Mesothelioma, including Hilmo

C3_MESOTHELIOMA_WIDE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C45
  • Hospital discharge: ICD-9 158|163
  • Hospital discharge: ICD-8 158|163
  • Cause of death: ICD-10 C45
  • Cause of death: ICD-9 158|163
  • Cause of death: ICD-8 158|163
  • Cancer registry: Topography ICD-O-3 ANY
  • Cancer registry: Morphology ICD-O-3 905[0-3]
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

478

4. Check minimum number of events

None

478

5. Include endpoints

None

478

6. Filter based on genotype QC (FinnGen only)

464

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze
DF12
Parent code in ICD-10
C45-C49
Name in latin
Mesothelioma

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 464 123 341
Unadjusted period prevalence (%) 0.13 0.04 0.16
Median age at first event (years) 70.92 66.79 72.41

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
478
Matched controls
4780
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
309.1
262
*
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
77.4
307.7
254
69
C45.0
ICD-10 Finland
Mesothelioma of pleura
+∞
307.7
353
*
H02AB02
ATC
dexamethasone; systemic
194.7
307.7
209
19
A03FA01
ATC
metoclopramide; systemic, rectal
20.3
246.7
250
245
A04AA01
ATC
ondansetron; systemic, rectal
58.4
233.0
135
32
Z51.5
ICD-10 Finland
Palliative care
28.6
229.6
172
92
J94.8
ICD-10 Finland
Other specified pleural conditions
42.2
178.0
111
34
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
46.2
177.8
108
30
N02AA05
ATC
oxycodone; systemic
12.3
174.8
265
439
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
24.1
163.0
126
70
9050/3-C38.4
ICD-O-3
Mesothelioma, malignant of pleura, NOS
+∞
156.0
141
*
TGA30
NOMESCO Finland
Thoracocentesis
74.4
128.7
70
11
9052/3-C38.4
ICD-O-3
Epithelioid mesothelioma, malignant of pleura, NOS
+∞
118.8
109
*
GAC01
NOMESCO Finland
Endoscopic biopsy of pleura
715.9
117.4
111
*
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
24.3
111.5
83
41
JN4BD
NOMESCO Finland
Extensive body CT
13.0
109.9
119
119
WX302
NOMESCO Finland
Thoracal epidural anesthesy
26.8
105.4
75
33
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
38.0
95.3
60
18
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
83.9
78
*
C45.9
ICD-10 Finland
Mesothelioma, unspecified
+∞
75.0
70
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
10.3
69.9
85
98
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
6.7
67.2
128
247
JN4AD
NOMESCO Finland
Body CT examination
8.6
66.5
95
134
C45.1
ICD-10 Finland
Mesothelioma of peritoneum
+∞
64.0
60
*
GAC00
NOMESCO Finland
Biopsy of pleura
184.2
62.6
64
*
A04AA02
ATC
granisetron; systemic, transdermal
681.7
62.3
60
*
L01CA04
ATC
vinorelbine; systemic
+∞
57.5
54
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
14.0
57.3
55
44
GD1AD
NOMESCO Finland
Thorax CT examination
8.0
53.9
80
117
UGC12
NOMESCO Finland
Flexible bronchoscopy
6.6
53.0
98
181
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
148.6
50.9
53
*
N02AA01
ATC
morphine; systemic, rectal
17.6
50.1
42
26
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
49.9
47
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
517.0
48.2
47
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
47.7
45
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
44.5
42
*
1BA04, ,
NOMESCO Finland
+∞
42.3
40
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
40.2
38
*
J94.9
ICD-10 Finland
Pleural condition, unspecified
69.0
38.8
44
7
9051/3-C38.4
ICD-O-3
Fibrous mesothelioma, malignant of pleura, NOS
+∞
38.0
36
*
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
7.8
37.7
55
78
ZX120
NOMESCO Finland
Intravenous
5.8
37.4
76
152
GA4AT
NOMESCO Finland
Cathetrisation of pleural cavity with ultrasound guidance
53.7
37.3
44
9
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.4
36.4
306
1645
D38.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pleura
+∞
34.8
33
*
GAA96
NOMESCO Finland
Other open or percutaneous drainage of pleural cavity
97.2
33.2
36
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
6.8
33.0
55
90
B03BA03
ATC
hydroxocobalamin; parenteral
4.9
32.7
81
192
C38.4
ICD-10 Finland
Malignant neoplasm: Pleura
+∞
31.6
30
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.4
31.5
156
602
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
117.9
31.1
33
*
J01MA14
ATC
moxifloxacin; systemic
4.4
29.6
84
221
WZC00
NOMESCO Finland
Treatment plan or consultation
3.2
29.2
164
679
A06AH03
ATC
naloxegol; oral
52.1
28.8
34
7
XX3DW
NOMESCO Finland
Time consuming IT work
6.4
28.5
50
86
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
28.4
27
*
R84
ICPC
Malignant neoplasm bronchus/lung
298.1
28.1
28
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.8
27.6
100
313
WX600
NOMESCO Finland
Single shot through catheter
66.1
27.3
31
5
GD1AT
NOMESCO Finland
Biopsy of the lung with ultrasound guidance
+∞
26.3
25
*
L03AA13
ATC
pegfilgrastim; parenteral
274.7
26.0
26
*
116
Kela drug reimbursment
Prostate cancer
+∞
25.2
24
*
WZC30
NOMESCO Finland
Teaching
3.7
25.1
94
300
J01MA12
ATC
levofloxacin; systemic
3.0
24.6
140
576
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
252.1
23.9
24
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
241.1
22.8
23
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.7
22.2
55
129
A79
ICPC
Malignancy NOS
+∞
22.0
21
*
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
84.2
21.9
24
*
GAA31
NOMESCO Finland
Thoracoscopy
230.1
21.8
22
*
L03AA02
ATC
filgrastim; parenteral
230.1
21.8
22
*
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
24.5
21.5
30
13
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
+∞
19.9
19
*
TK800
NOMESCO Finland
Hemodialysis
7.5
19.7
29
41
9053/3-C38.4
ICD-O-3
Mesothelioma, biphasic, malignant of pleura, NOS
+∞
18.9
18
*
A04AD12
ATC
aprepitant; systemic
+∞
18.9
18
*
GD1BA
NOMESCO Finland
Extensive X-ray examination of thorax
15.2
18.3
30
21
WW500
NOMESCO Finland
Blood transfusion
7.0
18.0
28
42
JN4CD
NOMESCO Finland
Very extensive body CT
14.5
18.0
30
22
C45
ICD-10 Finland
Mesothelioma
+∞
16.8
16
*
R85
ICPC
Malignant neopl respiratory other
+∞
16.8
16
*
QBC00
NOMESCO Finland
Removal of foreign body from skin of trunk or subcutaneous tissue
175.9
16.6
17
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.5
16.5
133
639
B01AB10
ATC
tinzaparin; parenteral
3.7
15.7
54
161
GDD20
NOMESCO Finland
Extended pneumonectomy
+∞
15.7
15
*
R82
ICPC
Pleurisy/pleural effusion
88.0
15.7
17
*
L02AE02
ATC
leuprorelin; implant, parenteral
88.0
15.7
17
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.5
15.3
56
174
C45.7
ICD-10 Finland
Mesothelioma of other sites
+∞
14.7
14
*
GA2AT
NOMESCO Finland
Pleural biopsy with ultrasound guidance
+∞
14.7
14
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
14.4
129
646
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
43.9
14.2
17
*
JAL30
NOMESCO Finland
Omentectomy
31.1
14.0
18
6
GAC97
NOMESCO Finland
Other endoscopic operation on pleura
77.4
13.7
15
*
GAC30
NOMESCO Finland
Artificial pneumothorax
+∞
13.6
13
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
13.6
13
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.8
13.6
73
285
GAC43
NOMESCO Finland
Total decortication of pleura
143.9
13.5
14
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
26.6
13.5
18
7
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
9.8
13.1
26
28
Z2446
NOMESCO Finland
Social worker
3.6
12.9
44
130
N03AX16
ATC
[U] pregabalin
2.3
12.8
118
595
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
12.6
12
*
C78.2
ICD-10 Finland
Secondary malignant neoplasm of pleura
+∞
12.6
12
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
12.6
12
*
H02AB06
ATC
prednisolone; systemic
2.0
12.3
239
1594
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
12.3
183
1111
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
4.8
12.3
28
61
ZXE40
NOMESCO Finland
More than seven and less than nine hours
6.2
12.2
21
35
R4110
NOMESCO Finland
Physiotherapy
2.2
12.1
137
749
J18.0
ICD-10 Finland
Bronchopneumonia, unspecified
5.9
12.1
22
39
JAL20
NOMESCO Finland
Excision or destruction of lesion of peritoneum
66.6
11.7
13
*
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
9.6
11.6
23
25
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
11.5
11
*
GDD96
NOMESCO Finland
Other pneumonectomy
+∞
11.5
11
*
9050/3-C48.2
ICD-O-3
Mesothelioma, malignant of peritoneum, NOS
+∞
11.5
11
*
J86.9
ICD-10 Finland
Pyothorax without fistula
10.9
11.4
21
20
SPAT1109
SPAT
Analgesia with portable analgesic pump
36.0
11.3
14
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
44.4
11.0
13
*
R18
ICD-10 Finland
Ascites
8.3
10.7
23
29
WPA10
NOMESCO Finland
Proactive palliative care treatment plan
61.4
10.7
12
*
NK6AN
NOMESCO Finland
Total body bone isotope imaging
112.4
10.5
11
*
C34.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bronchus and lung
+∞
10.5
10
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
10.5
10
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
10.5
10
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
10.5
10
*
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
+∞
10.5
10
*
R06.0
ICD-10 Finland
Dyspnoea
2.0
10.4
159
963
WF002
NOMESCO Finland
Radical radiotherapy
33.3
10.4
13
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.9
10.3
31
84
WW200, ,
SPAT
0.2
10.1
19
710
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
8.4
9.9
21
26
XX1XW
NOMESCO Finland
Extensive written report from radiologist
5.3
9.9
20
39
AA1BD
NOMESCO Finland
Extensive CT of head and brain
8.1
9.7
21
27
D70.82
ICD-10 Finland
Drug-induced neutropenia
56.2
9.7
11
*
N06DX01
ATC
memantine; oral
0.1
9.7
6
388
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
9.6
183
1187
GAC37
NOMESCO Finland
Endoscopic chemical pleurodesis
102.0
9.4
10
*
XW4AT
NOMESCO Finland
Biopsy of other inner organ with ultrasound guidance
102.0
9.4
10
*
Y77
ICPC
Malignant neoplasm prostate
102.0
9.4
10
*
JAH01
NOMESCO Finland
Laparoscopy
5.3
9.4
19
37
L02BB03
ATC
bicalutamide; oral
+∞
9.4
9
*
GD2FN
NOMESCO Finland
Lung ventilation distribution isotope examination (radiospirometry)
+∞
9.4
9
*
GA2CT
NOMESCO Finland
Pleural biopsy with CT guidance
+∞
9.4
9
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
9.4
9
*
A04AA03
ATC
tropisetron; systemic
+∞
9.4
9
*
KEC00
NOMESCO Finland
Retropubic radical prostatectomy
+∞
9.4
9
*
C34.90
ICD-10 Finland
Malignant tumor in unspecified location in bronchus and lung without histology
+∞
9.4
9
*
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
22.2
9.4
13
6
G30.1
ICD-10 Finland
Alzheimer disease with late onset
0.1
9.3
*
314
WX402
NOMESCO Finland
General anaesthesia
2.3
9.1
80
391
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
9.1
169
1084
J93.9
ICD-10 Finland
Pneumothorax, unspecified
24.5
8.9
12
5
N02AX02
ATC
tramadol; systemic, rectal
1.8
8.8
208
1434
B01AB05
ATC
enoxaparin; parenteral
1.9
8.6
147
916
GAC46
NOMESCO Finland
Partial decortication of pleura
91.6
8.4
9
*
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.0
8.4
38
134
1638X
ICD-9 Finland
Malignant neoplasm of pleura, Other specified sites of pleura
+∞
8.4
8
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
8.4
8
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
8.4
8
*
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
+∞
8.4
8
*
9052/3-C48.2
ICD-O-3
Epithelioid mesothelioma, malignant of peritoneum, NOS
+∞
8.4
8
*
C34.10
ICD-10 Finland
Malignant tumor of the upper lobe, bronchus or lung without histology
+∞
8.4
8
*
1580A
ICD-9 Finland
Malignant neoplasm of retroperitoneum and peritoneum, Retroperitoneum
+∞
8.4
8
*
C34.99
ICD-10 Finland
Malignant tumor in unspecified localization in bronchial and pulmonary other or unspecified histology
+∞
8.4
8
*
Z57.2
ICD-10 Finland
Occupational exposure to dust
9.2
8.1
16
18
N05CF01
ATC
zopiclone; oral
1.8
7.9
165
1089
Z2221
NOMESCO Finland
Medical doctor
1.9
7.8
121
727
WW200
NOMESCO Finland
Immunization
4.3
7.8
20
48
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
3.6
7.8
26
76
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
45.7
7.7
9
*
308
Kela drug reimbursment
Alprostadil, sildenafil and combination product containing aviptadil and phentolamine
45.7
7.7
9
*
B01AB04
ATC
dalteparin; parenteral
3.4
7.6
28
87
SPAT1062
SPAT
Lung clearance therapy
25.5
7.6
10
*
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
25.5
7.6
10
*
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
7.8
7.4
16
21
KE3AT
NOMESCO Finland
Transrectal gold marker implantation in prostate under ultrasound guidance
81.3
7.4
8
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
81.3
7.4
8
*
115
Kela drug reimbursment
Breast cancer
+∞
7.3
7
*
8140/3-C34.9
ICD-O-3
Adenocarcinoma, NOS, of lung, NOS
+∞
7.3
7
*
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
+∞
7.3
7
*
C34.9
ICD-10 Finland
Malignant neoplasm: Bronchus or lung, unspecified
+∞
7.3
7
*
1990X
ICD-9 Finland
Malignant neoplasm without specification of site, Disseminated
+∞
7.3
7
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
7.3
7
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
+∞
7.3
7
*
GAB10
NOMESCO Finland
Antero- or postero-lateral thoracotomy
16.0
7.3
11
7
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
4.6
7.2
17
38
XW3AT
NOMESCO Finland
Biopsy of other superficial organ with ultrasound guidance
30.5
7.2
9
*
A02BC02
ATC
pantoprazole; systemic
1.7
7.0
299
2373
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.1
6.9
69
354
J93.8
ICD-10 Finland
Other pneumothorax
14.0
6.9
11
8
GA3AT
NOMESCO Finland
Pleural cytology with ultrasound guidance
17.0
6.8
10
6
6101
FHL
Exploratory laparotomy, includes possible biopases
17.0
6.8
10
6
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
3.7
6.7
21
59
R96
ICPC
Asthma
0.1
6.6
*
241
R4190
NOMESCO Finland
Nutritional therapy
5.8
6.5
17
30
JN5KR
NOMESCO Finland
Very extensive PET-CT of upper body metabolism (eyebrows to thighs)
70.8
6.4
7
*
GAC36
NOMESCO Finland
Chemical pleurodesis
70.8
6.4
7
*
ZX112
NOMESCO Finland
Subcutaneous
11.2
6.3
11
10
OAB73
NOMESCO Finland
Prevention and treatment of malnutrition
18.3
6.3
9
5
128
Kela drug reimbursment
Cancers of female genital organs
+∞
6.3
6
*
C77.1
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intrathoracic lymph nodes
+∞
6.3
6
*
GAC20
NOMESCO Finland
Excision or destruction of lesion of pleura
+∞
6.3
6
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
6.3
6
*
C34.00
ICD-10 Finland
Malignant tumor of the main bronchus without histology
+∞
6.3
6
*
JAL01
NOMESCO Finland
Laparoscopic biopsy of peritoneum
+∞
6.3
6
*
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
+∞
6.3
6
*
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.1
6.2
25
83
TPH07
NOMESCO Finland
Cathetrisation of artery
2.1
6.0
60
308

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
160
30
79.66
291.89
2.5
1.1
—
—
—
0
0
147
38
55.42
249.19
2.0
1.2
—
—
—
0
0
152
48
45.97
244.36
2.1
1.3
1657.06
2442.40
e6/l
0.63
123
35
146
44
47.33
237.52
2.1
1.3
41990.77
188867.81
e6/l
0.52
105
26
167
86
29.31
226.27
1.7
1.2
—
—
—
0
0
109
40
35.00
165.17
2.0
1.3
—
—
—
0
0
150
177
11.89
124.39
2.4
1.3
2.21
2.89
ug/l
2.47
117
131
69
23
34.89
106.56
1.6
1.3
—
—
—
0
0
185
519
5.18
63.90
2.6
2.0
—
—
—
0
0
175
509
4.85
57.01
5.3
2.6
0.78
0.83
mmol/l
6.45
166
467
207
928
3.17
32.70
2.9
1.6
—
—
—
0
0
223
1093
2.95
29.34
5.8
4.1
—
—
—
0
0
288
1695
2.76
25.59
11.4
3.8
9.75
12.98
umol/l
3.83
283
1581
35
47
7.96
24.93
2.5
2.7
—
—
—
0
0
300
1834
2.71
24.18
16.0
5.7
5.25
4.55
e9/l
1.42
264
1580
258
1470
2.64
23.95
7.3
5.0
0.53
0.64
%
2.96
253
1355
258
1506
2.55
22.25
7.4
5.1
2.36
3.00
%
4.94
253
1389
261
1538
2.54
21.96
7.6
5.3
20.52
25.54
%
10.79
254
1421
257
1514
2.51
21.49
7.6
5.3
9.54
8.95
%
2.35
250
1396
167
820
2.59
20.39
8.2
3.6
85.18
80.12
%
2.23
160
799
254
1521
2.43
20.04
7.4
5.2
64.20
58.89
%
11.23
249
1412
266
1637
2.41
19.58
7.2
4.9
0.74
0.63
e9/l
6.57
226
1399
266
1642
2.40
19.38
7.2
4.9
0.04
0.04
e9/l
0.21
228
1408
74
239
3.48
19.18
1.2
1.1
—
—
—
0
0
98
377
3.01
19.00
1.5
1.4
—
—
—
0
0
267
1664
2.37
18.85
7.3
5.0
1.55
1.77
e9/l
4.25
231
1451
150
732
2.53
18.25
11.6
4.4
—
—
—
0
0
249
1530
2.31
17.86
7.6
3.8
30.69
35.09
g/l
19.10
242
1397
247
1520
2.29
17.56
7.7
5.4
—
—
—
0
0
266
1698
2.28
17.19
7.6
5.0
0.19
0.21
e9/l
0.79
232
1468
260
1648
2.27
17.04
7.9
5.3
1.20
1.20
mmol/l
0.33
247
1460
277
1810
2.26
16.75
9.3
5.8
1.20
1.21
mmol/l
0.45
243
1551
149
787
2.30
14.74
3.2
2.2
—
—
—
0
0
192
1131
2.17
14.46
6.0
2.1
2.34
2.35
mmol/l
0.31
173
910
179
1034
2.17
14.10
4.8
3.2
7.39
7.40
ph
0.69
31
160
177
1026
2.15
13.75
3.5
2.2
—
—
—
0
0
279
1919
2.09
13.71
9.6
20.6
1.15
1.44
inr
6.59
55
534
251
3332
0.48
13.67
5.7
6.9
40.95
41.26
mmol/mol
0.21
220
3038
21
15
14.58
12.87
1.3
1.1
—
—
—
0
0
130
691
2.21
12.38
5.8
2.2
2.52
2.44
mmol/l
11.08
117
573
70
281
2.75
12.30
4.3
3.8
7.40
7.38
ph
—
8
31
267
3414
0.51
11.68
3.8
4.9
4.30
4.30
mmol/l
0.00
224
3091
277
3499
0.50
11.63
4.0
5.6
2.51
2.50
mmol/l
0.08
230
3152
263
3375
0.51
11.55
3.9
4.9
1.39
1.39
mmol/l
0.00
222
3030
30
74
4.26
11.30
3.1
4.1
—
—
—
0
0
21
22
9.93
10.85
2.1
2.0
—
—
—
0
0
52
202
2.77
9.68
11.4
9.2
—
—
—
0
0
54
215
2.70
9.59
4.6
3.9
—
—
—
0
0
262
3263
0.56
8.48
3.5
4.4
1.21
1.26
mmol/l
0.55
215
2896
117
689
1.92
8.06
1.8
1.6
1.78
1.54
mg/l
0.40
96
542
150
963
1.81
7.86
2.6
3.0
—
—
—
0
0
214
1529
1.72
7.69
3.6
2.4
—
—
—
0
0
87
471
2.04
7.60
8.7
6.4
1.81
1.31
mmol/l
0.76
75
368
156
1022
1.78
7.59
2.6
3.0
0.79
0.42
e6/l
0.85
124
769
289
3470
0.58
7.54
4.9
5.1
6.19
6.15
mmol/l
0.14
253
3083
162
1088
1.74
7.16
3.6
2.2
53.55
61.46
u/l
0.92
153
1005
123
768
1.81
6.95
2.5
2.7
539.82
559.13
mosm/kgh2o
0.46
108
641
24
76
3.27
6.38
2.3
2.4
15.62
16.37
%
0.29
14
41
49
945
0.46
6.26
1.6
1.6
1.34
1.28
mmol/l
0.21
43
766
80
1310
0.53
6.22
2.9
3.3
27.85
179.80
mg/l
1.46
51
857
161
1126
1.65
5.92
2.7
3.1
45.78
128.55
e6/l
0.74
129
866
64
339
2.03
5.90
11.5
7.0
—
—
—
0
0
88
1381
0.56
5.83
3.6
3.9
7.07
9.79
mg/mmol
0.52
51
894
273
2177
1.59
5.77
7.8
4.5
6.88
6.97
mmol/l
0.30
264
2039
50
243
2.18
5.76
1.4
1.5
—
—
—
0
0
28
104
2.80
5.70
4.8
3.4
—
—
—
0
0
82
479
1.86
5.67
10.4
6.1
103.78
104.42
mmol/l
0.59
82
479
83
1314
0.55
5.64
2.9
3.2
8.48
7.66
mmol/l
0.80
64
1089
9
7
13.07
5.60
1.2
2.0
—
—
—
0
0
197
1469
1.58
5.47
13.9
8.4
0.01
0.00
e9/l
0.43
150
1189
15
29
5.30
5.43
1.5
1.9
2.58
11503.69
u/l
—
5
8
318
2650
1.60
5.40
14.6
5.2
90.79
78.17
u/l
3.09
308
2418
268
3185
0.64
5.35
5.4
4.2
2.13
2.02
mu/l
0.39
243
2830
70
396
1.90
5.33
1.4
1.3
388.57
560.79
titre
0.63
14
101
83
496
1.81
5.33
5.5
5.3
1.03
1.03
mmol/l
0.07
78
447
9
8
11.44
5.31
1.7
1.1
2.34
5.50
nmol/l
—
9
8
9
9
10.16
5.04
2.0
1.0
—
—
—
0
0
14
29
4.94
4.84
1.0
1.2
—
—
—
0
0
8
7
11.59
4.80
1.1
1.0
—
—
—
0
0
12
21
5.83
4.78
1.3
1.5
100.00
59.95
pmol/l
1.84
12
21
8
8
10.14
4.53
1.4
2.4
—
—
—
0
0
169
1266
1.52
4.38
3.1
3.5
87.07
98.57
e6/l
0.10
133
916
21
81
2.67
4.03
2.3
2.8
—
—
—
0
0
14
44
3.25
3.80
1.7
1.5
88.77
89.84
%
0.35
14
44
131
1725
0.67
3.73
1.9
2.1
94.82
91.71
pmol/l
0.32
79
914
22
91
2.49
3.69
1.9
2.3
126.53
133.55
g/l
0.39
15
70
9
16
5.71
3.67
7.1
2.7
—
—
—
0
0
79
520
1.62
3.55
2.1
2.5
17.28
23.13
%
3.63
71
440
11
26
4.31
3.52
6.4
2.5
—
—
—
0
0
88
598
1.58
3.46
2.4
2.8
1.79
1.87
e6/l
0.05
50
339
347
3787
0.69
3.04
46.6
21.3
124.65
135.65
g/l
26.24
337
3694
347
3787
0.69
3.04
46.4
21.2
8.23
6.91
e9/l
3.40
332
3636
347
3786
0.70
3.02
46.2
21.1
29.55
30.58
pg
16.62
337
3697
347
3786
0.70
3.02
47.2
21.3
38.00
39.85
%
6.25
313
3437
347
3786
0.70
3.02
46.3
21.2
4.28
4.46
e12/l
8.11
331
3631
347
3785
0.70
3.00
46.4
21.2
292.76
233.38
e9/l
25.65
331
3653
347
3785
0.70
3.00
46.3
21.1
90.31
91.86
fl
7.30
337
3696
5
5
10.09
2.98
1.6
1.0
74.80
83.80
nmol/l
—
5
5
106
774
1.47
2.98
2.3
2.4
4.49
4.27
e6/l
0.11
95
690
16
357
0.43
2.94
1.7
1.6
—
—
—
0
0
213
2504
0.73
2.89
4.7
3.3
15.07
15.03
pmol/l
0.09
195
2210
68
980
0.64
2.88
3.0
3.5
—
—
—
0
0
53
807
0.61
2.86
4.3
4.3
1.02
1.02
kg/l
—
7
128
16
67
2.44
2.66
1.6
1.5
87.44
61.64
mmol/l
—
9
56
107
800
1.43
2.64
5.1
3.9
91.77
367.58
ng/l
2.88
93
688
173
2075
0.74
2.56
4.7
4.2
2.58
2.12
ug/l
0.98
140
1847
9
26
3.51
2.49
1.6
1.2
—
—
—
0
0
0
66
0.00
2.42
0.0
1.3
—
—
—
0
0
342
3704
0.73
2.41
35.4
18.2
4.02
4.02
mmol/l
0.06
331
3589
342
3697
0.74
2.30
35.4
18.1
138.42
139.78
mmol/l
11.90
332
3583
22
113
1.99
2.29
1.4
1.4
1.04
1.14
g/l
0.41
22
108
78
1048
0.69
2.28
1.5
1.6
22.33
19.95
nmol/l
0.67
73
872
108
830
1.39
2.27
1.3
1.3
—
—
—
0
0
9
29
3.14
2.23
3.0
4.8
—
—
—
0
0
338
3654
0.74
2.21
18.3
9.3
24.14
25.17
u/l
0.63
328
3465
34
205
1.71
2.17
2.9
2.8
16.50
5.72
e9/l
0.47
25
146
34
211
1.66
1.97
3.9
3.8
0.47
0.53
%
0.08
15
58
12
51
2.39
1.96
4.2
2.5
58.75
60.63
%
0.14
12
51
12
51
2.39
1.96
4.0
2.2
4.11
4.93
e9/l
0.72
12
51
42
277
1.57
1.92
4.3
3.6
—
—
—
0
0
55
386
1.48
1.90
6.1
3.9
—
—
—
0
0
31
190
1.68
1.89
3.9
3.7
25.05
24.24
mmol/l
0.53
31
182
8
28
2.89
1.87
2.8
2.8
—
—
—
0
0
163
1368
1.29
1.86
3.5
3.1
1269.42
1843.17
ng/l
1.77
149
1186
330
3548
0.77
1.79
30.6
14.3
—
—
—
0
0
15
74
2.06
1.77
1.5
1.2
—
—
—
0
0
72
941
0.72
1.77
1.7
1.7
469.10
418.24
pmol/l
0.74
62
764
6
18
3.36
1.75
4.3
2.1
—
—
—
0
0
35
227
1.58
1.73
4.0
3.8
0.13
0.05
%
0.37
15
55
59
428
1.43
1.73
1.7
1.7
—
—
—
0
0
36
239
1.55
1.63
3.9
3.7
0.81
0.78
%
0.04
16
67
112
1357
0.77
1.61
2.2
2.2
76.35
77.31
nmol/l
0.12
95
1145
15
77
1.98
1.61
1.6
2.8
—
—
—
0
0
42
290
1.49
1.59
2.9
4.4
—
—
—
0
0
7
26
2.72
1.58
3.0
3.9
7.84
7.45
mmol/l
—
7
14
147
1716
0.79
1.55
3.8
3.8
0.00
0.00
estimate
-0.00
38
275
39
267
1.50
1.54
1.9
2.0
0.18
0.20
g/l
0.82
39
237
255
2800
0.81
1.51
40.5
19.4
326.47
332.44
g/l
15.47
249
2774
38
261
1.50
1.49
1.3
1.4
—
—
—
0
0
147
1705
0.80
1.44
3.8
3.8
0.00
0.00
estimate
0.50
39
309
5
122
0.40
1.39
1.2
1.4
—
—
—
0
0
32
216
1.52
1.37
4.0
3.8
0.08
0.02
%
0.31
12
45
147
1691
0.81
1.31
5.0
5.1
0.00
0.00
estimate
-0.00
39
279
10
192
0.51
1.30
1.0
1.2
—
—
—
0
0
66
826
0.77
1.21
3.7
3.8
—
—
—
0
0
8
39
2.07
1.15
1.1
1.1
—
—
—
0
0
15
245
0.60
1.14
2.2
3.1
—
—
—
0
0
15
88
1.73
1.12
5.2
5.9
10.27
11.47
mmol/l
0.73
15
83
15
88
1.73
1.12
5.2
5.9
103.60
105.49
mmol/l
0.51
15
83
25
360
0.68
1.10
2.8
3.1
—
—
—
0
0
10
175
0.56
1.00
2.4
4.2
—
—
—
0
0
0
31
0.00
0.96
0.0
1.6
—
—
—
0
0
0
32
0.00
0.95
0.0
3.4
—
19.28
—
0
26
240
2566
0.87
0.79
4.2
4.3
—
—
—
0
0
5
97
0.51
0.79
1.2
1.3
1103.00
514.65
mg/l
—
5
91
46
567
0.79
0.78
1.3
1.2
1.00
1.84
u/ml
—
5
151
21
150
1.42
0.74
1.1
1.3
—
—
—
0
0
7
38
1.85
0.74
1.0
1.4
—
—
—
0
0
61
513
1.22
0.70
1.4
1.3
31.79
40.69
iu/ml
0.32
13
145
5
27
1.86
0.68
1.0
1.1
—
—
—
0
0
51
422
1.23
0.68
3.8
3.3
6.08
5.84
kpa
0.61
51
409
79
899
0.85
0.61
1.6
1.8
1046.62
1139.01
nmol/l
0.39
50
676
43
517
0.82
0.60
1.4
1.2
2.11
2.84
g/l
1.06
24
298
0
20
0.00
0.60
0.0
3.4
—
29.33
—
0
12
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
1.4
—
93.43
—
0
21
55
468
1.20
0.58
1.3
1.3
33.66
12.94
u/ml
0.43
12
160
275
2880
0.89
0.57
38.4
16.6
15.67
15.33
%
0.46
270
2816
19
141
1.36
0.57
1.2
1.4
—
—
—
0
0
23
177
1.31
0.55
4.6
4.2
0.86
0.87
%
0.11
23
171
6
40
1.51
0.51
1.0
1.2
—
—
—
0
0
40
338
1.20
0.47
1.5
1.6
—
—
—
0
0
5
82
0.61
0.46
1.2
1.3
5.72
4.05
mmol/l
—
5
75
129
1192
1.11
0.45
5.0
4.3
—
—
—
0
0
86
950
0.88
0.45
4.3
4.0
0.00
0.00
estimate
-0.00
37
266
10
69
1.46
0.44
3.2
2.7
—
—
—
0
0
256
2451
1.10
0.44
4.6
4.2
—
—
—
0
0
59
520
1.15
0.43
1.9
2.0
1.73
1.73
%
0.00
53
456
6
93
0.64
0.42
1.3
1.1
—
—
—
0
0
12
87
1.39
0.42
1.1
1.2
—
3.14
—
0
13
0
15
0.00
0.41
0.0
1.3
—
1.46
—
0
15
0
15
0.00
0.41
0.0
7.1
—
25.02
—
0
15
0
16
0.00
0.41
0.0
1.0
—
35.99
—
0
10
0
16
0.00
0.41
0.0
1.2
—
126.47
—
0
16
16
205
0.77
0.41
1.3
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.5
—
11.12
—
0
17
0
18
0.00
0.40
0.0
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
3.7
—
—
—
0
0
18
225
0.79
0.39
3.4
3.6
—
—
—
0
0
9
66
1.37
0.38
1.2
1.6
—
—
—
0
0
9
69
1.31
0.37
1.0
1.3
—
—
—
0
0
26
310
0.83
0.37
1.4
1.3
—
—
—
0
0
10
72
1.40
0.37
3.2
2.6
4.34
4.13
mmol/l
—
10
72
10
72
1.40
0.37
3.2
2.6
105.00
104.28
mmol/l
—
10
72
9
71
1.27
0.36
1.0
1.1
—
—
—
0
0
44
386
1.15
0.36
2.2
2.0
65.49
67.03
e9/l
0.10
30
303
6
44
1.37
0.34
1.0
1.2
0.57
0.58
nmol/l
—
6
39
6
45
1.34
0.34
1.0
1.2
—
—
—
0
0
22
183
1.21
0.32
4.3
4.1
1.81
1.66
%
0.37
22
177
16
128
1.26
0.32
1.3
1.2
—
—
—
0
0
7
54
1.30
0.30
1.9
5.9
6.59
7.36
mmol/l
—
7
43
17
206
0.82
0.29
2.5
2.4
—
—
—
0
0
131
1384
0.93
0.29
2.7
2.7
397.19
155.29
ug/l
2.54
124
1252
171
1633
1.07
0.29
5.0
4.2
37.13
71.51
ng/l
0.90
150
1259
5
71
0.70
0.26
1.2
1.4
—
—
—
0
0
108
1142
0.93
0.25
3.2
2.8
0.82
0.78
ug/l
0.24
84
816
13
105
1.24
0.25
1.0
1.2
—
—
—
0
0
45
410
1.11
0.23
2.0
3.0
170.64
257.41
ng/l
1.34
39
381
5
40
1.25
0.22
1.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
8.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
1786.18
—
0
11
0
11
0.00
0.21
0.0
7.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
167.38
—
0
6
0
10
0.00
0.21
0.0
17.5
—
1472.50
—
0
10
0
10
0.00
0.21
0.0
11.1
—
792.20
—
0
10
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
5
43
1.16
0.21
1.0
1.3
21.42
50.59
mu/l
—
5
37
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
6.2
—
—
—
0
0
14
117
1.20
0.20
1.1
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
2.2
—
42385.71
—
0
14
25
281
0.88
0.20
1.2
1.4
—
—
—
0
0
339
3444
0.95
0.20
36.8
14.5
47.73
26.65
mg/l
15.05
319
2698
83
877
0.94
0.19
3.7
3.5
—
—
—
0
0
11
90
1.23
0.19
11.4
3.3
1.75
1.76
mg/l
0.01
11
78
6
52
1.16
0.19
2.0
1.4
—
—
—
0
0
6
53
1.13
0.18
1.0
1.1
—
—
—
0
0
18
157
1.15
0.17
2.1
1.9
—
—
—
0
0
94
982
0.95
0.16
2.7
2.7
11386.24
10377.97
umol/l
0.04
78
840
204
1999
1.04
0.12
4.9
3.0
59.52
51.77
u/l
0.54
187
1817
128
1243
1.04
0.12
2.5
2.2
324.89
287.70
u/l
0.19
122
1138
255
2590
0.97
0.12
4.6
4.0
25.09
12.90
mm/h
8.91
244
2330
33
352
0.93
0.11
4.8
2.8
4.66
4.47
kpa
0.23
33
338
7
65
1.08
0.08
2.4
2.3
58.43
64.30
%
—
7
65
104
1018
1.03
0.07
2.0
2.2
3.62
3.02
mg/l
1.41
94
854
14
128
1.10
0.06
3.9
4.1
—
—
—
0
0
20
211
0.95
0.04
2.6
2.6
0.33
0.23
e6/l
0.38
20
206
12
129
0.93
0.03
1.4
1.9
—
—
—
0
0
109
1097
0.99
0.01
3.9
3.2
—
—
—
0
0
11
105
1.05
0.00
1.3
1.3
—
—
—
0
0
20
205
0.97
0.00
2.7
2.5
0.59
0.64
%
0.35
20
205
14
143
0.98
0.00
2.1
2.6
0.20
0.26
g/l
—
6
43
44
444
0.99
0.00
1.2
1.2
—
—
—
0
0
14
142
0.99
0.00
1.4
1.2
37.56
102.61
iu/ml
—
5
57
21
209
1.01
0.00
3.1
2.6
1.30
1.11
%
0.81
21
209
25
251
1.00
0.00
1.4
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
5.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
5
49
1.02
-0.00
2.0
3.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
16.53
—
0
9
0
6
0.00
-0.00
0.0
2.3
—
79.00
—
0
6
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
89
1.01
-0.00
2.1
2.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
27
270
1.00
-0.00
1.4
1.5
—
—
—
0
0
5
49
1.02
-0.00
1.2
2.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
8.6
—
0.67
—
0
9
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_MESOTHELIOMA_WIDE – Mesothelioma, including Hilmo

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).