.1
65.45
80.20
u/l
0.29
20
201
16
179
0.88
0.13
3.3
2.6
—
—
—
0
0
29
312
0.90
0.13
5.0
5.3
22.29
25.47
%
0.89
29
280
22
201
1.12
0.12
3.4
1.9
—
—
—
0
0
28
298
0.92
0.10
5.1
5.1
0.69
0.63
%
0.22
28
269
29
307
0.92
0.09
4.9
5.0
59.96
59.14
%
0.13
29
276
8
92
0.86
0.07
1.4
1.3
—
—
—
0
0
16
148
1.10
0.06
5.8
3.5
—
—
—
0
0
10
110
0.90
0.05
2.2
1.7
28.31
30.01
s
—
10
105
35
361
0.96
0.04
14.7
17.5
1.47
1.44
inr
0.05
11
103
15
156
0.96
0.00
1.3
1.4
—
—
—
0
0
29
291
1.00
0.00
5.2
5.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
12.97
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
11.8
—
—
—
0
0
7
69
1.02
-0.00
2.7
3.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
6
62
0.97
-0.00
2.7
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
26.60
—
0
5
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.0
—
67.83
—
0
9
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
34.22
—
0
9
0
5
0.00
-0.00
0.0
2.2
—
2050.00
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
64
0.93
-0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
-0.00
6.2
3.8
2.13
1.71
mmol/l
—
6
52
0
7
0.00
-0.00
0.0
2.3
—
6.97
—
0
7
0
9
0.00
-0.00
0.0
4.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
71
0.98
-0.00
1.3
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
1.66
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_RESPIRATORY_INTRATHORACIC3_NAS_WIDE – Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs, including Hilmo

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).