Carcinoma in situ of penis

CD2_INSITU_PENIS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only males	226837
2. Check conditions not C3_PENIS	226721
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D07.4& Hospital discharge: ICD-9 — 2335 Cause of death: ICD-10 — D07.4& Cause of death: ICD-9 — 2335 Cancer registry: Topography ICD-O-3 — C60 Cancer registry: Morphology ICD-O-3 — ANY Cancer registry: Behaviour codes — 2 3 out of 7 registries used, show all original rules.	54
4. Check minimum number of events None	54
5. Include endpoints None	54
6. Filter based on genotype QC (FinnGen only)	54

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF9
Parent code in ICD-10: D07
Name in latin: Carcinoma in situ vesicae urinariae

NAME	CD2_INSITU_PENIS
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	1
INCLUDE
PRE_CONDITIONS
CONDITIONS	!C3_PENIS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D074
HD_ICD_9	2335
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D074
COD_ICD_9	2335
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO	C60
CANC_TOPO_EXCL
CANC_MORPH	ANY
CANC_MORPH_EXCL
CANC_BEHAV	2

Similar endpoints

↥

List of similar endpoints to Carcinoma in situ of penis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Carcinoma in situ of penis

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	54	-	54
Unadjusted period prevalence (%)	0.02	-	0.02
Median age at first event (years)	66.19	-	66.19

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768443) Skin Pathology biopsy report

11.15

12.11

1.6

1.2

—

(3042936) Bacteria identified in Isolate by Culture

3.82

4.95

1.8

2.8

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

5.11

4.29

2.3

1.7

—

(40768804) Tissue Pathology biopsy report

165

3.06

3.93

3.6

2.1

—

(42870588) Differential panel, method unspecified - Blood

151

2.99

3.79

13.2

6.7

—

(3000494) Fungus identified in Specimen by Culture

3.39

3.50

1.3

2.0

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

7.12

3.30

1.6

1.1

—

(40758558) Short blood count panel - Blood

2.83

3.19

14.1

7.0

—

(4035726)

3.41

3.18

1.7

1.4

—

(3002256) Pathology report gross observation

3.08

3.02

1.5

1.3

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.76

2.73

4.0

2.6

0.8

0.5

e6/l

0.17

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.72

2.66

3.9

2.3

0.2

0.6

e6/l

1.59

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.18

2.35

2.0

1.3

—

(3001604) Monocytes [#/volume] in Blood

219

2.30

2.25

9.6

6.1

0.7

0.6

e9/l

0.29

192

(3006315) Basophils [#/volume] in Blood

219

2.30

2.25

9.6

6.2

0.0

e9/l

0.08

193

(3013115) Eosinophils [#/volume] in Blood

223

2.23

2.11

10.8

6.5

0.2

e9/l

0.04

199

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.42

2.06

3.0

1.8

—

(36304419) Bacteria [Presence] in Urine

127

2.24

2.05

4.5

2.9

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.67

2.04

1.7

3.0

—

(3049717) Cytology report of Urine Cyto stain

3.67

2.04

3.0

3.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

179

2.17

2.03

2.4

1.8

95.5

86.4

pmol/l

0.34

108

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

3.50

1.95

2.4

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

2.32

1.89

3.1

3.5

31.9

173.0

ng/l

1.55

(3000492) Spirometry study

2.77

1.88

2.3

1.5

—

(3021589) Normoblasts [#/volume] in Blood

196

2.04

1.75

12.9

13.9

0.0

e9/l

0.51

165

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

3.82

1.65

1.2

1.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

191

1.97

1.61

4.9

5.9

—

(3044640) Blood type and Crossmatch panel - Blood

139

1.98

1.56

3.8

3.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.29

1.52

1.4

1.6

—

(3022948) Iron [Moles/volume] in Serum or Plasma

2.09

1.45

3.4

2.0

14.7

12.6

umol/l

0.37

(3009542) Hematocrit [Volume Fraction] of Blood

348

2.16

1.44

37.5

18.8

40.5

41.1

0.25

231

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

178

1.89

1.44

5.0

3.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

199

1.85

1.36

3.8

4.3

34.3

36.4

ng/l

0.07

154

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

2.09

1.33

3.7

1.9

28.7

23.4

0.41

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.21

1.33

2.1

1.7

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.04

1.32

3.3

1.9

2.2

g/l

0.01

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.95

1.31

1.0

1.8

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.95

1.31

8.6

41.7

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.95

1.31

3.6

1.7

—

(3023368) Bacteria identified in Blood by Culture

164

1.83

1.31

7.5

5.4

—

(1761868) Lipid panel - Serum or Plasma

149

0.46

1.29

3.1

3.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

105

1.90

1.25

4.2

3.4

—

(3000991) Gas panel - Venous blood

2.23

1.21

9.1

9.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.18

1.20

2.2

1.6

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.65

1.18

1.2

1.7

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.65

1.18

4.8

2.1

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

2.44

1.15

2.1

2.4

106.1

223.3

ng/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

218

1.71

1.10

3.3

2.3

—

(4034850)

0.00

1.01

0.0

14.5

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

347

1.75

0.93

15.1

8.8

89.4

79.6

u/l

0.58

331

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

395

1.83

0.85

27.9

17.1

78.5

78.3

ml/min/173m2

0.02

332

(3007853) Bacteria identified in Skin by Aerobe culture

1.82

0.85

1.5

2.1

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.80

0.0

1.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

423

1.86

0.79

33.4

18.5

40.0

27.0

mg/l

0.79

357

(40768797) Stomach Pathology biopsy report

1.73

0.77

1.3

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.91

0.76

2.0

1.4

—

(3022313) Gas panel - Capillary blood

2.01

0.72

9.6

4.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

284

1.53

0.72

6.6

4.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.76

0.71

3.7

1.6

—

(3000850) Epithelial cells [#/volume] in Urine

1.60

0.67

2.7

2.8

4.6

3.0

e6/l

0.37

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.60

0.67

4.6

2.9

—

(3007164) IgA [Mass/volume] in Serum or Plasma

1.66

0.65

1.7

1.3

2.1

2.5

g/l

—

(3003694) ABO and Rh group [Type] in Blood

107

1.56

0.64

1.2

1.4

—

(3003396) Base excess in Arterial blood by calculation

1.60

0.62

6.8

19.6

-0.3

1.2

mmol/l

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

342

1.51

0.60

5.7

5.1

3.7

3.6

ug/l

0.01

310

(3009343) pH of Capillary blood

1.75

0.59

9.2

4.1

—

7.4

—

(4010399)

1.70

0.58

1.0

1.3

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

1.49

0.55

1.3

1.2

—

0.8

—

(40761535) Cells panel - Urine sediment

1.60

0.55

8.2

3.1

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.56

0.50

1.9

1.8

1.5

2.2

—

(3022145) Colonoscopy Study observation

1.53

0.49

1.7

1.3

—

(3044889) 12 lead EKG panel

307

1.40

0.49

4.6

—

(40760892) CBC W Ordered Manual Differential panel - Blood

101

0.65

0.45

5.4

4.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.62

0.43

3.0

1.5

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.62

0.43

6.8

7.2

23.4

24.8

mmol/l

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

1.62

0.43

2.6

2.5

—

58.3

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

0.00

0.42

0.0

1.5

—

0.0

—

(3012501) Base excess in Blood by calculation

0.00

0.42

0.0

2.8

—

2.9

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.42

0.0

2.8

—

7.9

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.42

0.0

2.8

—

5.1

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.48

0.37

1.8

1.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

169

0.77

0.29

4.2

3.6

—

(3002032) Base excess in Venous blood by calculation

1.35

0.24

10.0

3.3

0.6

2.3

mmol/l

—

(4094501)

0.00

0.21

0.0

1.3

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.4

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

1.0

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.21

0.0

1.9

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.21

0.0

5.9

—

1.6

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.21

0.0

5.9

—

7.0

—

(40767503) Oxygen content in Capillary blood by calculation

0.00

0.21

0.0

3.2

—

15.0

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

0.00

0.21

0.0

3.0

—

122.3

—

(3050449) Albumin [Mass/time] in Urine collected for unspecified duration

0.00

0.20

0.0

2.3

—

228.6

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.21

0.19

4.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

119

0.80

0.17

2.6

3.4

—

(3026008) Bacteria identified in Urine by Culture

112

1.21

0.16

3.6

2.8

—

(40761511) CBC panel - Blood by Automated count

432

1.25

0.14

25.8

18.3

—

(3019225) pH of Specimen

1.10

0.10

8.4

5.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.10

0.09

11.3

9.0

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

272

1.06

0.02

4.2

4.5

16.6

21.7

1.00

140

(3032080) INR in Blood by Coagulation assay

214

1.05

0.00

9.2

10.7

1.5

1.3

inr

—

(3013512) EKG study

146

1.04

0.00

7.1

5.1

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

2.4

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.1

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

1.6

—

4.9

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

11.1

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.0

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.1

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.1

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.6

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

3.7

—

4.0

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3040151) Glucose [Moles/volume] in Capillary blood

0.00

0.0

5.0

—

6.5

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

0.85

0.00

2.4

5.3

3.1

81.6

ug/l

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

1.8

—

(3004451) EKG impression Narrative

0.00

0.0

1.3

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

2.4

—

15.6

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

0.3

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.0

2.0

—

1.6

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

16.8

—

1065.8

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.8

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

12.5

—

(3021788) Differential panel - Synovial fluid

0.00

0.0

1.1

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

3.7

—

105.2

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

9.6

—

584.8

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

4.5

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

2.2

—

59.3

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

3.7

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

0.0

1.5

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: CD2_INSITU_PENIS – Carcinoma in situ of penis

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Carcinoma in situ of penis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Carcinoma in situ of penis (CD2_INSITU_PENIS)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints